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1. Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Author: Lee DR, Park JS, Bae IH, Lee Y, and Kim BM
Subjects: LCNP, PIT, Sustained release, Bioavailability, Medicine (General), R5-920
Abstract: Dong Ryeol Lee,1,2 Ji Su Park,1 Il Hak Bae,1 Yan Lee,1 B Moon Kim1 1Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea; 2Technology Development Center, BASF Company Ltd., Hwaseong, Gyeonggi-do, Republic of Korea Abstract: Liquid crystal nanoparticles have been utilized as an efficient tool for drug delivery with enhanced bioavailability, drug stability, and targeted drug delivery. However, the high energy requirements and the high cost of the liquid crystal preparation have been obstacles to their widespread use in the pharmaceutical industry. In this study, we prepared liquid crystal nanoparticles using a phase-inversion temperature method, which is a uniquely low energy process. Particles prepared with the above method were estimated to be ~100 nm in size and exhibited a lamellar liquid crystal structure with orthorhombic lateral packing. Pharmacokinetic and tissue distribution studies of a hydrophobic peptide-based drug candidate formulated with the liquid crystal nanoparticles showed a five-fold enhancement of bioavailability, sustained release, and liver-specific drug delivery compared to a host–guest complex formulation. Keywords: LCNP, PIT, sustained release, bioavailability
Published: 2016

2. Surface segregation and oxidation of Pt3Ni(111) alloys under oxygen environment

Author: Lee, HC, Kim, BM, Jeong, CK, Toyoshima, R, Kondoh, H, Shimada, T, Mase, K, Mao, B, Liu, Z, Lee, H, Huang, Chuan-Qi, Li, WX, Ross, PN, and Mun, BS
Subjects: Engineering, Chemical Sciences, Physical Chemistry, Ambient pressure XPS, Pt alloys, Metal oxidation, DFT, Surface segregationa, Chemical sciences
Abstract: Utilizing ambient pressure X-ray photoelectron spectroscopy (AP-XPS), the surface segregation and oxidation of Pt3Ni(1 1 1) alloys are investigated as a function of temperature and oxygen pressure. The in situ AP-XPS measurements of oxygen oxidation process show that the Pt "skin" surface is not stable under the exposure of oxygen pressure of 100 mTorr at room temperature. As the temperature and pressure are elevated, the formations of Ni2O3, NiOx, and NiO are observed on surface while Pt atom starts to reduce its adsorbed oxygen, which is a clear sign of surface segregation of Ni to surface. Upon the evacuation of oxygen gas, i.e. ultrahigh vacuum condition, both of NiOx and NiO oxide get reduced and Ni2O3 remains on the surface. The DFT calculation is employed to explain the formation of surface oxides under oxidation condition.
Published: 2016

3. Surface segregation and oxidation of Pt3Ni(1 1 1) alloys under oxygen environment

Author: Lee, HC, Kim, BM, Jeong, CK, Toyoshima, R, Kondoh, H, Shimada, T, Mase, K, Mao, B, Liu, Z, Lee, H, Huang, CQ, Li, WX, Ross, PN, and Mun, BS
Subjects: Ambient pressure XPS, Pt alloys, Metal oxidation, DFT, Surface segregationa, Physical Chemistry, Chemical Sciences, Engineering
Abstract: Utilizing ambient pressure X-ray photoelectron spectroscopy (AP-XPS), the surface segregation and oxidation of Pt3Ni(1 1 1) alloys are investigated as a function of temperature and oxygen pressure. The in situ AP-XPS measurements of oxygen oxidation process show that the Pt "skin" surface is not stable under the exposure of oxygen pressure of 100 mTorr at room temperature. As the temperature and pressure are elevated, the formations of Ni2O3, NiOx, and NiO are observed on surface while Pt atom starts to reduce its adsorbed oxygen, which is a clear sign of surface segregation of Ni to surface. Upon the evacuation of oxygen gas, i.e. ultrahigh vacuum condition, both of NiOx and NiO oxide get reduced and Ni2O3 remains on the surface. The DFT calculation is employed to explain the formation of surface oxides under oxidation condition.
Published: 2016

4. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez- Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henninger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, 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Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D
Published: 2019
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5. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, 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Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge
Published: 2018
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6. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Author: Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, 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Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil 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Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D
Published: 2018
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7. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author: Campbell, Bruce C V, primary, Majoie, Charles B L M, additional, Albers, Gregory W, additional, Menon, Bijoy K, additional, Yassi, Nawaf, additional, Sharma, Gagan, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, Demchuk, Andrew M, additional, Guillemin, Francis, additional, White, Philip, additional, Dávalos, Antoni, additional, van der Lugt, Aad, additional, Butcher, Kenneth S, additional, Cherifi, Aboubaker, additional, Marquering, Henk A, additional, Cloud, Geoffrey, additional, Macho Fernández, Juan M, additional, Madigan, Jeremy, additional, Oppenheim, Catherine, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Shankar, Jai, additional, Lingsma, Hester, additional, Bonafé, Alain, additional, Raoult, Hélène, additional, Hernández-Pérez, María, additional, Bharatha, Aditya, additional, Jahan, Reza, additional, Jansen, Olav, additional, Richard, Sébastien, additional, Levy, Elad I, additional, Berkhemer, Olvert A, additional, Soudant, Marc, additional, Aja, Lucia, additional, Davis, Stephen M, additional, Krings, Timo, additional, Tisserand, Marie, additional, San Román, Luis, additional, Tomasello, Alejandro, additional, Beumer, Debbie, additional, Brown, Scott, additional, Liebeskind, David S, additional, Bracard, Serge, additional, Muir, Keith W, additional, Dippel, Diederik W J, additional, Goyal, Mayank, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, 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additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, 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Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2019
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8. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

Author: Román, Luis San, primary, Menon, Bijoy K, additional, Blasco, Jordi, additional, Hernández-Pérez, María, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, Campbell, Bruce C V, additional, Guillemin, Francis, additional, Lingsma, Hester, additional, Anxionnat, René, additional, Epstein, Jonathan, additional, Saver, Jeffrey L, additional, Marquering, Henk, additional, Wong, John H, additional, Lopes, Demetrius, additional, Reimann, Gernot, additional, Desal, Hubert, additional, Dippel, Diederik W J, additional, Coutts, Shelagh, additional, du Mesnil de Rochemont, Richard, additional, Yavagal, Dileep, additional, Ferre, Jean Christophe, additional, Roos, Yvo B W E M, additional, Liebeskind, David S, additional, Lenthall, Robert, additional, Molina, Carlos, additional, Al Ajlan, Fahad S, additional, Reddy, Vivek, additional, Dowlatshahi, Dar, additional, Sourour, Nader-Antoine, additional, Oppenheim, Catherine, additional, Mitha, Alim P, additional, Davis, Stephen M, additional, Weimar, Christian, additional, van Oostenbrugge, Robert J, additional, Cobo, Erik, additional, Kleinig, Timothy J, additional, Donnan, Geoffrey A, additional, van der Lugt, Aad, additional, Demchuk, Andrew M, additional, Berkhemer, Olvert A, additional, Boers, Anna M M, additional, Ford, Gary A, additional, Muir, Keith W, additional, Brown, B Scott, additional, Jovin, Tudor, additional, van Zwam, Wim H, additional, Mitchell, Peter J, additional, Hill, Michael D, additional, White, Phil, additional, Bracard, Serge, additional, Goyal, Mayank, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, 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additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez-Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, 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Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jansen, Olav, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, 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additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, 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additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Raoult, Hélène, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, White, Philip, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2018
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9. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Author: Campbell, Bruce C V, primary, van Zwam, Wim H, additional, Goyal, Mayank, additional, Menon, Bijoy K, additional, Dippel, Diederik W J, additional, Demchuk, Andrew M, additional, Bracard, Serge, additional, White, Philip, additional, Dávalos, Antoni, additional, Majoie, Charles B L M, additional, van der Lugt, Aad, additional, Ford, Gary A, additional, de la Ossa, Natalia Pérez, additional, Kelly, Michael, additional, Bourcier, Romain, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Bang, Oh Young, additional, Nogueira, Raul G, additional, Devlin, Thomas G, additional, van den Berg, Lucie A, additional, Clarençon, Frédéric, additional, Burns, Paul, additional, Carpenter, Jeffrey, additional, Berkhemer, Olvert A, additional, Yavagal, Dileep R, additional, Pereira, Vitor Mendes, additional, Ducrocq, Xavier, additional, Dixit, Anand, additional, Quesada, Helena, additional, Epstein, Jonathan, additional, Davis, Stephen M, additional, Jansen, Olav, additional, Rubiera, Marta, additional, Urra, Xabier, additional, Micard, Emilien, additional, Lingsma, Hester F, additional, Naggara, Olivier, additional, Brown, Scott, additional, Guillemin, Francis, additional, Muir, Keith W, additional, van Oostenbrugge, Robert J, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, Beumer, Debbie, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, 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D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Yassi, Nawaf, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Sharma, Gagan, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Bonafé, Alain, additional, Mendes Pereira, Vitor, additional, Jahan, Reza, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, 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additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, 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additional, Krieter, S, additional, Remonda, L, additional, Diepers, M, additional, Añon, J, additional, Nedeltchev, K, additional, Kahles, T, additional, Biethahn, S, additional, Lindner, M, additional, Chang, V, additional, Gächter, C, additional, Esperon, C, additional, Guglielmetti, M, additional, Arenillas Lara, JF, additional, Martínez Galdámez, M, additional, Calleja Sanz, AI, additional, Cortijo Garcia, E, additional, Garcia Bermejo, P, additional, Perez, S, additional, Mulero Carrillo, P, additional, Crespo Vallejo, E, additional, Ruiz Piñero, M, additional, Lopez Mesonero, L, additional, Reyes Muñoz, FJ, additional, Brekenfeld, C, additional, Buhk, J-H, additional, Krützelmann, A, additional, Thomalla, G, additional, Cheng, B, additional, Beck, C, additional, Hoppe, J, additional, Goebell, E, additional, Holst, B, additional, Grzyska, U, additional, Wortmann, G, additional, Starkman, S, additional, Duckwiler, G, additional, Jahan, R, additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, 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L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Albers, Gregory W, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Richard, Sébastien, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, 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additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, 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Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Brown, Martin M, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Cloud, Geoffrey, additional, Clifton, Andrew, additional, Madigan, Jeremy, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional
Published: 2018
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10. Production of charged pions, kaons and protons at large transverse momenta in pp and Pb–Pb collisions at √sNN = 2.76 TeV

Author: Piano, Stefano, Lea, Ramona, Camerini, Paolo, Luparello, Grazia, Margagliotti, Giacomo, Rui, Rinaldo, Abelev bt, B., Adam ak, J., Adamová cb, D., Aggarwal cf, M. M., Aglieri Rinella ah, G., Agnello cm, M., Agostinelli z, A., Agrawal ar, N., Ahammed dw, Z., Ahmad r, N., Ahmad Masoodi r, A., Ahmed o, I., Ahn bm, S. U., Ahn bm, S. A., Aimo cm, I., Aiola eb, S., Ajaz o, M., Akindinov bc, A., Aleksandrov cs, D., Alessandro dd, B., Alexandre cu, D., Alici cx, A., L, Alkin c, A., Alme ai, J., Alt am, T., Altini ae, V., Altinpinar q, S., Altsybeev dv, I., Alves Garcia Prado dl, C., Andrei bw, C., Andronic cp, A., Anguelov cl, V., Anielski ay, J., Anticˇic ́ cq, T., Antinori da, F., Antonioli cx, P., Aphecetche df, L., Appelshäuser aw, H., Arbor bp, N., Arcelli z, S., Armesto p, N., Arnaldi dd, R., Aronsson eb, T., Arsene u, I. C., Arslandok aw, M., Augustinus ah, A., Averbeck cp, R., Awes cc, T. C., Azmi r, M. D., Bach am, M., Badalà cz, A., Baek an, Y. W., Bagnasco dd, S., Bailhache aw, R., Bairathi cj, V., Bala ci, R., Baldisseri n, A., Baltasar Dos Santos Pedrosa ah, F., Bán bd, J., Baral bf, R. C., Barbera aa, R., Barile ae, F., Barnaföldi ea, G. G., Barnby cu, L. S., Barret bo, V., Bartke di, J., Basile z, M., Bastid bo, N., Basu dw, S., Bathen ay, B., Batigne df, G., Batyunya bk, B., Batzing u, P. C., Baumann aw, C., Bearden by, I. G., Beck aw, H., Bedda cm, C., Behera ar, N. K., Belikov az, I., Bellini z, F., Bellwied dn, R., Belmont Moreno bi, E., Bencedi ea, G., Beole y, S., Berceanu bw, I., Bercuci bw, A., Berdnikov cd, Y., 1, Berenyi ea, D., Berger ck, M. E., Bertens bb, R. A., Berzano y, D., Betev ah, L., Bhasin ci, A., Bhati cf, A. K., Bhattacharjee ao, B., Bhom ds, J., Bianchi y, L., Bianchi bq, N., Bianchin bb, C., Bielcˇík ak, J., Bielcˇíková cb, J., Bilandzic by, A., Bjelogrlic bb, S., Blanco j, F., Blau cs, D., Blume aw, C., Bock cl, F., Bogdanov bu, A., Bøggild by, H., Bogolyubsky de, M., Böhmer ck, F. V., Boldizsár ea, L., Bombara al, M., Book aw, J., Borel n, H., Borissov dz, A., Bornschein am, J., Bossú bj, F., Botje bz, M., Botta y, E., Böttger av, S., Braun Munzinger cp, P., Bregant dl, M., Breitner av, T., Broker aw, T. A., Browning cn, T. A., Broz aj, M., Bruna dd, E., Bruno ae, G. E., Budnikov cr, D., Buesching aw, H., Bufalino dd, S., Buncic ah, P., Busch cl, O., Buthelezi bj, Z., Caffarri ab, D., Cai g, X., Caines eb, H., Caliva bb, A., Calvo Villar cv, E., Canoa Roman ah, V., Carena ah, F., Carena ah, W., Carminati ah, F., Casanova Díaz bq, A., Castillo Castellanos n, J., Casula w, E. A. R., Catanescu bw, V., Cavicchioli ah, C., Ceballos Sanchez i, C., Cepila ak, J., Cerello dd, P., Chang do, B., Chapeland ah, S., Charvet n, J. L., Chattopadhyay dw, S., Chattopadhyay ct, S., Cherney ce, M., Cheshkov du, C., Cheynis du, B., Chibante Barroso ah, V., Chinellato dn, D. D., Chochula ah, P., Chojnacki by, M., Choudhury dw, S., Christakoglou bz, P., Christensen by, C. H., Christiansen af, P., Chujo ds, T., Chung co, S. U., Cicalo cy, C., Cifarelli l, L., Z, Cindolo cx, F., Cleymans ch, J., Colamaria ae, F., Colella ae, D., Collu w, A., Colocci z, M., Conesa Balbastre bp, G., Conesa del Valle au, Z., Connors eb, M. E., Contin x, G., Contreras k, J. G., Cormier cc, T. M., Corrales Morales y, Y., Cortese ad, P., Cortés Maldonado b, I., Cosentino bs, M. R., Costa ah, F., Crochet bo, P., Cruz Albino k, R., Cuautle bh, E., Cunqueiro bq, L., Dainese da, A., Dang g, R., Danu bg, A., Das ct, D., Das au, I., Das ct, K., Das d, S., Dash dm, A., Dash ar, S., De dw, S., Delagrange df, H., 2, Deloff bv, A., Dénes ea, E., D’Erasmo ae, G., de Barros dl, G. O. V., De Caro l, A., de Cataldo cw, G., de Cuveland am, J., De Falco w, A., De Gruttola ac, D., De Marco dd, N., De Pasquale ac, S., de Rooij bb, R., Diaz Corchero j, M. A., Dietel ay, T., Divià ah, R., Di Bari ae, D., Di Liberto db, S., Di Mauro ah, A., Di Nezza bq, P., Djuvsland q, Ø., Dobrin bb, A., Dobrowolski bv, T., Domenicis Gimenez dl, D., Dönigus aw, B., Dordic u, O., Dørheim ck, S., Dubey dw, A. K., Dubla bb, A., Ducroux du, L., Dupieux bo, P., Dutta Majumdar ct, A. K., Ehlers eb, R. J., Elia cw, D., Engel av, H., Erazmus ah, B., Erdal ai, H. A., Eschweiler am, D., Espagnon au, B., Estienne df, M., Esumi ds, S., Evans cu, D., Evdokimov de, S., Eyyubova u, G., Fabris da, D., Faivre bp, J., Falchieri z, D., Fantoni bq, A., Fasel cl, M., Fehlker q, D., Feldkamp ay, L., Felea bg, D., Feliciello dd, A., Feofilov dv, G., Ferencei cb, J., Fernández Téllez b, A., Ferreiro p, E. G., Ferretti y, A., Festanti ab, A., Figiel di, J., Figueredo dl, M. A. S., Filchagin cr, S., Finogeev ba, D., Fionda ae, F. M., Fiore ae, E. M., Floratos cg, E., Floris ah, M., Foertsch bj, S., Foka cp, P., Fokin cs, S., Fragiacomo dc, E., Francescon ab, A., Frankenfeld cp, U., Fuchs ah, U., Furget bp, C., Fusco Girard ac, M., Gaardhøje by, J. J., Gagliardi y, M., Gago cv, A. M., Gallio y, M., Gangadharan s, D. R., Ganoti cg, P., Garabatos cp, C., Garcia Solis m, E., Gargiulo ah, C., Garishvili bt, I., Gerhard am, J., Germain df, M., Gheata ah, A., Gheata bg, M., Ghidini ae, B., Ghosh dw, P., Ghosh d, S. K., Gianotti bq, P., Giubellino ah, P., Gladysz Dziadus di, E., Glässel cl, P., Gomez k, R., González Zamora j, P., Gorbunov am, S., Görlich di, L., Gotovac dh, S., Graczykowski dy, L. K., Grajcarek cl, R., Grelli bb, A., Grigoras ah, A., Grigoras ah, C., Grigoriev bu, V., Grigoryan a, A., Grigoryan bk, S., Grinyov c, B., Grion dc, N., Grosse Oetringhaus ah, J. F., Grossiord du, J. Y., Grosso ah, R., Guber ba, F., Guernane bp, R., Guerzoni z, B., Guilbaud du, M., Gulbrandsen by, K., Gulkanyan a, H., Gunji dr, T., Gupta ci, A., Gupta ci, R., Khan o, K. H., Haake ay, R., Haaland q, Ø., Hadjidakis au, C., Haiduc bg, M., Hamagaki dr, H., Hamar ea, G., Hanratty cu, L. D., Hansen by, A., Harris eb, J. W., Hartmann am, H., Harton m, A., Hatzifotiadou cx, D., Hayashi dr, S., Heckel aw, S. T., Heide ay, M., Helstrup ai, H., Herghelegiu bw, A., Herrera Corral k, G., Hess ag, B. A., Hetland ai, K. F., Hicks eb, B., Hippolyte az, B., Hladky be, J., Hristov ah, P., Huang q, M., Humanic s, T. J., Hutter am, D., Hwang t, D. S., Ilkaev cr, R., Ilkiv bv, I., Inaba ds, M., Incani w, E., Innocenti y, G. M., Ionita ah, C., Ippolitov cs, M., Irfan r, M., Ivanov cp, M., Ivanov cd, V., Ivanytskyi c, O., Jachołkowski aa, A., Jacobs bs, P. M., Jahnke dl, C., Jang bm, H. J., Janik dy, M. A., Jayarathna dn, P. H. S. Y., Jena ar, S., Jimenez Bustamante bh, R. T., Jones cu, P. G., Jung an, H., Jusko cu, A., Kalcher am, S., Kalinak bd, P., Kalweit ah, A., Kamin aw, J., Kang ec, J. H., Kaplin bu, V., Kar dw, S., Karasu Uysal bn, A., Karavichev ba, O., Karavicheva ba, T., Karpechev ba, E., Kebschull av, U., Keidel ed, R., Ketzer ck, B., Khan r, M. M., 3, Khan ct, P., Khan dw, S. A., Khanzadeev cd, A., Kharlov de, Y., Kileng ai, B., Kim ec, B., Kim bm, D. W., Kim do, D. J., Kim an, J. S., Kim an, M., Kim ec, M., Kim t, S., Kim ec, T., Kirsch am, S., Kisel am, I., Kiselev bc, S., Kisiel dy, A., Kiss ea, G., Klay f, J. L., Klein cl, J., Klein Bösing ay, C., Kluge ah, A., Knichel cp, M. L., Knospe dj, A. G., Kobdaj ah, C., Kofarago ah, M., Köhler cp, M. K., Kollegger am, T., Kolojvari dv, A., Kondratiev dv, V., Kondratyeva bu, N., Konevskikh ba, A., Kovalenko dv, V., Kowalski ah, M., Kox bp, S., Koyithatta Meethaleveedu ar, G., Kral do, J., Králik bd, I., Kramer aw, F., Kravcˇáková al, A., Krelina ak, M., Kretz am, M., Krivda cu, M., Krizek cb, F., Krus ak, M., Kryshen cd, E., Krzewicki cp, M., Kucˇera cb, V., Kucheriaev cs, Y., Kugathasan ah, T., Kuhn az, C., Kuijer bz, P. G., Kulakov aw, I., Kumar ar, J., Kurashvili bv, P., Kurepin ba, A., Kurepin ba, A. B., Kuryakin cr, A., Kushpil cb, S., Kushpil cb, V., Kweon cl, M. J., Kwon ec, Y., Ladron de Guevara bh, P., Lagana Fernandes dl, C., Lakomov au, I., Langoy dx, R., Lara av, C., Lardeux df, A., Lattuca y, A., La Pointe dd, S. L., La Rocca aa, P., Leardini cl, L., Lee cu, G. R., Legrand ah, I., Lehnert aw, J., Lemmon ca, R. C., Lenhardt cp, M., Lenti cw, V., Leogrande bb, E., Leoncino y, M., León Monzón dk, I., Lévai ea, P., Li g, S., Lien dx, J., Lietava cu, R., Lindal u, S., Lindenstruth am, V., Lippmann cp, C., Lisa s, M. A., Ljunggren af, H. M., Lodato bb, D. F., Loenne q, P. I., Loggins dz, V. R., Loginov bu, V., Lohner cl, D., Loizides bs, C., Lopez bo, X., López Torres i, E., Lu cl, X. G., Luettig aw, P., Lunardon ab, M., Luo g, J., Luzzi ah, C., Ma eb, R., Maevskaya ba, A., Mager ah, M., Mahapatra bf, D. P., Maire cl, A., Malaev cd, M., Maldonado Cervantes bh, I., Malinina bk, L., 4, Mal’Kevich bc, D., Malzacher cp, P., Mamonov cr, A., Manceau dd, L., Manko cs, V., Manso bo, F., Manzari ah, V., Marchisone y, M., Mareš be, J., Margotti cx, A., Marín cp, A., Markert ah, C., Marquard aw, M., Martashvili dq, I., Martin cp, N. A., Martinengo ah, P., Martínez b, M. I., Martínez García df, G., Martin Blanco df, J., Martynov c, Y., Mas df, A., Masciocchi cp, S., Masera y, M., Masoni cy, A., Massacrier df, L., Mastroserio ae, A., Matyja di, A., Mayer di, C., Mazer dq, J., Mazumder as, R., Mazzoni db, M. A., Meddi v, F., Menchaca Rocha bi, A., Meninno ac, E., Mercado Pérez cl, J., Meres aj, M., Miake ds, Y., Mikhaylov bc, K., Milano ah, L., Milosevic u, J., 5, Mischke bb, A., Mishra as, A. N., Mis ́kowiec cp, D., Mitu bg, C. M., Mlynarz dz, J., Mohanty dw, B., Molnar az, L., Montaño Zetina k, L., Montes j, E., Morando ab, M., Moreira De Godoy dl, D. A., Moretto ab, S., Morreale do, A., Morsch ah, A., Muccifora bq, V., Mudnic dh, E., Muhuri dw, S., Mukherjee dw, M., Müller ah, H., Munhoz dl, M. G., Murray ch, S., Musa ah, L., Musinsky bd, J., Nandi ar, B. K., Nania cx, R., Nappi cw, E., Nattrass dq, C., Nayak dw, T. K., Nazarenko cr, S., Nedosekin bc, A., Nicassio cp, M., Niculescu bg, M., Nielsen by, B. S., Nikolaev cs, S., Nikulin cs, S., Nikulin cd, V., Nilsen ce, B. S., Noferini l, F., Nomokonov bk, P., Nooren bb, G., Nyanin cs, A., Nystrand q, J., Oeschler cl, H., Oh eb, S., Oh bl, S. K., An, 6, Okatan bn, A., Olah ea, L., Oleniacz dy, J., Oliveira Da Silva dl, A. C., Onderwaater cp, J., Oppedisano dd, C., Ortiz Velasquez af, A., Oskarsson af, A., Otwinowski cp, J., Oyama cl, K., Pachmayer cl, Y., Pachr ak, M., Pagano ac, P., Paic ́ bh, G., Painke am, F., Pajares p, C., Pal dw, S. K., Palmeri cz, A., Pant ar, D., Papikyan a, V., Pappalardo cz, G. S., Park cp, W. J., Passfeld ay, A., Patalakha de, D. I., Paticchio cw, V., Paul ct, B., Pawlak dy, T., Peitzmann bb, T., Pereira Da Costa n, H., Pereira De Oliveira Filho dl, E., Peresunko cs, D., Pérez Lara bz, C. E., Peryt dy, W., Pesci cx, A., Pestov e, Y., Petrácˇek ak, V., Petran ak, M., Petris bw, M., Petrovici bw, M., Petta aa, C., Pikna aj, M., Pillot df, P., Pinazza ah, O., Pinsky dn, L., Piyarathna dn, D. B., Płoskon ́ bs, M., Planinic cq, M., Pluta dy, J., Pochybova ea, S., Podesta Lerma dk, P. L. M., Poghosyan ah, M. G., Pohjoisaho ap, E. H. O., Polichtchouk de, B., Poljak cq, N., Pop bw, A., Porteboeuf Houssais bo, S., Porter bs, J., Pospisil ak, V., Potukuchi ci, B., Prasad d, S. K., Preghenella cx, R., Prino dd, F., Pruneau dz, C. A., Pshenichnov ba, I., Puddu w, G., Punin cr, V., Putschke dz, J., Qvigstad u, H., Rachevski dc, A., Raha d, S., Rak do, J., Rakotozafindrabe n, A., Ramello ad, L., Raniwala cj, R., Raniwala cj, S., Räsänen ap, S. S., Rascanu aw, B. T., Rathee cf, D., Rauf o, A. W., Razazi w, V., Read dq, K. F., Real bp, J. S., Redlich bv, K., 7, Reed eb, R. J., Rehman q, A., Reichelt aw, P., Reicher bb, M., Reidt cl, F., Renfordt aw, R., Reolon bq, A. R., Reshetin ba, A., Rettig am, F., Revol ah, J. P., Reygers cl, K., Riabov cd, V., Ricci br, R. A., Richert af, T., Richter u, M., Riedler ah, P., Riegler ah, W., Riggi aa, F., Rivetti dd, A., Rocco bb, E., Rodríguez Cahuantzi b, M., Rodriguez Manso bz, A., Røed u, K., Rogochaya bk, E., Rohni ci, S., Rohr am, D., Röhrich q, D., Romita dp, R., Ronchetti bq, F., Ronflette df, L., Rosnet bo, P., Rossegger ah, S., Rossi ah, A., Roukoutakis cg, F., Roy as, A., Roy az, C., Roy ct, P., Rubio Montero j, A. J., Russo y, R., Ryabinkin cs, E., Ryabov cd, Y., Rybicki di, A., Sadovsky de, S., Šafarˇík ah, K., Sahlmuller aw, B., Sahoo as, R., Sahu bf, P. K., Saini dw, J., Salgado p, C. A., Salzwedel s, J., Sambyal ci, S., Samsonov cd, V., Sanchez Castro az, X., Sánchez Rodríguez dk, F. J., Šándor bd, L., Sandoval bi, A., Sano ds, M., Santagati aa, G., Sarkar dw, D., Scapparone cx, E., Scarlassara ab, F., Scharenberg cn, R. P., Schiaua bw, C., Schicker cl, R., Schmidt cp, C., Schmidt ag, H. R., Schuchmann aw, S., Schukraft ah, J., Schulc ak, M., Schuster eb, T., Schutz ah, Y., Schwarz cp, K., Schweda cp, K., Scioli z, G., Scomparin dd, E., Scott cu, P. A., Scott dq, R., Segato ab, G., Seger ce, J. E., Selyuzhenkov cp, I., Seo co, J., Serradilla j, E., Sevcenco bg, A., Shabetai df, A., Shabratova bk, G., Shahoyan ah, R., Shangaraev de, A., Sharma dq, N., Sharma ci, S., Shigaki aq, K., Shtejer y, K., Sibiriak cs, Y., Siddhanta cy, S., Siemiarczuk bv, T., Silvermyr cc, D., Silvestre bp, C., Simatovic dt, G., Singaraju dw, R., Singh ci, R., Singha bx, S., Singhal dw, V., Sinha dw, B. C., Sinha ct, T., Sitar aj, B., Sitta ad, M., Skaali u, T. B., Skjerdal q, K., Smakal ak, R., Smirnov eb, N., Snellings bb, R. J. M., Søgaard af, C., Soltz bt, R., Song co, J., Song ec, M., Soramel ab, F., Sorensen dq, S., Spacek ak, M., Sputowska di, I., Spyropoulou Stassinaki cg, M., Srivastava cn, B. K., Stachel cl, J., Stan bg, I., Stefanek bv, G., Steinpreis s, M., Stenlund af, E., Steyn bj, G., Stiller cl, J. H., Stocco df, D., Stolpovskiy de, M., Strmen aj, P., Suaide dl, A. A. P., Subieta Vasquez y, M. A., Sugitate aq, T., Suire au, C., Suleymanov o, M., Sultanov bc, R., Šumbera cb, M., Susa cq, T., Symons bs, T. J. M., Szanto de Toledo dl, A., Szarka aj, I., Szczepankiewicz ah, A., Szymanski dy, M., Takahashi dm, J., Tangaro ae, M. A., Tapia Takaki au, J. D., 8, Tarantola Peloni aw, A., Tarazona Martinez ah, A., Tarzila bw, M. G., Tauro ah, A., Tejeda Muñoz b, G., Telesca ah, A., Terrevoli w, C., Ter Minasyan bu, A., Thäder cp, J., Thomas bb, D., Tieulent du, R., Timmins dn, A. R., Toia da, A., Torii dr, H., Trubnikov c, V., Trzaska do, W. H., Tsuji dr, T., Tumkin cr, A., Turrisi da, R., Tveter u, T. S., Ulery aw, J., Ullaland q, K., Uras du, A., Usai w, G. L., Vajzer cb, M., Vala bk, M., Valencia Palomo au, L., Vallero y, S., Vande Vyvre ah, P., Vannucci br, L., Van Der Maarel bb, J., Van Hoorne ah, J. W., van Leeuwen bb, M., Vargas b, A., Varma ar, R., Vasileiou cg, M., Vasiliev cs, A., Vechernin dv, V., Veldhoen bb, M., Velure q, A., Venaruzzo x, M., Vercellin y, E., Vergara Limón b, S., Vernet h, R., Verweij dz, M., Vickovic dh, L., Viesti ab, G., Viinikainen do, J., Vilakazi bj, Z., Villalobos Baillie cu, O., Vinogradov cs, A., Vinogradov dv, L., Vinogradov cr, Y., Virgili ac, T., Viyogi dw, Y. P., Vodopyanov bk, A., Völkl cl, M. A., Voloshin bc, K., Voloshin dz, S. A., Volpe ah, G., von Haller ah, B., Vorobyev dv, I., Vranic cp, D., Vrláková al, J., Vulpescu bo, B., Vyushin cr, A., Wagner q, B., Wagner cp, J., Wagner ak, V., Wang g, M., Wang cl, Y., Watanabe ds, D., Weber dn, M., Wessels ay, J. P., Westerhoff ay, U., Wiechula ag, J., Wikne u, J., Wilde ay, M., Wilk bv, G., Wilkinson cl, J., Williams cx, M. C. S., Windelband cl, B., Winn cl, M., Xiang g, C., Yaldo dz, C. G., Yamaguchi dr, Y., Yang bb, H., Yang g, P., Yang q, S., Yano aq, S., Yasnopolskiy cs, S., Yi co, J., Yin g, Z., Yoo co, I. K., Yushmanov cs, I., Zaccolo by, V., Zach ak, C., Zaman o, A., Zampolli cx, C., Zaporozhets bk, S., Zarochentsev dv, A., Závada be, P., Zaviyalov cr, N., Zbroszczyk dy, H., Zgura bg, I. S., Zhalov cd, M., Zhang g, F., Zhang g, H., Zhang bo, X., Bs, G, Zhangg, Y., Zhaou, C., Zhoug, D., Zhoug, F., Zhoubb, Y., Zhug, H., Zhudf, J., G, Zhug, J., Zhug, X., Zichichil, A., Zimmermann cl, A., Zimmermann ay, M. B., Zinovjev c, G., Zoccarato du, Y., Zynovyev c, M., Zyzak aw, M., Piano, Stefano, Lea, Ramona, Camerini, Paolo, Luparello, Grazia, Margagliotti, Giacomo, Rui, Rinaldo, B., Abelev bt, J., Adam ak, D., Adamová cb, M. M., Aggarwal cf, G., Aglieri Rinella ah, M., Agnello cm, Dd, A., Agostinelli z, N., Agrawal ar, Z., Ahammed dw, N., Ahmad r, A., Ahmad Masoodi r, I., Ahmed o, S. U., Ahn bm, S. A., Ahn bm, I., Aimo cm, S., Aiola eb, M., Ajaz o, A., Akindinov bc, D., Aleksandrov c, B., Alessandro dd, D., Alexandre cu, A., Alici cx, L, A., Alkin c, J., Alme ai, T., Alt am, V., Altini ae, S., Altinpinar q, I., Altsybeev dv, C., Alves Garcia Prado dl, C., Andrei bw, A., Andronic cp, V., Anguelov cl, J., Anielski ay, T., Anticˇic ́ cq, F., Antinori da, P., Antonioli cx, L., Aphecetche df, H., Appelshäuser aw, N., Arbor bp, S., Arcelli z, N., Armesto p, R., Arnaldi dd, T., Aronsson eb, I. C., Arsene u, Cp, M., Arslandok aw, A., Augustinus ah, R., Averbeck cp, T. C., Awes cc, M. D., Azmi r, Ch, M., Bach am, A., Badalà cz, Y. W., Baek an, Bo, S., Bagnasco dd, R., Bailhache aw, V., Bairathi cj, R., Bala ci, A., Baldisseri n, F., Baltasar Dos Santos Pedrosa ah, J., Bán bd, R. C., Baral bf, R., Barbera aa, F., Barile ae, G. G., Barnaföldi ea, L. S., Barnby cu, V., Barret bo, J., Bartke di, M., Basile z, N., Bastid bo, S., Basu dw, B., Bathen ay, G., Batigne df, B., Batyunya bk, P. C., Batzing u, C., Baumann aw, I. G., Bearden by, H., Beck aw, C., Bedda cm, N. K., Behera ar, I., Belikov az, F., Bellini z, R., Bellwied dn, E., Belmont Moreno bi, G., Bencedi ea, S., Beole y, I., Berceanu bw, A., Bercuci bw, Y., Berdnikov cd, D., Berenyi ea, M. E., Berger ck, R. A., Bertens bb, D., Berzano y, L., Betev ah, A., Bhasin ci, A. K., Bhati cf, B., Bhattacharjee ao, J., Bhom d, L., Bianchi y, N., Bianchi bq, C., Bianchin bb, J., Bielcˇík ak, J., Bielcˇíková cb, A., Bilandzic by, S., Bjelogrlic bb, F., Blanco j, D., Blau c, C., Blume aw, F., Bock cl, Bs, A., Bogdanov bu, H., Bøggild by, M., Bogolyubsky de, F. V., Böhmer ck, L., Boldizsár ea, M., Bombara al, J., Book aw, H., Borel n, A., Borissov dz, Co, J., Bornschein am, F., Bossú bj, M., Botje bz, E., Botta y, S., Böttger av, P., Braun Munzinger cp, M., Bregant dl, T., Breitner av, T. A., Broker aw, T. A., Browning cn, M., Broz aj, Ak, E., Bruna dd, G. E., Bruno ae, D., Budnikov cr, H., Buesching aw, S., Bufalino dd, P., Buncic ah, O., Busch cl, Z., Buthelezi bj, D., Caffarri ab, X., Cai g, H., Caines eb, A., Caliva bb, E., Calvo Villar cv, V., Canoa Roman ah, F., Carena ah, W., Carena ah, F., Carminati ah, A., Casanova Díaz bq, J., Castillo Castellanos n, E. A. R., Casula w, V., Catanescu bw, C., Cavicchioli ah, C., Ceballos Sanchez i, J., Cepila ak, P., Cerello dd, B., Chang do, S., Chapeland ah, J. L., Charvet n, S., Chattopadhyay dw, S., Chattopadhyay ct, M., Cherney ce, C., Cheshkov du, B., Cheynis du, V., Chibante Barroso ah, D. D., Chinellato dn, Dm, P., Chochula ah, M., Chojnacki by, S., Choudhury dw, P., Christakoglou bz, C. H., Christensen by, P., Christiansen af, T., Chujo d, S. U., Chung co, C., Cicalo cy, L., Cifarelli l, Z, F., Cindolo cx, J., Cleymans ch, F., Colamaria ae, D., Colella ae, A., Collu w, M., Colocci z, G., Conesa Balbastre bp, Z., Conesa del Valle au, Ah, M. E., Connors eb, Contin x, G., J. G., Contreras k, T. M., Cormier cc, Dz, Y., Corrales Morales y, P., Cortese ad, I., Cortés Maldonado b, M. R., Cosentino b, Dl, F., Costa ah, P., Crochet bo, R., Cruz Albino k, E., Cuautle bh, L., Cunqueiro bq, A., Dainese da, R., Dang g, A., Danu bg, D., Das ct, I., Das au, K., Das ct, S., Das d, A., Dash dm, S., Dash ar, S., De dw, H., Delagrange df, A., Deloff bv, E., Dénes ea, G., D’Erasmo ae, G. O. V., de Barros dl, A., De Caro l, Ac, G., de Cataldo cw, J., de Cuveland am, A., De Falco w, D., De Gruttola ac, N., De Marco dd, S., De Pasquale ac, R., de Rooij bb, M. A., Diaz Corchero j, T., Dietel ay, R., Divià ah, D., Di Bari ae, S., Di Liberto db, A., Di Mauro ah, P., Di Nezza bq, Ø., Djuvsland q, A., Dobrin bb, T., Dobrowolski bv, D., Domenicis Gimenez dl, B., Dönigus aw, O., Dordic u, S., Dørheim ck, A. K., Dubey dw, A., Dubla bb, L., Ducroux du, P., Dupieux bo, A. K., Dutta Majumdar ct, R. J., Ehlers eb, D., Elia cw, H., Engel av, B., Erazmus ah, Df, H. A., Erdal ai, D., Eschweiler am, B., Espagnon au, M., Estienne df, S., Esumi d, D., Evans cu, S., Evdokimov de, G., Eyyubova u, D., Fabris da, J., Faivre bp, D., Falchieri z, A., Fantoni bq, M., Fasel cl, D., Fehlker q, L., Feldkamp ay, D., Felea bg, A., Feliciello dd, G., Feofilov dv, J., Ferencei cb, A., Fernández Téllez b, E. G., Ferreiro p, A., Ferretti y, A., Festanti ab, J., Figiel di, M. A. S., Figueredo dl, Dp, S., Filchagin cr, D., Finogeev ba, F. M., Fionda ae, E. M., Fiore ae, E., Floratos cg, M., Floris ah, S., Foertsch bj, P., Foka cp, S., Fokin c, E., Fragiacomo dc, A., Francescon ab, U., Frankenfeld cp, U., Fuchs ah, C., Furget bp, M., Fusco Girard ac, J. J., Gaardhøje by, M., Gagliardi y, A. M., Gago cv, M., Gallio y, D. R., Gangadharan, P., Ganoti cg, Cc, C., Garabatos cp, E., Garcia Solis m, C., Gargiulo ah, I., Garishvili bt, J., Gerhard am, M., Germain df, A., Gheata ah, M., Gheata bg, B., Ghidini ae, P., Ghosh dw, S. K., Ghosh d, P., Gianotti bq, P., Giubellino ah, E., Gladysz Dziadus di, P., Glässel cl, R., Gomez k, P., González Zamora j, S., Gorbunov am, L., Görlich di, S., Gotovac dh, L. K., Graczykowski dy, R., Grajcarek cl, A., Grelli bb, A., Grigoras ah, C., Grigoras ah, V., Grigoriev bu, A., Grigoryan a, S., Grigoryan bk, B., Grinyov c, N., Grion dc, J. F., Grosse Oetringhaus ah, J. Y., Grossiord du, R., Grosso ah, F., Guber ba, R., Guernane bp, B., Guerzoni z, M., Guilbaud du, K., Gulbrandsen by, H., Gulkanyan a, T., Gunji dr, A., Gupta ci, R., Gupta ci, K. H., Khan o, R., Haake ay, Ø., Haaland q, C., Hadjidakis au, M., Haiduc bg, H., Hamagaki dr, G., Hamar ea, L. D., Hanratty cu, A., Hansen by, J. W., Harris eb, H., Hartmann am, A., Harton m, D., Hatzifotiadou cx, S., Hayashi dr, S. T., Heckel aw, M., Heide ay, H., Helstrup ai, A., Herghelegiu bw, G., Herrera Corral k, B. A., Hess ag, K. F., Hetland ai, B., Hicks eb, B., Hippolyte az, J., Hladky be, P., Hristov ah, M., Huang q, T. J., Humanic, D., Hutter am, D. S., Hwang t, R., Ilkaev cr, I., Ilkiv bv, M., Inaba d, E., Incani w, G. M., Innocenti y, C., Ionita ah, M., Ippolitov c, M., Irfan r, M., Ivanov cp, V., Ivanov cd, O., Ivanytskyi c, A., Jachołkowski aa, P. M., Jacobs b, C., Jahnke dl, H. J., Jang bm, M. A., Janik dy, P. H. S. Y., Jayarathna dn, S., Jena ar, Dn, R. T., Jimenez Bustamante bh, P. G., Jones cu, H., Jung an, A., Jusko cu, S., Kalcher am, P., Kalinak bd, A., Kalweit ah, J., Kamin aw, J. H., Kang ec, V., Kaplin bu, S., Kar dw, A., Karasu Uysal bn, O., Karavichev ba, T., Karavicheva ba, E., Karpechev ba, U., Kebschull av, R., Keidel ed, B., Ketzer ck, M. M., Khan r, P., Khan ct, S. A., Khan dw, A., Khanzadeev cd, Y., Kharlov de, B., Kileng ai, B., Kim ec, D. W., Kim bm, An, D. J., Kim do, J. S., Kim an, M., Kim an, M., Kim ec, S., Kim t, T., Kim ec, S., Kirsch am, I., Kisel am, S., Kiselev bc, A., Kisiel dy, G., Kiss ea, J. L., Klay f, J., Klein cl, C., Klein Bösing ay, A., Kluge ah, M. L., Knichel cp, A. G., Knospe dj, C., Kobdaj ah, Dg, M., Kofarago ah, M. K., Köhler cp, T., Kollegger am, A., Kolojvari dv, V., Kondratiev dv, N., Kondratyeva bu, A., Konevskikh ba, V., Kovalenko dv, M., Kowalski ah, Di, S., Kox bp, G., Koyithatta Meethaleveedu ar, J., Kral do, I., Králik bd, F., Kramer aw, A., Kravcˇáková al, M., Krelina ak, M., Kretz am, M., Krivda cu, Bd, F., Krizek cb, Ap, M., Krus ak, E., Kryshen cd, M., Krzewicki cp, V., Kucˇera cb, Y., Kucheriaev c, T., Kugathasan ah, C., Kuhn az, P. G., Kuijer bz, I., Kulakov aw, J., Kumar ar, P., Kurashvili bv, A., Kurepin ba, A. B., Kurepin ba, A., Kuryakin cr, S., Kushpil cb, V., Kushpil cb, M. J., Kweon cl, At, Y., Kwon ec, P., Ladron de Guevara bh, C., Lagana Fernandes dl, I., Lakomov au, R., Langoy dx, C., Lara av, A., Lardeux df, A., Lattuca y, S. L., La Pointe dd, Bb, P., La Rocca aa, L., Leardini cl, G. R., Lee cu, I., Legrand ah, J., Lehnert aw, R. C., Lemmon ca, M., Lenhardt cp, V., Lenti cw, E., Leogrande bb, M., Leoncino y, I., León Monzón dk, P., Lévai ea, S., Li g, J., Lien dx, R., Lietava cu, S., Lindal u, V., Lindenstruth am, C., Lippmann cp, M. A., Lisa, H. M., Ljunggren af, D. F., Lodato bb, P. I., Loenne q, V. R., Loggins dz, V., Loginov bu, D., Lohner cl, C., Loizides b, X., Lopez bo, E., López Torres i, X. G., Lu cl, P., Luettig aw, M., Lunardon ab, J., Luo g, C., Luzzi ah, R., Ma eb, A., Maevskaya ba, M., Mager ah, D. P., Mahapatra bf, A., Maire cl, Az, M., Malaev cd, I., Maldonado Cervantes bh, L., Malinina bk, D., Mal’Kevich bc, P., Malzacher cp, A., Mamonov cr, L., Manceau dd, V., Manko c, F., Manso bo, V., Manzari ah, Cw, M., Marchisone y, J., Mareš be, A., Margotti cx, A., Marín cp, C., Markert ah, Dj, M., Marquard aw, I., Martashvili dq, N. A., Martin cp, P., Martinengo ah, M. I., Martínez b, G., Martínez García df, J., Martin Blanco df, Y., Martynov c, A., Mas df, S., Masciocchi cp, M., Masera y, A., Masoni cy, L., Massacrier df, A., Mastroserio ae, A., Matyja di, C., Mayer di, J., Mazer dq, R., Mazumder a, M. A., Mazzoni db, F., Meddi v, A., Menchaca Rocha bi, E., Meninno ac, J., Mercado Pérez cl, M., Meres aj, Y., Miake d, K., Mikhaylov bc, Bk, L., Milano ah, J., Milosevic u, A., Mischke bb, A. N., Mishra a, D., Mis ́kowiec cp, C. M., Mitu bg, J., Mlynarz dz, B., Mohanty dw, Bx, L., Molnar az, L., Montaño Zetina k, E., Montes j, M., Morando ab, D. A., Moreira De Godoy dl, S., Moretto ab, A., Morreale do, A., Morsch ah, V., Muccifora bq, E., Mudnic dh, S., Muhuri dw, M., Mukherjee dw, H., Müller ah, M. G., Munhoz dl, S., Murray ch, L., Musa ah, J., Musinsky bd, B. K., Nandi ar, R., Nania cx, E., Nappi cw, C., Nattrass dq, T. K., Nayak dw, S., Nazarenko cr, A., Nedosekin bc, M., Nicassio cp, M., Niculescu bg, B. S., Nielsen by, S., Nikolaev c, S., Nikulin c, V., Nikulin cd, B. S., Nilsen ce, F., Noferini l, Cx, P., Nomokonov bk, G., Nooren bb, A., Nyanin c, J., Nystrand q, H., Oeschler cl, Ax, S., Oh eb, S. K., Oh bl, An, 6, A., Okatan bn, L., Olah ea, J., Oleniacz dy, A. C., Oliveira Da Silva dl, J., Onderwaater cp, C., Oppedisano dd, A., Ortiz Velasquez af, A., Oskarsson af, J., Otwinowski cp, K., Oyama cl, Y., Pachmayer cl, M., Pachr ak, P., Pagano ac, G., Paic ́ bh, F., Painke am, C., Pajares p, S. K., Pal dw, A., Palmeri cz, D., Pant ar, V., Papikyan a, G. S., Pappalardo cz, W. J., Park cp, A., Passfeld ay, D. I., Patalakha de, V., Paticchio cw, B., Paul ct, T., Pawlak dy, T., Peitzmann bb, H., Pereira Da Costa n, E., Pereira De Oliveira Filho dl, D., Peresunko c, C. E., Pérez Lara bz, W., Peryt dy, A., Pesci cx, Y., Pestov e, V., Petrácˇek ak, M., Petran ak, M., Petris bw, M., Petrovici bw, C., Petta aa, M., Pikna aj, P., Pillot df, O., Pinazza ah, L., Pinsky dn, D. B., Piyarathna dn, M., Płoskon ́ b, M., Planinic cq, Dt, J., Pluta dy, S., Pochybova ea, P. L. M., Podesta Lerma dk, M. G., Poghosyan ah, Ce, E. H. O., Pohjoisaho ap, B., Polichtchouk de, N., Poljak cq, A., Pop bw, S., Porteboeuf Houssais bo, J., Porter b, V., Pospisil ak, B., Potukuchi ci, S. K., Prasad d, R., Preghenella cx, F., Prino dd, C. A., Pruneau dz, I., Pshenichnov ba, G., Puddu w, V., Punin cr, J., Putschke dz, H., Qvigstad u, A., Rachevski dc, S., Raha d, J., Rak do, A., Rakotozafindrabe n, L., Ramello ad, R., Raniwala cj, S., Raniwala cj, S. S., Räsänen ap, B. T., Rascanu aw, D., Rathee cf, A. W., Rauf o, V., Razazi w, K. F., Read dq, J. S., Real bp, K., Redlich bv, R. J., Reed eb, A., Rehman q, P., Reichelt aw, M., Reicher bb, F., Reidt cl, R., Renfordt aw, A. R., Reolon bq, A., Reshetin ba, F., Rettig am, J. P., Revol ah, K., Reygers cl, V., Riabov cd, R. A., Ricci br, T., Richert af, M., Richter u, P., Riedler ah, W., Riegler ah, F., Riggi aa, A., Rivetti dd, E., Rocco bb, M., Rodríguez Cahuantzi b, A., Rodriguez Manso bz, K., Røed u, E., Rogochaya bk, S., Rohni ci, D., Rohr am, D., Röhrich q, R., Romita dp, Ca, F., Ronchetti bq, L., Ronflette df, P., Rosnet bo, S., Rossegger ah, A., Rossi ah, F., Roukoutakis cg, A., Roy a, C., Roy az, P., Roy ct, A. J., Rubio Montero j, R., Russo y, E., Ryabinkin c, Y., Ryabov cd, A., Rybicki di, S., Sadovsky de, K., Šafarˇík ah, B., Sahlmuller aw, R., Sahoo a, P. K., Sahu bf, J., Saini dw, C. A., Salgado p, J., Salzwedel, S., Sambyal ci, V., Samsonov cd, X., Sanchez Castro az, Bh, F. J., Sánchez Rodríguez dk, L., Šándor bd, A., Sandoval bi, M., Sano d, G., Santagati aa, D., Sarkar dw, E., Scapparone cx, F., Scarlassara ab, R. P., Scharenberg cn, C., Schiaua bw, R., Schicker cl, C., Schmidt cp, H. R., Schmidt ag, S., Schuchmann aw, J., Schukraft ah, M., Schulc ak, T., Schuster eb, Y., Schutz ah, K., Schwarz cp, K., Schweda cp, G., Scioli z, E., Scomparin dd, P. A., Scott cu, R., Scott dq, G., Segato ab, J. E., Seger ce, I., Selyuzhenkov cp, J., Seo co, E., Serradilla j, Bi, A., Sevcenco bg, A., Shabetai df, G., Shabratova bk, R., Shahoyan ah, A., Shangaraev de, N., Sharma dq, Bf, S., Sharma ci, K., Shigaki aq, K., Shtejer y, Y., Sibiriak c, S., Siddhanta cy, T., Siemiarczuk bv, D., Silvermyr cc, C., Silvestre bp, G., Simatovic dt, R., Singaraju dw, R., Singh ci, S., Singha bx, Dw, V., Singhal dw, B. C., Sinha dw, T., Sinha ct, B., Sitar aj, M., Sitta ad, T. B., Skaali u, K., Skjerdal q, R., Smakal ak, N., Smirnov eb, R. J. M., Snellings bb, C., Søgaard af, R., Soltz bt, J., Song co, M., Song ec, F., Soramel ab, S., Sorensen dq, M., Spacek ak, I., Sputowska di, M., Spyropoulou Stassinaki cg, B. K., Srivastava cn, J., Stachel cl, I., Stan bg, G., Stefanek bv, M., Steinpreis, E., Stenlund af, G., Steyn bj, J. H., Stiller cl, D., Stocco df, M., Stolpovskiy de, P., Strmen aj, A. A. P., Suaide dl, M. A., Subieta Vasquez y, T., Sugitate aq, C., Suire au, M., Suleymanov o, R., Sultanov bc, M., Šumbera cb, T., Susa cq, T. J. M., Symons b, A., Szanto de Toledo dl, I., Szarka aj, A., Szczepankiewicz ah, M., Szymanski dy, J., Takahashi dm, M. A., Tangaro ae, J. D., Tapia Takaki au, A., Tarantola Peloni aw, A., Tarazona Martinez ah, M. G., Tarzila bw, A., Tauro ah, G., Tejeda Muñoz b, A., Telesca ah, C., Terrevoli w, A., Ter Minasyan bu, J., Thäder cp, D., Thomas bb, R., Tieulent du, A. R., Timmins dn, A., Toia da, Aw, H., Torii dr, V., Trubnikov c, W. H., Trzaska do, T., Tsuji dr, A., Tumkin cr, R., Turrisi da, T. S., Tveter u, J., Ulery aw, K., Ullaland q, A., Uras du, G. L., Usai w, M., Vajzer cb, M., Vala bk, L., Valencia Palomo au, S., Vallero y, Cl, P., Vande Vyvre ah, L., Vannucci br, J., Van Der Maarel bb, J. W., Van Hoorne ah, M., van Leeuwen bb, A., Vargas b, R., Varma ar, M., Vasileiou cg, A., Vasiliev c, V., Vechernin dv, M., Veldhoen bb, A., Velure q, M., Venaruzzo x, E., Vercellin y, S., Vergara Limón b, R., Vernet h, M., Verweij dz, L., Vickovic dh, G., Viesti ab, J., Viinikainen do, Z., Vilakazi bj, O., Villalobos Baillie cu, A., Vinogradov c, L., Vinogradov dv, Y., Vinogradov cr, T., Virgili ac, Y. P., Viyogi dw, A., Vodopyanov bk, M. A., Völkl cl, K., Voloshin bc, S. A., Voloshin dz, G., Volpe ah, B., von Haller ah, I., Vorobyev dv, D., Vranic cp, J., Vrláková al, B., Vulpescu bo, A., Vyushin cr, B., Wagner q, J., Wagner cp, V., Wagner ak, M., Wang g, Y., Wang cl, D., Watanabe d, M., Weber dn, J. P., Wessels ay, U., Westerhoff ay, J., Wiechula ag, J., Wikne u, M., Wilde ay, G., Wilk bv, J., Wilkinson cl, M. C. S., Williams cx, B., Windelband cl, M., Winn cl, C., Xiang g, C. G., Yaldo dz, Y., Yamaguchi dr, H., Yang bb, P., Yang g, S., Yang q, S., Yano aq, S., Yasnopolskiy c, J., Yi co, Z., Yin g, I. K., Yoo co, I., Yushmanov c, Zaccolo by, V., C., Zach ak, A., Zaman o, C., Zampolli cx, S., Zaporozhets bk, A., Zarochentsev dv, P., Závada be, N., Zaviyalov cr, H., Zbroszczyk dy, I. S., Zgura bg, M., Zhalov cd, F., Zhang g, H., Zhang g, X., Zhang bo, G, B, Y., Zhangg, C., Zhaou, D., Zhoug, F., Zhoug, Y., Zhoubb, H., Zhug, J., Zhudf, G, J., Zhug, X., Zhug, A., Zichichil, A., Zimmermann cl, M. B., Zimmermann ay, G., Zinovjev c, Y., Zoccarato du, M., Zynovyev c, and M., Zyzak aw
Subjects: Particle ratios, ALICE, High pT, Nuclear modification factor, Identified particle production, Particle ratio, LHC, Baryon anomaly
Abstract: Transverse momentum spectra of π±, K± and p(p ̄) up to pT = 20 GeV/c at mid-rapidity in pp, peripheral (60–80%) and central (0–5%) Pb–Pb collisions at √sNN = 2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pion ratios both show a distinct peak at pT ≈ 3 GeV/c in central Pb–Pb collisions. Below the peak, pT < 3 GeV/c, both ratios are in good agreement with hydrodynamical calculations, suggesting that the peak itself is dominantly the result of radial flow rather than anomalous hadronization processes. For pT > 10 GeV/c particle ratios in pp and Pb–Pb collisions are in agreement and the nuclear modification factors for π±, K± and p(p ̄) indicate that, within the systematic and statistical uncertainties, the suppression is the same. This suggests that the chemical composition of leading particles from jets in the medium is similar to that of vacuum jets.
Published: 2014

11. 114 N-acetyl-l-cysteine (NAC) controls osteoclastogenesis through regulating th17 differentiation and rankl production in rheumatoid arthritis

Author: Kim, HR, primary, Kim, BM, additional, Lee, KA, additional, Lee, SH, additional, and Kim, KW, additional
Published: 2017
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12. Cancer gene therapy using a novel secretable trimeric TRAIL

Author: Kim M, Paul D. Robbins, Kim Th, Jeong M, Kim Cy, Dai-Wu Seol, Timothy R. Billiar, Kim Wb, Kim Mh, Kim Bm, Ko Jp, and Hajime Mushiake
Subjects: Male, medicine.medical_treatment, Genetic enhancement, Genetic Vectors, Neoplasms, Nerve Tissue, Transplantation, Heterologous, Gene Expression, Apoptosis, Mice, SCID, Biology, Adenoviridae, Viral vector, TNF-Related Apoptosis-Inducing Ligand, HeLa, Mice, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Molecular Biology, Cells, Cultured, Membrane Glycoproteins, Histocytochemistry, Tumor Necrosis Factor-alpha, Genetic Therapy, Glioma, biology.organism_classification, Cytokine, Cell culture, Immunology, Cancer cell, Cancer research, Molecular Medicine, Tumor necrosis factor alpha, Apoptosis Regulatory Proteins, Neoplasm Transplantation
Abstract: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, is a type II transmembrane cytokine molecule. Soluble TRAIL has been shown to induce apoptosis in a wide variety of cancer cells in vitro and to suppress tumor growth specifically without damaging normal cells and tissues in vivo. In our previous report, we have demonstrated that an artificial gene encoding the polypeptide composed of the three functional elements (a secretion signal, a trimerization domain and an apoptosis-inducing moiety of TRAIL gene sequence) expresses and secretes highly apoptotic trimeric TRAIL into the culture supernatant. Here, as an approach to TRAIL-based cancer gene therapy, we developed an adenoviral vector delivering the gene that encodes our secretable trimeric TRAIL (stTRAIL). This adenovirus (Ad-stTRAIL) potently induced apoptosis in vitro in cancer cell lines such as HeLa, MDA-MB-231, A549, HCT116 and U-87MG. In an animal xenograft tumor model bearing a human glioma cell line U-87MG, intratumoral delivery of Ad-stTRAIL dramatically suppressed tumor growth without showing detectable adverse side effects. Histological analysis revealed that Ad-stTRAIL suppresses tumor growth by inducing apoptotic cell death. Contrary to the known rapid clearance of systemically delivered TRAIL protein from the blood circulation, stTRAIL expressed by Ad-stTRAIL in tumor tissues persisted for more than 4 days. In a comparison of tumor suppressor activity between Ad-stTRAIL and Ad-flTRAIL (delivering the full-length TRAIL gene) after mixing infected cells with uninfected cells and implanting these mixed cells in nude mice, Ad-stTRAIL showed higher tumor suppressor activity than that of Ad-flTRAIL. Our data reveal that a gene therapy using Ad-stTRAIL has a promising potential to treat human cancers including gliomas.
Published: 2005
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13. Clavaric Acid and Steroidal Analogues as Ras- and FPP-Directed Inhibitors of Human Farnesyl-Protein Transferase

Author: Russell B. Lingham, Jackson B. Gibbs, James D. Bergstrom, Rew Dj, Francine R. Wilson, Kim Bm, Samuel L. Graham, Hiranthi Jayasuriya, Kenneth S. Koblan, Sheo B. Singh, Schaber, Amo Se, Keith C. Silverman, and Nancy E. Kohl
Subjects: Farnesyl-diphosphate farnesyltransferase, Farnesyl Protein Transferase, biology, Squalene synthase activity, Reductase, biology.organism_classification, chemistry.chemical_compound, Biochemistry, chemistry, Enzyme inhibitor, Drug Discovery, Clavariadelphus truncatus, biology.protein, Molecular Medicine, Protein prenylation, Clavaric acid
Abstract: We have identified a novel fungal metabolite that is an inhibitor of human farnesyl-protein transferase (FPTase) by randomly screening natural product extracts using a high-throughput biochemical assay. Clavaric acid [24, 25-dihydroxy-2-(3-hydroxy-3-methylglutaryl)lanostan-3-one] was isolated from Clavariadelphus truncatus; it specifically inhibits human FPTase (IC50 = 1.3 microM) and does not inhibit geranylgeranyl-protein transferase-I (GGPTase-I) or squalene synthase activity. It is competitive with respect to Ras and is a reversible inhibitor of FPTase. An alkaline hydrolysis product of clavaric acid, clavarinone [2,24,25-trihydroxylanostan-3-one], lacking the 3-hydroxy-3-methylglutaric acid side chain is less active as a FPTase inhibitor. Similarly, a methyl ester derivative of clavaric acid is also inactive. In Rat1 ras-transformed cells clavaric acid and lovastatin inhibited Ras processing without being overtly cytotoxic. Excess mevalonate reversed the effects of lovastatin but not of clavaric acid suggesting that the block on Ras processing by clavaric acid was due to inhibition of FPTase and not due to inhibition of HMG-CoA reductase. Despite these results, the possibility existed that clavaric acid inhibited Ras processing by directly inhibiting HMG-CoA reductase. To directly examine the effects of clavaric acid and clavarinone on HMG-CoA reductase, cholesterol synthesis was measured in HepG2 cells. No inhibition of HMG-CoA reductase was observed indicating that the inhibition of Ras processing by this class of compounds is due to inhibition of FPTase. To date, clavaric acid is the second reported nitrogen-free compound that competes with Ras to inhibit FPTase activity. A series of related compounds derived from computer-based similarity searches and subsequent rational chemical synthetic design provided compounds that exhibited a range of activity (0.04 --> 100 microM) against FPTase. Modest changes in the structures of these inhibitors dramatically change the inhibitory activity of these inhibitors.
Published: 1998
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14. Optimization for axial resolution, depth range, and sensitivity of spectral domain optical coherence tomography at 1.3 μm

Author: Lee, SW, Jeong, HW, Kim, BM, Ahn, YC, Jung, W, and Chen, Z
Subjects: Physical Sciences, Mathematical Sciences, Applied Physics
Abstract: We have developed high-speed and high-resolution spectral domain optical coherence tomography at 1.3 μn using an InGaAs line-scan camera and a broadband light source with the bandwidth of 170 nm that produces a theoretical axial resolution of 4.4 μm in air. We compared axial resolutions from point spread functions (PSFs) and depth ranges while changing the full spectral bandwidth detected by the camera and describing the optimization process for the axial resolution, the depth range, and the sensitivity for SD-OCT system. We found that SD-OCT at 1.3 μm cannot satisfy the conditions both below the axial resolution of 5 μm and above the depth range of 2 mm because of the restricted pixel number of the line-scan camera. To scan a large depth range, the axial resolution has to be sacrificed. In addition, the sensitivity rolls off slowly as a function of the depth if a large depth range is scanned. On the other hand, if the axial resolution needs to be close to the theoretical one, the depth range becomes limited and the sensitivity decays quickly. Since we have to maintain a reasonable depth range of 2.0 mm, we chose the spectrum full bandwidth of 214 nm captured by the detector to balance the axial resolution of 8.2 μm. In this setting, the sensitivity of our OCT system was measured at 107.1 dB. Theoretical and experimental results are compared and presented in this paper.
Published: 2009
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15. Possible novel therapy for malignant gliomas with secretable trimeric TRAIL

Author: Jeong, M, Kwon, YS, Park, SH, Kim, CY, Jeun, SS, Song, KW, Ko, Y, Robbins, PD, Billiar, TR, Kim, BM, Seol, DW, Jeong, M, Kwon, YS, Park, SH, Kim, CY, Jeun, SS, Song, KW, Ko, Y, Robbins, PD, Billiar, TR, Kim, BM, and Seol, DW
Abstract: Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inclucing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancers, but concerns over delivery and toxicity have limited progress. We have developed a secretable trimeric TRAIL (stTRAIL) and here evaluated the therapeutic potential of this stTRAIL-based gene therapy in brain tumors. An adenovirus (Ad-stTRAIL) delivering stTRAIL was injected into intra-cranial human glioma tumors established in nude mice and tumor growth monitored using the magnetic resonance imaging (MRI). Ad-stTRAIL gene therapy showed potent tumor suppressor activity with no toxic side effects at therapeutically effective doses. When compared with 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a conventional therapy for malignant gliomas, Ad-stTRAIL suppressed tumor growth more potently. The combination of Ad-stTRAIL and BCNU significantly increased survival compared to the control mice or mice receiving Ad-stTRAIL alone. Our data indicate that Ad-stTRAIL, either alone or combined with BCNU, has promise as a novel therapy for malignant gliomas. Copyright: © 2009 Jeong et al.
Published: 2009

16. Outcomes and prognostic factors of intracranial unruptured vertebrobasilar artery dissection.

Author: Kim BM, Kim SH, Kim DI, Shin YS, Suh SH, Kim DJ, Park SI, Park KY, and Ahn SS
Published: 2011
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17. Combined treatment with the Cox-2 inhibitor niflumic acid and PPARγ ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells.

Author: Kim BM, Maeng K, Lee KH, Hong SH, Kim, Byeong Mo, Maeng, Kyungah, Lee, Kee-Ho, and Hong, Sung Hee
Abstract: The present study was performed to investigate the possible combined use of the Cox-2 inhibitor niflumic acid and the PPARγ ligand ciglitazone and to elucidate the mechanisms underlying enhanced apoptosis by this combination treatment in human lung cancer cells. Combined niflumic acid-ciglitazone treatment synergistically induced apoptotic cell death, activated caspase-9, caspase-3, and induced caspase-3-mediated PARP cleavage. The combination treatment also triggered apoptosis through caspase-8/Bid/Bax activation, and the inhibition of caspase-8 suppressed caspase-8/Bid activation, caspase-3-mediated PARP cleavage, and concomitant apoptosis. In addition, combined niflumic acid-ciglitazone treatment significantly induced ER stress responses, and suppression of CHOP expression significantly attenuated the combined niflumic acid-ciglitazone treatment-induced activation of caspase-8 and caspase-3, and the subsequent apoptotic cell death, indicating a role of ER stress in caspase-8 activation and apoptosis. Interestingly, the pro-apoptotic effects of combined niflumic acid-ciglitazone treatment were realized through Cox-2- and PPARγ-independent mechanisms. Taken together, these results suggest that sequential ER stress and caspase-8 activation are critical in combined niflumic acid-ciglitazone treatment-induced apoptosis in human lung cancer cells. [ABSTRACT FROM AUTHOR]
Published: 2011
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18. Controlling recurrent papillary thyroid carcinoma in the neck by ultrasonography-guided percutaneous ethanol injection.

Author: Kim BM, Kim MJ, Kim EK, Park SI, Park CS, Chung WY, Kim, Byung Moon, Kim, Min Jung, Kim, Eun-Kyung, Park, Sung Il, Park, Cheong Soo, and Chung, Woong Youn
Abstract: The purpose of this study was to retrospectively evaluate the efficacy of ultrasonography-guided percutaneous ethanol injection (PEI) for neck recurrence of papillary thyroid carcinoma (NR-PTC). Twenty-seven patients (19-80 years old; mean, 53.2) with 47 NR-PTCs were treated by PEI and were followed-up (14-38 months; mean, 28.2). Ethanol (99%) was repeatedly injected with adjusting needle position until the entire volume of NR-PTC was ablated. All patients received follow-up ultrasonography at 3-6-month intervals, and the percent volume decrease was measured. The NR-PTCs with decreased volume and no tumor vascularity on power-Doppler study were regarded as treatment-effective. The NR-PTCs with stable or enlarged volume or with tumor vascularity were considered as treatment-failed, in which case PEI was repeated. The number of sessions and the total volume of ethanol per NR-PTC, and the volume of ethanol per session per NR-PTC were evaluated. All NR-PTCs significantly decreased in volume (range, 30-100%; mean, 93.6%). The mean number of sessions, the total volume of ethanol per NR-PTC, and the mean volume of ethanol per session per NR-PTC were 2.1 sessions (range 1-6), 2.4 ml (range 0.3-10.1), and 1.1 ml/session (range 0.3-3.0), respectively. PEI appears to be an alternative option for controlling NR-PTCs in the selected patients who are poor surgical candidates. [ABSTRACT FROM AUTHOR]
Published: 2008
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19. Whole body protein synthesis and catabolism in septic man

Author: Long, CL, primary, Jeevanandam, M, additional, Kim, BM, additional, and Kinney, JM, additional
Published: 1977
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20. Intensive Blood Pressure Lowering in Acute Stroke with Intracranial Stenosis Post-Thrombectomy: a secondary analysis of the OPTIMAL-BP trial.

Author: Kim KH, Yun J, Jung JW, Kim YD, Heo J, Lee H, Choi JK, Lee IH, Lim IH, Hong SH, Baik M, Kim BM, Kim DJ, Shin NY, Cho BH, Ahn SH, Park H, Sohn SI, Hong JH, Song TJ, Chang Y, Kim GS, Seo KD, Lee K, Chang JY, Seo JH, Lee S, Baek JH, Cho HJ, Shin DH, Kim J, Yoo J, Lee KY, Jung YH, Hwang YH, Kim CK, Kim JG, Lee CJ, Park S, Lee HS, Kwon SU, Bang OY, Heo JH, and Nam HS
Abstract: Background: Intensive blood pressure (BP) management within 24 hours after successful reperfusion following endovascular thrombectomy (EVT) is associated with worse functional outcomes than conventional BP management in Asian randomized controlled trials. Given the high prevalence of intracranial atherosclerotic stenosis (ICAS) in Asia, ICAS may influence these outcomes., Aims: We aimed to assess whether ICAS affects the outcomes of intensive BP management after successful EVT., Methods: We conducted a secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy-Optimal Blood Pressure Control trial, which enrolled participants from June 2020 to November 2022. Patients with anterior circulation large vessel occlusion (LVO) were stratified into ICAS-related and embolic LVO groups. Clinical outcomes for intensive (target systolic BP<140 mmHg) and conventional BP management (target systolic BP 140-180 mmHg) were analyzed in each group. The primary outcome was a favorable outcome, defined as a modified Rankin Scale score of 0 to 2 at 3 months. Safety outcomes included symptomatic intracerebral hemorrhage within 36 hours and stroke-related death within 3 months., Results: Among 192 patients, 59 were in the ICAS-related LVO group, and 133 were in the embolic LVO group. In the ICAS-related LVO group, the rate of achieving a favorable outcome at 3 months was 37.5% with intensive BP management and 55.6% with conventional management (adjusted OR, 0.49 [95% CI, 0.14-1.75]; P=0.27). In the embolic LVO group, these rates were 29.9% and 42.4%, respectively (adjusted OR, 0.64 [95% CI, 0.28-1.45]; P=0.29). No significant interaction was found (P for interaction=0.68). Additionally, the ICAS-related LVO group receiving intensive BP management had lower rates of successful reperfusion at 24 hours compared to conventional management (67.7% vs 91.7%; P=0.03), while no significant difference was found in the embolic LVO group. A significant interaction effect on successful reperfusion at 24 hours was observed between ICAS-related and embolic LVO groups (P for interaction=0.04). No significant differences in safety outcomes were observed between intensive BP management and conventional management within both ICAS-related LVO and embolic LVO groups., Conclusions: ICAS did not significantly affect outcomes of intensive BP management within 24 hours after successful EVT. After successful reperfusion by EVT, intensive BP management should be avoided regardless of ICAS presence.
Published: 2024
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21. Long-Term Outcome of Rescue Stenting for Acute Intracranial Atherosclerotic Stenosis Related Large Vessel Occlusion in Anterior Circulation.

Author: Park H, Kim BM, Kim JW, Kim JW, Baek JH, Kim DJ, Kim MJ, Yoon S, Jang CK, Kim S, Heo J, Lee JK, Lim IH, Heo JH, Nam HS, and Kim YD
Abstract: Background and Purpose: Rescue stent (RS) is an accepted rescue option after failed mechanical thrombectomy (MT) for acute ischemic stroke due to intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusion (LVO). However, the long-term outcomes (≥ 12 months) of RS have not yet been elucidated., Materials and Methods: We retrospectively analyzed the data of 154 patients with RS for ICAS-related LVO, which were identified from prospectively maintained multicenter database of RS after MT failure, to assess good outcome (mRS 0-2), mortality, stroke recurrence, symptomatic intracranial hemorrhage (SICH) and stent patency., Results: Among 154 patients, successful recanalization was achieved in 132 (85.7%) after RS. Clinical follow-up was available in 148 patients at 3 months, of whom 126 were followed longer than 12 months. Good outcome was observed in 53.4% (79/148) at 3 months and 53.2% (67/126) at the final assessment among survivors (median [interquartile range (IQR)] months, 33 [13-91]). The overall incidence of mortality was 16.2% (24/148) Mortality occurred in 8.8% (13/148) of patients at 3 months and 8.7% (11/126) thereafter, respectively. Stroke recurrence was 0.7% (1/148) within 3 months and 3.2% (4/126) thereafter. The overall incidence of SICH was 9.5% (14/148). SICH occurred in 8.8% (13/148) within the first 3 months, and in 0.8% (1/126) thereafter. The stented vessel was patent in 81.1% (99/122) at the first follow-up (median [IQR] days, 3 [1-125]) and 96.7% (89/92) at the final follow-up (median [IQR] months, 18 [13-68])., Conclusions: Patients with RS for ICAS-LVO showed a low stroke recurrence rate in the long term. The long-term patency of rescue stent appears to remain durable, particularly when it remains patent during the initial follow-upABBREVIATIONS: ICAS = intracranial atherosclerotic stenosis; LVO = large vessel occlusion; AIS = acute ischemic stroke; MT = mechanical thrombectomy; RS = rescue stenting; CT = computed tomography; MR = magnetic resonance; MMD = moyamoya disease; Intra-arterial = IA; Intravenous = IV; DAPT = dual antiplatelet therapy., Competing Interests: The authors declare no conflicts of interest related to the content of this article., (© 2024 by American Journal of Neuroradiology.)
Published: 2024
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22. A Pharmacist Medication Titration Program for Patients with Cardiac Sarcoidosis and Systolic Heart Failure: A Retrospective Cohort Study.

Author: Sykora D, Olson N, Churchill R, Kim BM, Bratcher M, Elwazir M, Young K, Ryan S, Brodin M, Anderson J, Saunders J, Ezzeddine OA, Bois J, Giudicessi J, Cooper L, and Rosenbaum A
Abstract: Background: A multidisciplinary approach improves guideline-directed medical therapy (GDMT) in systolic heart failure (HF), but its efficacy in patients with HF due to cardiac sarcoidosis (CS) is unreported., Methods and Results: In a retrospective cohort study, we reviewed 848 patients from our institutional CS clinics, identifying those with a CS diagnosis, HF (LVEF < 50%) at index evaluation, and echocardiograms within 90 days and 11-36 months. Patients were stratified by participation in a pharmacist-led medication therapy management (MTM) program for GDMT optimization (MTM vs non-MTM [NMTM]) without randomization. Demographics, LVEF, GDMT (quantified by Kansas City Medical Optimization [KCMO] score), and immunosuppressive therapy were assessed. Primary outcomes included changes in KCMO score, LVEF, and cardiovascular event-free survival (unplanned HF hospitalization, LVAD/heart transplant, or death). The final cohort included 111 patients (median age 57 years, 34% female, 64% NYHA Class I-II); 43 (39%) were MTM and 68 (61%) were NMTM. Mean KCMO score was similar at index evaluation (MTM: 23.2; NMTM: 29.6, p=0.83). At follow-up (median 16 months), the KCMO score increased significantly in both groups (MTM: 23.2 to 74.8, p<0.001; NMTM: 29.6 to 58.7, p<0.001), but was higher in MTM (p=0.001). Mean LVEF trended towards higher values in MTM (44.4% vs 40.0%, p=0.05). The primary clinical outcome occurred in 1 MTM (2.3%) and 16 NMTM (23.5%) patients, with higher risk in NMTM (HR 11.97 [95%CI 1.58 - 90.54], p=0.002)., Conclusions: In this retrospective cohort study, a pharmacist-led MTM program was associated with favorable GDMT optimization and lower risk of adverse cardiovascular outcomes in CS patients with HF.
Published: 2024
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23. Mechanism for Site-Selective Hydroboration of C 70 Fullerene with Borane by DFT-D3 Study.

Author: Choi JW, Kim BM, Osawa E, Lee JY, Lee C, and Lee KH
Abstract: We studied the hydroboration of the C 70 fullerene using both B3LYP-D3(BJ)/6-311G(d,p) and M06-2X-D3/6-311G(d,p) levels of theory, incorporating the empirical dispersion interaction, and Fukui index calculations. Potential energy surfaces (PESs) and Gibbs free energy surfaces (GFESs) were calculated for the pathways from four BH 3 adducts (located at the AB , CC , D , and E sites) on the C 70 to eight products formed by the 1,2-addition of BH 3 across the four [6,6]-ring fused bonds ( AB , CC , DE , and EE ) and across the two [5,6]-ring fused bonds ( AA and DD ). These pathways are two-step consecutive reactions. We denoted the positions on the fullerene cage as A through E , from the pole to the equator, based on the D 5h symmetry of the C 70 fullerene. In the first step reaction, the product ratios for the four adduct intermediates should be as the primary intermediate BH 3 ( D ), the secondary intermediate BH 3 ( AB ), the tertiary intermediate BH 3 ( CC ), and the minor intermediate BH 3 ( E ), based on the Fukui indices. In addition, in the second step reaction, transition states (TSs) from four adduct intermediates to eight product isomers, namely, BH 2 ( A )H ( B ) to BH 2 ( E )H ( E ), were obtained using the QST2 method. The calculated reaction coordinates showed exothermic reactions for all bonds except the EE bond. We also confirmed the transition states by frequency calculations and intrinsic reaction coordinate (IRC) analyses. The PESs and GFESs suggest spontaneous processes for the four isomers, of which the primary products are BH 2 ( A )H ( B ) and its isomer BH 2 ( B )H ( A ), the secondary product is BH 2 ( C )H ( C ), and the tertiary product is BH 2 ( D )H ( D ), all formed through adduct intermediates. Therefore, through the hydroboration reaction of C 70 , we could predict and design the site selectivity of C 70 by controlling the energy barrier of the transition state in the second step of the reaction. This implies that we could selectively synthesize mainly BH 2 ( B )H ( A ) isomers across the AB-[6,6]-ring fused bond and also design BH 2 ( D )H( D ) isomers across the DD-[5,6]-ring fused bond. Also, the calculations of formation rate constants can well simulate the experimental ratio of two C 70 H 2 isomers by the hydrolysis of BH 2 ( A )H( B ), BH 2 ( B )H( A ), and BH 2 ( C )H( C ) products at room temperature.
Published: 2024
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24. Effects of calcium lactate on in vitro fertilization and embryonic development in cattle.

Author: Kim BM, Lee SH, Heo G, Kim JD, Lee GH, Sim JM, Lim KT, and Cui XS
Abstract: Objective: Growing demand for embryo transfer is steadily expanding and further studies on in vitro fertilization of cattle. To assess the effect of calcium lactate by replacing Tyrode's Albumin Lactate Pyruvate (TALP) medium composition during fertilization and embryonic development., Methods: Sodium lactate and CaCl2 were replaced with 2.0, 3.0, 4.5 mM calcium lactate for TALP medium during fertilization in Experiment 1. In Experiment 2, the concentrations of sodium lactate and CaCl2 were re-modified as control, in comparison with the same concentration of calcium lactate at 4.5 mM. Zygotes were moved to sequential media to match early-and late-stage environments. Embryonic development was examined on day 8 after insemination., Results: 4.5 mM calcium lactate enhanced the rate of fertilization and blastocyst formation (p<0.0001, p<0.01, respectively). It represented differences in the ROS (p<0.01) and GSH levels (p<0.05) and increased blastocyst diameter and total cell number (p<0.05). In Experiment 2, fertilization (p<0.05) and blastocyst formation rates (p<0.01) were increased in 4.5mM calcium lactate under same concentration effect of sodium lactate and CaCl2. Additionally, it reduced the ROS (p<0.01) and increased the GSH levels (p<0.05), leading increase embryo quality., Conclusion: The replacement of calcium lactate in TALP medium enhances fertilization and embryonic development while also improving oxidative stress. Specifically, it has been determined that a concentration of 4.5 mM calcium lactate is the most effective, irrespective of the varying concentrations of sodium lactate and CaCl2. This study presents a novel formulation of a modified TALP medium intended for implantation withing the bovine embryo industry. The current implications of the study are discussed in relation to previously stated objectives and hypotheses.
Published: 2024
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25. Nationwide prevalence and geographic variation of idiopathic intracranial hypertension among women in the United States.

Author: Fraz MA, Kim BM, Chen JJ, Lum F, Chen J, Liu GT, and Hamedani AG
Abstract: Objective: The prevalence of idiopathic intracranial hypertension (IIH) is increasing, but this has not been examined on a nationwide scale. Our objective was to determine the nationwide prevalence and geographic distribution of IIH among women in the U.S., Design: Retrospective cross-sectional study using Medicaid claims and electronic health record data from the IRIS® Registry (Intelligent Research in Sight) and Sight Outcomes Research Collaborative (SOURCE)., Participants: Female Medicaid beneficiaries aged 18-55 with IIH diagnoses and prescriptions for acetazolamide or methazolamide in 2018, excluding those with other causes of intracranial hypertension. We also calculated the proportion of female IIH patients in the U.S. who were insured by Medicaid by combining analyses from the IRIS® Registry and SOURCE., Methods: To calculate the total number of IIH patients in the U.S. and by state, we divided the number of Medicaid beneficiaries with IIH by the proportion of IIH patients insured by Medicaid. We then used census data from the 2018 American Community Survey to calculate prevalence., Main Outcome Measures: We compared the geographic distribution of IIH to obesity prevalence data from the 2018 Behavioral Risk Factor Surveillance System, using the Moran's I statistic to test for spatial variation. In a validation study, we compared the calculated prevalence of IIH in Minnesota to similar data from the Rochester Epidemiology Project., Results: Of 13,959 female Medicaid beneficiaries with IIH, 6,828 had a prescription for acetazolamide or methazolamide. In the IRIS® Registry and SOURCE, 25% of IIH patients were insured by Medicaid (95 % CI: 16-33%), suggesting that there were 27,312 women aged 18-55 with IIH taking acetazolamide or methazolamide in 2018 (6,828 / 0.25 = 27,312). Prevalence was 3.44 per 10,000 (95% CI: 2.61-5.39), and there was significant geographic variation (Moran's I statistic 0.20, P = 0.03) with higher prevalence in states where obesity was more common. The calculated prevalence of IIH in Minnesota was statistically equivalent to Rochester Epidemiology Project data (P < 0.05 for equivalence test)., Conclusions: IIH affects 3.44 per 10,000 women aged 18-55 in the U.S., and there is significant geographic variation, some of which is explained by variation in obesity prevalence., (Copyright © 2024. Published by Elsevier Inc.)
Published: 2024
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26. On-Device Deep Learning to Detect Carotid Stenosis With Smartphones: Development and Validation.

Author: Heo J, Lee H, Yoon S, Kim MJ, Park E, Kim BM, Kim DJ, Kim YD, Kim BH, and Nam HS
Abstract: Competing Interests: None.
Published: 2024
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27. Incidence, Mechanisms, and Clinical Characteristics of Traumatic Iritis: A Population-Based Analysis.

Author: Wang KY, Kim BM, Xu TT, Reynolds MM, Hodge DO, and Smith WM
Abstract: Purpose: To describe the incidence, mechanisms, and clinical characteristics of patients diagnosed with traumatic iritis in a U.S. Midwestern county population., Methods: Retrospective population-based cohort of all residents of Olmsted County, Minnesota diagnosed with traumatic iritis from January 1, 2006, to December 31, 2015. The medical records of patients with traumatic iritis were identified using the Rochester Epidemiology Project database, which contains virtually all medical care in the county. Medical records were reviewed for demographics, presentation, and follow-up data. Incidence rates were calculated per 100,000 per year., Results: There were 156 incident diagnoses of traumatic iritis during the 10-year study period, yielding an age- and sex-adjusted incidence rate of 10.7 per 100,000 per year. Traumatic iritis disproportionately occurred in male ( p < 0.001) and Black ( p < 0.001) patients. The mean age of diagnosis was 33 years (range: 4-96 years), mean number of traumatic iritis-specific follow-up visits was 2.1 (range: 0-26), and median duration of traumatic iritis-specific follow-up was 11 days (range: 1 day-1.6 years). There were 155 (99.4%) patients with unilateral disease. The most frequent mechanisms of traumatic iritis were sports-related ( N = 29, 18.6%), assault-related ( N = 23, 14.7%), scratch ( N = 22, 14.1%), and work-related ( N = 21, 13.5%) injuries. The mean initial and final best-corrected visual acuity (BCVA) of the affected eye was 20/40 and 20/30, respectively. Loss of follow-up was more frequently observed in Black patients ( p < 0.001) and patients with smoking history ( p = 0.004)., Conclusion: Traumatic iritis was most frequently observed in younger males and Black patients. Common mechanisms included sports, assault, scratch, and work-related injuries.
Published: 2024
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28. Outcomes of Hyperbaric Oxygen Treatment for Central Retinal Artery Occlusion: A Single Center Experience.

Author: Kim BM, Wang KY, Xu TT, Hooshmand SJ, Toups GN, Millman MP, Steinkraus LW, Tooley AA, Barkmeier AJ, and Chen JJ
Abstract: Purpose: To describe the outcomes of hyperbaric oxygen therapy (HBOT) for patients with central retinal artery occlusion (CRAO) at a single tertiary care center., Design: Retrospective clinical cohort study., Methods: Medical records of all patients diagnosed with CRAO who received HBOT at Mayo Clinic in Rochester, Minnesota from January 1, 2009 to December 31, 2020 were reviewed to confirm diagnosis, time from onset to presentation, exam findings, treatments, and follow-up data. Main outcome measures included final visual acuity (VA) and number of lines of improvement., Results: There were 41 patients diagnosed with CRAO who received HBOT during the 12-year study period. Median time from symptom onset to HBOT treatment was 9.5 h (interquartile range [IQR] 6.5, 14.0 h), and patients received a median of 4 HBOT sessions (IQR 2.5, 6.0 sessions). There were 20 patients who received HBOT within 9 h, 14 (70%) of which had clinically meaningful improvement in VA of ≥0.3 logMAR. In comparison, of the 21 patients treated after 9 h, 6 (28.6%) had VA improvement of ≥0.3 logMAR (P = .008). For all patients, the median logMAR VA at presentation was 2.00 (IQR 1.70, 2.30) and the median logMAR VA at follow-up was 1.94 (IQR 1.00, 2.00) (P < .001), with median lines of improvement of 3.0 (IQR 0.0, 7.0). For patients treated within 9 h, the median logMAR VA at presentation was 2.00 (IQR 1.93, 2.30) and the median logMAR VA at follow-up was 1.70 (IQR 0.54, 2.00). Patients treated within 9 h had statistically significant greater median lines of VA improvement than cases that were treated after >9 h from symptom onset at 5.9 (IQR 3.0, 10.0) and 0.0 (IQR 0.0, 3.0), respectively (P < .001). There was no difference in VA recovery associated with specific retinal exam findings such as cherry-red spot (P = .22) and cilioretinal artery perfusion (P = .36) compared to patients without those findings., Conclusion: There was a statistically significant improvement in VA after HBOT treatment in CRAO patients among patients that received early HBOT, with patients receiving the most benefit when receiving treatment within 9 h. Randomized control trials in patients with CRAO are required to confirm the efficacy of HBOT., (Copyright © 2024. Published by Elsevier Inc.)
Published: 2024
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29. Comparative analysis of SNaPshot and massively parallel sequencing for body fluid-specific DNA methylation markers.

Author: Kim BM, Park SU, and Lee HY
Subjects: Humans, Female, Male, Genetic Markers genetics, Sequence Analysis, DNA methods, Reproducibility of Results, Saliva chemistry, Cervix Mucus chemistry, DNA analysis, DNA genetics, DNA blood, Semen chemistry, Sensitivity and Specificity, DNA Methylation, High-Throughput Nucleotide Sequencing methods, Body Fluids chemistry, Forensic Genetics methods
Abstract: The identification of tissue-specific differentially methylated regions has significantly contributed to the field of forensic genetics, particularly in body fluid identification crucial for linking evidence to crimes. Among the various approaches to analyzing DNA methylation, the SNaPshot assay has been popularly studied in numerous researches. However, there is a growing interest in exploring alternative methods such as the use of massively parallel sequencing (MPS), which can process a large number of samples simultaneously. This study compares SNaPshot and MPS multiplex assays using nine cytosine-phosphate-guanine markers for body fluid identification. As a result of analyzing 112 samples, including blood, saliva, vaginal fluid, menstrual blood, and semen, both methods demonstrated high sensitivity and specificity, indicating their reliability in forensic investigations. A total of 92.0% samples were correctly identified by both methods. Although both methods accurately identified all blood, saliva, and semen samples, some vaginal fluid samples showed unexpected methylation signals at nontarget loci in addition to the target loci. In the case of menstrual blood samples, due to their complexity, independent typing criteria were applied, and successful menstrual blood typing was possible, whereas a few samples showed profiles similar to vaginal fluid. The MPS method worked better in vaginal fluid samples, and the SNaPshot method performed better in menstrual blood samples. This study offers valuable insights into body fluid identification based on the characteristics of the SNaPshot and MPS methods, which may help in more efficient forensic applications., (© 2024 The Author(s). ELECTROPHORESIS published by Wiley‐VCH GmbH.)
Published: 2024
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30. Identifying Current Collectors that Enable Light-Battery Interactions.

Author: Pujari A, Kim BM, Greenham NC, and De Volder M
Abstract: In recent years, there has been an increased focus on studying light-battery interactions in the context of operando optical studies and integrated photoelectrochemical energy harvesting. However, there has been little insight into identifying suitable "light-accepting" current collectors for this class of batteries. In this study, fluorine-doped tin oxide, indium-tin oxide, and silver nanowire-graphene films are analyzed along with carbon paper, carbon nanotube paper, and stainless-steel mesh as current collectors for optical batteries. They are categorized into two classes - transmissive and non-transmissive, based on the orientation of the light-electrode interaction. Various methods to prepare the electrode are highlighted, including drop casting and the fabrication of free-standing electrodes. The optical and electrical properties of these current collectors as well as their electrochemical stability are measured using linear sweep voltammetry against zinc and lithium anodes. Finally, the rate performance and long-term cycling stability of lithium manganese oxide (LiMn 2 O 4 ) cathodes are measured against lithium anodes with these current collectors and their performance is compared. These results show which current collector to choose depends on the application and cell chemistry. These guidelines will assist in the design of future optical cells for in-situ measurements and photoelectrochemical energy storage., (© 2024 The Authors. Small Methods published by Wiley‐VCH GmbH.)
Published: 2024
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31. Arrhythmic manifestations and outcomes of definite and probable cardiac sarcoidosis.

Author: Sykora D, Rosenbaum AN, Churchill RA, Kim BM, Elwazir MY, Bois JP, Giudicessi JR, Bratcher M, Young KA, Ryan SM, Sugrue AM, Killu AM, Chareonthaitawee P, Kapa S, Deshmukh AJ, Abou Ezzeddine OF, Cooper LT, and Siontis KC
Subjects: Humans, Female, Male, Middle Aged, Death, Sudden, Cardiac prevention & control, Death, Sudden, Cardiac etiology, Death, Sudden, Cardiac epidemiology, Retrospective Studies, Follow-Up Studies, Tachycardia, Ventricular etiology, Tachycardia, Ventricular physiopathology, Tachycardia, Ventricular therapy, Arrhythmias, Cardiac etiology, Arrhythmias, Cardiac therapy, Arrhythmias, Cardiac physiopathology, Survival Rate trends, Prognosis, Defibrillators, Implantable, Sarcoidosis complications, Sarcoidosis diagnosis, Sarcoidosis physiopathology, Cardiomyopathies physiopathology, Cardiomyopathies diagnosis, Cardiomyopathies etiology, Cardiomyopathies therapy
Abstract: Background: The 2014 Heart Rhythm Society consensus statement defines histological (definite) and clinical (probable) diagnostic categories of cardiac sarcoidosis (CS), but few studies have compared their arrhythmic phenotypes and outcomes., Objective: The purpose of this study was to evaluate the electrophysiological/arrhythmic phenotype and outcomes of patients with definite and probable CS., Methods: We analyzed the arrhythmic/electrophysiological phenotype in a single-center North American cohort of 388 patients (median age 56 years; 39% female, n = 151) diagnosed with definite (n = 58) or probable (n = 330) CS (2000-2022). The primary composite outcome was survival to first ventricular tachycardia/fibrillation (VT/VF) event or sudden cardiac death. Key secondary outcomes were also assessed., Results: At index evaluation, in situ cardiac implantable electronic devices and antiarrhythmic drug use were more common in definite CS. At a median follow-up of 3.1 years, the primary outcome occurred in 22 patients with definite CS (38%) and 127 patients with probable CS (38%) (log-rank, P = .55). In multivariable analysis, only a higher ratio of the 18 F-fluorodeoxyglucose maximum standardized uptake value of the myocardium to the maximum standardized uptake value of the blood pool (hazard ratio 1.09; 95% confidence interval 1.03-1.15; P = .003, per 1 unit increase) was associated with the primary outcome. During follow-up, patients with definite CS had a higher burden of device-treated VT/VF events (mean 2.86 events per patient-year vs 1.56 events per patient-year) and a higher rate of progression to heart transplant/left ventricular assist device implantation but no difference in all-cause mortality compared with patients with probable CS., Conclusion: Patients with definite and probable CS had similarly high risks of first sustained VT/VF/sudden cardiac death and all-cause mortality, though patients with definite CS had a higher overall arrhythmia burden. Both CS diagnostic groups as defined by the 2014 Heart Rhythm Society criteria require an aggressive approach to prevent arrhythmic complications., Competing Interests: Disclosures No relevant disclosures by any of the authors., (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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32. A structure-based mechanism of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (MpaCobU) from Methylocapsa palsarum.

Author: Nam Y, Ahn YY, Kim BM, Kim K, Lee JH, and Do H
Abstract: Adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) is one of the key enzymes that participate in the biosynthesis of cobalamin, specifically lining the lower ligand 5,6-dimethylbenzimidazole in the α-position of cyclic tetrapyrrolidine. During this process, CobU exhibits two distinct activities: kinase and nucleotidyl transferase, using two nucleoside triphosphates. A structural study of CobU from Salmonella typhimurium showed that guanosine triphosphate binding induces a conformational rearrangement of helix 2. This rearrangement decreases the distance between the phosphate binding loop (P-loop) and helix 2, which is important for the subsequent guanylylation step of the reaction. However, these findings provide only partial insights into the mechanism of CobU at the structural level, and the precise molecular details of this mechanism have not yet been studied. As a first step towards elucidating the molecular mechanisms and sequence of events involved in the phosphorylation and guanylylation steps, we report the high-resolution crystal structures of phosphorylated -MpaCobU (1.8 Å), the C91S mutant (1.5 Å), the guanosine diphosphate complex (1.9 Å), and the adenosylcobinamide-phosphate complex (2.6 Å) from Methylocapsa palsarum for the first time. High-resolution structures revealed the crucial elements governing the catalytic steps of MpaCobU, thereby contributing to understanding the catalytic mechanism of CobU at the molecular level., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2024
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33. Designing few-layered graphitic carbons with atomic-sized cobalt hydroxide by harnessing hollow metal-organic frameworks.

Author: Cho EJ, Kim BM, Moon W, Park DG, Ju YW, Choi WH, and Shin J
Abstract: Graphitic carbon exhibits distinctive characteristics that can be modulated by varying the number of carbon layers. Here, we developed a method to control the growth of graphitic carbon layers through pyrolysis of zeolitic imidazolate frameworks (ZIFs). The key is to pyrolyze hollow-structured ZIF-8 containing Co ions to simultaneously obtain an amorphous carbon source for graphitic carbons and Co metal nanoparticles for catalyzing graphitization of amorphous carbons. Owing to sparsely distributed Co ions within ZIF-8, Co nanoparticles are formed, which leads to localized graphitization. The graphitic carbon obtained contained two to five layers, unlike carbonized ZIF-67. The few-layered graphitic carbon was subjected to KOH activation and employed as a support for atomic-sized Co(OH) 2 owing to the short routes for Co nanoparticle egress and OH - ion movement. Our strategy does not involve any highly corrosive process for catalyst leaching and can even be used to produce atomic-sized Co(OH) 2 with few-layered graphitic carbons., Competing Interests: The authors declare no competing financial interest., (This journal is © The Royal Society of Chemistry.)
Published: 2024
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34. Effects of Kimchi Intake on the Gut Microbiota and Metabolite Profiles of High-Fat-Induced Obese Rats.

Author: Kim DW, Nguyen QA, Chanmuang S, Lee SB, Kim BM, Lee HJ, Jang GJ, and Kim HJ
Subjects: Animals, Male, Rats, Weight Gain, Metabolomics, Metabolome, Adipose Tissue metabolism, Bile Acids and Salts metabolism, Probiotics administration & dosage, Probiotics pharmacology, Gastrointestinal Microbiome drug effects, Obesity microbiology, Obesity metabolism, Diet, High-Fat adverse effects, Fermented Foods, Rats, Sprague-Dawley
Abstract: With rising global obesity rates, the demand for effective dietary strategies for obesity management has intensified. This study evaluated the potential of kimchi with various probiotics and bioactive compounds as a dietary intervention for high-fat diet (HFD)-induced obesity in rats. Through a comprehensive analysis incorporating global and targeted metabolomics, gut microbiota profiling, and biochemical markers, we investigated the effects of the 12-week kimchi intake on HFD-induced obesity. Kimchi intake modestly mitigated HFD-induced weight gain and remarkably altered gut microbiota composition, steroid hormones, bile acids, and metabolic profiles, but did not reduce adipose tissue accumulation. It also caused significant shifts in metabolomic pathways, including steroid hormone metabolism, and we found substantial interactions between dietary interventions and gut microbiota composition. Although more research is required to fully understand the anti-obesity effects of kimchi, our findings support the beneficial role of kimchi in managing obesity and related metabolic disorders.
Published: 2024
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35. Medical Therapy and Clinical Outcomes in Cardiac Sarcoidosis Patients With Systolic Heart Failure.

Author: Sykora D, Bratcher M, Churchill R, Kim BM, Elwazir M, Young K, Ryan S, Kolluri N, Abou Ezzeddine O, Bois J, Giudicessi J, Cooper L, and Rosenbaum A
Abstract: Background: Cardiac sarcoidosis (CS) may result in systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), but its response to guideline-directed medical therapy (GDMT) remains uncertain., Methods and Results: We investigated 881 patients evaluated for CS to identify those with diagnosed CS, left ventricular ejection fraction (LVEF) ≤40% at diagnosis, and follow-up echocardiogram within 11-24 months. Demographics, LVEF, GDMT as quantified by Kansas City Medical Optimization (KCMO) score, and immunosuppressive treatment were recorded. The primary outcome was a composite of event-free survival (unplanned heart failure hospitalization, left ventricular assist device [LVAD]/heart transplant, or death). Seventy-nine (9%) CS patients met the inclusion criteria (35% female, median age 57 years, mean LVEF 30.9%, median New York Heart Association class II [46%], mean number of GDMT agents 1.7, and mean KCMO score 31.8). Most (87%) were treated with immunosuppressive treatment. At follow-up (median 16 months), the mean number of GDMT agents increased to 2.2 (P=0.02), and the mean KCMO score to 70.1 (P<0.001). Mean LVEF improved to 39.9% (excluding LVAD/transplant; P<0.001) and the change in LVEF was correlated with follow-up KCMO score (P<0.001). The primary outcome occurred in 13 (16%) patients and differed by KCMO score (log-rank P<0.001), but not by immunosuppressive treatment (log-rank P=0.36)., Conclusions: GDMT optimization is associated with better cardiac remodeling and clinical outcomes in CS patients with HFrEF.
Published: 2024
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36. Thrombi With a Higher Erythrocyte Composition Are More Fragile in Acute Stroke.

Author: Baek JH, Kwon I, Kim S, Nam HS, Kim YD, Kim BM, Kim DJ, Song TJ, and Heo JH
Published: 2024
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37. Radiomics using non-contrast CT to predict hemorrhagic transformation risk in stroke patients undergoing revascularization.

Author: Heo J, Sim Y, Kim BM, Kim DJ, Kim YD, Nam HS, Choi YS, Lee SK, Kim EY, and Sohn B
Subjects: Humans, Male, Female, Aged, Retrospective Studies, Middle Aged, Cerebral Hemorrhage diagnostic imaging, Cerebral Hemorrhage etiology, Magnetic Resonance Imaging methods, Thrombectomy methods, Risk Assessment methods, Radiomics, Tomography, X-Ray Computed methods, Stroke diagnostic imaging, Stroke etiology
Abstract: Objectives: This study explores whether textural features from initial non-contrast CT scans of infarcted brain tissue are linked to hemorrhagic transformation susceptibility., Materials and Methods: Stroke patients undergoing thrombolysis or thrombectomy from Jan 2012 to Jan 2022 were analyzed retrospectively. Hemorrhagic transformation was defined using follow-up magnetic resonance imaging. A total of 94 radiomic features were extracted from the infarcted tissue on initial NCCT scans. Patients were divided into training and test sets (7:3 ratio). Two models were developed with fivefold cross-validation: one incorporating first-order and textural radiomic features, and another using only textural radiomic features. A clinical model was also constructed using logistic regression with clinical variables, and test set validation was performed., Results: Among 362 patients, 218 had hemorrhagic transformations. The LightGBM model with all radiomics features had the best performance, with an area under the receiver operating characteristic curve (AUROC) of 0.986 (95% confidence interval [CI], 0.971-1.000) on the test dataset. The ExtraTrees model performed best when textural features were employed, with an AUROC of 0.845 (95% CI, 0.774-0.916). Minimum, maximum, and ten percentile values were significant predictors of hemorrhagic transformation. The clinical model showed an AUROC of 0.544 (95% CI, 0.431-0.658). The performance of the radiomics models was significantly better than that of the clinical model on the test dataset (p < 0.001)., Conclusions: The radiomics model can predict hemorrhagic transformation using NCCT in stroke patients. Low Hounsfield unit was a strong predictor of hemorrhagic transformation, while textural features alone can predict hemorrhagic transformation., Clinical Relevance Statement: Using radiomic features extracted from initial non-contrast computed tomography, early prediction of hemorrhagic transformation has the potential to improve patient care and outcomes by aiding in personalized treatment decision-making and early identification of at-risk patients., Key Points: • Predicting hemorrhagic transformation following thrombolysis in stroke is challenging since multiple factors are associated. • Radiomics features of infarcted tissue on initial non-contrast CT are associated with hemorrhagic transformation. • Textural features on non-contrast CT are associated with the frailty of the infarcted tissue., (© 2024. The Author(s), under exclusive licence to European Society of Radiology.)
Published: 2024
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38. Convolutional neural networks can detect orthostatic hypotension in Parkinson's disease using resting-state functional near-infrared spectroscopy data.

Author: Lee SH, Paik SH, Kang SY, Phillips Z 5th, Kim JB, Kim BJ, and Kim BM
Subjects: Humans, Male, Female, Rest, Aged, Middle Aged, Parkinson Disease diagnostic imaging, Parkinson Disease physiopathology, Spectroscopy, Near-Infrared, Hypotension, Orthostatic physiopathology, Hypotension, Orthostatic diagnostic imaging, Neural Networks, Computer
Abstract: Neurological disorders such as Parkinson's disease (PD) often adversely affect the vascular system, leading to alterations in blood flow patterns. Functional near-infrared spectroscopy (fNIRS) is used to monitor hemodynamic changes via signal measurement. This study investigated the potential of using resting-state fNIRS data through a convolutional neural network (CNN) to evaluate PD with orthostatic hypotension. The CNN demonstrated significant efficacy in analyzing fNIRS data, and it outperformed the other machine learning methods. The results indicate that judicious input data selection can enhance accuracy by over 85%, while including the correlation matrix as an input further improves the accuracy to more than 90%. This study underscores the promising role of CNN-based fNIRS data analysis in the diagnosis and management of the PD. This approach enhances diagnostic accuracy, particularly in resting-state conditions, and can reduce the discomfort and risks associated with current diagnostic methods, such as the head-up tilt test., (© 2024 The Author(s). Journal of Biophotonics published by Wiley‐VCH GmbH.)
Published: 2024
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39. Effects of high-fat diet on folic acid-induced kidney injury in mice.

Author: Kim D, Son M, Ha S, Kim J, Kim MJ, Yoo J, Kim BM, Chung HY, Lee H, Kim D, Kim S, and Chung KW
Subjects: Animals, Mice, Male, Mice, Inbred C57BL, Kidney metabolism, Kidney pathology, Kidney drug effects, Fibrosis, Pyroptosis drug effects, Kidney Diseases metabolism, Kidney Diseases pathology, Kidney Diseases etiology, Kidney Diseases chemically induced, Lipid Metabolism drug effects, Signal Transduction drug effects, Folic Acid administration & dosage, Folic Acid pharmacology, Diet, High-Fat adverse effects, Obesity metabolism, Inflammasomes metabolism
Abstract: Obesity is recognized as a significant contributor to the onset of kidney disease. However, the key processes involved in the development of kidney disease in obese individuals are not well understood. Here, we investigated the effects of high-fat diet (HFD)-induced obesity on folic acid (FA)-induced kidney injury in mice. Mice were fed an HFD for 12 weeks to induce obesity, followed by an additional intraperitoneal injection of FA. The results showed that mice fed HFD developed higher levels of kidney damage than those in the chow group. In contrast, mice exposed to both HFD and FA showed less fibrosis and inflammatory responses compared to the FA only treated group. Furthermore, the HFD with FA group exhibited elevated lipid accumulation in the kidney and reduced expression of mitochondrial proteins compared to the FA-treated group. Under in vitro experimental conditions, we found that lipid accumulation induced by oleic acid treatment reduced inflammatory and fibrotic responses in both renal tubules and fibroblasts. Finally, RNA sequencing analysis revealed that the inflammasome and pyroptosis signaling pathways were significantly increased in the HFD group with FA injection. In summary, these findings suggest that obesity increases renal injury due to a lack of appropriate inflammatory, fibrotic, and metabolic responses and the activation of the inflammasome and pyroptosis signaling pathways., Competing Interests: Declaration of competing interest The authors have declared that no conflict of interest exists., (Copyright © 2024 Elsevier B.V. All rights reserved.)
Published: 2024
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40. Calorie restriction exacerbates folic acid-induced kidney fibrosis by altering mitochondria metabolism.

Author: Kim MJ, Hwang T, Ha S, Kim H, Kim J, Kim D, Yoo JA, Kim BM, Chung HY, Kim D, Lee J, Lee H, Kim S, and Chung KW
Subjects: Animals, Male, Mice, Oxidative Phosphorylation drug effects, Cell Line, Acute Kidney Injury metabolism, Acute Kidney Injury chemically induced, Folic Acid pharmacology, Folic Acid administration & dosage, Caloric Restriction, Mitochondria metabolism, Mitochondria drug effects, Fibrosis, Kidney metabolism, Kidney drug effects, Kidney pathology, Mice, Inbred C57BL
Abstract: Calorie restriction (CR) is known to confer health benefits, including longevity and disease prevention. Although CR is promising in preventing chronic kidney disease (CKD), its potential impact on the progression of kidney fibrosis from acute kidney injury (AKI) to CKD remains unclear. Here, we present evidence that CR exacerbates renal damage in a mouse model of folic acid (FA)-induced renal fibrosis by altering mitochondrial metabolism and inflammation. Mice subjected to CR (60% of ad libitum) for three days were subjected to high dose of FA (250 mg/kg) injection and maintained under CR for an additional week before being sacrificed. Biochemical analyses showed that CR mice exhibited increased kidney injury and fibrosis. RNA sequencing analysis demonstrated decreased electron transport and oxidative phosphorylation (OXPHOS) in CR kidneys with injury, heightened inflammatory, and fibrotic responses. CR significantly decreased OXPHOS gene and protein levels and reduced β-oxidation-associated proteins in the kidney. To determine whether defects in mitochondrial metabolism is associated with inflammation in the kidney, further in vitro experiments were performed. NRK52E kidney epithelial cells were treated with antimycin A to induce mitochondrial damage. Antimycin A treatment significantly increased chemokine expression via a STING-dependent pathway. Serum restriction in NRK49F kidney fibroblasts was observed to enhance the fibrotic response induced by TGFβ under in vitro conditions. In summary, our results indicate that CR exacerbates fibrosis and inflammatory responses in the kidney by altering mitochondrial metabolism, highlighting the importance of adequate energy supply for an effective response to AKI and fibrosis development., Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
Published: 2024
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41. Arrhythmic prognosis according to left ventricular systolic dysfunction severity in cardiac sarcoidosis.

Author: Kim BM, Sykora D, Rosenbaum AN, Ahmed E, Churchill RA, Bratcher M, Elwazir MY, Bois JP, Giudicessi JR, Sugrue AM, Killu AM, Kapa S, Deshmukh AJ, Asirvatham SJ, Cooper LT, Abou Ezzeddine OF, and Siontis KC
Abstract: Background: Current guidelines present varying classes of recommendations for implantable cardioverter-defibrillator (ICD) utilization in patients with cardiac sarcoidosis (CS) and left ventricular ejection fraction (LVEF) <50%., Objective: The purpose of this study was to investigate the ventricular arrhythmia risk in CS patients with ICDs and varying degrees of left ventricular systolic dysfunction., Methods: The study included CS patients with an ICD and LVEF <50% at index evaluation. The primary outcome was survival free of sustained ventricular tachycardia (VT)/ventricular fibrillation (VF) after ICD implantation and was assessed comparatively for LVEF ≤35% vs 36%-49% and for primary vs secondary prevention ICD indication., Results: The study included 61 patients (median age 57 years; 61% male) with LVEF 36%-49% (n = 23) or LVEF ≤35% (n = 38). An ICD was implanted for secondary prevention in 24% and 44% of the LVEF ≤35% and 36%-49% groups, respectively (P = .11). The primary outcome did not differ between the 2 groups in univariable analysis (LVEF ≤35% vs 36%-49%: hazard ratio [HR] 0.85; 95% confidence interval [CI] 0.39-1.82; P = .67). In multivariable analysis, secondary prevention ICD indication was the only significant predictor of incident sustained VT/VF (HR 2.86; 95% CI 1.23-6.67; P = .015). Mean sustained VT/VF event burden was higher in the secondary compared with the primary prevention ICD patients (0.47 vs 0.11 events per patient-year; P = .005) but did not differ significantly between LVEF ≤35% and 36%-49% patients., Conclusion: CS patients with ICD indications and LVEF 36%-49% carry similarly high arrhythmic risk as those with LVEF ≤35%. Patients with secondary prevention ICDs have the highest overall risk., Competing Interests: Disclosures The authors have no conflicts to disclose., (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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42. First Report of a Phytoplasma Strain in the Elm Yellows Group (16SrV) associated with Virginia Creeper in Maryland, USA.

Author: Padmanabhan C, Nunziata S, Kim BM, Rivera Y, and Costanzo S
Abstract: Virginia creeper ( Parthenocissus quinquefolia [L.] Planch.) is a deciduous flowering vine in the Vitaceae family. Native to eastern North America, it is often used ornamentally as a climbing vine or as ground cover due to its rapid growth and foliage color in the fall. In July of 2022, along exterior walls of a private property in Lanham, MD, two Virginia creeper (VC) vines were observed displaying symptoms of yellow mottling and premature reddening of leaves. To investigate the cause of these symptoms, two symptomatic leaf samples and one asymptomatic leaf samples from a third vine in the same vicinity were collected for further analysis. A Qiagen DNeasy Plant Mini Kit was used to extract total DNA from leaf tissues according to the manufacturer's instructions. A phytoplasma-specific real-time PCR (Hodgetts et al. 2009) was used to test the DNA extracts, which detected the presence of phytoplasmas in the two DNA samples derived from symptomatic vines. The near full-length of the 16S ribosomal RNA gene was then amplified by seminested PCR from these samples with primers P1/16S-SR followed by P1A/16S-SR (Deng, and Hiruki 1991; Lee et al. 2004) and Sanger sequenced using primers P1A and 16S-SR. Analysis of the obtained 16S rDNA sequences revealed no variation between the two plant samples, and one sequence was deposited in GenBank representing the phytoplasma strain named VC-MD1 (GenBank PP746981). A BLASTn search of the 16S rRNA gene sequence in the NCBI nucleotide database, showed 99.93% sequence identity with the phytoplasma strain AldY-WA1 (GenBank MZ557341) from red alder in Washington, a phytoplasma associated with VC plants in southern Florida (GenBank AF305198) (Harrison et al. 2001), and other strains detected in grapevines in Europe described as "flavescence dorée" phytoplasma (GenBank AF176319) (Davis, and Dally 2001). The virtual restriction fragment length polymorphism pattern derived from i PhyClassifier (Zhao et al. 2009), indicated that VC-MD1 is indeed a member of the 16SrV-C phytoplasma subgroup. To confirm the identification, the partial spc operon and the partial tuf gene were amplified as previously described (Lee et al. 2010; Makarova et al. 2012). Specifically, the spc operon region was amplified using a nested PCR approach with primer set L15F1A-a/MapR1 followed by L15F1A-b/MapR1A-b. Sequence data obtained from the two loci were deposited to GenBank with accession numbers PP746982 ( spc ) and PP746983 ( tuf ). BLAST searches querying the nucleotide sequences of the spc operon and tuf gene showed 95.39% and 99.05% identity, respectively, to the corresponding loci of ' Candidatus Phytoplasma rubi' strain RS (GenBank CP114006) and hemp dogbane yellows phytoplasma strain HD1 (GenBank FR686506). Phylogenetic analysis based on secY and tuf gene sequences suggest that the VC-MD1 strain is evolutionary closest to 16SrV-C phytoplasma strains detected in various hosts in the United States, including HD1 and AldY-WA1. These North American strains cluster together on a distinct branch within the elm yellows group phytoplasmas. For the State of Maryland, this detection represents the first report of a phytoplasma strain member of the16SrV-C subgroup infecting VC plants. A phytoplasma of the same subgroup was previously detected in Florida in asymptomatic VC vines (Harrison et al. 2001). The 16S rRNA gene sequences of the two VC phytoplasma strains are nearly identical, differing by just a single nucleotide. The disease transmission vectors of the VC-MD1 strain and the prevalence of the disease in the region remains undetermined.
Published: 2024
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43. i PhyDSDB: Phytoplasma Disease and Symptom Database.

Author: Wei W, Shao J, Zhao Y, Inaba J, Ivanauskas A, Bottner-Parker KD, Costanzo S, Kim BM, Flowers K, and Escobar J
Abstract: Phytoplasmas are small, intracellular bacteria that infect a vast range of plant species, causing significant economic losses and impacting agriculture and farmers' livelihoods. Early and rapid diagnosis of phytoplasma infections is crucial for preventing the spread of these diseases, particularly through early symptom recognition in the field by farmers and growers. A symptom database for phytoplasma infections can assist in recognizing the symptoms and enhance early detection and management. In this study, nearly 35,000 phytoplasma sequence entries were retrieved from the NCBI nucleotide database using the keyword "phytoplasma" and information on phytoplasma disease-associated plant hosts and symptoms was gathered. A total of 945 plant species were identified to be associated with phytoplasma infections. Subsequently, links to symptomatic images of these known susceptible plant species were manually curated, and the Phytoplasma Disease Symptom Database ( i PhyDSDB) was established and implemented on a web-based interface using the MySQL Server and PHP programming language. One of the key features of i PhyDSDB is the curated collection of links to symptomatic images representing various phytoplasma-infected plant species, allowing users to easily access the original source of the collected images and detailed disease information. Furthermore, images and descriptive definitions of typical symptoms induced by phytoplasmas were included in i PhyDSDB. The newly developed database and web interface, equipped with advanced search functionality, will help farmers, growers, researchers, and educators to efficiently query the database based on specific categories such as plant host and symptom type. This resource will aid the users in comparing, identifying, and diagnosing phytoplasma-related diseases, enhancing the understanding and management of these infections.
Published: 2024
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44. Effects of High-Speed Shearing Treatment on the Physical Properties of Carbohydrate-Binder Mixture during Gelatinization for Preparing Freeze-Dried Soup Products.

Author: Lee GY, Jung MJ, Kim BM, Kim HR, Jun JY, and Kim NH
Abstract: Modernization has led to a large convenience food market, and the demand for freeze-dried (FD) soup products is increasing in the Republic of Korea. FD soup products are easy to eat without cooking and can be stored for long periods. However, it is often difficult to ensure sensory satisfaction after rehydration of FD soup products; in particular, the ingredients are not evenly dispersed. Therefore, a stable dispersion or reconstitution of the FD soup products is required after rehydration. Here, the effects of high-speed shearing homogenization on the physical properties of a carbohydrate-binder mixture comprising maltodextrin, potato starch, and rice flour were investigated during hydrothermal gelatinization. To find a suitable treatment condition, different homogenization eras, speeds, and concentrations of the binder mixture were considered; in particular, the homogenization eras were set by considering the hydrothermal property of the binder mixture profiled using differential scanning calorimetry. The viscosity of the binder mixture and the compression strength and microstructure of the FD binder block, including the dispersion stability after rehydration, were evaluated. The quality of the FD binder block was improved by homogenization above 5000 rpm when the core temperature of the binder mixture reached approximately T o at 14.5-21.8% concentrations. The improved FD binder block exhibited a fine surface and tiny porous microstructure compared with the control (with continuous agitation at 250 rpm). The control block was divided into two phases, whereas the improved block maintained the initial dispersion stability at 50 °C for 1 h. These results are expected to be referenced for the purpose of improving the quality of the FD soup products.
Published: 2024
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45. Fermented Gold Kiwi for Improved Gastric Health: Evaluation of Efficacy and Safety in a Randomised, Double-Blind, Placebo-Controlled Trial.

Author: Shin SM, Youn SJ, Choi Y, Kim BM, Lee NY, Oh HJ, Kwon HS, and Ko H
Subjects: Humans, Double-Blind Method, Female, Male, Adult, Middle Aged, Fermented Foods, Treatment Outcome, Dietary Supplements, Fermentation, Quality of Life, Dyspepsia drug therapy
Abstract: This randomised double-blind placebo-controlled trial evaluated the efficacy and safety of fermented gold kiwi (FGK) in improving gastrointestinal health. A total of 100 participants were enrolled and randomly assigned to treatment or placebo groups. Over 8 weeks, the participants consumed an FGK or placebo preparation daily. Primary outcomes included changes in gastrointestinal symptoms assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and the Korean version of the Nepean Dyspepsia Index (NDI-K), as well as quality of life assessed using the Functional Dyspepsia-related Quality of Life questionnaire. The FGK group showed significant improvements in GSRS and NDI-K total and subdomain scores compared with the placebo group. Moreover, the quality of life scores were significantly better in the FGK group than in the placebo group. Safety evaluations revealed no significant adverse events or clinically meaningful changes upon assessing laboratory test results. This study demonstrated that FGK is a safe and effective dietary supplement for improving gastrointestinal health in adults with gastrointestinal symptoms.
Published: 2024
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46. Impact of intensive blood pressure lowering after multiple-attempt endovascular thrombectomy: A secondary analysis of the OPTIMAL-BP trial.

Author: Jung JW, Kim KH, Yun J, Kim YD, Heo J, Lee H, Choi JK, Lee H Il, Lim IH, Hong SH, Kim BM, Kim DJ, Shin NY, Cho BH, Ahn SH, Park H, Sohn SI, Hong JH, Song TJ, Chang Y, Kim GS, Seo KD, Lee K, Chang JY, Seo JH, Lee S, Baek JH, Cho HJ, Shin DH, Kim J, Yoo J, Baik M, Lee KY, Jung YH, Hwang YH, Kim CK, Kim JG, Lee CJ, Park S, Jeon S, Lee HS, Kwon SU, Young Bang O, Heo JH, and Nam HS
Abstract: Background: Multiple attempts of thrombectomy have been linked to a higher risk of intracerebral hemorrhage and worsened functional outcomes, potentially influenced by blood pressure (BP) management strategies. Nonetheless, the impact of intensive BP management following successful recanalization through multiple attempts remains uncertain., Aims: This study aimed to investigate whether conventional and intensive BP managements differentially affect outcomes according to multiple-attempt recanalization (MAR) and first-attempt recanalization (FAR) groups., Methods: In this secondary analysis of the OPTIMAL-BP trial, which was a comparison of intensive (systolic BP target: <140 mm Hg) and conventional (systolic BP target = 140-180 mm Hg) BP managements during the 24 h after successful recanalization, we included intention-to-treat population of the trial. Patients were divided into the MAR and the FAR groups. We examined a potential interaction between the number of thrombectomy attempts (MAR and FAR groups) and the effect of BP managements on clinical and safety outcomes. The primary outcome was functional independence at 3 months. Safety outcomes were symptomatic intracerebral hemorrhage within 36 h and mortality within 3 months., Results: Of the 305 patients (median = 75 years), 102 (33.4%) were in the MAR group and 203 (66.6%) were in the FAR group. The intensive BP management was significantly associated with a lower rate of functional independence in the MAR group (intensive, 32.7% vs conventional, 54.9%, adjusted odds ratio (OR) = 0.33, 95% confidence interval (CI) = 0.12-0.90, p = 0.03). In the FAR group, the proportion of patients with functional independence was not significantly different between the BP managements (intensive, 42.5% vs conventional, 54.2%, adjusted OR = 0.73, 95% CI = 0.38-1.40). Incidences of symptomatic intracerebral hemorrhage and mortality rates were not significantly different according to the BP managements in both MAR and FAR groups., Conclusions: Among stroke patients who received multiple attempts of thrombectomy, intensive BP management for 24 h resulted in a reduced chance of functional independence at 3 months and did not reduce symptomatic intracerebral hemorrhage following successful reperfusion., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Published: 2024
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47. An magnetic resonance imaging-pathology correlation case report of cardiac sarcoidosis mimicking arrhythmogenic biventricular cardiomyopathy.

Author: Kim BM, Bois MC, Del-Carpio Munoz F, Rosenbaum AN, and Chang IC
Abstract: Background: Cardiac sarcoidosis (CS) is a granulomatous disease that can manifest as conduction defects, ventricular arrhythmias, and heart failure. The diagnosis of CS is inherently difficult due to variable presentations; as such, endomyocardial biopsy is often required but lacks sensitivity due to patchy myocardial involvement. Moreover, the diagnostic criteria of CS and arrhythmogenic cardiomyopathy overlap, particularly in right-side dominant or biventricular presentations, which further complicates an already challenging differential diagnosis., Case Summary: A 53-year-old man with no prior chronic medical conditions presented with ventricular tachycardia (VT) and heart failure with reduced ejection fraction. He was found to have biventricular cardiomyopathy and late gadolinium enhancement on cardiac magnetic resonance imaging, resulting in an initial diagnosis of arrhythmogenic cardiomyopathy. Implantable cardioverter-defibrillator was placed, but he was readmitted for recurrent VT 2 months later. Despite an aggressive VT therapy (combination of antiarrhythmic drugs, epicardial and endocardial ablation, and stellate ganglion block), he continued with refractory VT and developed cardiogenic shock. Extra-corporeal membrane oxygenation was initiated as a bridge to heart transplantation. Pathology of the explanted heart revealed the underlying disease to be CS., Discussion: Cardiac sarcoidosis can mimic arrhythmogenic biventricular cardiomyopathy and may be difficult to distinguish by the proposed diagnostic criteria. High clinical suspicion and thorough investigation are necessary for an earlier diagnosis and initiation of treatment., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Published: 2024
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48. PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease.

Author: Ha S, Kim HW, Kim KM, Kim BM, Kim J, Son M, Kim D, Kim MJ, Yoo J, Yu HS, Jung YS, Lee J, Chung HY, and Chung KW
Subjects: Animals, Mice, Humans, Mice, Inbred C57BL, Mice, Knockout, Cellular Senescence, Fibrosis, Receptor, PAR-2 metabolism, Receptor, PAR-2 genetics, Inflammation metabolism, Inflammation pathology, Aging metabolism, Renal Insufficiency, Chronic metabolism, Renal Insufficiency, Chronic pathology
Abstract: Cellular senescence contributes to inflammatory kidney disease via the secretion of inflammatory and profibrotic factors. Protease-activating receptor 2 (PAR2) is a key regulator of inflammation in kidney diseases. However, the relationship between PAR2 and cellular senescence in kidney disease has not yet been described. In this study, we found that PAR2-mediated metabolic changes in renal tubular epithelial cells induced cellular senescence and increased inflammatory responses. Using an aging and renal injury model, PAR2 expression was shown to be associated with cellular senescence. Under in vitro conditions in NRK52E cells, PAR2 activation induces tubular epithelial cell senescence and senescent cells showed defective fatty acid oxidation (FAO). Cpt1α inhibition showed similar senescent phenotype in the cells, implicating the important role of defective FAO in senescence. Finally, we subjected mice lacking PAR2 to aging and renal injury. PAR2-deficient kidneys are protected from adenine- and cisplatin-induced renal fibrosis and injury, respectively, by reducing senescence and inflammation. Moreover, kidneys lacking PAR2 exhibited reduced numbers of senescent cells and inflammation during aging. These findings offer fresh insights into the mechanisms underlying renal senescence and indicate that targeting PAR2 or FAO may be a promising therapeutic approach for managing kidney injury., (© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)
Published: 2024
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49. Novel locally nebulized indocyanine green for simultaneous identification of tumor margin and intersegmental plane.

Author: Jeon OH, Kim K, Kim CG, Choi BH, Lee JH, Kim BM, and Kim HK
Subjects: Animals, Rabbits, Dogs, Nebulizers and Vaporizers, Optical Imaging, Disease Models, Animal, Pneumonectomy, Lung diagnostic imaging, Lung pathology, Margins of Excision, Coloring Agents administration & dosage, Indocyanine Green administration & dosage, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology
Abstract: Background: Segmentectomy, recommended for early-stage lung cancer or compromised lung function, demands precise tumor detection and intersegmental plane identification. While indocyanine green (ICG) commonly aids in these aspects using near-infrared imaging, its separate administrations through different routes and times can lead to complications and patient anxiety. This study aims to develop a lung-specific delivery method by nebulizing low-dose ICG to targeted lung segments, allowing simultaneous detection of lung tumors and intersegmental planes across diverse animal models., Methods: To optimizing the dose of ICG for lung tumor and interlobar fissure detection, different doses of ICG (0.25, 0.1, and 0.05 mg/kg) were nebulized to rabbit lung tumor models. The distribution of locally nebulized ICG in targeted segments was studied to evaluate the feasibility of detecting lung tumor and intersegmental planes in canine lung pseudotumor models., Results: Near-infrared fluorescence imaging demonstrated clear visualization of lung tumor margin and interlobar fissure using local nebulization of 0.1 mg/kg ICG for only 4 min during surgery in the rabbit models. In the canine model, the local nebulization of 0.05 mg/kg of ICG into the target segment enabled clear visualization of pseudotumor and intersegmental planes for 30 min., Conclusions: This innovative approach achieves a reduction in ICG dose and prolonged the visualization time of the intersegmental plane and effectively eliminates the need for the hurried marking of tumors and intersegmental planes. The authors anticipate that lung-specific delivery of ICG will prove valuable for image-guided limited resection of lung tumors in clinical practice., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Published: 2024
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50. Photothermal Enhancement of Prussian Blue Cathodes for Li-Ion Batteries.

Author: Tan L, Kim BM, Pujari A, He Z, Boruah BD, and De Volder M
Abstract: Photoenhanced batteries, where light improves the electrochemical performance of batteries, have gained much interest. Recent reports suggest that light-to-heat conversion can also play an important role. In this work, we study Prussian blue analogues (PBAs), which are known to have a high photothermal heating efficiency and can be used as cathodes for Li-ion batteries. PBAs were synthesized directly on a carbon collector electrode and tested under different thermally controlled conditions to show the effect of photothermal heating on battery performance. Our PBA electrodes reach temperatures that are 14% higher than reference electrodes using a blue LED, and a capacity enhancement of 38% was achieved at a current density of 1600 mA g -1 . Additionally, these batteries show excellent cycling stability with a capacity retention of 96.6% in dark conditions and 94.8% in light over 100 cycles. Overall, this work shows new insights into the effects leading to improved battery performance in photobatteries.
Published: 2024
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