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6. DIALYSIS BONE DISEASE

Author

Fusaro, M., primary, Giannini, S., additional, Miozzo, D., additional, Noale, M., additional, Tripepi, G., additional, Plebani, M., additional, Zaninotto, M., additional, Piccoli, A., additional, Vilei, M. T., additional, Cristofaro, R., additional, Gallieni, M., additional, Hamamoto, K., additional, Inaba, M., additional, Okuno, S., additional, Imanishi, Y., additional, Ishimura, E., additional, Yamakawa, T., additional, Shoji, S., additional, Rothe, H. M., additional, Eller, P., additional, Mayer, G., additional, Ketteler, M., additional, Kramar, R., additional, Shaheen, F., additional, Al Rukhaimi, M., additional, Alsahow, A., additional, Al-Ali, F., additional, Al Salmi, I., additional, Al Ghareeb, S., additional, Wang, M., additional, Bieber, B., additional, Robinson, B. M., additional, Pisoni, R. L., additional, Waniewski, J., additional, Debowska, M., additional, Wojcik-Zaluska, A., additional, Ksiazek, A., additional, Zaluska, W., additional, De Broe, M. E., additional, Wilson, R. J., additional, Copley, J. B., additional, Hiramtasu, R., additional, Ubara, Y., additional, Hoshino, J., additional, Takaichi, K., additional, Ghalli, F. G., additional, Ibakkanavar, R., additional, Chess, J., additional, Roberts, G., additional, Riley, S., additional, Oliveira, A. S. A., additional, Carvalho, C. J. B., additional, Oliveira, C. B. L., additional, Pessoa, C. T. B. C., additional, Leao, R. A. S., additional, Gueiros, J. E. B., additional, Gueiros, A. P. S., additional, Okano, K., additional, Tsuruta, Y., additional, Hibi, A., additional, Tsukada, M., additional, Miwa, N., additional, Kimata, N., additional, Tsuchiya, K., additional, Akiba, T., additional, Nitta, K., additional, Mizobuchi, M., additional, Ogata, H., additional, Hosaka, N., additional, Sanada, D., additional, Arai, N., additional, Koiwa, F., additional, Kinugasa, E., additional, Shibata, T., additional, Akizawa, T., additional, Delanaye, P., additional, Krzesinski, J.-M., additional, Warling, X., additional, Moonen, M., additional, Smelten, N., additional, Medart, L., additional, Pottel, H., additional, Cavalier, E., additional, Souberbielle, J.-C., additional, Gadisseur, R., additional, Dubois, B. E., additional, Matias, P., additional, Jorge, C., additional, Mendes, M., additional, Azevedo, A., additional, Navarro, D., additional, Ferreira, C., additional, Amaral, T., additional, Aires, I., additional, Gil, C., additional, Ferreira, A., additional, Kikuchi, H., additional, Shimada, H., additional, Karasawa, R., additional, Suzuki, M., additional, An, W. S., additional, Lee, S. M., additional, Oh, Y. J., additional, Son, Y. K., additional, De Paola, L., additional, Lombardi, G., additional, Panzino, M. T., additional, Lombardi, L., additional, Reichel, H., additional, Hahn, K.-M., additional, Kohnle, M., additional, Guggenberger, C., additional, Delanna, F., additional, Sasaki, N., additional, Tsunoda, M., additional, Ikee, R., additional, Hashimoto, N., additional, Sola, L., additional, Leyun, M. N., additional, Diaz, J. C., additional, Sehabiague, C., additional, Gonzalez, S., additional, Alallon, W., additional, Bourbeau, K., additional, Lajoie, C., additional, Macway, F., additional, Fujii, T., additional, Suzuki, S., additional, Shinozaki, M., additional, Tanaka, H., additional, Klingele, M., additional, Seiler, S., additional, Poppleton, A., additional, Lepper, P., additional, Fliser, D., additional, Seidel, R., additional, Lun, L., additional, Liu, D., additional, Li, X., additional, Wei, X., additional, Miao, J., additional, Gao, Z., additional, Hu, R., additional, Gros, B., additional, Galan, A., additional, Gonzalez-Parra, E., additional, Herrero, J. A., additional, Echave, M., additional, Vegter, S., additional, Tolley, K., additional, Oyaguez, I., additional, Gutzwiller, F. S., additional, Braunhofer, P. G., additional, Szucs, T. D., additional, Schwenkglenks, M., additional, Yilmaz, V. T., additional, Ozdem, S., additional, Donmez, L., additional, Kocak, H., additional, Dinckan, A., additional, Cetinkaya, R., additional, Suleymanlar, G., additional, and Ersoy, F. F., additional

Published
2014
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7. Catheter dysfunction and thrombosis of double-lumen hemodialysis catheters placed in the femoral vein

Author

Kosaku Nitta, Akira Kawashima, T Aoki, T Haga, Naoko Miwa, K Suzuki, Kimata N, Yuzo Watanabe, Takashi Akiba, Hiroshi Nihei, E Nishida, and K Tominaga

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Hemodialysis Catheter, Femoral vein, Lumen (anatomy), Catheters, Indwelling, Renal Dialysis, medicine, Humans, Thrombus, Aged, Ultrasonography, Aged, 80 and over, business.industry, Thrombosis, General Medicine, Femoral Vein, Middle Aged, medicine.disease, Surgery, Catheter, Nephrology, cardiovascular system, Equipment Failure, Female, Hemodialysis, business, Venous return curve
Abstract

Objective Intraluminal thrombosis of the catheter was thought to be a major cause of catheter dysfunction. We evaluated if thrombi appear in the luminal side or outside of the catheters placed in the femoral vein in 21 hemodialysis patients. Methods 23 double-lumen catheter (25 cm long and 4 mm diameter polyurethane) strippings were consecutively performed. Mean catheter dwell time was 17.9 +/- 11.2 days (2-45 days). The femoral vein was observed with ultrasound echography, and thrombo-venous ratio (thrombus diameter/vein diameter) was calculated. X-rays were also taken to clearly visualize the thrombi followed by contrast medium injection through the catheter. Results Tube-shaped thrombi were echographically detected in 22 of 23 catheters (95.7%) when the catheter was stripped. Ten catheters (43.5%) were stripped due to the reduced blood flow, and tube-shaped thrombi were observed in the femoral vein, whereas no thrombus was found in the intraluminal side of the catheter. In 7 of 23 patients (30.4%) with leg edema on the same side of the catheter, the thrombovenous ratio was 78.9 +/- 7.4%, which was higher than that in the patients without leg edema (52.1 +/- 11.1%). Conclusion The tube-shaped thrombi, formed around the double-lumen catheter, may cause catheter dysfunction and reduced venous return of the lower legs. The catheter should be removed as soon as thrombosis is diagnosed, especially when accompanied by leg edema.

Published
2002

8. CKD-MBD II

Author

Fujii, T., primary, Suzuki, S., additional, Shinozaki, M., additional, Tanaka, H., additional, Bell, S., additional, Cooper, S., additional, Lomonte, C., additional, Libutti, P., additional, Chimienti, D., additional, Casucci, F., additional, Bruno, A., additional, Antonelli, M., additional, Lisi, P., additional, Cocola, L., additional, Basile, C., additional, Negri, A., additional, Del Valle, E., additional, Zanchetta, M., additional, Zanchetta, J., additional, Di Vico, M. C., additional, Ferraresi, M., additional, Pia, A., additional, Aroasio, E., additional, Gonella, S., additional, Mongilardi, E., additional, Clari, R., additional, Moro, I., additional, Piccoli, G. B., additional, Gonzalez-Parra, E., additional, Rodriguez-Osorio, L., additional, Ortiz-Arduan, A., additional, de la Piedra, C., additional, Egido, J., additional, Perez Gomez, M. V., additional, Tabikh, A. A., additional, Afsar, B., additional, Kirkpantur, A., additional, Imanishi, Y., additional, Yamagata, M., additional, Nagata, Y., additional, Ohara, M., additional, Michigami, T., additional, Yukimura, T., additional, Inaba, M., additional, Bieber, B., additional, Robinson, B., additional, Mariani, L., additional, Jacobson, S., additional, Frimat, L., additional, Bommer, J., additional, Pisoni, R., additional, Tentori, F., additional, Ciceri, P., additional, Elli, F., additional, Brancaccio, D., additional, Cozzolino, M., additional, Adamczak, M., additional, Wiecek, A., additional, Kuczera, P., additional, Sezer, S., additional, Bal, Z., additional, Tutal, E., additional, Kal, O., additional, Yavuz, D., additional, Y ld r m, I., additional, Sayin, B., additional, Ozelsancak, R., additional, Ozkurt, S., additional, Turk, S., additional, Ozdemir, N., additional, Lehmann, R., additional, Roesel, M., additional, Fritz, P., additional, Braun, N., additional, Ulmer, C., additional, Steurer, W., additional, Dagmar, B., additional, Ott, G., additional, Dippon, J., additional, Alscher, D., additional, Kimmel, M., additional, Latus, J., additional, Turkvatan, A., additional, Balci, M., additional, Mandiroglu, S., additional, Seloglu, B., additional, Alkis, M., additional, Serin, M., additional, Calik, Y., additional, Erkula, S., additional, Gorboz, H., additional, Mandiroglu, F., additional, Lindley, E., additional, Cruz Casal, M., additional, Rogers, S., additional, Pancirova, J., additional, Kernc, J., additional, Copley, J. B., additional, Fouque, D., additional, Kiss, I., additional, Kiss, Z., additional, Szabo, A., additional, Szegedi, J., additional, Balla, J., additional, Ladanyi, E., additional, Csiky, B., additional, orkossy, O., additional, Torok, M., additional, Turi, S., additional, Ambrus, C., additional, Deak, G., additional, Tisler, A., additional, Kulcsar, I., additional, K d r, V., additional, Altuntas, A., additional, Akp nar, A., additional, Orhan, H., additional, Sezer, M., additional, Filiopoulos, V., additional, Manolios, N., additional, Arvanitis, D., additional, Pani, I., additional, Panagiotopoulos, K., additional, Vlassopoulos, D., additional, Rodriguez-Ortiz, M. E., additional, Canalejo, A., additional, Herencia, C., additional, Martinez-Moreno, J. M., additional, Peralta-Ramirez, A., additional, Perez-Martinez, P., additional, Navarro-Gonzalez, J. F., additional, Rodriguez, M., additional, Peter, M., additional, Gundlach, K., additional, Steppan, S., additional, Passlick-Deetjen, J., additional, Munoz-Castaneda, J. R., additional, Almaden, Y., additional, Rodriguez-Ortiz, M., additional, Martinez-Moreno, J., additional, Lopez, I., additional, Aguilera-Tejero, E., additional, Hanafusa, N., additional, Masakane, I., additional, Ito, S., additional, Nakai, S., additional, Maeda, K., additional, Suzuki, H., additional, Tsunoda, M., additional, Ikee, R., additional, Sasaki, N., additional, Sato, M., additional, Hashimoto, N., additional, Wang, M.-H., additional, Hung, K.-Y., additional, Chiang, C.-K., additional, Huang, J.-W., additional, Lu, K.-C., additional, Lang, C.-L., additional, Okano, K., additional, Yamashita, T., additional, Tsuruta, Y., additional, Hibi, A., additional, Miwa, N., additional, Kimata, N., additional, Tsuchiya, K., additional, Nitta, K., additional, Akiba, T., additional, Harb, L., additional, Komaba, H., additional, Kakuta, T., additional, Suga, T., additional, Fukagawa, M., additional, Kikuchi, H., additional, Shimada, H., additional, Karasawa, R., additional, Suzuki, M., additional, Zhelyazkova-Savova, M., additional, Gerova, D., additional, Paskalev, D., additional, Ikonomov, V., additional, Zortcheva, R., additional, Galunska, B., additional, Jean, G., additional, Deleaval, P., additional, Hurot, J.-M., additional, Lorriaux, C., additional, Mayor, B., additional, Chazot, C., additional, Vannucchi, H., additional, Vannucchi, M. T., additional, Martins, J. C., additional, Merino, J. L., additional, Teruel, J. L., additional, Fernandez-Lucas, M., additional, Villafruela, J. J., additional, Bueno, B., additional, Gomis, A., additional, Paraiso, V., additional, Quereda, C., additional, Ibrahim, F. H., additional, Fadhlina, N. Z., additional, Ng, E. K., additional, Thong, K. M., additional, Goh, B. L., additional, Sulaiman, D. M., additional, Fatimah, D. A. N., additional, Evi, D. O., additional, Siti, S. R., additional, Wilson, R. J., additional, Keith, M., additional, Gros, B., additional, Galan, A., additional, Herrero, J. A., additional, Oyaguez, I., additional, Casado, M. A., additional, Lucisano, S., additional, Coppolino, G., additional, Villari, A., additional, Cernaro, V., additional, Lupica, R., additional, Trimboli, D., additional, Aloisi, C., additional, and Buemi, M., additional

Published
2013
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10. Cell signalling / Pathophysiology

Author

Cerini, C., primary, Gondouin, B., additional, Dou, L., additional, Duval-Sabatier, A., additional, Brunet, P., additional, Dignat- George, F., additional, Burtey, S., additional, Okano, K., additional, Iwasaki, T., additional, Jinnai, H., additional, Hibi, A., additional, Miwa, N., additional, Kimata, N., additional, Nitta, K., additional, Akiba, T., additional, Dolley-Hitze, T., additional, Verhoest, G., additional, Jouan, F., additional, Arlot-Bonnemains, Y., additional, Lavenu, A., additional, Belaud-Rotureau, M.-A., additional, Rioux-Leclercq, N., additional, Vigneau, C., additional, Cox, S. N., additional, Sallustio, F., additional, Serino, G., additional, Loverre, A., additional, Pesce, F., additional, Gigante, M., additional, Zaza, G., additional, Stifanelli, P., additional, Ancona, N., additional, Schena, F. P., additional, Marc, P., additional, Jacques, T., additional, Green, J. M., additional, Mortensen, R. B., additional, Verma, R., additional, Leu, K., additional, Schatz, P. J., additional, Wojchowski, D. M., additional, Ihoriya, C., additional, Satoh, M., additional, Sasaki, T., additional, Kashihara, N., additional, Jung, Y. J., additional, Kang, K. P., additional, Lee, A. S., additional, Lee, J. E., additional, Lee, S., additional, Park, S. K., additional, Kim, W., additional, Florian, T., additional, Tepel, M., additional, Ying, L., additional, Katharina, K., additional, Nora, F., additional, Antje, W., additional, Alexandra, S., additional, Chiu, Y.-T., additional, Wu, M.-J., additional, Liu, Z.-H., additional, Liang, Y., additional, Zheng, C.-X., additional, Chen, Z.-H., additional, Zeng, C.-H., additional, Ranzinger, J., additional, Rustom, A., additional, Kihm, L., additional, Heide, D., additional, Scheurich, P., additional, Zeier, M., additional, Schwenger, V., additional, Liu, J., additional, Zhong, F., additional, Xu, L., additional, Zhou, Q., additional, Hao, X., additional, Wang, W., additional, Chen, N., additional, Liu, X., additional, Lu, Y., additional, Guo, S., additional, Lin, D., additional, Vilasi, A., additional, Deplano, S., additional, Cutillas, P., additional, Unwin, R., additional, Tam, F. W. K., additional, Medrano-Andres, D., additional, Lopez-Martinez, V., additional, Martinez-Miguel, P., additional, Cano, J. L., additional, Arribas, I., additional, Rodiguez-Puyol, M., additional, Lopez-Ongil, S., additional, Kadoya, H., additional, Nagasu, H., additional, Lindeberg, E., additional, Grundstrom, G., additional, Alexandra, M., additional, Ghosh, C. C., additional, David, S., additional, Mukherjee, A., additional, John, S. G., additional, Mcintyre, C. W., additional, Haller, H., additional, Parikh, S. M., additional, Troyano, N., additional, Del Nogal, M., additional, Olmos, G., additional, Mora, I., additional, DE Frutos, S., additional, Rodriguez-Puyol, M., additional, Ruiz, M. P., additional, Rothe, H., additional, Shapiro, W., additional, Ketteler, M., additional, Ramakrishnan, S. K., additional, Loupy, A., additional, Houillier, P., additional, Guilhermino Pereira, L., additional, Boim, M., additional, Aragao, D., additional, Casarini, D., additional, Jin, Y., additional, Moon, J.-Y., additional, Kim, Y.-G., additional, Lee, S.-H., additional, Lee, T.-W., additional, Ihm, C.-G., additional, Kim, E.-Y., additional, Lee, H.-J., additional, Wi, J.-G., additional, Jeong, K.-H., additional, Ruan, X. Z., additional, LI, L.-C., additional, Varghese, Z., additional, Chen, J.-B., additional, Lee, C.-T., additional, Moorhead, J., additional, Cerini, C., additional, Poitevin, S., additional, Dignat-George, F., additional, Stephane, B., additional, Bonanni, A., additional, Verzola, D., additional, Maggi, D., additional, Brunori, G., additional, Sofia, A., additional, Mannucci, I., additional, Maffioli, S., additional, Salani, B., additional, D'amato, E., additional, Saffioti, S., additional, Laudon, A., additional, Cordera, R., additional, Garibotto, G., additional, Maquigussa, E., additional, and Arnoni, C., additional

Published
2012
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11. Protein-energy wasting, inflammation and oxidative stress in CKD 5D

Author

Rosales, L., primary, Vega, O., additional, Usvyat, L., additional, Thijssen, S., additional, Levin, N., additional, Kotanko, P., additional, Miyamoto, T., additional, Witasp, A., additional, Rashid Qureshi, A., additional, Heimburger, O., additional, Barany, P., additional, Nordfors, L., additional, Lindholm, B., additional, Stenvinkel, P., additional, Jesus Carrero, J., additional, Kalousova, M., additional, Benakova, H., additional, Kubena, A. A., additional, Dusilova-Sulkova, S., additional, Tesar, V., additional, Zima, T., additional, Lee, Y. J., additional, Kim, M. S., additional, Song, B. G., additional, Cho, S., additional, Kim, S. R., additional, Stockler-Pinto, M., additional, Lobo, J., additional, Moraes, C., additional, Barros, A., additional, Farage, N., additional, Boaventura, G., additional, Mafra, D., additional, Malm, O., additional, Matsuda, S., additional, Akaike, N., additional, Kajiwara, K., additional, Tovbin, D., additional, Kesari, S., additional, Sola-Del Valle, D., additional, Barasch, J., additional, Douvdevani, A., additional, Zlotnik, M., additional, Abd Elkadir, A., additional, Storch, S., additional, Sarikaya, M., additional, Sari, F., additional, Gunes, J., additional, Eren, M., additional, Cetinkaya, R., additional, Hwang, J.-C., additional, Ma, T.-L., additional, Wang, C.-T., additional, Ogawa, H., additional, Nagaya, T., additional, Ota, Y., additional, Sarai, M., additional, Oda, O., additional, Biavo, B., additional, Uezima, C., additional, Costa, M. E., additional, Barros, C., additional, Martins, J. P., additional, Ribeiro Jr, E., additional, Tzanno-Martins, C., additional, Honda, H., additional, Kimata, N., additional, Wakai, K., additional, Akizawa, T., additional, Droulias, J., additional, Filliponi, V., additional, Argyropoulos, C., additional, Fischer, R., additional, Papakonstantinou, C., additional, Papadopoulos, C., additional, Kouvelis, A., additional, Zervas, G., additional, Dampolia, E., additional, Zerefos, N., additional, Valis, D., additional, Sarcina, C., additional, Baragetti, I., additional, Uboldi, P., additional, Buzzi, L., additional, Garlaschelli, K., additional, Ferrario, F., additional, Terraneo, V., additional, Norata, G. D., additional, Catapano, A. L., additional, Pozzi, C., additional, Conti, G., additional, Santoro, D., additional, Caccamo, D., additional, Condello, S., additional, Pazzano, D., additional, Savica, V., additional, Jentile, R., additional, Fede, C., additional, Bellinghieri, G., additional, Zortcheva, R., additional, Ikonomov, V., additional, Galunska, B., additional, Paskalev, D., additional, Dobreva, D., additional, Ivanova, D., additional, Tsunoda, M., additional, Ikee, R., additional, Sasaki, N., additional, Sato, N., additional, Hashimoto, N., additional, Korol, L., additional, Dudar, I., additional, Migal, L., additional, Gonchar, Y., additional, Seleznova, I., additional, Ischenko, V., additional, Erkmen Uyar, M., additional, Tutal, E., additional, Bal, Z., additional, Ahmed, N., additional, Sezer, S., additional, Fedak, D., additional, Kuzniewski, M., additional, Pawlica, D., additional, Kusnierz-Cabala, B., additional, Solnica, B., additional, Drozdz, M., additional, Janda, K., additional, Sulowicz, W., additional, Kopec, J., additional, Banach, M., additional, and Leal, V., additional

Published
2011
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12. Cardiovascular complications in CKD 5D (1)

Author

Kuo, K.-L., primary, Hung, S.-C., additional, Tarng, D.-C., additional, Selim, G., additional, Stojceva-Taneva, O., additional, Tozija, L., additional, Gelev, S., additional, Stojcev, N., additional, Dzekova, P., additional, Trajcevska, L., additional, Severova, G., additional, Pavleska, S., additional, Sikole, A., additional, Combe, C., additional, Thumma, J., additional, Gillespie, B., additional, De Sequera, P., additional, Yamamoto, H., additional, Robinson, B., additional, Matsushita, Y., additional, Tasaki, H., additional, Tohara, Y., additional, Yamauchi, E., additional, Matsuoka, K., additional, Arizono, K., additional, Bellasi, A., additional, Ferramosca, E., additional, Ratti, C., additional, Block, G., additional, Raggi, P., additional, Drozdz, M., additional, Krasniak, A., additional, Chmiel, G., additional, Podolec, P., additional, Pasowicz, M., additional, Tracz, W., additional, Kowalczyk-Michalek, M., additional, Sulowicz, W., additional, Kalantzi, K., additional, Korantzopoulos, P., additional, Bechlioulis, A., additional, Vlachopanou, A., additional, Foulidis, V., additional, Pagiati, E., additional, Nikolopoulos, P., additional, Gouva, C., additional, Arroyave, I., additional, Rodelo, J., additional, Cardona, M., additional, Garcia, A., additional, Henao, J., additional, Mejia, G., additional, Rico, J., additional, Arbelaez, M., additional, Fujimori, A., additional, Okada, S., additional, Yamamoto, K., additional, Okamoto, S., additional, Kamiura, N., additional, Sakai, M., additional, Tanikake, M., additional, Kutlay, S., additional, Sengul, S., additional, Keven, K., additional, Nergizoglu, G., additional, Erturk, S., additional, Ates, K., additional, Duman, N., additional, Karatan, O., additional, Erbay, B., additional, Sameiro-Faria, M., additional, Costa, E., additional, Rocha-Pereira, P., additional, Borges, A., additional, Nascimento, H., additional, Mendonca, D., additional, Amado, L., additional, Reis, F., additional, Miranda, V., additional, Quintanilha, A., additional, Belo, L., additional, Santos-Silva, A., additional, Oh, J. S., additional, Kim, S. M., additional, Sin, Y. H., additional, Kim, J. K., additional, Ishihara, M., additional, Otsubo, S., additional, Kimata, N., additional, Akiba, T., additional, Nitta, K., additional, Kim, K. M., additional, Baek, C. H., additional, Kim, S. B., additional, Testa, A., additional, Sanguedolce, M. C., additional, Spoto, B., additional, Mallamaci, F., additional, Malatino, L., additional, Tripepi, G., additional, Zoccali, C., additional, Lee, J. E., additional, Moon, S. J., additional, Kim, J.-K., additional, An, H. R., additional, Ha, S. K., additional, Pakr, H. C., additional, Bahlmann, F. H., additional, Becker, E., additional, Sperber, V., additional, Triem, S., additional, Noll, C., additional, Zewinger, S., additional, Fliser, D., additional, Laufs, U., additional, Thijssen, S., additional, Usvyat, L. A., additional, Raimann, J. G., additional, Balter, P., additional, Kotanko, P., additional, Levin, N. W., additional, Hornum, M., additional, Bay, J. T., additional, Clausen, P., additional, Melchior Hansen, J., additional, Mathiesen, E. R., additional, Feldt-Rasmussen, B., additional, Garred, P., additional, Sural, S., additional, Panja, C. S., additional, Bhattacharya, S. K., additional, Cernaro, V., additional, Lacquaniti, A., additional, Lorenzano, G., additional, Romeo, A., additional, Donato, V., additional, Buemi, M., additional, Usvyat, L., additional, Rogus, J., additional, Lacson, E., additional, Robinson, B. M., additional, Karaboyas, A., additional, Sen, A., additional, Hecking, M., additional, Mendelssohn, D., additional, Jadoul, M., additional, Kawanishi, H., additional, Saran, R., additional, Kolarz, M., additional, Undas, A., additional, Wyroslak, J., additional, Malyszko, J., additional, Klejna, K., additional, Naumnik, B., additional, Koc-Zurawska, E., additional, Mysliwiec, M., additional, Piecha, G., additional, Kuczera, P., additional, Adamczak, M., additional, Fedorova, O. V., additional, Bagrov, A. Y., additional, Wiecek, A., additional, Gungor, O., additional, Kircelli, F., additional, Asci, G., additional, Carrero, J. J., additional, Tatar, E., additional, Demirci, M., additional, Toz, H., additional, Ozkahya, M., additional, Ok, E., additional, Bansal, V., additional, Shareain, K., additional, Hoppensteadt, D., additional, Litinas, E., additional, Fareed, J., additional, Kim, M.-J., additional, Lee, S. W., additional, Song, J. H., additional, Kweon, J., additional, Kim, W. H., additional, Sasaki, K., additional, Yasuda, K., additional, Hatanaka, M., additional, Hayashi, T., additional, Katsipi, I., additional, Tatsiopoulos, A., additional, Papanikolaou, P., additional, Doulgerakis, C., additional, Kollia, K., additional, Kardouli, E., additional, Asmanis, E., additional, Gennadiou, M., additional, Kyriazis, J., additional, Panizo, S., additional, Barrio-Vazquez, S., additional, Carrillo-Lopez, N., additional, Fernandez-Vazquez, A., additional, Braga, S., additional, Rodriguez-Rebollar, A., additional, Naves-Diaz, M., additional, Cannata-Andia, J. B., additional, Nikodimopoulou, M., additional, Liakos, S., additional, and Kapoulas, S., additional

Published
2011
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13. Cell signalling

Author

Negoro, H., primary, Kobayashi, H., additional, Teng, B., additional, Schafer, I., additional, Starker, G., additional, Miller, E., additional, Mao, Y., additional, Park, J.-K., additional, Haller, H., additional, Schiffer, M., additional, Lu, Y., additional, Zhong, F., additional, Zhou, Q., additional, Hao, X., additional, Li, C., additional, Guo, S., additional, Wang, W., additional, Chen, N., additional, Okano, K., additional, Jinnai, H., additional, Iwasaki, T., additional, Miwa, N., additional, Kimata, N., additional, Akiba, T., additional, Nitta, K., additional, Chen, C.-A., additional, Cheng, Y.-C., additional, Hwang, J.-C., additional, Chang, J.-M. C., additional, Guh, J.-Y., additional, Chen, H.-C., additional, Garcia-Sanchez, O., additional, Lopez-Novoa, J. M., additional, Lopez-Hernandez, F. J., additional, Hirai, Y., additional, Iyoda, M., additional, Shibata, T., additional, Kuno, Y., additional, Akizawa, T., additional, Shimizu, H., additional, Bolati, D., additional, Niwa, T., additional, Kim, Y. K., additional, Nam, S. A., additional, Kim, W.-Y., additional, Park, S. H., additional, Song, H. C., additional, Choi, E. J., additional, Kim, J., additional, Sirolli, V., additional, Giardinelli, A., additional, Morabito, C., additional, Di Cesare, M., additional, Di Pietro, N., additional, Di Liberato, L., additional, Amoroso, L., additional, Mariggio, M. A., additional, Formoso, G., additional, Pandolfi, A., additional, Bonomini, M., additional, Shalhoub, V., additional, Shatzen, E., additional, Ward, S., additional, Damore, M., additional, Boedigheimer, M., additional, Campbell, M., additional, Pan, Z., additional, Davis, J., additional, Henley, C., additional, Richards, W., additional, Yoshida, T., additional, Yamashita, M., additional, Hayashi, M., additional, Bodor, C., additional, Nemeth, A., additional, Berzsenyi, V., additional, Vegh, B., additional, Sebe, A., additional, Rosivall, L., additional, Koken, T., additional, Hunkerler, Z., additional, Kahraman, A., additional, Verzola, D., additional, Villaggio, B., additional, Tosetti, F., additional, Cappuccino, L., additional, Gianiorio, F., additional, Simonato, A., additional, Parodi, E., additional, Garibotto, G., additional, Chai, Y., additional, Liu, J., additional, Sun, B., additional, Zhao, X., additional, Qian, J., additional, and Xing, C., additional

Published
2011
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18. The survival advantage for haemodialysis patients taking vitamin D is questioned: findings from the Dialysis Outcomes and Practice Patterns Study

Author

Tentori, F., primary, Albert, J. M., additional, Young, E. W., additional, Blayney, M. J., additional, Robinson, B. M., additional, Pisoni, R. L., additional, Akiba, T., additional, Greenwood, R. N., additional, Kimata, N., additional, Levin, N. W., additional, Piera, L. M., additional, Saran, R., additional, Wolfe, R. A., additional, and Port, F. K., additional

Published
2008
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23. Facility Hemodialysis Vascular Access Use and Mortality in Countries Participating in DOPPS: An Instrumental Variable Analysis.

Author

Pisoni RL, Arrington CJ, Albert JM, Ethier J, Kimata N, Krishnan M, Rayner HC, Saito A, Sands JJ, Saran R, Gillespie B, Wolfe RA, and Port FK

Abstract

BACKGROUND: Previously, the Dialysis Outcomes and Practice Patterns Study (DOPPS) has shown large international variations in vascular access practice. Greater mortality risks have been seen for hemodialysis (HD) patients dialyzing with a catheter or graft versus a native arteriovenous fistula (AVF). To further understand the relationship between vascular access practice and outcomes, we have applied practice-based analyses (using an instrumental variable approach) to decrease the treatment-by-indication bias of prior patient-level analyses. STUDY DESIGN: A prospective observational study of HD practices. SETTING & PARTICIPANTS: Data collected from 1996 to 2004 from 28,196 HD patients from more than 300 dialysis units participating in the DOPPS in 12 countries. PREDICTOR OR FACTOR: Patient-level or case-mix-adjusted facility-level vascular access use. OUTCOMES/MEASUREMENTS: Mortality and hospitalization risks. RESULTS: After adjusting for demographics, comorbid conditions, and laboratory values, greater mortality risk was seen for patients using a catheter (relative risk, 1.32; 95% confidence interval, 1.22 to 1.42; P < 0.001) or graft (relative risk, 1.15; 95% confidence interval, 1.06 to 1.25; P < 0.001) versus an AVF. Every 20% greater case-mix-adjusted catheter use within a facility was associated with 20% greater mortality risk (versus facility AVF use, P < 0.001); and every 20% greater facility graft use was associated with 9% greater mortality risk (P < 0.001). Greater facility catheter and graft use were both associated with greater all-cause and infection-related hospitalization. Catheter and graft use were greater in the United States than in Japan and many European countries. More than half the 36% to 43% greater case-mix-adjusted mortality risk for HD patients in the United States versus the 5 European countries from the DOPPS I and II was attributable to differences in vascular access practice, even after adjusting for other HD practices. Vascular access practice differences accounted for nearly 30% of the greater US mortality compared with Japan. LIMITATIONS: Possible existence of unmeasured facility- and patient-level confounders that could impact the relationship of vascular access use with outcomes. CONCLUSIONS: Facility-based analyses diminish treatment-by-indication bias and suggest that less catheter and graft use improves patient survival. Copyright © 2009 American Society for Nutrition [ABSTRACT FROM AUTHOR]

Published
2009
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25. An Evaluation of 1–84 PTH Measurement in Relation to Bone Alkaline Phosphatase and Bone Gla Protein in Hemodialysis Patients

Author

Miwa, N., Nitta, K., Kimata, N., Watanabe, Y., Suzuki, K., Kawashima, A., Haga, M., Watanabe, R., Aoki, T., Akiba, T., and Nihei, H.

Abstract

AbstractBackground/Aim: It has been suggested that higher levels of parathyroid hormone (PTH) are required to maintain normal bone turnover in chronic hemodialysis (HD) patients. Serum PTH levels determined by intact PTH (i-PTH) assay may overestimate the actual activity of circulating PTH in HD patients. The aim of the present study was to assess the clinical usefulness of whole PTH assay on the evaluation of bone turnover in HD patients. Materials and Methods: We performed measurement of parameters on bone turnover in 179 HD patients (116 men, 63 women; mean age 61.0 ± 13.1 years). Serum whole PTH levels were determined as cyclase-activating PTH (CAP) by an immunoradiometric assay, and compared with those of i-PTH. Cyclase-inactivating PTH (CIP) was calculated as (i-PTH-CAP). The correlations between serum whole PTH levels and clinical parameters such as serum levels of Ca, P, bone alkaline phosphatase (BAP), bone Gla protein (BGP), total protein (TP), albumin (Alb), urea nitrogen (SUN), and creatinine (Cr) were analyzed using multivariate analysis. Results: The mean values of i-PTH and CAP were 124.1 ± 97.4 and 86.9 ± 71.6 pg/ml, respectively, indicating that the serum CAP levels were about 70% of i-PTH levels. The serum CAP levels significantly correlated with that of i-PTH (r = 0.959, p &lt; 0.001). Moreover, a significant positive correlation between serum CAP levels and metabolic bone markers such as BAP (r = 0.400, p &lt; 0.01) and BGP (r = 0.481, p &lt; 0.01) was observed. Stepwise multivariate analysis revealed that serum levels of CAP were significantly determined by serum levels of Ca, P, Alb, and oral dosage of vitamin D (F ratio = 18.81, adjusted r2 = 0.302). Conclusions: These data suggest that the biological activity of circulating PTH in HD patients is lower than the levels estimated by conventional i-PTH assay.Copyright © 2003 S. Karger AG, Basel

Published
2003

28. Measuring Systems for Audio Production Lines

Author

Kimata, N.

Subjects
Performance Measurement, Stereo Systems, Radio Equipment, Radio Communication, Audiology, Measurement, Meters, Instruments, Testing, Quality Control, Automatic Test Equipment, Manufacturing, Automation, Test Equipment, Assembly Line, Meguro Electronics
Published
1984

36. Mineral metabolism and haemoglobin concentration among haemodialysis patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Author

Justin M. Albert, Tadao Akizawa, Naoki Kimata, José Manuel Barrueco Cruz, Friedrich K. Port, Sudtida Satayathum, Ronald L. Pisoni, Takashi Akiba, Vittorio E. Andreucci, Eric W. Young, Kimata, N, Akiba, T, Pisoni, Rl, Albert, Jm, Satayathum, S, Cruz, Jm, Akizawa, T, Andreucci, VITTORIO EMANUELE, Young, Ew, and Port, F. K.

Subjects
Adult, Male, medicine.medical_specialty, Anemia, medicine.medical_treatment, Parathyroid hormone, Hemoglobins, Erythroid Cells, Renal Dialysis, Internal medicine, medicine, Vitamin D and neurology, Humans, Erythropoietin, Dialysis, Aged, Cell Proliferation, Transplantation, business.industry, Cell Differentiation, Phosphorus, Odds ratio, Middle Aged, medicine.disease, Recombinant Proteins, Endocrinology, Parathyroid Hormone, Nephrology, Calcium, Female, Hemodialysis, business, Body mass index, Kidney disease
Abstract

Bone and mineral metabolism is abnormal in most chronic haemodialysis patients and is associated with a high mortality risk. Because of possible pathogenic links between anaemia and intact parathyroid hormone (iPTH), the present study evaluated associations of mineral metabolism indicators with haemoglobin (Hb).Data were collected from 317 facilities (12 089 haemodialysis patients) in Australia, Belgium, Canada, France, Germany, Italy, Japan, New Zealand, Spain, Sweden, the United Kingdom and the United States by the Dialysis Outcomes and Practice Patterns Study (DOPPS). The major outcome studied was probability of haemodialysis patients having a target Hb, per guidelines, of/=11 g/dl at baseline. Major predictor variables were patient characteristics and laboratory markers of mineral metabolism: albumin-corrected serum calcium (calcium(Alb)), serum phosphorus (PO(4)) and iPTH. Analyses were adjusted for demographics, 15 comorbidity classes, baseline laboratory values, body mass index, years on dialysis, erythropoietin dose, vitamin D and catheter use, cause of end-stage renal disease and country.The adjusted odds ratio (AOR) of having Hb/=11 g/dl was significantly higher (P0.0001) in patients with higher calcium(Alb) (AOR = 1.32 per 1 mg/dl), higher PO(4) (AOR = 1.08 per 1 mg/dl) and lower iPTH (AOR = 0.96 per 100 pg/ml). Furthermore, 4 month intrapatient changes in Hb concentration were significantly (P0.0001) related to 4 month changes in calcium(Alb) (0.17 g/dl Hb rise per 1 mg/dl higher calcium(Alb)) and PO(4) (0.11 g/dl Hb rise per 1 mg/dl higher PO(4)). Mean weekly recombinant human erythropoietin (rHuEpo) doses were higher for patients with high PO(4) or iPTH levels, but lower for patients with calcium(Alb)9.5 mg/dl, after patient mix and Hb concentration adjustments.The results of this study indicate that higher serum calcium(Alb) and PO(4) levels are each independently associated with better anaemia control. This relationship is independent of vitamin D use, PTH levels and prescribed rHuEpo dose. Despite this benefit of better anaemia control at higher serum calcium(Alb) and PO(4) concentrations, lower calcium and PO(4) levels, as recommended by the K/DOQI guidelines, should still serve as the long-term goal for HD patients in order to minimize tissue calcification and mortality risk.

Published
2005

37. Successful Premedication With Sublingual Midazolam Using a Suction Toothbrush.

Author

Hirokawa J and Kimata N

Subjects
Male, Humans, Adult, Administration, Sublingual, Suction, Premedication, Preanesthetic Medication methods, Anesthesia, General, Double-Blind Method, Hypnotics and Sedatives, Midazolam, Toothbrushing
Abstract

Premedication is often used to reduce the stress associated with anesthesia-related procedures. However, in some cases, patients may not cooperate with medication delivery because of significant fear and anxiety. We report a case of an uncooperative patient with severe intellectual disabilities who was successfully premedicated with the unique technique of sublingual midazolam administration using a suction toothbrush. The 38-year-old male patient was planned to receive dental treatment under deep intravenous sedation (IVS), but he refused both intravenous cannulation and mask induction. Preanesthetic medication delivery using other routes was attempted but not accepted. As the patient tolerated toothbrushing, we used repeated practice with sublingual water administration through the toothbrush's suction hole to gradually desensitize the patient. Using that same method, sublingual midazolam was administered as a successful premedication to allow placement of a face mask for inhalational induction without distress and completion of the dental treatment under IVS. For patients who refuse other premedication routes, sublingual administration during toothbrushing with a suction toothbrush may provide a successful alternative., (© 2023 by the American Dental Society of Anesthesiology.)

Published
2023
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38. Peritoneal Dialysis Registry With 2013 Survey Report.

Author

Masakane I, Hasegawa T, Ogata S, Kimata N, Nakai S, Hanafusa N, Hamano T, Wakai K, Wada A, and Nitta K

Subjects
Catheter-Related Infections, Hemodiafiltration statistics & numerical data, Humans, Japan, Health Care Surveys statistics & numerical data, Peritoneal Dialysis statistics & numerical data, Registries statistics & numerical data
Abstract

Since 2009, the peritoneal dialysis (PD) registry has been carried out as part of the annual nationwide survey conducted by the Statistical Survey Committee of the Japanese Society for Dialysis Therapy with the cooperation of the Japanese Society for Peritoneal Dialysis. In this study, the current status of PD patients is reported on the basis of the results of the survey conducted at the end of 2013. The subjects were PD patients who lived in Japan and participated in the 2013 survey. Descriptive analysis was performed for various items including the current status of the combined use of PD and another dialysis method such as hemodialysis (HD) or hemodiafiltration (HDF), the method of exchanging dialysate, the use of an automated peritoneal dialysis (APD) machine, and the incidences of peritonitis and catheter exit-site infection. From the results of the facility survey in 2013, the number of PD patients was 9392, a decrease of 122 from that in 2012. Among the entire dialysis patient population, 3.0% were PD patients, a decrease of 0.1%. Among the studied patients, 292 had a peritoneal catheter and underwent peritoneal lavage, 174 were started on PD in 2013 but introduced to other blood purification methods in 2013, and 1920 underwent both PD and another dialysis method such as HD or HDF. The percentage of patients who underwent PD and another dialysis method increased with the number of years on PD: <1 year, 3.5%; 1 to < 2 years, 8.4%; 2 to < 4 years, 15.3%; 4 to < 6 years, 27.1%; 6 to < 8 years, 39.3%; 8 to < 10 years, 47.1%; and ≥ 10 years, 57.5%. The percentage of PD patients for whom the dialysate was completely manually exchanged was 31.6%, whereas the percentages of PD patients who used a bag-exchange device based on ultraviolet-light irradiation and that based on thermal sterile joint systems were 52.1 and 14.9%, respectively. The mean incidence of peritonitis was 0.22 per patient per year (once per 54.5 patients per month). The mean incidence of catheter exit-site infection was 0.34 per patient per year (once per 35.3 patients per month)., (© 2016 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.)

Published
2016
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39. Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.

Author

Kimata N, Pope A, Eilers M, Opefi CA, Ziliox M, Hirshfeld A, Zaitseva E, Vogel R, Sheves M, Reeves PJ, and Smith SO

Subjects
Cell Line, HEK293 Cells, Humans, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Protein Structure, Tertiary, Spectroscopy, Fourier Transform Infrared, Retina physiology, Retinaldehyde chemistry, Rhodopsin metabolism
Abstract

The 11-cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsin and isomerizes to the all-trans configuration following absorption of light. The mechanism by which this isomerization event drives the outward rotation of transmembrane helix H6, a hallmark of activated G protein-coupled receptors, is not well established. To address this question, we use solid-state NMR and FTIR spectroscopy to define the orientation and interactions of the retinal chromophore in the active metarhodopsin II intermediate. Here we show that isomerization of the 11-cis retinal chromophore generates strong steric interactions between its β-ionone ring and transmembrane helices H5 and H6, while deprotonation of its protonated Schiff's base triggers the rearrangement of the hydrogen-bonding network involving residues on H6 and within the second extracellular loop. We integrate these observations with previous structural and functional studies to propose a two-stage mechanism for rhodopsin activation.

Published
2016
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40. Volume elastic modulus of the brachial artery and coronary artery stenosis in patients with suspected stable coronary artery disease.

Author

Munakata R, Otsuka T, Uchiyama S, Shimura T, Kurihara O, Kimata N, Inami T, Murakami D, Ohba T, Takano M, Ibuki C, Seino Y, and Shimizu W

Subjects
Aged, Area Under Curve, Coronary Angiography, Coronary Artery Disease diagnosis, Coronary Stenosis diagnosis, Elastic Modulus, Female, Humans, Japan, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Oscillometry, Predictive Value of Tests, ROC Curve, Risk Factors, Severity of Illness Index, Brachial Artery physiopathology, Coronary Artery Disease physiopathology, Coronary Stenosis physiopathology, Vascular Stiffness
Abstract

This study aimed to examine the association between the non-invasive measurement of the brachial artery volume elastic modulus (V E), an index of arterial stiffness, and the presence of coronary artery stenosis in patients with suspected stable coronary artery disease (CAD). A total of 135 patients with suspected stable CAD (87 men, mean age, 64 ± 12 years) underwent oscillometric measurement of the brachial artery to obtain V E. Coronary angiography was thereafter carried out to diagnose CAD, defined as having ≥75 % stenosis in the epicardial coronary arteries. V E was significantly higher in patients with CAD (1.94 ± 0.34 mmHg/%) than in those without CAD (1.71 ± 0.35 mmHg/%, P < 0.001). In multiple logistic regression analysis, V E was an independent predictor for the presence of CAD (odds ratio 1.19 per 0.1 mmHg/% increase, 95 % CI 1.04-1.51) even after adjusting for multiple potential confounders including the Framingham risk score (FRS). The area under the curve of the receiver operating characteristic curve analysis for discriminating CAD increased significantly after the addition of V E to the FRS (from 0.75 to 0.81, P = 0.034). The category-free net reclassification improvement and the integrated discrimination improvement by adding V E to the FRS were 0.476 (95 % CI 0.146-0.806) and 0.086 (95 % CI 0.041-0.132), respectively. In conclusion, the brachial V E was significantly associated with the presence of coronary artery stenosis. The additional measurement of V E to the FRS improved the ability to identify patients with coronary artery stenosis among those with suspected stable CAD.

Published
2016
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41. Free backbone carbonyls mediate rhodopsin activation.

Author

Kimata N, Pope A, Sanchez-Reyes OB, Eilers M, Opefi CA, Ziliox M, Reeves PJ, and Smith SO

Subjects
Allosteric Regulation, Animals, Cattle, HEK293 Cells, Humans, Hydrogen Bonding, Ketones chemistry, Light Signal Transduction, Models, Molecular, Protein Binding, Protein Conformation, alpha-Helical, Rhodopsin physiology, Transducin chemistry, Rhodopsin chemistry
Abstract

Conserved prolines in the transmembrane helices of G-protein-coupled receptors (GPCRs) are often considered to function as hinges that divide the helix into two segments capable of independent motion. Depending on their potential to hydrogen-bond, the free C=O groups associated with these prolines can facilitate conformational flexibility, conformational switching or stabilization of the receptor structure. To address the role of conserved prolines in family A GPCRs through solid-state NMR spectroscopy, we focus on bovine rhodopsin, a GPCR in the visual receptor subfamily. The free backbone C=O groups on helices H5 and H7 stabilize the inactive rhodopsin structure through hydrogen-bonds to residues on adjacent helices. In response to light-induced isomerization of the retinal chromophore, hydrogen-bonding interactions involving these C=O groups are released, thus facilitating repacking of H5 and H7 onto the transmembrane core of the receptor. These results provide insights into the multiple structural and functional roles of prolines in membrane proteins.

Published
2016
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42. [Roles of and Team Medical Care Involving Clinical Engineers in Blood Purification Therapy].

Author

Abe T, Ishimori I, Murakami J, Kaneko I, Miura H, Kimata N, Hanafusa N, Mineshima M, Kawashima M, Nitta K, and Tsuchiya K

Subjects
Medical Laboratory Personnel, Renal Dialysis, Biomedical Engineering, Patient Care Team
Abstract

Progress in medical care strongly depends on the development of pharmaceutical and medical technologies. Multi-disciplinary care by a medical team is required for the diversity of medical care. "Clinical engineering technician (CET) " is one of the national medical licenses in Japan. Many CETs are engaged in blood purification therapies. Team medical care, involving medical doctors, nurses, CETs, etc., in the hemodialysis field is useful for the early detection of complications in dialysis patients and provision of appropriate treatments. In some medical facilities, for example, progressive approaches such as appropriate nutritional guidance by a dietitian or exercise therapy by a physical therapist are practiced in advance. Clinical laboratory technologists (CLTs), furthermore, play an important role in team medical care for dial- ysis therapy. They can use ultrasonic equipment for vascular access management. Based on the results of the ABI and SPP measurements by CLTs, medical doctors can diagnose PAD in dialysis patients. [Review].

Published
2016

43. Linkage of sleep-disordered breathing and acute aortic dissection with patent false lumen.

Author

Inami T, Seino Y, Shimura T, Kurihara O, Kimata N, Murakami D, Munakata R, Takano M, Ohba T, and Shimizu W

Subjects
Aged, Aortic Dissection diagnostic imaging, Aortic Dissection epidemiology, Aortic Aneurysm diagnostic imaging, Aortic Aneurysm epidemiology, Aortography methods, Blood Pressure, Computed Tomography Angiography, Cross-Sectional Studies, Female, Humans, Hypoxia diagnosis, Hypoxia epidemiology, Incidence, Japan epidemiology, Male, Middle Aged, Polysomnography, Prevalence, Risk Factors, Severity of Illness Index, Sleep Apnea Syndromes diagnosis, Sleep Apnea Syndromes epidemiology, Aortic Dissection physiopathology, Aortic Aneurysm physiopathology, Hypoxia physiopathology, Sleep Apnea Syndromes physiopathology
Abstract

Sleep-disordered breathing (SDB) is known as a cardiovascular risk factor and has high prevalence in hypertension, which is a major risk factor of aortic dissection (AD). However, the impact of SDB on AD has not been fully clarified. The aim of this study is to elucidate the impact of SDB on AD, especially on the type of false lumen in AD. We enrolled twenty-three consecutive patients with acute AD (mean age: 66 ± 13 years). All subjects were evaluated by an ambulatory polygraphic sleep monitoring within 1 month from the onset. AD was evaluated by axial images of computed tomography. We comparatively analyzed SDB and AD. 35 % of the subjects presented severe OSA (apnea-hypopnea index: AHI ≥30). The patent false lumen group showed significantly higher systolic and diastolic blood pressure (BP) on arrival and AHI, and lower percutaneous oxygen saturation (SaO2) compared with those in the thrombosed false lumen group. The prevalence of severe SDB was higher in the patent false lumen group (60 vs 15 %, p = 0.039). Systolic BP on arrival was significantly correlated with AHI (r = 0.457, p = 0.033) and the minimum SaO2 (r = -0.537, p = 0.010). The present study revealed close linkage between SDB and AD, and a high prevalence of SDB among AD patients. Severe SDB was related to the development of AD, especially for the patent false lumen type through highly elevated BP which might be easily evoked in the presence of severe SDB. Repetitive occurrence of intrathoracic negative pressure also might influence the repair or closure of false lumen of AD, although the present analysis did not reach statistical significance.

Published
2016
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44. An Overview of Regular Dialysis Treatment in Japan (As of 31 December 2013).

Author

Masakane I, Nakai S, Ogata S, Kimata N, Hanafusa N, Hamano T, Wakai K, Wada A, and Nitta K

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Diabetic Nephropathies epidemiology, Diabetic Nephropathies therapy, Extracorporeal Circulation methods, Female, Glomerulonephritis epidemiology, Glomerulonephritis therapy, Health Surveys, Hemodiafiltration methods, Hemodiafiltration statistics & numerical data, Humans, Japan, Male, Middle Aged, Peritoneal Dialysis methods, Renal Dialysis methods, Renal Dialysis statistics & numerical data, Renal Insufficiency epidemiology, Renal Insufficiency physiopathology, Peritoneal Dialysis statistics & numerical data, Renal Insufficiency therapy
Abstract

A nationwide survey of 4325 dialysis facilities was conducted at the end of 2013, among which 4268 (98.7%) responded. The number of new dialysis patients was 38,095 in 2013. Since 2008, the number of new dialysis patients has remained almost the same without any marked increase or decrease. The number of dialysis patients who died in 2013 was 30,751. The dialysis patient population has been growing every year in Japan; it was 314,438 at the end of 2013. The number of dialysis patients per million at the end of 2013 was 2470. The crude death rate of dialysis patients in 2013 was 9.8%. The mean age of new dialysis patients was 68.7 years and the mean age of the entire dialysis patient population was 67.2 years. The most common primary cause of renal failure among new dialysis patients was diabetic nephropathy (43.8%). The actual number of new dialysis patients with diabetic nephropathy has almost been unchanged for the last few years. Diabetic nephropathy was also the most common primary disease among the entire dialysis patient population (37.6%), followed by chronic glomerulonephritis (32.4%). The percentage of dialysis patients with diabetic nephropathy has been increasing continuously, whereas the percentage of dialysis patients with chronic glomerulonephritis has been decreasing. The number of patients who underwent hemodiafiltration (HDF) at the end of 2013 was 31,371, a marked increase from that in 2012. This number is more than twice that at the end of 2011 and approximately 1.5 times the number at the end of 2012. In particular, the number of patients who underwent online HDF increased approximately fivefold over the last 2 years. Among 151,426 dialysis patients with primary causes of renal failure other than diabetic nephropathy, 10.8% had a history of diabetes. Among those with a history of diabetes, 26.8% used glycoalbumin as an indicator of blood glucose level; and 33.0 and 27.6% were administered insulin and dipeptidyl peptidase (DPP)-4 inhibitor, respectively, as a medication of diabetes. The facility survey showed that 9392 patients underwent peritoneal dialysis (PD). The patient survey revealed that 1920 of these PD patients also underwent another dialysis method using extracorporeal circulation, such as hemodialysis (HD) or HDF. The number of patients who underwent HD at home at the end of 2013 was 461, a marked increase from that at the end of 2012 (393)., (© 2015 Japanese Society for Dialysis Therapy Reproduced with permission.)

Published
2015
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45. Peritoneal Dialysis Registry With 2012 Survey Report.

Author

Hasegawa T, Nakai S, Moriishi M, Ito Y, Itami N, Masakane I, Hanafusa N, Taniguchi M, Hamano T, Shoji T, Yamagata K, Shinoda T, Kazama J, Watanabe Y, Shigematsu T, Marubayashi S, Morita O, Wada A, Hashimoto S, Suzuki K, Kimata N, Wakai K, Fujii N, Ogata S, Tsuchida K, Nishi H, Iseki K, Tsubakihara Y, and Nakamoto H

Subjects
Humans, Japan, Surveys and Questionnaires, Peritoneal Dialysis statistics & numerical data, Registries
Abstract

Since 2009, the peritoneal dialysis (PD) registry survey has been carried out as part of the annual nationwide survey conducted by the Statistical Survey Committee of the Japanese Society for Dialysis Therapy with the cooperation of the Japanese Society for Peritoneal Dialysis. In this report, the current status of PD patients is presented on the basis of the results of the survey conducted at the end of 2012. The subjects were PD patients who lived in Japan and participated in the 2012 survey. Descriptive analysis of various items was performed, which included the current status of the combined use of PD and another dialysis method such as hemodialysis (HD) or hemodiafiltration (HDF), the method of exchanging dialysate, the use of an automated peritoneal dialysis (APD) machine, and the rates of peritonitis and catheter exit-site infection. From the results of the facility survey in 2012, the number of PD patients was 9514, a decrease of 128 from 2011. Among the entire dialysis patient population, 3.1% were PD patients, a decrease of 0.1%. Among the studied patients, 347 had a peritoneal catheter and underwent peritoneal lavage, 175 were started on PD in 2012 but introduced to other blood purification methods in the same year, and 1932 underwent both PD and another dialysis method such as HD or HDF. The percentage of patients who underwent PD and another dialysis method increased with PD vintage: <1 year, 4.8%; 1 to <2 years, 9.2%; 2 to <4 years, 16.3%; 4 to <8 years, 32.0%; and ≥8 years, 47.5%. The percentage of PD patients who completely manually exchanged the dialysate was 29.8%. The percentages of PD patients who used a double-bag exchange system with ultraviolet-light irradiation and those who used the same system but with a sterile connecting device were 54.7 and 13.9%, respectively. The percentage of patients on PD for <1 year using an APD machine was 43.4%, and it decreased with a PD vintage of ≥2 years. The mean rate of peritonitis was 0.22 per patient per year. The mean rate of catheter exit-site infections was 0.36 per patient per year., (© 2015 Japanese Society for Dialysis Therapy Reproduced with permission.)

Published
2015
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46. Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.

Author

Kimata N, Reeves PJ, and Smith SO

Subjects
Binding Sites, Protein Binding, Protein Conformation, Receptors, G-Protein-Coupled chemistry, Receptors, G-Protein-Coupled ultrastructure, Structure-Activity Relationship, Amino Acids chemistry, Nuclear Magnetic Resonance, Biomolecular methods, Rhodopsin chemistry, Rhodopsin ultrastructure
Abstract

G protein-coupled receptors (GPCRs) span cell membranes with seven transmembrane helices and respond to a diverse array of extracellular signals. Crystal structures of GPCRs have provided key insights into the architecture of these receptors and the role of conserved residues. However, the question of how ligand binding induces the conformational changes that are essential for activation remains largely unanswered. Since the extracellular sequences and structures of GPCRs are not conserved between receptor subfamilies, it is likely that the initial molecular triggers for activation vary depending on the specific type of ligand and receptor. In this article, we describe NMR studies on the rhodopsin subfamily of GPCRs and propose a mechanism for how retinal isomerization switches the receptor to the active conformation. These results suggest a general approach for determining the triggers for activation in other GPCR subfamilies using NMR spectroscopy., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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47. Differences in the Characteristics of Dialysis Patients in Japan Compared with Those in Other Countries.

Author

Kimata N, Tsuchiya K, Akiba T, and Nitta K

Subjects
Europe, Humans, Incidence, Japan, Kidney Transplantation statistics & numerical data, Mortality, Prevalence, Treatment Outcome, United States, Renal Dialysis statistics & numerical data
Abstract

Background: Japanese patients undergoing dialysis have an extremely low mortality rate compared with those in the United States and Europe. As shown in the Dialysis Outcomes 38; Practice Patterns Study (DOPPS), certain features of dialysis treatment, such as single treatment time and amount of blood flow, are unique to Japan, but factors contributing to the low mortality risk are unclear. Although DOPPS is a multi-country prospective cohort study, the study results may not entirely reflect the real trend in Japan because the number of Japanese institutions participating in the study is small., Summary: In this article, we review the data reported for Japan and other countries and reveal country-specific differences, particularly in patient age distribution and duration of dialysis., Key Messages: The mean age of prevalent dialysis patients is rising every year in Japan, and the proportion of patients undergoing dialysis for long periods of time is also increasing. In addition, the proportion of dialysis patients with diabetes, one of the primary diseases, has increased to a level similar to that observed in Western countries. However, no significant decline in the crude death rate among prevalent dialysis patients has been observed in Japan, presumably because of technological advances in dialysis treatment, but further studies are needed to elucidate the contributing factors., (© 2015 S. Karger AG, Basel.)

Published
2015
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48. Sequential structural changes in rhodopsin occurring upon photoactivation.

Author

Kimata N, Pope A, Rashid D, Reeves PJ, and Smith SO

Subjects
Amino Acids chemistry, Cell Line, Humans, Lipid Bilayers chemistry, Nuclear Magnetic Resonance, Biomolecular, Photochemistry, Protein Structure, Secondary, Rhodopsin chemistry
Abstract

We describe the use of solid-state magic angle spinning NMR spectroscopy for characterizing the structure and dynamics of dark, inactive rhodopsin and the active metarhodopsin II intermediate. Solid-state NMR spectroscopy is well suited for structural measurements in both detergent micelles and membrane bilayer environments. We first outline the methods for large-scale production of stable, functional rhodopsin containing (13)C- and (15)N-labeled amino acids. The expression methods make use of eukaryotic HEK293S cell lines that produce correctly folded, fully functional receptors. We subsequently describe the basic methods used for solid-state magic angle spinning NMR measurements of chemical shifts and dipolar couplings, which provide information on rhodopsin structure and dynamics, and describe the use of low-temperature methods to trap the active metarhodopsin II intermediate.

Published
2015
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49. An overview of regular dialysis treatment in Japan (as of 31 December 2012).

Author

Nakai S, Hanafusa N, Masakane I, Taniguchi M, Hamano T, Shoji T, Hasegawa T, Itami N, Yamagata K, Shinoda T, Kazama JJ, Watanabe Y, Shigematsu T, Marubayashi S, Morita O, Wada A, Hashimoto S, Suzuki K, Nakamoto H, Kimata N, Wakai K, Fujii N, Ogata S, Tsuchida K, Nishi H, Iseki K, and Tsubakihara Y

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Diabetic Nephropathies epidemiology, Diabetic Nephropathies therapy, Extracorporeal Circulation methods, Female, Glomerulonephritis epidemiology, Glomerulonephritis therapy, Health Surveys, Hemodiafiltration methods, Hemodiafiltration statistics & numerical data, Humans, Japan, Male, Middle Aged, Peritoneal Dialysis methods, Renal Dialysis methods, Renal Insufficiency epidemiology, Renal Insufficiency physiopathology, Young Adult, Peritoneal Dialysis statistics & numerical data, Renal Dialysis statistics & numerical data, Renal Insufficiency therapy
Abstract

A nationwide statistical survey of 4279 dialysis facilities was conducted at the end of 2012, among which 4238 responded (99.0%). The number of new dialysis patients was 38055 in 2012. Since 2008, the number of new dialysis patients has remained almost the same without any marked increase or decrease. The number of dialysis patients who died in 2012 was 30710; a slight decrease from 2011 (30743). The dialysis patient population has been growing every year in Japan; it was 310007 at the end of 2012, which exceeded 310000 for the first time. The number of dialysis patients per million at the end of 2012 was 2431.2. The crude death rate of dialysis patients in 2012 was 10.0%, a slight decrease from that in 2011 (10.2%). The mean age of new dialysis patients was 68.5 years and the mean age of the entire dialysis patient population was 66.9 years. The most common primary cause of renal failure among new dialysis patients was diabetic nephropathy (44.2%). The actual number of new dialysis patients with diabetic nephropathy has been approximately 16000 for the last few years. Diabetic nephropathy was also the most common primary disease among the entire dialysis patient population (37.1%), followed by chronic glomerulonephritis (33.6%). The percentage of dialysis patients with diabetic nephropathy has been continuously increasing, whereas not only the percentage but also the actual number of dialysis patients with chronic glomerulonephritis has decreased. The number of patients who underwent hemodiafiltration (HDF) at the end of 2012 was 21725, a marked increase from that in 2011 (14115). In particular, the number of patients who underwent on-line HDF increased threefold from 4890 in 2011 to 14069 in 2012. From the results of the facility survey, the number of patients who underwent peritoneal dialysis (PD) was 9514 and that of patients who did not undergo PD despite having a PD catheter in the abdominal cavity was 347. From the results of the patient survey, among the PD patients, 1932 also underwent another dialysis method using extracorporeal circulation, such as hemodialysis (HD) and HDF. The number of patients who underwent HD at home in 2012 was 393, a marked increase from that in 2011 (327)., (© 2014 Japanese Society for Dialysis Therapy. Reproduced with permission.)

Published
2014
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50. Associations among epoetin therapy, inflammation, nutritional status, and mortality in patients on hemodialysis.

Author

Honda H, Kimata N, Wakai K, and Akizawa T

Subjects
Aged, Body Mass Index, C-Reactive Protein metabolism, Cohort Studies, Diabetes Mellitus epidemiology, Female, Follow-Up Studies, Hematinics therapeutic use, Hemoglobins metabolism, Humans, Male, Middle Aged, Renal Insufficiency drug therapy, Erythropoietin therapeutic use, Inflammation epidemiology, Nutritional Status, Renal Dialysis mortality, Renal Insufficiency epidemiology
Abstract

Objective: Inflammation contributes to hemopoiesis by lowering responses to epoetin (EPO) and to an increase in the mortality of patients on hemodialysis. However, nutritional status might alter associations among inflammation, EPO responsiveness, and the risk of mortality. We assessed the effect of inflammation on mortality according to nutritional status among EPO responses in a cohort of prevalent hemodialysis patients., Design and Methods: The observational cohort study analyzed data from the Japanese Dialysis Registry (2005-2006; n = 36,956; mean follow-up 11.5 months). Patients were categorized into tertiles of the EPO responsiveness index (ERI; the weekly weight-adjusted EPO dose [IU/kg/week] divided by hemoglobin [g/dL]) and an EPO-free group. Body mass index (BMI) and C-reactive protein (CRP) levels were measured., Results: Bimodal peaks indicated associations between CRP and BMI in each group. Hazard ratio (HR) curves of CRP for mortality according to BMI in the upper ERI tertile, particularly among those with diabetes mellitus (DM), were reverse J-shaped. However, HR curves in the other groups were increased below a threshold BMI of 21 kg/m(2). These associations were confirmed in propensity score-matched populations., Conclusion: Risk of CRP for death is apparently changed by BMI in hemodialysis patients with a lower EPO response, especially in those with DM., (Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)

Published
2014
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