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2. Efficacy and safety of outpatient fludarabine, cyclophosphamide, and rituximab based allogeneic hematopoietic cell transplantation in adults with severe aplastic anemia

Author

Gilmore, Rachel M., Abernathy, Karin, Shultes, Kendall, Eplin, Dwight D., Orton, Lindsay, Kassim, Adetola, Sengsayadeth, Salyka, Chinratanalab, Wichai, Kim, Tae Kon, Dholaria, Bhagirathbhai, Jayani, Reena V., Savani, Bipin N., McNeer, Elizabeth, Choi, Leena, and Gatwood, Katie

Published
2024
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3. A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes/neoplasms or acute myeloid leukemia refractory to hypomethylating agents

Author

Bewersdorf, Jan Philipp, Shallis, Rory M., Sharon, Elad, Park, Silvia, Ramaswamy, Rahul, Roe, Caroline E., Irish, Jonathan M., Caldwell, Anne, Wei, Wei, Yacoub, Abdulraheem, Madanat, Yazan F., Zeidner, Joshua F., Altman, Jessica K., Odenike, Olatoyosi, Yerrabothala, Swaroopa, Kovacsovics, Tibor, Podoltsev, Nikolai A., Halene, Stephanie, Little, Richard F., Piekarz, Richard, Gore, Steven D., Kim, Tae Kon, and Zeidan, Amer M.

Published
2024
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5. Data-driven, harmonised classification system for myelodysplastic syndromes: a consensus paper from the International Consortium for Myelodysplastic Syndromes

Author

Komrokji, Rami S, Lanino, Luca, Ball, Somedeb, Bewersdorf, Jan P, Marchetti, Monia, Maggioni, Giulia, Travaglino, Erica, Al Ali, Najla H, Fenaux, Pierre, Platzbecker, Uwe, Santini, Valeria, Diez-Campelo, Maria, Singh, Avani, Jain, Akriti G, Aguirre, Luis E, Tinsley-Vance, Sarah M, Schwabkey, Zaker I, Chan, Onyee, Xie, Zhouer, Brunner, Andrew M, Kuykendall, Andrew T, Bennett, John M, Buckstein, Rena, Bejar, Rafael, Carraway, Hetty E, DeZern, Amy E, Griffiths, Elizabeth A, Halene, Stephanie, Hasserjian, Robert P, Lancet, Jeffrey, List, Alan F, Loghavi, Sanam, Odenike, Olatoyosi, Padron, Eric, Patnaik, Mrinal M, Roboz, Gail J, Stahl, Maximilian, Sekeres, Mikkael A, Steensma, David P, Savona, Michael R, Taylor, Justin, Xu, Mina L, Sweet, Kendra, Sallman, David A, Nimer, Stephen D, Hourigan, Christopher S, Wei, Andrew H, Sauta, Elisabetta, D’Amico, Saverio, Asti, Gianluca, Castellani, Gastone, Delleani, Mattia, Campagna, Alessia, Borate, Uma M, Sanz, Guillermo, Efficace, Fabio, Gore, Steven D, Kim, Tae Kon, Daver, Navel, Garcia-Manero, Guillermo, Rozman, Maria, Orfao, Alberto, Wang, Sa A, Foucar, M Kathryn, Germing, Ulrich, Haferlach, Torsten, Scheinberg, Phillip, Miyazaki, Yasushi, Iastrebner, Marcelo, Kulasekararaj, Austin, Cluzeau, Thomas, Kordasti, Shahram, van de Loosdrecht, Arjan A, Ades, Lionel, Zeidan, Amer M, and Della Porta, Matteo G

Published
2024
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6. Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes—Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS])

Author

Aakash, Fnu, Gisriel, Savanah D., Zeidan, Amer M., Bennett, John M., Bejar, Rafael, Bewersdorf, Jan Philipp, Borate, Uma M., Boultwood, Jacqueline, Brunner, Andrew M., Buckstein, Rena, Carraway, Hetty E., Churpek, Jane E., Daver, Naval G., DeZern, Amy E., Efficace, Fabio, Fenaux, Pierre, Figueroa, Maria E., Garcia-Manero, Guillermo, Gore, Steven D., Greenberg, Peter L., Griffiths, Elizabeth A., Halene, Stephanie, Hourigan, Christopher S., Kim, Tae Kon, Kim, Nina, Komrokji, Rami S., Kutchroo, Vijay K., List, Alan F., Little, Richard F., Majeti, Ravindra, Nazha, Aziz, Nimer, Stephen D., Odenike, Olatoyosi, Padron, Eric, Patnaik, Mrinal M., Platzbecker, Uwe, Della Porta, Matteo G., Roboz, Gail J., Sallman, David A., Santini, Valeria, Sanz, Guillermo, Savona, Michael R., Sekeres, Mikkael A., Stahl, Maximilian, Starczynowski, Daniel T., Steensma, David P., Taylor, Justin, Abdel-Wahab, Omar, Wei, Andrew H., Xie, Zhuoer, Xu, Mina L., Hasserjian, Robert P., and Loghavi, Sanam

Published
2024
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8. PD-1H/VISTA mediates immune evasion in acute myeloid leukemia

Author

Kim, Tae Kon, Han, Xue, Hu, Qianni, Vandsemb, Esten N., Fielder, Carly M., Hong, Junshik, Kim, Kwang Woon, Mason, Emily F., Plowman, R. Skipper, Wang, Jun, Wang, Qi, Zhang, Jian-Ping, Badri, Ti, Sanmamed, Miguel F., Zheng, Linghua, Zhang, Tianxiang, Alawa, Jude, Lee, Sang Won, Zeidan, Amer M., Halene, Stephanie, Pillai, Manoj M., Chandhok, Namrata S., Lu, Jun, Xu, Mina L., Gore, Steven D., and Chen, Lieping

Subjects
United States. Food and Drug Administration -- Analysis, T cells -- Analysis, Immune response -- Analysis, Cancer -- Care and treatment, Apoptosis -- Analysis, Health care industry, Yale University. School of Medicine, Vanderbilt University. Medical Center
Abstract

Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti-programmed cell death protein (anti-PD) therapy. We demonstrate that programmed death-1 homolog (PD-1H), an immune coinhibitory molecule, is highly expressed in blasts from the bone marrow of AML patients, while normal myeloid cell subsets and T cells express PD-1H. In studies employing syngeneic and humanized AML mouse models, overexpression of PD-1H promoted the growth of AML cells, mainly by evading T cell-mediated immune responses. Importantly, ablation of AML cell-surface PD-1H by antibody blockade or genetic knockout significantly inhibited AML progression by promoting T cell activity. In addition, the genetic deletion of PD-1H from host normal myeloid cells inhibited AML progression, and the combination of PD- 1H blockade with anti-PD therapy conferred a synergistic antileukemia effect. Our findings provide the basis for PD- 1H as a potential therapeutic target for treating human AML., Introduction Acute myeloid leukemia (AML) is a heterogenous clonal disorder that is characterized by uncontrolled clonal expansion of myeloid progenitor cells (blasts) that leads to BM failure (1). AML is [...]

Published
2024
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9. Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS)

Author

Stahl, Maximilian, Bewersdorf, Jan Philipp, Xie, Zhuoer, Porta, Matteo Giovanni Della, Komrokji, Rami, Xu, Mina L., Abdel-Wahab, Omar, Taylor, Justin, Steensma, David P., Starczynowski, Daniel T., Sekeres, Mikkael A., Sanz, Guillermo, Sallman, David A., Roboz, Gail J., Platzbecker, Uwe, Patnaik, Mrinal M., Padron, Eric, Odenike, Olatoyosi, Nimer, Stephen D., Nazha, Aziz, Majeti, Ravi, Loghavi, Sanam, Little, Richard F., List, Alan F., Kim, Tae Kon, Hourigan, Christopher S., Hasserjian, Robert P., Halene, Stephanie, Griffiths, Elizabeth A., Gore, Steven D., Greenberg, Peter, Figueroa, Maria E., Fenaux, Pierre, Efficace, Fabio, DeZern, Amy E., Daver, Naval G., Churpek, Jane E., Carraway, Hetty E., Buckstein, Rena, Brunner, Andrew M., Boultwood, Jacqueline, Borate, Uma, Bejar, Rafael, Bennett, John M., Wei, Andrew H., Santini, Valeria, Savona, Michael R., and Zeidan, Amer M.

Published
2023
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10. Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes

Author

Zeidan, Amer M., Bewersdorf, Jan Philipp, Buckstein, Rena, Sekeres, Mikkael A., Steensma, David P., Platzbecker, Uwe, Loghavi, Sanam, Boultwood, Jacqueline, Bejar, Rafael, Bennett, John M., Borate, Uma, Brunner, Andrew M., Carraway, Hetty, Churpek, Jane E., Daver, Naval G., Della Porta, Matteo, DeZern, Amy E., Efficace, Fabio, Fenaux, Pierre, Figueroa, Maria E., Greenberg, Peter, Griffiths, Elizabeth A., Halene, Stephanie, Hasserjian, Robert P., Hourigan, Christopher S., Kim, Nina, Kim, Tae Kon, Komrokji, Rami S., Kutchroo, Vijay, List, Alan F., Little, Richard F., Majeti, Ravi, Nazha, Aziz, Nimer, Stephen D., Odenike, Olatoyosi, Padron, Eric, Patnaik, Mrinal M., Roboz, Gail J., Sallman, David A., Sanz, Guillermo, Stahl, Maximilian, Starczynowski, Daniel T., Taylor, Justin, Xie, Zhuoer, Xu, Mina, Savona, Michael R., Wei, Andrew H., Abdel-Wahab, Omar, and Santini, Valeria

Published
2022
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11. Differences in classification schemata for myelodysplastic/myeloproliferative overlap neoplasms

Author

Patnaik, Mrinal M., Zeidan, Amer M., Padron, Eric, Platzbecker, Uwe, Sallman, David A., DeZern, Amy E., Bejar, Rafael, Sekeres, Mikkael, Taylor, Justin, Little, Richard F., Bewersdorf, Jan P., Kim, Tae Kon., Kim, Nina, Hourigan, Christopher S., Dela Porta, Matteo G., Stahl, Maximilian, Steensma, David, Xu, Mina L., Odenike, Olatoyosi, Carraway, Hetty, Fenaux, Pierre, Nazha, Aziz, Komrokji, Rami, Loghavi, Sanam, Xie, Zhuoer, Hasserjian, Robert, Savona, Michael, and Bennett, John M.

Published
2022
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12. Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS)

Author

Bewersdorf, Jan Philipp, Xie, Zhuoer, Bejar, Rafael, Borate, Uma, Boultwood, Jacqueline, Brunner, Andrew M., Buckstein, Rena, Carraway, Hetty E., Churpek, Jane E., Daver, Naval G., Porta, Matteo Giovanni Della, DeZern, Amy E., Fenaux, Pierre, Figueroa, Maria E., Gore, Steven D., Griffiths, Elizabeth A., Halene, Stephanie, Hasserjian, Robert P., Hourigan, Christopher S., Kim, Tae Kon, Komrokji, Rami, Kuchroo, Vijay K., List, Alan F., Loghavi, Sanam, Majeti, Ravindra, Odenike, Olatoyosi, Patnaik, Mrinal M., Platzbecker, Uwe, Roboz, Gail J., Sallman, David A., Santini, Valeria, Sanz, Guillermo, Sekeres, Mikkael A., Stahl, Maximilian, Starczynowski, Daniel T., Steensma, David P., Taylor, Justin, Abdel-Wahab, Omar, Xu, Mina L., Savona, Michael R., Wei, Andrew H., and Zeidan, Amer M.

Published
2023
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15. LAIR-1 agonism as a therapy for acute myeloid leukemia

Author

Lovewell, Rustin R., Hong, Junshik, Kundu, Subhadip, Fielder, Carly M., Hu, Qianni, Kim, Kwang Woon, Ramsey, Haley E., Gorska, Agnieszka E., Fuller, Londa S., Tian, Linjie, Kothari, Priyanka, Paucarmayta, Ana, Mason, Emily F., Meza, Ingrid, Manzanarez, Yanira, Bosiacki, Jason, Maloveste, Karla, Mitchell, Ngan, Barbu, Emilia A., Morawski, Aaron, Maloveste, Sebastien, Cusumano, Zac, Patel, Shashank J., Savona, Michael R., Langermann, Solomon, Myint, Han, Flies, Dallas B., and Kim, Tae Kon

Subjects
STEMCELL Technologies Inc., Viral antibodies -- Health aspects -- Analysis, Collagen -- Analysis -- Health aspects, B cells -- Analysis -- Health aspects, Cancer -- Care and treatment, Diagnostic reagents industry -- Analysis -- Health aspects, Hematopoietic stem cells -- Health aspects -- Analysis, Apoptosis -- Analysis -- Health aspects, Antibodies -- Health aspects -- Analysis, Health care industry, Vanderbilt University. Medical Center
Abstract

Effective eradication of leukemic stem cells (LSCs) remains the greatest challenge in treating acute myeloid leukemia (AML). The immune receptor LAIR-1 has been shown to regulate LSC survival; however, the therapeutic potential of this pathway remains unexplored. We developed a therapeutic LAIR-1 agonist antibody, NC525, that induced cell death of LSCs, but not healthy hematopoietic stem cells in vitro, and killed LSCs and AML blasts in both cell- and patient-derived xenograft models. We showed that LAIR-1 agonism drives a unique apoptotic signaling program in leukemic cells that was enhanced in the presence of collagen. NC525 also significantly improved the activity of azacitidine and venetodaxto establish LAIR-1 targeting as a therapeutic strategy for AML that may synergize with standard-of-care therapies., Introduction Acute leukemias are characterized by the uncontrolled production of malignant hematopoietic progenitors. Acute myeloid leukemia (AML) is the most common adult acute leukemia (1). While extensive research has led [...]

Published
2023
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19. Unraveling the impact of lysosomal dysfunction on myeloproliferative neoplasm.

Author

Yoon, Hyundong, Lee, Dohoon, Song, Seulki, Koo, Bonil, Park, Jihyun, Kim, Tae Kon, Kim, Sun, Kim, Sheehyun, Hong, Junshik, Byun, Ja Min, Shin, Dong‐Yeop, Kim, Inho, Koh, Youngil, and Yoon, Sung‐Soo

Subjects
LYSOSOMAL storage diseases, POLYCYTHEMIA vera, MYELOPROLIFERATIVE neoplasms, LOGISTIC regression analysis, RNA sequencing
Abstract

Background: Lysosomal dysfunction (LD) impacts cytokine regulation, inflammation, and immune responses, influencing the development and progression of cancer. Inflammation is implicated in the pathogenesis of myeloproliferative neoplasm (MPN). With a hypothesis that LD significantly contributes to MPN carcinogenesis by inducing abnormal inflammation, our objective was to elucidate the pathophysiological mechanisms of MPN arising from an LD background. Methods: Genotyping of the LD background was performed in a cohort of MPN patients (n = 190) and healthy controls (n = 461). Logistic regression modeling, utilizing genotype data, was employed to estimate the correlation between LD and MPN. Whole transcriptome sequencing (WTS) (LD carriers = 8, non‐carriers = 6) and single‐cell RNA sequencing data (LD carriers = 2, non‐carriers = 2, healthy controls = 2) were generated and analyzed. Results: A higher variant frequency of LD was observed in MPN compared to healthy controls (healthy, 4.9%; MPN, 7.8%), with the highest frequency seen in polycythemia vera (PV) (odds ratio = 2.33, p = 0.03). WTS revealed that LD carriers exhibited upregulated inflammatory cytokine ligand–receptor genes, pathways, and network modules in MPNs compared to non‐carriers. At the single‐cell level, there was monocyte expansion and elevation of cytokine ligand–receptor interactions, inflammatory transcription factors, and network modules centered on monocytes. Notably, Oncostatin‐M (OSM) consistently emerged as a candidate molecule involved in the pathogenesis of LD‐related PV. Conclusions: In summary, an LD background is prevalent in MPN patients and leads to increased cytokine dysregulation and inflammation. OSM, as one of the potential molecules, plays a crucial role in PV pathogenesis by impairing lysosomal function. Lysosomal dysfunction (LD) impacts cytokine regulation, inflammation, and immune responses, influencing the development and progression of cancer. Inflammation is implicated in the pathogenesis of myeloproliferative neoplasm (MPN). With a hypothesis that LD significantly contributes to MPN carcinogenesis by inducing abnormal inflammation, our objective was to elucidate the pathophysiological mechanisms of MPN arising from an LD background. Genotyping of the LD background was performed in a cohort of MPN patients (n = 190) and healthy controls (n = 461). Logistic regression modeling, utilizing genotype data, was employed to estimate the correlation between LD and MPN. Whole transcriptome sequencing (WTS) (LD carriers = 8, non‐carriers = 6) and single‐cell RNA‐sequencing data (LD carriers = 2, non‐carriers = 2, healthy controls = 2) were generated and analyzed. A higher variant frequency of LD was observed in MPN compared to healthy controls (healthy, 4.9%; MPN, 7.8%), with the highest frequency seen in polycythemia vera (PV) (odds ratio = 2.33, p = 0.03). WTS revealed that LD carriers exhibited upregulated inflammatory cytokine ligand‐receptor genes, pathways, and network modules in MPNs compared to non‐carriers. At the single‐cell level, there was monocyte expansion and elevation of cytokine ligand‐receptor interactions, inflammatory transcription factors, and network modules centered on monocytes. Notably, Oncostatin‐M (OSM) consistently emerged as a candidate molecule involved in the pathogenesis of LD‐related PV. In summary, an LD background is prevalent in MPN patients and leads to increased cytokine dysregulation and inflammation. OSM may play a crucial role in PV pathogenesis by impairing lysosomal function. [ABSTRACT FROM AUTHOR]

Published
2024
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21. PD-1H/VISTA mediates immune evasion in acute myeloid leukemia

Author

Kim, Tae Kon, primary, Han, Xue, additional, Hu, Qianni, additional, Vandsemb, Esten N., additional, Fielder, Carly M., additional, Hong, Junshik, additional, Kim, Kwang Woon, additional, Mason, Emily F., additional, Plowman, R. Skipper, additional, Wang, Jun, additional, Wang, Qi, additional, Zhang, Jian-Ping, additional, Badri, Ti, additional, Sanmamed, Miguel F., additional, Zheng, Linghua, additional, Zhang, Tianxiang, additional, Alawa, Jude, additional, Lee, Sang Won, additional, Zeidan, Amer M., additional, Halene, Stephanie, additional, Pillai, Manoj M., additional, Chandhok, Namrata S., additional, Lu, Jun, additional, Xu, Mina L., additional, Gore, Steven D., additional, and Chen, Lieping, additional

Published
2023
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25. Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Author

Sun, Jun, primary, Ince, M. Nedim, additional, Abraham, Clara, additional, Barrett, Terrence, additional, Brenner, Lisa A., additional, Cong, Yingzi, additional, Dashti, Reza, additional, Dudeja, Pradeep K., additional, Elliott, David, additional, Griffith, Thomas S., additional, Heeger, Peter S., additional, Hoisington, Andrew, additional, Irani, Kaikobad, additional, Kim, Tae Kon, additional, Kapur, Neeraj, additional, Leventhal, Joseph, additional, Mohamadzadeh, Mansour, additional, Mutlu, Ece, additional, Newberry, Rodney, additional, Peled, Jonathan U., additional, Rubinstein, Israel, additional, Sengsayadeth, Salyka, additional, Tan, Chen Sabrina, additional, Tan, Xiao-Di, additional, Tkaczyk, Eric, additional, Wertheim, Jason, additional, and Zhang, Zheng Jenny, additional

Published
2023
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27. Allogeneic Hematopoietic Stem Cell Transplantation Following the Use of Hypomethylating Agents among Patients with Relapsed or Refractory AML: Findings from an International Retrospective Study

Author

Stahl, Maximilian, DeVeaux, Michelle, Montesinos, Pau, Itzykson, Raphaël, Ritchie, Ellen K., Sekeres, Mikkael A., Majhail, Navneet, Barnard, John, Podoltsev, Nikolai A., Brunner, Andrew M., Komrokji, Rami S., Bhatt, Vijaya R., Al-Kali, Aref, Cluzeau, Thomas, Santini, Valeria, Roboz, Gail J., Fenaux, Pierre, Litzow, Mark, Fathi, Amir T., Perreault, Sarah, Kim, Tae Kon, Prebet, Thomas, Vey, Norbert, Verma, Vivek, Kobbe, Guido, Bergua, Juan, Serrano, Josefina, Gore, Steven D., and Zeidan, Amer M.

Published
2018
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30. Updates in classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium of MDS (icMDS)

Author

Stahl, Maximilian, primary, Bewersdorf, Jan Philipp, additional, Xie, Zhuoer, additional, Porta, Matteo Giovanni Della, additional, Komrokji, Rami, additional, Xu, Mina L., additional, Abdel-Wahab, Omar, additional, Taylor, Justin, additional, Steensma, David P., additional, Starczynowski, Daniel T., additional, Sekeres, Mikkael A., additional, Sanz, Guillermo, additional, Sallman, David A., additional, Roboz, Gail J., additional, Platzbecker, Uwe, additional, Patnaik, Mrinal M., additional, Padron, Eric, additional, Odenike, Olatoyosi, additional, Nimer, Stephen D., additional, Nazha, Aziz, additional, Majeti, Ravi, additional, Loghavi, Sanam, additional, Little, Richard F., additional, List, Alan F., additional, Kim, Tae Kon, additional, Hourigan, Christopher S., additional, Hasserjian, Robert P., additional, Halene, Stephanie, additional, Griffiths, Elizabeth A., additional, Gore, Steven D., additional, Greenberg, Peter, additional, Figueroa, Maria E., additional, Fenaux, Pierre, additional, Efficace, Fabio, additional, DeZern, Amy E., additional, Daver, Naval G., additional, Churpek, Jane E., additional, Carraway, Hetty E., additional, Buckstein, Rena, additional, Brunner, Andrew M., additional, Boultwood, Jacqueline, additional, Borate, Uma, additional, Bejar, Rafael, additional, Bennett, John M., additional, Wei, Andrew H., additional, Santini, Valeria, additional, Savona, Michael R., additional, and Zeidan, Amer M., additional

Published
2023
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32. Supplementary Data from A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Author

Sanmamed, Miguel F., primary, Nie, Xinxin, primary, Desai, Shruti S., primary, Villaroel-Espindola, Franz, primary, Badri, Ti, primary, Zhao, Dejian, primary, Kim, Anthony W., primary, Ji, Lan, primary, Zhang, Tianxiang, primary, Quinlan, Edward, primary, Cheng, Xiaoxiao, primary, Han, Xue, primary, Vesely, Matthew D., primary, Nassar, Ala F., primary, Sun, Jingwei, primary, Zhang, Yu, primary, Kim, Tae Kon, primary, Wang, Jun, primary, Melero, Ignacio, primary, Herbst, Roy S., primary, Schalper, Kurt A., primary, and Chen, Lieping, primary

Published
2023
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33. Data from A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Author

Sanmamed, Miguel F., primary, Nie, Xinxin, primary, Desai, Shruti S., primary, Villaroel-Espindola, Franz, primary, Badri, Ti, primary, Zhao, Dejian, primary, Kim, Anthony W., primary, Ji, Lan, primary, Zhang, Tianxiang, primary, Quinlan, Edward, primary, Cheng, Xiaoxiao, primary, Han, Xue, primary, Vesely, Matthew D., primary, Nassar, Ala F., primary, Sun, Jingwei, primary, Zhang, Yu, primary, Kim, Tae Kon, primary, Wang, Jun, primary, Melero, Ignacio, primary, Herbst, Roy S., primary, Schalper, Kurt A., primary, and Chen, Lieping, primary

Published
2023
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34. Supplementary Figures from A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Author

Sanmamed, Miguel F., primary, Nie, Xinxin, primary, Desai, Shruti S., primary, Villaroel-Espindola, Franz, primary, Badri, Ti, primary, Zhao, Dejian, primary, Kim, Anthony W., primary, Ji, Lan, primary, Zhang, Tianxiang, primary, Quinlan, Edward, primary, Cheng, Xiaoxiao, primary, Han, Xue, primary, Vesely, Matthew D., primary, Nassar, Ala F., primary, Sun, Jingwei, primary, Zhang, Yu, primary, Kim, Tae Kon, primary, Wang, Jun, primary, Melero, Ignacio, primary, Herbst, Roy S., primary, Schalper, Kurt A., primary, and Chen, Lieping, primary

Published
2023
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35. Supplementary Tables from A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Author

Sanmamed, Miguel F., primary, Nie, Xinxin, primary, Desai, Shruti S., primary, Villaroel-Espindola, Franz, primary, Badri, Ti, primary, Zhao, Dejian, primary, Kim, Anthony W., primary, Ji, Lan, primary, Zhang, Tianxiang, primary, Quinlan, Edward, primary, Cheng, Xiaoxiao, primary, Han, Xue, primary, Vesely, Matthew D., primary, Nassar, Ala F., primary, Sun, Jingwei, primary, Zhang, Yu, primary, Kim, Tae Kon, primary, Wang, Jun, primary, Melero, Ignacio, primary, Herbst, Roy S., primary, Schalper, Kurt A., primary, and Chen, Lieping, primary

Published
2023
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36. An Agenda to Advance Research in Myelodysplastic Syndromes: A TOP 10 Priority List From the First International Workshop in MDS

Author

Stahl, Maximilian, Abdel-Wahab, Omar, Wei, Andrew H., Savona, Michael R., Xu, Mina L., Xie, Zhuoer, Taylor, Justin, Starczynowski, Daniel, Sanz, Guillermo F., Sallman, David A., Santini, Valeria, Roboz, Gail J., Patnaik, Mrinal M., Padron, Eric, Odenike, Olatoyosi, Nazha, Aziz, Nimer, Stephen D., Majeti, Ravindra, Little, Richard F., Gore, Steven, List, Alan F., Kutchroo, Vijay, Komrokji, Rami S., Kim, Tae Kon, Kim, Nina, Hourigan, Christopher S., Hasserjian, Robert P., Halene, Stephanie, Griffiths, Elizabeth A., Greenberg, Peter L., Figueroa, Maria, Fenaux, Pierre, Efficace, Fabio, DeZern, Amy E., Della Porta, Matteo G., Daver, Naval G., Churpek, Jane E., Carraway, Hetty E., Brunner, Andrew M., Borate, Uma, Bennett, John M., Bejar, Rafael, Boultwood, Jacqueline, Loghavi, Sanam, Bewersdorf, Jan Philipp, Platzbecker, Uwe, Steensma, David P., Sekeres, Mikkael A., Buckstein, Rena J., Zeidan, Amer M., Stahl, Maximilian, Abdel-Wahab, Omar, Wei, Andrew H., Savona, Michael R., Xu, Mina L., Xie, Zhuoer, Taylor, Justin, Starczynowski, Daniel, Sanz, Guillermo F., Sallman, David A., Santini, Valeria, Roboz, Gail J., Patnaik, Mrinal M., Padron, Eric, Odenike, Olatoyosi, Nazha, Aziz, Nimer, Stephen D., Majeti, Ravindra, Little, Richard F., Gore, Steven, List, Alan F., Kutchroo, Vijay, Komrokji, Rami S., Kim, Tae Kon, Kim, Nina, Hourigan, Christopher S., Hasserjian, Robert P., Halene, Stephanie, Griffiths, Elizabeth A., Greenberg, Peter L., Figueroa, Maria, Fenaux, Pierre, Efficace, Fabio, DeZern, Amy E., Della Porta, Matteo G., Daver, Naval G., Churpek, Jane E., Carraway, Hetty E., Brunner, Andrew M., Borate, Uma, Bennett, John M., Bejar, Rafael, Boultwood, Jacqueline, Loghavi, Sanam, Bewersdorf, Jan Philipp, Platzbecker, Uwe, Steensma, David P., Sekeres, Mikkael A., Buckstein, Rena J., and Zeidan, Amer M.

Published
2023

39. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis

Author

Kim, Sang-Hun, primary, Adams, Taylor S, additional, Hu, Qianni, additional, Shin, Hyeon Jun, additional, Chae, Ganghee, additional, Lee, Sang Eun, additional, Sharma, Lokesh, additional, Kwon, Hyuk-Kwon, additional, Lee, Francis Y, additional, Park, Hong-Jai, additional, Huh, Won Jae, additional, Manning, Edward, additional, Kaminski, Naftali, additional, Sauler, Maor, additional, Chen, Lieping, additional, Song, Jin Woo, additional, Kim, Tae Kon, additional, and Kang, Min-Jong, additional

Published
2022
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41. A Phase 1, Open-Label, Safety, Tolerability, and Efficacy Study of NC525 in Subjects with Advanced Myeloid Neoplasms

Author

Short, Nicholas, primary, Kim, Tae Kon, additional, Lovewell, Rustin, additional, Griffiths, Elizabeth A., additional, Carraway, Hetty E., additional, Zeidan, Stephanie, additional, Knowles, Elizabeth, additional, Nelson, Megan, additional, Shaik, Jahangheer, additional, Zhou, Chelsea, additional, Barbu, Emilia Alina, additional, Cusumano, Zachary, additional, Kundu, Subhadip, additional, Sharee, Sasan, additional, Copeland, Ron, additional, Flies, Dallas, additional, Langermann, Solomon, additional, Myint, Han, additional, Altman, Jessica K., additional, and Ravandi, Farhad, additional

Published
2022
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42. TP53 Mutations Are Associated with Increased Infections and Reduced Hematopoietic Cell Transplantation Rates in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Author

Marvin-Peek, Jennifer, primary, Kishtagari, Ashwin, additional, Jayani, Reena, additional, Dholaria, Bhagirathbhai, additional, Kim, Tae Kon, additional, Mason, Emily F, additional, Engelhardt, Brian G., additional, Chen, Heidi, additional, Kassim, Adetola A., additional, Savona, Michael R., additional, Savani, Bipin, additional, and Byrne, Michael, additional

Published
2022
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43. A Multi-Center Phase Ib Trial of the Histone Deactylase Inhibitor (HDACi) Entinostat in Combination with Anti-PD1 Antibody Pembrolizumab in Patients with Refractory/Relapsed Myelodysplastic Syndromes (RR-MDS) or Oligoblastic Acute Myeloid Leukemia (RR-AML) after Hypomethylating Agent (HMA) Failure

Author

Bewersdorf, Jan Philipp, primary, Shallis, Rory Michael, additional, Sharon, Elad, additional, Caldwell, Anne, additional, Wei, Wei, additional, Yacoub, Abdulraheem, additional, Madanat, Yazan F., additional, Zeidner, Joshua F., additional, Altman, Jessica K., additional, Odenike, Olatoyosi, additional, Yerrabothala, Swaroopa, additional, Kovacsovics, Tibor, additional, Podoltsev, Nikolai A., additional, Halene, Stephanie, additional, Little, Richard F., additional, Piekarz, Richard, additional, Gore, Steven D., additional, Kim, Tae Kon, additional, and Zeidan, Amer M., additional

Published
2022
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45. Efficacy and Safety of a Novel Non-Myeloablative Conditioning Regimen for Hematopoietic Cell Transplantation in Adults with Severe Aplastic Anemia

Author

Gilmore, Rachel M, primary, Abernathy, Karin M, additional, Shultes, Kendall C, additional, Eplin, Dwight D, additional, Orton, Lindsay, additional, Kassim, Adetola A., additional, Savani, Bipin N., additional, Sengsayadeth, Salyka M., additional, Engelhardt, Brian G., additional, Chinratanalab, Wichai, additional, Kim, Tae Kon, additional, Dholaria, Bhagirathbhai, additional, Jayani, Reena, additional, Choi, Leena, additional, McNeer, Elizabeth, additional, and Gatwood, Katie S., additional

Published
2022
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46. An agenda to advance research in MDS: A TOP 10 Priority List from the first international workshop in MDS (iwMDS)

Author

Stahl, Maximilian, primary, Abdel-Wahab, Omar, additional, Wei, Andrew H., additional, Savona, Michael R, additional, Xu, Mina L, additional, Xie, Zhuoer, additional, Taylor, Justin, additional, Starczynowski, Daniel T, additional, Sanz, Guillermo F., additional, Sallman, David A., additional, Santini, Valeria, additional, Roboz, Gail J., additional, Patnaik, Mrinal M., additional, Padron, Eric, additional, Odenike, Olatoyosi, additional, Nazha, Aziz, additional, Nimer, Stephen D, additional, Majeti, Ravindra, additional, Little, Richard F, additional, Gore, Steven D, additional, List, Alan F., additional, Kuchroo, Vijay, additional, Komrokji, Rami S., additional, Kim, Tae Kon, additional, Kim, Nina, additional, Hourigan, Christopher S, additional, Hasserjian, Robert P, additional, Halene, Stephanie, additional, Griffiths, Elizabeth A, additional, Greenberg, Peter L., additional, Figueroa, Maria E., additional, Fenaux, Pierre, additional, Efficace, Fabio, additional, DeZern, Amy E., additional, Della Porta, Matteo G, additional, Daver, Naval G., additional, Churpek, Jane E., additional, Carraway, Hetty E, additional, Brunner, Andrew M., additional, Borate, Uma, additional, Bennett, John M, additional, Bejar, Rafael, additional, Boultwood, Jacqueline, additional, Loghavi, Sanam, additional, Bewersdorf, Jan Philipp, additional, Platzbecker, Uwe, additional, Steensma, David P., additional, Sekeres, Mikkael A., additional, Buckstein, Rena J., additional, and Zeidan, Amer M., additional

Published
2022
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