8 results on '"Kimberly Morel"'
Search Results
2. eP161: Homozygous deletion of the terminal exon of DSG3 associated with acantholytic blistering of the oral and laryngeal mucosa
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Theresa Kowalski, Nan Jiang, Christine Lauren, Kimberly Morel, Susannah Hills, Taylor Sewell, Jun Liao, and Lakshmi Mehta
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Genetics (clinical) - Published
- 2022
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3. MEMPSEP‐II. Forecasting the Properties of Solar Energetic Particle Events Using a Multivariate Ensemble Approach
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Maher A. Dayeh, Subhamoy Chatterjee, Andrés Muñoz‐Jaramillo, Kimberly Moreland, Hazel M. Bain, and Samuel T. Hart
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space weather ,forecasting SEP occurrence ,forecasting SEP properties ,Meteorology. Climatology ,QC851-999 ,Astrophysics ,QB460-466 - Abstract
Abstract Solar Energetic Particles (SEPs) form a critical component of Space Weather. The complex, intertwined dynamics of SEP sources, acceleration, and transport make their forecasting very challenging. Yet, information about SEP arrival and their properties (e.g., peak flux) is crucial for space exploration on many fronts. We have recently introduced a novel probabilistic ensemble model called the Multivariate Ensemble of Models for Probabilistic Forecast of Solar Energetic Particles (MEMPSEP). Its primary aim is to forecast the occurrence and physical properties of SEPs. The occurrence forecasting, thoroughly discussed in a preceding paper (MEMPSEP‐I by Chatterjee et al., 2024a, https://doi.org/10.1029/2023sw003568), is complemented by the work presented here, which focuses on forecasting the physical properties of SEPs. The MEMPSEP model relies on an ensemble of Convolutional Neural Networks, which leverage a multi‐variate data set comprising full‐disc magnetogram sequences and numerous derived and in‐situ data from various sources (MEMPSEP‐III by Moreland et al., 2024, https://doi.org/10.1029/2023SW003765). Skill scores demonstrate that MEMPSEP exhibits improved predictions on SEP properties for the test set data with SEP occurrence probability above 50%, compared to those with a probability below 50%. Results present a promising approach to address the challenging task of forecasting SEP physical properties, thus improving our forecasting capabilities and advancing our understanding of the dominant parameters and processes that govern SEP production.
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- 2024
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4. MEMPSEP‐I. Forecasting the Probability of Solar Energetic Particle Event Occurrence Using a Multivariate Ensemble of Convolutional Neural Networks
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Subhamoy Chatterjee, Maher A. Dayeh, Andrés Muñoz‐Jaramillo, Hazel M. Bain, Kimberly Moreland, and Samuel Hart
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Meteorology. Climatology ,QC851-999 ,Astrophysics ,QB460-466 - Abstract
Abstract The Sun continuously affects the interplanetary environment through a host of interconnected and dynamic physical processes. Solar flares, Coronal Mass Ejections (CMEs), and Solar Energetic Particles (SEPs) are among the key drivers of space weather in the near‐Earth environment and beyond. While some CMEs and flares are associated with intense SEPs, some show little to no SEP association. To date, robust long‐term (hours‐days) forecasting of SEP occurrence and associated properties (e.g., onset, peak intensities) does not effectively exist and the search for such development continues. Through an Operations‐2‐Research support, we developed a self‐contained model that utilizes a comprehensive data set and provides a probabilistic forecast for SEP event occurrence and its properties. The model is named Multivariate Ensemble of Models for Probabilistic Forecast of Solar Energetic Particles (MEMPSEP). MEMPSEP workhorse is an ensemble of Convolutional Neural Networks that ingests a comprehensive data set (MEMPSEP‐III by Moreland et al. (2024, https://doi.org/10.1029/2023SW003765)) of full‐disc magnetogram‐sequences and in situ data from different sources to forecast the occurrence (MEMPSEP‐I—this work) and properties (MEMPSEP‐II by Dayeh et al. (2024, https://doi.org/10.1029/2023SW003697)) of a SEP event. This work focuses on estimating true SEP occurrence probabilities achieving a 2.5% improvement in reliability and a Brier score of 0.14. The outcome provides flexibility for the end‐users to determine their own acceptable level of risk, rather than imposing a detection threshold that optimizes an arbitrary binary classification metric. Furthermore, the model‐ensemble, trained to utilize the large class‐imbalance between events and non‐events, provides a clear measure of uncertainty in our forecast.
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- 2024
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5. MEMPSEP‐III. A Machine Learning‐Oriented Multivariate Data Set for Forecasting the Occurrence and Properties of Solar Energetic Particle Events Using a Multivariate Ensemble Approach
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Kimberly Moreland, Maher A. Dayeh, Hazel M. Bain, Subhamoy Chatterjee, Andrés Muñoz‐Jaramillo, and Samuel T. Hart
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SEPs ,forecasting ,data set ,model ,data curation ,machine learning ,Meteorology. Climatology ,QC851-999 ,Astrophysics ,QB460-466 - Abstract
Abstract We introduce a new multivariate data set that utilizes multiple spacecraft collecting in‐situ and remote sensing heliospheric measurements shown to be linked to physical processes responsible for generating solar energetic particles (SEPs). Using the Geostationary Operational Environmental Satellites (GOES) flare event list from Solar Cycle (SC) 23 and part of SC 24 (1998–2013), we identify 252 solar events (>C‐class flares) that produce SEPs and 17,542 events that do not. For each identified event, we acquire the local plasma properties at 1 au, such as energetic proton and electron data, upstream solar wind conditions, and the interplanetary magnetic field vector quantities using various instruments onboard GOES and the Advanced Composition Explorer spacecraft. We also collect remote sensing data from instruments onboard the Solar Dynamic Observatory, Solar and Heliospheric Observatory, and the Wind solar radio instrument WAVES. The data set is designed to allow for variations of the inputs and feature sets for machine learning (ML) in heliophysics and has a specific purpose for forecasting the occurrence of SEP events and their subsequent properties. This paper describes a data set created from multiple publicly available observation sources that is validated, cleaned, and carefully curated for our ML pipeline. The data set has been used to drive the newly‐developed Multivariate Ensemble of Models for Probabilistic Forecast of SEPs (MEMPSEP; see MEMPSEP‐I (Chatterjee et al., 2024, https://doi.org/10.1029/2023SW003568) and MEMPSEP‐II (Dayeh et al., 2024, https://doi.org/10.1029/2023SW003697) for accompanying papers).
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- 2024
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6. Assessment of Infantile Hemangiomas Using a Handheld Wireless Diffuse Optical Spectroscopic Device
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Lauren Geller, Jennifer W. Hoi, Maria C. Garzon, Christine T. Lauren, June Wu, Andreas H. Hielscher, Nina Antonov, Hyun K. Kim, Kimberly Morel, Nicole Weitz, and Christopher J. Fong
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medicine.medical_specialty ,Adrenergic beta-Antagonists ,Timolol ,Pilot Projects ,Dermatology ,Propranolol ,Article ,Lesion ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Vascularity ,030225 pediatrics ,Medicine ,Humans ,Longitudinal Studies ,Child ,Spectroscopy, Near-Infrared ,business.industry ,Infant ,Oxygenation ,Hypoxia (medical) ,Response to treatment ,Surgery ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business ,Nuclear medicine ,Normal skin ,Hemangioma ,Wireless Technology ,medicine.drug - Abstract
Background/Objectives Infantile hemangiomas (IHs) are vascular tumors with the potential for significant morbidity. There is a lack of validated objective tools to assess IH severity and response to treatment. Diffuse optical spectroscopy (DOS), a noninvasive, nonionizing imaging modality, can measure total hemoglobin concentration and hemoglobin oxygen saturation in tissue to assess IH vascularity and response to treatment. Our objective was to evaluate the utility of a wireless, handheld DOS system to assess IH characteristics at selected points during their clinical course. Methods Thirteen subjects (initial age 5.8 ± 2.0 mos) with 15 IHs were enrolled. IHs were classified as proliferative, plateau phase, or involuting. Nine patients with 11 IHs were untreated; four patients with 4 IHs were treated with timolol or propranolol. Each IH was evaluated by placing the DOS system directly on the lesion as well a normal contralateral skin site. IH vascularity and oxygenation were scored using a newly defined normalized hypoxia fraction (NHF) coefficient. Measurements were recorded at various intervals from the initial visit to 1 to 2 years of age. Results For the nine untreated IHs, the NHF was highest at 6 months of age, during proliferation. Differences in NHFs between the proliferation and the plateau (p = 0.02) and involuting (p < 0.001) stages were statistically significant. In treated patients, the NHF normalized to 60% after 2 months. One treated IH came within 5% of the NHF for normal skin after 12 months. Conclusions DOS can be used to assess the vascularity and tissue oxygenation of IHs and monitor their progression and response to treatment.
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- 2017
7. Adult naris closure profoundly reduces tyrosine hydroxylase expression in mouse olfactory bulb
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Donna M. Stone, Harriet Baker, Joel A. Maruniak, and Kimberly Morel
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Male ,Olfactory system ,medicine.medical_specialty ,Tyrosine 3-Monooxygenase ,Dopamine ,Glutamate decarboxylase ,Central nervous system ,Biology ,Mice ,Internal medicine ,medicine ,Animals ,Neurons, Afferent ,Molecular Biology ,In Situ Hybridization ,Denervation ,Tyrosine hydroxylase ,Glutamate Decarboxylase ,General Neuroscience ,Immunohistochemistry ,Olfactory Bulb ,Olfactory bulb ,Smell ,Phenotype ,Endocrinology ,medicine.anatomical_structure ,biology.protein ,Neurology (clinical) ,Nasal Obstruction ,Sensory Deprivation ,Olfactory marker protein ,Biomarkers ,Developmental Biology ,medicine.drug - Abstract
Peripheral afferent innervation appears to be required for the expression of the dopamine phenotype in the rodent main olfactory bulb. Experiments utilizing neonatal naris closure as a means of sensory deprivation also suggest that odor-induced afferent activity is required for the expression of the phenotype. These experiments are confounded, however, by the significant postnatal maturation of the dopamine system. The current experiments utilized adult unilateral naris closure to address this issue. As with neonatal closure, adult deprivation produces a profound reduction in the expression of tyrosine hydroxylase (TH), the first enzyme in the dopamine biosynthetic pathway. By 4 days a small decrease is observed in TH activity and immunoreactivity. Activity reaches a nadir of 12% of control levels at about 1 month. TH mRNA is reduced similarly when analyzed at about 2 months post-closure. Glutamic acid decarboxylase protein and mRNA expression, which are co-localized with TH, remain at close to control levels indicating the continued presence of the dopamine neurons. The time-course of the loss of TH is identical to that for zinc sulphate-induced denervation of the olfactory bulb. These data support the hypothesis that odor modulated afferent activity is required for expression of the dopamine phenotype and that, if a trophic factor is involved, its release is also activity dependent.
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- 1993
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8. Homogenizing SOHO/EIT and SDO/AIA 171 Å Images: A Deep-learning Approach
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Subhamoy Chatterjee, Andrés Muñoz-Jaramillo, Maher A. Dayeh, Hazel M. Bain, and Kimberly Moreland
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Solar corona ,Convolutional neural networks ,Calibration ,Solar atmosphere ,Solar extreme ultraviolet emission ,Astrophysics ,QB460-466 - Abstract
Extreme-ultraviolet (EUV) images of the Sun are becoming an integral part of space weather prediction tasks. However, having different surveys requires the development of instrument-specific prediction algorithms. As an alternative, it is possible to combine multiple surveys to create a homogeneous data set. In this study, we utilize the temporal overlap of Solar and Heliospheric Observatory Extreme ultraviolet Imaging Telescope and Solar Dynamics Observatory Atmospheric Imaging Assembly 171 Å surveys to train an ensemble of deep-learning models for creating a single homogeneous survey of EUV images for two solar cycles. Prior applications of deep learning have focused on validating the homogeneity of the output while overlooking the systematic estimation of uncertainty. We use an approach called “approximate Bayesian ensembling” to generate an ensemble of models whose uncertainty mimics that of a fully Bayesian neural network at a fraction of the cost. We find that ensemble uncertainty goes down as the training set size increases. Additionally, we show that the model ensemble adds immense value to the prediction by showing higher uncertainty in test data that are not well represented in the training data.
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- 2023
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