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6,176 results on '"Kim, Sung-Hoon"'

11. Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential

Author

Helen, Helen, Gunawan, Mega Carensia, Halim, Princella, Dinata, Muhammad Riza, Ahmed, Amer, Dalimunthe, Aminah, Marianne, Marianne, Ribeiro, Rosy Iara Maciel De Azambuja, Hasibuan, Poppy Anjelisa Zaitun, Nurkolis, Fahrul, Hey-hawkins, Evamarie, Park, Moon Nyeo, Harahap, Urip, Kim, Sung-Hoon, Kim, Bonglee, and Syahputra, Rony Abdi

Published
2024
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17. Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle

Author

Sacharidou, Anastasia, Chambliss, Ken, Peng, Jun, Barrera, Jose, Tanigaki, Keiji, Luby-Phelps, Katherine, Özdemir, İpek, Khan, Sohaib, Sirsi, Shashank R., Kim, Sung Hoon, Katzenellenbogen, Benita S., Katzenellenbogen, John A., Kanchwala, Mohammed, Sathe, Adwait A., Lemoff, Andrew, Xing, Chao, Hoyt, Kenneth, Mineo, Chieko, and Shaul, Philip W.

Published
2023
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24. Dye, Functional

Author

Kim, Sung-Hoon, Lee, Eun-Mi, Luo, Ming Ronnier, Section editor, and Shamey, Renzo, editor

Published
2023
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27. An improved upper bound for the size of the sphere of influence graph

Author

Ismailescu, Dan, Kim, Sung Hoon, and Park, Taeyang David

Subjects
Mathematics - Combinatorics, 05C75
Abstract

Let $V$ be a set of $n$ points in the plane. For each $x\in V$, let $B_x$ be the closed circular disk centered at $x$ with radius equal to the distance from $x$ to its closest neighbor. The {\it closed sphere of influence graph} on $V$ is defined as the undirected graph where $x$ and $y$ are adjacent if and only if the $B_x$ and $B_y$ have nonempty intersection. It is known that every $n$-vertex closed sphere of influence graph has at most $cn$ edges, for some absolute positive constant $c$. The first result was obtained in 1985 by Avis and Horton who provided the value $c=29$. Their result was successively improved by several authors: Bateman and Erd\H{o}s (c=18), Michael and Quint (c=17.5), and Soss (c=15). In this paper we prove that one can take $c=14.5$.

Published
2020

28. Clinical, neuroradiological, and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder

Author

Accogli, Andrea, Lin, Sheng-Jia, Severino, Mariasavina, Kim, Sung-Hoon, Huang, Kevin, Rocca, Clarissa, Landsverk, Megan, Zaki, Maha S., Al-Maawali, Almundher, Srinivasan, Varunvenkat M., Al-Thihli, Khalid, Schaefer, G. Bradly, Davis, Monica, Tonduti, Davide, Doneda, Chiara, Marten, Lara M., Mühlhausen, Chris, Gomez, Maria, Lamantea, Eleonora, Mena, Rafael, Nizon, Mathilde, Procaccio, Vincent, Begtrup, Amber, Telegrafi, Aida, Cui, Hong, Schulz, Heidi L., Mohr, Julia, Biskup, Saskia, Loos, Mariana Amina, Aráoz, Hilda Verónica, Salpietro, Vincenzo, Keppen, Laura Davis, Chitre, Manali, Petree, Cassidy, Raymond, Lucy, Vogt, Julie, Sawyer, Lindsey B., Basinger, Alice A., Pedersen, Signe Vandal, Pearson, Toni S., Grange, Dorothy K., Lingappa, Lokesh, McDunnah, Paige, Horvath, Rita, Cognè, Benjamin, Isidor, Bertrand, Hahn, Andreas, Gripp, Karen W., Jafarnejad, Seyed Mehdi, Østergaard, Elsebet, Prada, Carlos E., Ghezzi, Daniele, Gowda, Vykuntaraju K., Taylor, Robert W., Sonenberg, Nahum, Houlden, Henry, Sissler, Marie, Varshney, Gaurav K., and Maroofian, Reza

Published
2023
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35. Improvement in Willingness to Purchase Taurine-Containing Jelly Needs High Degrees of Interest and Preference: Focused on Korean College Students

Author

Park, So Hyun, Han, Sang Duk, Park, Hyeong Keun, Kim, Sung Hoon, Chang, Kyung Ja, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Schaffer, Stephen W., editor, El Idrissi, Abdeslem, editor, and Murakami, Shigeru, editor

Published
2022
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36. Effects of Dietary Taurine-Containing Jelly Supplementation on Academic-Related Characteristics and Academic Achievement in Korean College Entrance Examinees: A Pilot Study

Author

Park, So Hyun, Kang, Dong Hyeok, Kim, Sung Hoon, Chang, Kyung Ja, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Schaffer, Stephen W., editor, El Idrissi, Abdeslem, editor, and Murakami, Shigeru, editor

Published
2022
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37. The Effects of Dietary Taurine-Containing Jelly Supplementation on Cognitive Function and Memory Ability of the Elderly with Subjective Cognitive Decline

Author

Bae, Mi Ae, Lee, Eun Seok, Cho, Sung Mo, Kim, Sung Hoon, Chang, Kyung Ja, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Schaffer, Stephen W., editor, El Idrissi, Abdeslem, editor, and Murakami, Shigeru, editor

Published
2022
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40. Traffic-Aware Backscatter Communications in Wireless-Powered Heterogeneous Networks

Author

Kim, Sung Hoon and Kim, Dong In

Subjects
Computer Science - Information Theory
Abstract

With the emerging Internet-of-Things services, massive machine-to-machine (M2M) communication will be deployed on top of human-to-human (H2H) communication in the near future. Due to the coexistence of M2M and H2H communications, the performance of M2M (i.e., secondary) network depends largely on the H2H (i.e., primary) network. In this paper, we propose ambient backscatter communication for the M2M network which exploits the energy (signal) sources of the H2H network, referring to traffic applications and popularity. In order to maximize the harvesting and transmission opportunities offered by varying traffic sources of the H2H network, we adopt a Bayesian nonparametric (BNP) learning algorithm to classify traffic applications (patterns) for secondary user (SU). We then analyze the performance of SU using the stochastic geometrical approach, based on a criterion for optimal traffic pattern selection. Results are presented to validate the performance of the proposed BNP classification algorithm and the criterion, as well as the impact of traffic sources and popularity., Comment: 14 pages, 10 figures

Published
2018

41. Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis

Author

Atkinson, Kelley C, Lee, Jeong Bin, Hasselmann, Jonathan PC, Kim, Sung Hoon, Drew, Alyson, Soto, Joselyn, Katzenellenbogen, John A, Harris, Neil G, Obenaus, Andre, and Tiwari-Woodruff, Seema K

Subjects
Biomedical Imaging, Estrogen, Multiple Sclerosis, Brain Disorders, Autoimmune Disease, Neurosciences, Neurodegenerative, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Neurological, Animals, Corpus Callosum, Cuprizone, Demyelinating Diseases, Diffusion Tensor Imaging, Disease Models, Animal, Estrogen Receptor beta, Female, Indazoles, Magnetic Resonance Imaging, Male, Mice, Neuroprotective Agents, Remyelination, Cuprizone diet, Demyelination, Neurodegeneration, Neuroprotection, Oligodendrocyte, Clinical Sciences, Neurology & Neurosurgery
Abstract

Diffusion tensor imaging (DTI) has been shown to detect white matter degeneration in multiple sclerosis (MS), a neurodegenerative autoimmune disease that presents with diffuse demyelination of the central nervous system. However, the utility of DTI in evaluating therapeutic remyelination has not yet been well-established. Here, we assessed the ability of DTI to distinguish between remyelination and neuroprotection following estrogen receptor β ligand (Indazole chloride, IndCl) treatment, which has been previously shown to stimulate functional remyelination, in the cuprizone (CPZ) diet mouse model of MS. Adult C57BL/6 J male and female mice received a normal diet (control), demyelination-inducing CPZ diet (9wkDM), or CPZ diet followed by two weeks of a normal diet (i.e., remyelination period) with either IndCl (RM + IndCl) or vehicle (RM + Veh) injections. We evaluated tissue microstructure of the corpus callosum utilizing in vivo and ex vivo DTI and immunohistochemistry (IHC) for validation. Compared to control mice, the 9wkDM group showed decreased fractional anisotropy (FA), increased radial diffusivity (RD), and no changes in axial diffusivity (AD) both in vivo and ex vivo. Meanwhile, RM + IndCl groups showed increased FA and decreased RD ex vivo compared to the RM + Veh group, in accordance with the evidence of remyelination by IHC. In conclusion, the DTI technology used in the present study can identify some changes in myelination and is a valuable translational tool for evaluating MS pathophysiology and therapeutic efficacy.

Published
2019

42. Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis.

Author

Karim, Hawra, Kim, Sung Hoon, Lauderdale, Kelli, Lapato, Andrew S, Atkinson, Kelley, Yasui, Norio, Yamate-Morgan, Hana, Sekyi, Maria, Katzenellenbogen, John A, and Tiwari-Woodruff, Seema K

Abstract

Pharmaceutical agents currently approved for the treatment of multiple sclerosis reduce relapse rates, but do not reverse or prevent neurodegeneration nor initiate myelin repair. The highly selective estrogen receptor (ER) β ligand chloroindazole (IndCl) shows particular promise promoting both remyelination while reducing inflammatory cytokines in the central nervous system of mice with experimental autoimmune encephalomyelitis. To optimize these benefits, we developed and screened seven novel IndCl analogues for their efficacy in promoting primary oligodendrocyte (OL) progenitor cell survival, proliferation, and differentiation in vitro by immunohistochemistry. Two analogues, IndCl-o-chloro and IndCl-o-methyl, induced proliferation and differentiation equivalent to IndCl and were selected for subsequent in vivo evaluation for their impact on clinical disease course, white matter pathology, and inflammation. Both compounds ameliorated disease severity, increased mature OLs, and improved overall myelination in the corpus callosum and white matter tracts of the spinal cord. These effects were accompanied by reduced production of the OL toxic molecules interferon-γ and chemokine (C-X-C motif) ligand, CXCL10 by splenocytes with no discernable effect on central nervous system-infiltrating leukocyte numbers, while IndCl-o-methyl also reduced peripheral interleukin (IL)-17. In addition, expression of the chemokine CXCL1, which is associated with developmental oligodendrogenesis, was upregulated by IndCl and both analogues. Furthermore, callosal compound action potential recordings from analogue-treated mice demonstrated a larger N1 component amplitude compared to vehicle, suggesting more functionally myelinated fibers. Thus, the o-Methyl and o-Chloro IndCl analogues represent a class of ERβ ligands that offer significant remyelination and neuroprotection as well as modulation of the immune system; hence, they appear appropriate to consider further for therapeutic development in multiple sclerosis and other demyelinating diseases.

Published
2019

43. Dual-mechanism estrogen receptor inhibitors

Author

Min, Jian, Nwachukwu, Jerome C., Min, Charles K., Njeri, Jacqline W., Srinivasan, Sathish, Rangarajan, Erumbi S., Nettles, Charles C., Guillen, Valeria Sanabria, Ziegler, Yvonne, Yan, Shunchao, Carlson, Kathryn E., Hou, Yingwei, Kim, Sung Hoon, Novick, Scott, Pascal, Bruce D., Houtman, Rene, Griffin, Patrick R., Izard, Tina, Katzenellenbogen, Benita S., Katzenellenbogen, John A., and Nettles, Kendall W.

Published
2021

50. Highly Safe, Ultra‐Thin MOF‐Based Solid Polymer Electrolytes for Superior All‐Solid‐State Lithium‐Metal Battery Performance.

Author

Nguyen, Manh Cuong, Nguyen, Hoang Long, Duong, Thi Phuong Mai, Kim, Sung‐Hoon, Kim, Ji‐Young, Bae, Jee‐Hwan, Kim, Hyun‐Kyung, Lim, Sung Nam, and Ahn, Wook

Subjects
SOLID electrolytes, IONIC conductivity, POLYETHYLENE oxide, POLYELECTROLYTES, ELECTROLYTES, IONIC liquids, LITHIUM cells
Abstract

Polyethylene oxide (PEO)/lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) is among the most promising candidates for developing solid polymer electrolytes (SPEs) for all‐solid‐state lithium‐metal batteries (ASSLMBs). However, practical applications of the PEO/LiTFSI system face challenges due to its relatively low ionic conductivity and low Li+ transference number. To address these issues, a method is proposed that incorporates multiple components, including zeolitic imidazolate frameworks (ZIF‐67) as fillers and ionic liquid electrolytes (ILEs) as plasticizers, into a PEO/LiTFSI matrix. By optimizing the fabrication process, ultra‐thin membranes of the integrated electrolyte PEO/LiTFSI‐ILE‐ZIF‐67 (PLiZ) with a thickness of 32 µm are developed, achieving high ionic conductivity (1.19 × 10−4 S cm−1 at 25 °C), broad electrochemical stability (5.66 V), and high lithium‐ion mobility (0.8). As a result, the fabricated ASSLMBs exhibited excellent cycle stability at both room temperature and 60 °C, delivering an initial specific discharge capacity of 166.4 mAh g−1 and an impressive capacity retention of 83.7% after 1000 cycles at 3C under 60 °C, corresponding to a low fading rate of 0.0163% per cycle. Additionally, the designed SPEs demonstrated high safety properties, as shown by the successful cutting and folding of a working LiFePO4/PLiZ/Li pouch cell. Therefore, this study presents a comprehensively improved method for developing high‐performance ASSLMBs. [ABSTRACT FROM AUTHOR]

Published
2024
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