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3,497 results on '"Kim, Sang-Hoon"'

10. Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study

Author

Oh, Ji-Yoon, Kang, Sung-Yoon, Kang, Noeul, Won, Ha-Kyeong, Jo, Eun-Jung, Lee, Seung-Eun, Lee, Ji-Hyang, Shim, Ji-Su, Kim, Young-Chan, Yoo, Youngsang, An, Jin, Lee, Hwa Young, Park, So-Young, Kim, Mi-Yeong, Lee, Ji-Ho, Kim, Byung-Keun, Park, Han-Ki, Kim, Min-Hye, Kim, Sae-Hoon, Kim, Sang-Heon, Chang, Yoon-Seok, Kim, Sang-Hoon, Lee, Byung-Jae, Chung, Kian Fan, Cho, Sang-Heon, and Song, Woo-Jung

Published
2024
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13. SARS-CoV-2 evolved variants optimize binding to cellular glycocalyx

Author

Kim, Sang Hoon, Kearns, Fiona L, Rosenfeld, Mia A, Votapka, Lane, Casalino, Lorenzo, Papanikolas, Micah, Amaro, Rommie E, and Freeman, Ronit

Subjects
Prevention, Biodefense, Infectious Diseases, Emerging Infectious Diseases, Vaccine Related, ACE2, Brownian dynamics, COVID-19, SARS-CoV-2, biomimetic, biosensor, electrostatic potential, heparan sulfate, heparin, lateral-flow assay, spike
Abstract

Viral variants of concern continue to arise for SARS-CoV-2, potentially impacting both methods for detection and mechanisms of action. Here, we investigate the effect of an evolving spike positive charge in SARS-CoV-2 variants and subsequent interactions with heparan sulfate and the angiotensin converting enzyme 2 (ACE2) in the glycocalyx. We show that the positively charged Omicron variant evolved enhanced binding rates to the negatively charged glycocalyx. Moreover, we discover that while the Omicron spike-ACE2 affinity is comparable to that of the Delta variant, the Omicron spike interactions with heparan sulfate are significantly enhanced, giving rise to a ternary complex of spike-heparan sulfate-ACE2 with a large proportion of double-bound and triple-bound ACE2. Our findings suggest that SARS-CoV-2 variants evolve to be more dependent on heparan sulfate in viral attachment and infection. This discovery enables us to engineer a second-generation lateral-flow test strip that harnesses both heparin and ACE2 to reliably detect all variants of concern, including Omicron.

Published
2023

16. Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study

Author

Rhyou, Hyo-In, Kim, Hyun-Kyoung, Song, Woo-Jung, Lee, Sang Min, Kim, Sang-Ha, Kwon, Jae-Woo, Park, Han-Ki, Park, Hye-Kyung, Kim, Sang Hoon, Choi, Jeong-Hee, Kim, Sujeong, Park, So-Young, Kim, Sae-Hoon, Moon, Ji-Yong, Jung, Jae-Woo, Cho, Young-Joo, Park, Chan Sun, Kim, Byung Keun, Kim, Joo-Hee, Yang, Min-Suk, Kim, Min-Hye, Nam, Young-Hee, Lee, Taehoon, Lee, Byung-Jae, Bhavsar, Pankaj, Adcock, Ian M., Chung, Kian Fan, and Kim, Tae-Bum

Published
2024
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18. Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study

Author

Jo, Eun-Jung, Lee, Ji-Hyang, Won, Ha-Kyeong, Kang, Noeul, Kang, Sung-Yoon, Lee, Seung Eun, Lee, Ji-Ho, Kim, Mi-Yeong, Shim, Ji-Su, An, Jin, Yoo, Youngsang, Park, So-Young, Kim, Byung-Keun, Moon, Ji-Yong, Park, Han-Ki, Kim, Min-Hye, Kwon, Hyouk-Soo, Kim, Sae-Hoon, Kim, Sang-Heon, Chang, Yoon-Seok, Kim, Sang-Hoon, Birring, Surinder S., Lee, Byung-Jae, and Song, Woo-Jung

Published
2023
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23. Sayer: Using Implicit Feedback to Optimize System Policies

Author

Lécuyer, Mathias, Kim, Sang Hoon, Nanavati, Mihir, Jiang, Junchen, Sen, Siddhartha, Sharma, Amit, and Slivkins, Aleksandrs

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

We observe that many system policies that make threshold decisions involving a resource (e.g., time, memory, cores) naturally reveal additional, or implicit feedback. For example, if a system waits X min for an event to occur, then it automatically learns what would have happened if it waited

Published
2021

27. GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses

Author

Kim, Sang Hoon, Kearns, Fiona L, Rosenfeld, Mia A, Casalino, Lorenzo, Papanikolas, Micah J, Simmerling, Carlos, Amaro, Rommie E, and Freeman, Ronit

Subjects
Vaccine Related, Emerging Infectious Diseases, Prevention, Biodefense, Infectious Diseases, Lung, Infection, Chemical Sciences
Abstract

Inspired by the role of cell-surface glycoproteins as coreceptors for pathogens, we report the development of GlycoGrip: a glycopolymer-based lateral flow assay for detecting SARS-CoV-2 and its variants. GlycoGrip utilizes glycopolymers for primary capture and antispike antibodies labeled with gold nanoparticles for signal-generating detection. A lock-step integration between experiment and computation has enabled efficient optimization of GlycoGrip test strips which can selectively, sensitively, and rapidly detect SARS-CoV-2 and its variants in biofluids. Employing the power of the glycocalyx in a diagnostic assay has distinct advantages over conventional immunoassays as glycopolymers can bind to antigens in a multivalent capacity and are highly adaptable for mutated strains. As new variants of SARS-CoV-2 are identified, GlycoGrip will serve as a highly reconfigurable biosensor for their detection. Additionally, via extensive ensemble-based docking simulations which incorporate protein and glycan motion, we have elucidated important clues as to how heparan sulfate and other glycocalyx components may bind the spike glycoprotein during SARS-CoV-2 host-cell infection. GlycoGrip is a promising and generalizable alternative to costly, labor-intensive RT-PCR, and we envision it will be broadly useful, including for rural or low-income populations that are historically undertested and under-reported in infection statistics.

Published
2022

28. Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells

Author

Kim, Sang Hoon, Song, Jae Ho, Kim, Min Ji, Song, Mun Gu, Ku, Angel A, Bandyopadhyay, Sourav, McCormick, Frank, and Kim, Sung Eun

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Pancreatic Cancer, Digestive Diseases, Cancer, Orphan Drug, Biotechnology, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, macropinocytosis, pancreatic cancer, Informer set library screening, cancer metabolism, nutrient scavenging, Analytical Chemistry, Clinical Sciences, Biochemistry and cell biology, Medical biochemistry and metabolomics, Analytical chemistry
Abstract

Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS signaling, such as pancreatic cancer. However, the absence of a clinically available inhibitor, as well as the gap of knowledge in macropinocytosis regulation, remain a hurdle for its use for cancer therapy. Here, we use the Informer set library to identify novel regulators of macropinocytosis-dependent growth in pancreatic cancer cells. Understanding how these regulators function will allow us to provide novel opportunities for therapeutic intervention.

Published
2022

30. Acoustic imaging by three-dimensional acoustic Luneburg meta-lens with lattice columns

Author

Kim, Jung-Woo, Lee, Seong-Jin, Jo, Jun-Yeong, Wang, Semyung, and Kim, Sang-Hoon

Subjects
Physics - Applied Physics
Abstract

A three-dimensional acoustic Luneburg meta-lens has the advantage of refracting sound waves for all incident angles and focusing higher sound pressure compared to a two-dimensional lens. The lens made of plastic with a diameter of 120 mm was designed with thousands of lattice column-shaped meta-atoms to maintain its three-dimensional shape. The lens's three-dimensional focusing performance and acoustic imaging were simulated and measured at the frequency range of 5 kHz ~ 20 kHz. The omnidirectional property was confirmed by rotating the lens to change the incident angle and measuring the sound pressure. The development of these spherical Luneburg meta-lenses is expected to improve the performance of devices that require acoustic focusing., Comment: 5 pages, 5 figures

Published
2020
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45. Sound Reception System by an Acoustic Luneburg Lens

Author

Kim, Sang-Hoon, Byeong-Won, Kyung-Min, and Lim, Gung Su

Subjects
Physics - Applied Physics
Abstract

Applying the directionality of a Luneburg lens, a sound reception system for ships is designed. A two-dimensional acoustic Luneburg lens which is made of 253 acrylic pipes of different radii which control the refractive index is used. It has a large disk shape; a diameter of 180 cm and a height of 20 cm. The 8 microphones were installed around the edges of the lens. The sound reception ability of the lens was tested on the sea using the horn of a university training ship as an emitter and the lens loaded on a small boat as a receiver. Both are moving at 20 ~ 40 km/h at a distance of between 300 ~ 700 m. The lens could focus to recognize the direction of the input sound in the frequency range between 300 ~ 900 Hz., Comment: 5 pages, 6 figures

Published
2019

47. Functions of Opsins in Drosophila Taste

Author

Leung, Nicole Y, Thakur, Dhananjay P, Gurav, Adishthi S, Kim, Sang Hoon, Di Pizio, Antonella, Niv, Masha Y, and Montell, Craig

Subjects
Biomedical and Clinical Sciences, Neurosciences, Eye Disease and Disorders of Vision, Animals, Drosophila Proteins, Drosophila melanogaster, Female, Male, Opsins, Random Allocation, Taste, Taste Perception, Drosophila, GPCR, TRP channel, chromophore, gustatory, labellum, opsin, phospholipase C, retinal, rhodopsin, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Psychology
Abstract

Rhodopsin is a light receptor comprised of an opsin protein and a light-sensitive retinal chromophore. Despite more than a century of scrutiny, there is no evidence that opsins function in chemosensation. Here, we demonstrate that three Drosophila opsins, Rh1, Rh4, and Rh7, are needed in gustatory receptor neurons to sense a plant-derived bitter compound, aristolochic acid (ARI). The gustatory requirements for these opsins are light-independent and do not require retinal. The opsins enabled flies to detect lower concentrations of aristolochic acid by initiating an amplification cascade that includes a G-protein, phospholipase Cβ, and the TRP channel, TRPA1. In contrast, responses to higher levels of the bitter compound were mediated through direct activation of TRPA1. Our study reveals roles for opsins in chemosensation and raise questions concerning the original roles for these classical G-protein-coupled receptors.

Published
2020

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