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1,339 results on '"Kim, Yeon Ju"'

2. What if...?: Thinking Counterfactual Keywords Helps to Mitigate Hallucination in Large Multi-modal Models

Author

Kim, Junho, Kim, Yeon Ju, and Ro, Yong Man

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, Computer Science - Computation and Language
Abstract

This paper presents a way of enhancing the reliability of Large Multi-modal Models (LMMs) in addressing hallucination, where the models generate cross-modal inconsistent responses. Without additional training, we propose Counterfactual Inception, a novel method that implants counterfactual thinking into LMMs using self-generated counterfactual keywords. Our method is grounded in the concept of counterfactual thinking, a cognitive process where human considers alternative realities, enabling more extensive context exploration. Bridging the human cognition mechanism into LMMs, we aim for the models to engage with and generate responses that span a wider contextual scene understanding, mitigating hallucinatory outputs. We further introduce Plausibility Verification Process (PVP), a simple yet robust keyword constraint that effectively filters out sub-optimal keywords to enable the consistent triggering of counterfactual thinking in the model responses. Comprehensive analyses across various LMMs, including both open-source and proprietary models, corroborate that counterfactual thinking significantly reduces hallucination and helps to broaden contextual understanding based on true visual clues., Comment: Project page: https://ivy-lvlm.github.io/Counterfactual-Inception/

Published
2024

37. 1‐Dehydro‐6‐Gingerdione Exerts Anticancer Effects on MDA‐MB‐231 Cells and in the Xenograft Mouse Model by Promoting the Ferroptosis Pathway.

Author

Tran, Thi Hoa My, Dhandapani, Sanjeevram, Abdus, Samad, and Kim, Yeon‐Ju

Abstract

Breast cancer (BC) is the most prevalent malignancy among women, with millions of newly diagnosed cases emerging annually. Therefore, identifying novel pharmaceuticals for therapeutic purposes is imperative. Several natural compounds and their products have demonstrated potential in the treatment of cancer. This study examined the effects of the ginger derivative 1‐dehydro‐6‐gingerdione (1‐D‐6‐G) on BC and its mechanisms of action. MTT and colony formation assays were used to check the anticancer effect of 1‐D‐6‐G. Then the anticancer mechanism of 1‐D‐6‐G was predicted using proteomics analysis. The molecular pathway was verified by qRT‐PCR and immunobloting analysis. Additionally, the anticancer properties of 1‐D‐6‐G were investigated in vivo using xenograft mice model. Finally, an in silico study was conducted to examine the interaction of 1‐D‐6‐G and pathway‐related proteins. MTT and colony formation assay results indicated that 1‐D‐6‐G has potent cytotoxic properties against BC cells. Proteomic analysis revealed that the anticancer mechanism of 1‐D‐6‐G on MDA‐MB‐231 cells is associated with the ferroptosis signaling pathway. In addition, qRT‐PCR and immunoblotting analyses revealed that the cytotoxic effects of 1‐D‐6‐G on MDA‐MB‐231 cells were associated with ferroptosis signaling induction. Our in vivo results further confirmed the in vitro findings. The administration of 1‐D‐6‐G for 14 days exhibited anticancer properties in xenograft mice by stimulating the ferroptosis pathway without causing damage to essential organs such as the liver and kidneys. Additionally, in silico results confirmed the structural stability of the molecular interaction between 1‐D‐6‐G and ferroptosis target proteins. Our findings indicate that 1‐D‐6‐G has the potential to serve as a novel therapeutic agent for inhibiting BC progression by targeting the ferroptosis pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Author Correction: Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Author

Park, Ji Hye, Kim, Hyeok, Moon, Hyung Ryong, Park, Bong-Woo, Park, Jae-Hyun, Sim, Woo-Sup, Kim, Jin-Ju, Lim, Hye Ji, Kim, Yeon-Ju, Ji, Seung Taek, Jang, Woong Bi, Rethineswaran, Vinoth Kumar, Van, Le Thi Hong, Giang, Ly Thanh Truong, Yun, Jisoo, Ha, Jong Seong, Ban, Kiwon, Chung, Hae Young, Baek, Sang Hong, Park, Hun-Jun, and Kwon, Sang-Mo

Published
2022
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