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16 results on '"Kimble, J. Brian"'

1. Rift Valley Fever

Author

Kimble, J. Brian, Noronha, Leela, Trujillo, Jessie D., Mitzel, Dana, Richt, Juergen A., and Wilson, William C.

Published
2024
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2. A single dose intranasal combination panebolavirus vaccine

Author

Malherbe, Delphine C, primary, Kimble, J Brian, additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Meyer, Michelle, additional, Cody, S. Gabrielle, additional, Hyde, Matthew, additional, Alter, Galit, additional, and Bukreyev, Alexander, additional

Published
2023
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3. Swine-to-Ferret Transmission of Antigenically Drifted Contemporary Swine H3N2 Influenza A Virus Is an Indicator of Zoonotic Risk to Humans

Author

Souza, Carine K., primary, Kimble, J. Brian, additional, Anderson, Tavis K., additional, Arendsee, Zebulun W., additional, Hufnagel, David E., additional, Young, Katharine M., additional, Gauger, Phillip C., additional, Lewis, Nicola S., additional, Davis, C. Todd, additional, Thor, Sharmi, additional, and Vincent Baker, Amy L., additional

Published
2023
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4. Antigenic Characterization and Pandemic Risk Assessment of North American H1 Influenza A Viruses Circulating in Swine

Author

Venkatesh, Divya, primary, Anderson, Tavis K., additional, Kimble, J. Brian, additional, Chang, Jennifer, additional, Lopes, Sara, additional, Souza, Carine K., additional, Pekosz, Andrew, additional, Shaw-Saliba, Kathryn, additional, Rothman, Richard E., additional, Chen, Kuan-Fu, additional, Lewis, Nicola S., additional, and Vincent Baker, Amy L., additional

Published
2022
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6. Interspecies Transmission from Pigs to Ferrets of Antigenically Distinct Swine H1 Influenza A Viruses with Reduced Reactivity to Candidate Vaccine Virus Antisera as Measures of Relative Zoonotic Risk

Author

Kimble, J. Brian, primary, Souza, Carine K., additional, Anderson, Tavis K., additional, Arendsee, Zebulun W., additional, Hufnagel, David E., additional, Young, Katharine M., additional, Lewis, Nicola S., additional, Davis, C. Todd, additional, Thor, Sharmi, additional, and Vincent Baker, Amy L., additional

Published
2022
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7. Interspecies transmission from pigs to ferrets of antigenically distinct swine H1 influenza A viruses with loss in reactivity to human vaccine virus antisera as measures of relative zoonotic risk

Author

Kimble, J. Brian, primary, Souza, Carine K., additional, Anderson, Tavis K., additional, Arendsee, Zebulun W., additional, Hufnagel, David E., additional, Young, Katharine M., additional, Lewis, Nicola S., additional, Davis, C. Todd, additional, and Vincent Baker, Amy L., additional

Published
2022
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12. Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine

Author

Kimble, J. Brian, primary, Malherbe, Delphine C., additional, Meyer, Michelle, additional, Gunn, Bronwyn M., additional, Karim, Marcus M., additional, Ilinykh, Philipp A., additional, Iampietro, Mathieu, additional, Mohamed, Khaled S., additional, Negi, Surendra, additional, Gilchuk, Pavlo, additional, Huang, Kai, additional, Wolf, Yuri I., additional, Braun, Werner, additional, Crowe, James E., additional, Alter, Galit, additional, and Bukreyev, Alexander, additional

Published
2019
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13. Aerosol transmission from i nfected swine to ferrets of an H3N2 virus collected from an agricultural fair and associated with human variant infections.

Author

Kaplan, Bryan S., Kimble, J. Brian, Chang, Jennifer, Anderson, Tavis K., Gauger, Phillip C., Janas-Martindale, Alicia, Killian, Mary Lea, Bowman, Andrew S., and Vincent, Amy L.

Subjects
*AGRICULTURAL exhibitions, *INFLUENZA A virus, H3N2 subtype, *FERRET, *SWINE, *PANDEMICS, *AEROSOLS, *SWINE breeding, *HUMAN-machine relationship
Abstract

Influenza A viruses (IAV) sporadically transmit from swine to humans, typically associated with agricultural fairs in the USA. A human seasonal H3 from the 2010-2011 IAV season was introduced into the US swine population and termed H3.2010.1 to differentiate from the previous swine H3. This H3N2 lineage became widespread in the US commercial swine population, subsequently spilling over into exhibition swine, and caused a majority of H3N2 variant (H3N2v) cases in humans in 2016 and 2017. A cluster of human H3N2v cases were reported at an agricultural fair in Ohio in 2017 where 2010.1 H3N2 IAV was concurrently detected in exhibition swine. Genomic analysis showed the swine and human isolates were nearly identical. Here we evaluated the propensity of a 2010.1 H3N2 IAV (A/swine/Ohio/A01354299/2017; sw/OH/2017) isolated from a pig in the agricultural fair outbreak to replicate in ferrets and transmit from swine to ferret. Sw/OH/2017 displayed robust replication in the ferret respiratory tract, causing slight fever and moderate weight loss. Further, sw/OH/2017 was capable of efficient respiratory droplet transmission from infected pigs to contact ferrets. These findings establish a model for evaluating the propensity of swine IAV to transmit from pig-to-ferret as a measure of risk to the human population. The identification of higher risk swine strains can then be targeted for control measures to limit the dissemination at human-swine interfaces to reduce the risk of zoonotic infections and inform pandemic planning. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Swine Influenza A Viruses and the Tangled Relationship with Humans.

Author

Anderson TK, Chang J, Arendsee ZW, Venkatesh D, Souza CK, Kimble JB, Lewis NS, Davis CT, and Vincent AL

Subjects
Animals, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype genetics, Influenza A Virus, H1N2 Subtype genetics, Influenza A Virus, H3N2 Subtype genetics, Orthomyxoviridae Infections transmission, Orthomyxoviridae Infections virology, Phylogeny, Influenza A virus genetics, Influenza, Human epidemiology, Orthomyxoviridae Infections epidemiology, Swine virology
Abstract

Influenza A viruses (IAVs) are the causative agents of one of the most important viral respiratory diseases in pigs and humans. Human and swine IAV are prone to interspecies transmission, leading to regular incursions from human to pig and vice versa. This bidirectional transmission of IAV has heavily influenced the evolutionary history of IAV in both species. Transmission of distinct human seasonal lineages to pigs, followed by sustained within-host transmission and rapid adaptation and evolution, represent a considerable challenge for pig health and production. Consequently, although only subtypes of H1N1, H1N2, and H3N2 are endemic in swine around the world, extensive diversity can be found in the hemagglutinin (HA) and neuraminidase (NA) genes, as well as the remaining six genes. We review the complicated global epidemiology of IAV in swine and the inextricably entangled implications for public health and influenza pandemic planning., (Copyright © 2021 Cold Spring Harbor Laboratory Press; all rights reserved.)

Published
2021
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