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Your search keyword '"Kim, Woong-Hee"' showing total 41 results
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41 results on '"Kim, Woong-Hee"'

1. Advances of LINAC-based boron neutron capture therapy in Korea

Author

Bae, Young-soon, Kim, Dong-Su, Seo, Hyo Jung, Han, Je-Un, Yoon, Hyung Jin, Hwang, Jung Jin, Kim, Ju Jin, Woo, Byung Hyo, Kim, Hyo Jin, Jang, Yoo Soon, Han, Seok Chang, Kim, Woong Hee, Kang, Do Goo, Seo, Hyun Jin, Lee, Soo Young, Jeon, Sang June, Yi, Jungyu, Lee, Jeongwoo, Seo, Il Hyeok, Kim, Se Hyun, Kim, Woo Hyoung, Park, Na Hyung, Lee, Myeng Hyun, Bae, Sung June, Lee, Seung Hoon, Cho, Gyu Ho, Kim, Seong Han, Moon, Seong Hwan, Lee, Min Kyu, Choi, Jae Won, Lee, Kyu Young, Huh, Dong Seok, Kim, Dong Woo, Min, Kyung June, Yoon, Hyoung Min, Kyung, Hyunhye, Yang, Jieun, Na, Dasom, Lee, Sangbong, Han, Jaehwan, Kwak, Yongho, Lee, Sei-Young, Nam, Joo Young, Choi, Byung-Ho, Moon, Young-Kwan, Do, Won, Yoo, Mooyoung, and Park, Sun-Sun

Published
2022
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2. Empirical Study of Drone Sound Detection in Real-Life Environment with Deep Neural Networks

Author

Jeon, Sungho, Shin, Jong-Woo, Lee, Young-Jun, Kim, Woong-Hee, Kwon, YoungHyoun, and Yang, Hae-Yong

Subjects
Computer Science - Sound, Computer Science - Learning
Abstract

This work aims to investigate the use of deep neural network to detect commercial hobby drones in real-life environments by analyzing their sound data. The purpose of work is to contribute to a system for detecting drones used for malicious purposes, such as for terrorism. Specifically, we present a method capable of detecting the presence of commercial hobby drones as a binary classification problem based on sound event detection. We recorded the sound produced by a few popular commercial hobby drones, and then augmented this data with diverse environmental sound data to remedy the scarcity of drone sound data in diverse environments. We investigated the effectiveness of state-of-the-art event sound classification methods, i.e., a Gaussian Mixture Model (GMM), Convolutional Neural Network (CNN), and Recurrent Neural Network (RNN), for drone sound detection. Our empirical results, which were obtained with a testing dataset collected on an urban street, confirmed the effectiveness of these models for operating in a real environment. In summary, our RNN models showed the best detection performance with an F-Score of 0.8009 with 240 ms of input audio with a short processing time, indicating their applicability to real-time detection systems., Comment: IEEE 5 Pages, Submitted

Published
2017

17. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside fromArtemisia capillarisThunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo

Author

Yim, Soon-Ho, primary, Tabassum, Nadia, additional, Kim, Woong-Hee, additional, Cho, Haaglim, additional, Lee, Ji-Hyung, additional, Batkhuu, Galzad J., additional, Kim, Hyun Jung, additional, Oh, Won Keun, additional, Jung, Da-Woon, additional, and Williams, Darren R., additional

Published
2017
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18. Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment

Author

Kim, Yong Sook, primary, Jeong, Hye-yun, additional, Kim, Ah Ra, additional, Kim, Woong-Hee, additional, Cho, Haaglim, additional, Um, JungIn, additional, Seo, Youngha, additional, Kang, Wan Seok, additional, Jin, Suk-Won, additional, Kim, Min Chul, additional, Kim, Yong-Chul, additional, Jung, Da-Woon, additional, Williams, Darren R., additional, and Ahn, Youngkeun, additional

Published
2016
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25. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo.

Author

Yim, Soon-Ho, Tabassum, Nadia, Kim, Woong-Hee, Cho, Haaglim, Lee, Ji-Hyung, Batkhuu, Galzad J., Kim, Hyun Jung, Oh, Won Keun, Jung, Da-Woon, and Williams, Darren R.

Subjects
HYPOPIGMENTATION, ANIMAL experimentation, EPITHELIAL cells, FISHES, MELANINS, MOLECULAR structure, TRANSCRIPTION factors, PLANT extracts, ANIMAL coloration, HYPERPIGMENTATION, THERAPEUTICS
Abstract

Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg. The novel compound isofraxidin 7-O-(6′-O-p-coumaroyl)-β-glucopyranoside (compound 1) was isolated and its pigmentation activity was characterized in mammalian melanocytes. Compound 1 stimulated melanin accumulation and increased tyrosinase activity, which regulates melanin synthesis. Moreover, compound 1 increased the expression of tyrosinase and the key melanogenesis regulator microphthalmia-associated transcription factor (MITF) in melanocytes. Compared to the parent compound, isofraxidin, compound 1 produced greater effects on these pigmentation parameters. To validate compound 1 as a novel hyperpigmentation agent in vivo, we utilized the zebrafish vertebrate model. Zebrafish treated with compound 1 showed higher melanogenesis and increased tyrosinase activity. Compound 1 treated embryos had no developmental defects and displayed normal cardiac function, indicating that this compound enhanced pigmentation without producing toxicity. In summary, our results describe the characterization of novel natural product compound 1 and its bioactivity as a pigmentation enhancer, demonstrating its potential as a therapeutic to treat hypopigmentation disorders. [ABSTRACT FROM AUTHOR]

Published
2017
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41. Reprogram or Reboot: Small Molecule Approaches for the Production of Induced Pluripotent Stem Cells and Direct Cell Reprogramming

Author

Jung, Da-Woon, Kim, Woong-Hee, and Williams, Darren Reece

Abstract

Stem cell transplantation is a potential therapy for regenerative medicine, which aims to restore tissues damaged by trauma, aging, and diseases. Since its conception in the late 1990s, chemical biology has provided powerful and diverse small molecule tools for modulating stem cell function. Embryonic stem cells could be an ideal source for transplantation, but ethical concerns restrict their development for cell therapy. The seminal advance of induced pluripotent stem cell (iPSC) technology provided an attractive alternative to human embryonic stem cells. However, iPSCs are not yet considered an ideal stem cell source, due to limitations associated with the reprogramming process and their potential tumorigenic behavior. This is an area of research where chemical biology has made a significant contribution to facilitate the efficient production of high quality iPSCs and elucidate the biological mechanisms governing their phenotype. In this review, we summarize these advances and discuss the latest progress in developing small molecule modulators. Moreover, we also review a new trend in stem cell research, which is the direct reprogramming of readily accessible cell types into clinically useful cells, such as neurons and cardiac cells. This is a research area where chemical biology is making a pivotal contribution and illustrates the many advantages of using small molecules in stem cell research.

Published
2014
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