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663 results on '"Kim, S. R."'

1. Development of MMC-based lithium molybdate cryogenic calorimeters for AMoRE-II

Author

Agrawal, A., Alenkov, V. V., Aryal, P., Bae, H., Beyer, J., Bhandari, B., Boiko, R. S., Boonin, K., Buzanov, O., Byeon, C. R., Chanthima, N., Cheoun, M. K., Choe, J. S., Choi, S., Choudhury, S., Chung, J. S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavrilyuk, Y. M., Gezhaev, A. M., Gileva, O., Grigorieva, V. D., Gurentsov, V. I., Ha, C., Ha, D. H., Ha, E. J., Hwang, D. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, W. G., Kazalov, V. V., Kempf, S., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, H. J., Kim, H. L., Kim, H. S., Kim, M. B., Kim, S. C., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Kwon, D. H., Lee, C. H., Lee, D. Y., Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Makarov, E. P., Nyanda, P., Oh, Y., Olsen, S. L., Panasenko, S. I., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S., Ratkevich, S. S., Rooh, G., Sari, M. B., Seo, J., Seo, K. M., Sharma, B., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J., Sokur, N. V., Son, J. K., Song, J. W., Srisittipokakun, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yeon, H. J., Yoon, Y. S., and Yue, Q.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The AMoRE collaboration searches for neutrinoless double beta decay of $^{100}$Mo using molybdate scintillating crystals via low temperature thermal calorimetric detection. The early phases of the experiment, AMoRE-pilot and AMoRE-I, have demonstrated competitive discovery potential. Presently, the AMoRE-II experiment, featuring a large detector array with about 90 kg of $^{100}$Mo isotope, is under construction.This paper discusses the baseline design and characterization of the lithium molybdate cryogenic calorimeters to be used in the AMoRE-II detector modules. The results from prototype setups that incorporate new housing structures and two different crystal masses (316 g and 517 - 521 g), operated at 10 mK temperature, show energy resolutions (FWHM) of 7.55 - 8.82 keV at the 2.615 MeV $^{208}$Tl $\gamma$ line, and effective light detection of 0.79 - 0.96 keV/MeV. The simultaneous heat and light detection enables clear separation of alpha particles with a discrimination power of 12.37 - 19.50 at the energy region around $^6$Li(n, $\alpha$)$^3$H with Q-value = 4.785 MeV. Promising detector performances were demonstrated at temperatures as high as 30 mK, which relaxes the temperature constraints for operating the large AMoRE-II array.

Published
2024

2. Improved limit on neutrinoless double beta decay of \mohundred~from AMoRE-I

Author

Agrawal, A., Alenkov, V. V., Aryal, P., Beyer, J., Bhandari, B., Boiko, R. S., Boonin, K., Buzanov, O., Byeon, C. R., Chanthima, N., Cheoun, M. K., Choe, J. S., Choi, Seonho, Choudhury, S., Chung, J. S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavrilyuk, Y. M., Gezhaev, A. M., Gileva, O., Grigorieva, V. D., Gurentsov, V. I., Ha, C., Ha, D. H., Ha, E. J., Hwang, D. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, W. G., Kazalov, V. V., Kempf, S., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, Ho-Jong, Kim, H. J., Kim, H. L., Kim, H. S., Kim, M. B., Kim, S. C., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Kwon, D. H., Lee, C. H., Lee, DongYeup, Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Makarov, E. P., Nyanda, P., Oh, Y., Olsen, S. L., Panasenko, S. I., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S., Ratkevich, S. S., Rooh, G., Sari, M. B., Seo, J., Seo, K. M., Sharma, B., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J., Sokur, N. V., Son, J. K., Song, J. W., Srisittipokakun, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yeon, H. J., Yoon, Y. S., and Yue, Q.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

AMoRE searches for the signature of neutrinoless double beta decay of $^{100}$Mo with a 100 kg sample of enriched $^{100}$Mo. Scintillating molybdate crystals coupled with a metallic magnetic calorimeter operate at milli-Kelvin temperatures to measure the energy of electrons emitted in the decay. As a demonstration of the full-scale AMoRE, we conducted AMoRE-I, a pre-experiment with 18 molybdate crystals, at the Yangyang Underground Laboratory for over two years. The exposure was 8.02 kg$\cdot$year (or 3.89 kg$_{\mathrm{^{100}Mo}}\cdot$year) and the total background rate near the Q-value was 0.025 $\pm$ 0.002 counts/keV/kg/year. We observed no indication of $0\nu\beta\beta$ decay and report a new lower limit of the half-life of $^{100}$Mo $0\nu\beta\beta$ decay as $ T^{0\nu}_{1/2}>3.0\times10^{24}~\mathrm{years}$ at 90\% confidence level. The effective Majorana mass limit range is $m_{\beta\beta}<$(210--610) meV using nuclear matrix elements estimated in the framework of different models, including the recent shell model calculations., Comment: 7 pages, 4 figures

Published
2024

3. Projected background and sensitivity of AMoRE-II

Author

Agrawal, A., Alenkov, V. V., Aryal, P., Beyer, J., Bhandari, B., Boiko, R. S., Boonin, K., Buzanov, O., Byeon, C. R., Chanthima, N., Cheoun, M. K., Choe, J. S., Choi, Seonho, Choudhury, S., Chung, J. S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavrilyuk, Y. M., Gezhaev, A. M., Gileva, O., Grigorieva, V. D., Gurentsov, V. I., Ha, C., Ha, D. H., Ha, E. J., Hwnag, D. H., Jeona, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, W. G., Kazalov, V. V., Kempf, S., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, Ho-Jong, Kim, H. J., Kim, H. L., Kim, H. S., Kim, M. B., Kim, S. C., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kuzminov, V. Kornoukhov V. V., Kwon, D. H., Lee, C. H., Lee, DongYeup, Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Makarov, E. P., Nyanda, P., Oh, Y., Olsen, S. L., Panasenko, S. I., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S., Rooh, S. S. Ratkevich G., Sari, M. B., Seob, J., Seo, K. M., Sharma, B., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J., Sokur, N. V., Son, J. K., Song, J. W., Srisittipokakun, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yeon, H. J., Yoon, Y. S., and Yue, Q.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

AMoRE-II aims to search for neutrinoless double beta decay with an array of 423 Li$_2$$^{100}$MoO$_4$ crystals operating in the cryogenic system as the main phase of the Advanced Molybdenum-based Rare process Experiment (AMoRE). AMoRE has been planned to operate in three phases: AMoRE-pilot, AMoRE-I, and AMoRE-II. AMoRE-II is currently being installed at the Yemi Underground Laboratory, located approximately 1000 meters deep in Jeongseon, Korea. The goal of AMoRE-II is to reach up to $T^{0\nu\beta\beta}_{1/2}$ $\sim$ 6 $\times$ 10$^{26}$ years, corresponding to an effective Majorana mass of 15 - 29 meV, covering all the inverted mass hierarchy regions. To achieve this, the background level of the experimental configurations and possible background sources of gamma and beta events should be well understood. We have intensively performed Monte Carlo simulations using the GEANT4 toolkit in all the experimental configurations with potential sources. We report the estimated background level that meets the 10$^{-4}$counts/(keV$\cdot$kg$\cdot$yr) requirement for AMoRE-II in the region of interest (ROI) and show the projected half-life sensitivity based on the simulation study.

Published
2024

4. Background study of the AMoRE-pilot experiment

Author

Agrawal, A., Alenkov, V. V., Aryal, P., Beyer, J., Bhandari, B., Boiko, R. S., Boonin, K., Buzanov, O., Byeon, C. R., Chanthima, N., Cheoun, M. K., Choe, J. S., Choi, Seonho, Choudhury, S., Chung, J. S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavrilyuk, Yu. M., Gezhaev, A. M., Gileva, O., Grigorieva, V. D., Gurentsov, V. I., Ha, C., Ha, D. H., Ha, E. J., Hwang, D. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, W. G., Kazalov, V. V., Kempf, S., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, Ho-Jong, Kim, H. J., Kim, H. L., Kim, H. S., Kim, M. B., Kim, S. C., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Kwon, D. H., Lee, C. H., Lee, DongYeup, Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Makarov, E. P., Nyanda, P., Oh, Y., Olsen, S. L., Panasenko, S. I., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S., Ratkevich, S. S., Rooh, G., Sari, M. B., Seo, J., Seo, K. M., Sharma, B., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J., Sokur, N. V., Son, J. K., Song, J. W., Srisittipokakun, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yeon, H. J., Yoon, Y. S., and Yue, Q.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report a study on the background of the Advanced Molybdenum-Based Rare process Experiment (AMoRE), a search for neutrinoless double beta decay (\znbb) of $^{100}$Mo. The pilot stage of the experiment was conducted using $\sim$1.9 kg of \CAMOO~ crystals at the Yangyang Underground Laboratory, South Korea, from 2015 to 2018. We compared the measured $\beta/\gamma$ energy spectra in three experimental configurations with the results of Monte Carlo simulations and identified the background sources in each configuration. We replaced several detector components and enhanced the neutron shielding to lower the background level between configurations. A limit on the half-life of $0\nu\beta\beta$ decay of $^{100}$Mo was found at $T_{1/2}^{0\nu} \ge 3.0\times 10^{23}$ years at 90\% confidence level, based on the measured background and its modeling. Further reduction of the background rate in the AMoRE-I and AMoRE-II are discussed.

Published
2024

5. Status and performance of the AMoRE-I experiment on neutrinoless double beta decay

Author

Kim, H. B., Ha, D. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kang, C. S., Kang, W. G., Kim, H. S., Kim, S. C., Kim, S. G., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kwon, D. H., Lee, E. S., Lee, H. J., Lee, H. S., Lee, J. S., Lee, M. H., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Nyanda, P. B., Oh, Y. M., Sari, M. B., Seo, J. W., Seo, K. M., Seo, S. H., So, J. H., Woo, K. R., and Yoon, Y. S.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

AMoRE is an international project to search for the neutrinoless double beta decay of $^{100}$Mo using a detection technology consisting of magnetic microcalorimeters (MMCs) and molybdenum-based scintillating crystals. Data collection has begun for the current AMORE-I phase of the project, an upgrade from the previous pilot phase. AMoRE-I employs thirteen $^\mathrm{48depl.}$Ca$^{100}$MoO$_4$ crystals and five Li$_2$$^{100}$MoO$_4$ crystals for a total crystal mass of 6.2 kg. Each detector module contains a scintillating crystal with two MMC channels for heat and light detection. We report the present status of the experiment and the performance of the detector modules., Comment: 8 pages, 4 figures, published in Journal of Low Temperature Physics (2022)

Published
2022
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9. First Results from the AMoRE-Pilot neutrinoless double beta decay experiment

Author

Alenkov, V., Bae, H. W., Beyer, J., Boiko, R. S., Boonin, K., Buzanov, O., Chanthima, N., Cheoun, M. K., Chernyak, D. M., Choe, J. S., Choi, S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavriljuk, Yu. M., Gezhaev, A. M., Grigoryeva, V. D., Gurentsov, V. I., Gylova, O., Ha, C., Ha, D. H., Ha, E. J., Hahn, I. S., Jang, C. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, S. J., Kang, W. G., Kazalov, V. V., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, H. J., Kim, H. L., Kim, H. S., Kim, I., Kim, S. C., Kim, S. G., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Kwon, D. H., Lee, C., Lee, E. K., Lee, H. J., Lee, H. S., Lee, J. S., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, S. H., Leonard, D., Li, J., Li, Y., Limkitjaroenporn, P., Makarov, E. P., Oh, S. Y., Oh, Y. M., Olsen, S. L., Pabitra, A., Panasenko, S. I., Pandey, I., Park, C. W., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Poda, D. V., Polischuk, O. G., Prihtiadi, H., Ra, S. J., Ratkevich, S. S., Rooh, G., Sari, M. B., Seo, K. M., Shin, J. W., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J. H., Son, J. K., Srisittipokakun, N., Sujita, K., Tretyak, V. I., Wirawan, R., Woo, K. R., Yoon, Y. S., Yue, Q., and Zaman, S. U.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Advanced Molybdenum-based Rare process Experiment (AMoRE) aims to search for neutrinoless double beta decay (0$\nu\beta\beta$) of $^{100}$Mo with $\sim$100 kg of $^{100}$Mo-enriched molybdenum embedded in cryogenic detectors with a dual heat and light readout. At the current, pilot stage of the AMoRE project we employ six calcium molybdate crystals with a total mass of 1.9 kg, produced from $^{48}$Ca-depleted calcium and $^{100}$Mo-enriched molybdenum ($^{48\textrm{depl}}$Ca$^{100}$MoO$_4$). The simultaneous detection of heat(phonon) and scintillation (photon) signals is realized with high resolution metallic magnetic calorimeter sensors that operate at milli-Kelvin temperatures. This stage of the project is carried out in the Yangyang underground laboratory at a depth of 700 m. We report first results from the AMoRE-Pilot $0\nu\beta\beta$ search with a 111 kg$\cdot$d live exposure of $^{48\textrm{depl}}$Ca$^{100}$MoO$_4$ crystals. No evidence for $0\nu\beta\beta$ decay of $^{100}$Mo is found, and a upper limit is set for the half-life of 0$\nu\beta\beta$ of $^{100}$Mo of $T^{0\nu}_{1/2} > 9.5\times10^{22}$ y at 90% C.L.. This limit corresponds to an effective Majorana neutrino mass limit in the range $\langle m_{\beta\beta}\rangle\le(1.2-2.1)$ eV.

Published
2019
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10. Radioassay of the materials for AMoRE-II experiment

Author

Agrawal, A., primary, Alenkov, V. V., additional, Aryal, P., additional, Bae, H., additional, Beyer, J., additional, Bhandari, B., additional, Boiko, R. S., additional, Boonin, K., additional, Buzanov, O., additional, Byeon, C. R., additional, Chanthima, N., additional, Cheoun, M. K., additional, Choe, J. S., additional, Choi, S., additional, Choudhury, S., additional, Chung, J. S., additional, Danevich, F. A., additional, Djamal, M., additional, Drung, D., additional, Enss, C., additional, Fleischmann, A., additional, Gangapshev, A. M., additional, Gastaldo, L., additional, Gavrilyuk, Y. M., additional, Gezhaev, A. M., additional, Gileva, O., additional, Grigorieva, V. D., additional, Gurentsov, V. I., additional, Ha, C., additional, Ha, D. H., additional, Ha, E. J., additional, Hwang, D. H., additional, Jeon, E. J., additional, Jeon, J. A., additional, Jo, H. S., additional, Kaewkhao, J., additional, Kang, C. S., additional, Kang, W. G., additional, Kazalov, V. V., additional, Kempf, S., additional, Khan, A., additional, Khan, S., additional, Kim, D. Y., additional, Kim, G. W., additional, Kim, H. B., additional, Kim, H. J., additional, Kim, H. L., additional, Kim, H. S., additional, Kim, M. B., additional, Kim, S. C., additional, Kim, S. K., additional, Kim, S. R., additional, Kim, W. T., additional, Kim, Y. D., additional, Kim, Y. H., additional, Kirdsiri, K., additional, Ko, Y. J., additional, Kobychev, V. V., additional, Kornoukhov, V., additional, Kuzminov, V. V., additional, Kwon, D. H., additional, Lee, C. H., additional, Lee, D. Y., additional, Lee, E. K., additional, Lee, H. J., additional, Lee, H. S., additional, Lee, J., additional, Lee, J. Y., additional, Lee, K. B., additional, Lee, M. H., additional, Lee, M. K., additional, Lee, S. W., additional, Lee, Y. C., additional, Leonard, D. S., additional, Lim, H. S., additional, Mailyan, B., additional, Makarov, E. P., additional, Nyanda, P., additional, Oh, Y., additional, Olsen, S. L., additional, Panasenko, S. I., additional, Park, H. K., additional, Park, H. S., additional, Park, K. S., additional, Park, S. Y., additional, Polischuk, O. G., additional, Prihtiadi, H., additional, Ra, S., additional, Ratkevich, S. S., additional, Rooh, G., additional, Sari, M. B., additional, Seo, J., additional, Seo, K. M., additional, Sharma, B., additional, Shin, K. A., additional, Shlegel, V. N., additional, Siyeon, K., additional, So, J., additional, Sokur, N. V., additional, Son, J. K., additional, Song, J. W., additional, Srisittipokakun, N., additional, Tretyak, V. I., additional, Wirawan, R., additional, Woo, K. R., additional, Yeon, H. J., additional, Yoon, Y. S., additional, and Yue, Q., additional

Published
2024
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11. Alpha backgrounds in the AMoRE-Pilot experiment

Author

Alenkov, V., Bae, H. W., Beyer, J., Boiko, R. S., Boonin, K., Buzanov, O., Chanthima, N., Cheoun, M. K., Choi, S. H., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A., Gastaldo, L., Gavriljuk, Yu. M., Gezhaev, A., Grigoryeva, V. D., Gurentsov, V., Ha, D. H., Ha, C., Ha, E. J., Hahn, I., Jeon, E. J., Jeon, J., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, S. J., Kang, W. G., Karki, S., Kazalov, V., Khan, A., Khan, S., Kim, D.-Y., Kim, G. W., Kim, H. B., Kim, H. J., Kim, H. L., Kim, H. S., Kim, I., Kim, W. T., Kim, S. R., Kim, S. C., Kim, S. K., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuz’minov, V., Kwon, D. H., Lee, C., Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. S., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. H., Lee, S. W., Lee, S. W., Leonard, D. S., Li, J., Li, Y., Limkitjaroenporn, P., Mailyan, B., Makarov, E. P., Oh, S. Y., Oh, Y. M., Gileva, O., Olsen, S., Pabitra, A., Panasenko, S., Pandey, I., Park, C. W., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S. J., Ratkevich, S., Rooh, G., Sari, M. B., Seo, J., Seo, K. M., Shin, J. W., Shin, K. A., Shlegel, V. N., Siyeon, K., Sokur, N. V., Son, J.-K., Srisittipokakun, N., Toibaev, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yoon, Y. S., and Yue, Q.

Published
2022
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13. A CaMoO4 Crystal Low Temperature Detector for the AMoRE Neutrinoless Double Beta Decay Search

Author

Kim, G. B., Choi, S., Danevich, F. A., Fleischmann, A., Kang, C. S., Kim, H. J., Kim, S. R., Kim, Y. D., Kim, Y. H., Kornoukhov, V. A., Lee, H. J., Lee, J. H., Lee, M. K., Lee, S. J., So, J. H., and Yoon, W. S.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

We report the development of a CaMoO4 crystal low temperature detector for the AMoRE neutrinoless double beta decay (0{\nu}\b{eta}\b{eta}) search experiment. The prototype detector cell was composed of a 216 g CaMoO4 crystal and a metallic magnetic calorimeter. An over-ground measurement demonstrated FWHM resolution of 6-11 keV for full absorption gamma peaks. Pulse shape discrimination was clearly demonstrated in the phonon signals, and 7.6 {\sigma} of discrimination power was found for the {\alpha} and \b{eta}/{\gamma} separation. The phonon signals showed rise-times of about 1 ms. It is expected that the relatively fast rise-time will increase the rejection efficiency of two-neutrino double beta decay pile-up events which can be one of the major background sources in 0{\nu}\b{eta}\b{eta} searches., Comment: 6 pages, 8 figures, 1 table. Published in Advanced in High Energy Physics

Published
2016
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14. Technical Design Report for the AMoRE $0\nu\beta\beta$ Decay Search Experiment

Author

Alenkov, V., Aryal, P., Beyer, J., Boiko, R. S., Boonin, K., Buzanov, O., Chanthima, N., Chernyak, M. K. Cheoun D. M., Choi, J., Choi, S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavriljuk, Yu. M., Gezhaev, A. M., Gurentsov, V. I., Ha, D. H, Hahn, I. S., Jang, J. H., Jeon, E. J., Jo, H. S., Joo, H., Kaewkhao, J., Kang, C. S., Kang, S. J., Kang, W. G, Karki, S., Kazalov, V. V., Khanbekov, N., Kim, G. B., Kim, H. J., Kim, H. L., Kim, H. O., Kim, I., Kim, J. H., Kim, K., Kim, S. K., Kim, S. R., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Lee, H. J., Lee, H. S., Lee, J. H., Lee, J. M., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Leonard, D. S., Li, J., Li, Y. J., Limkitjaroenporn, P., Ma, K. J., Mineev, O. V., Mokina, V. M., Olsen, S. L., Panasenko, S. I., Pandey, I., Park, H. K., Park, H. S., Park, K. S., Poda, D. V., Polischuk, O. G., Polozov, P., Prihtiadi, H., Ra, S. J., Ratkevich, S. S., Rooh, G., Siyeon, K., Srisittipokakun, N., So, J. H., Son, J. K., Tekueva, J. A., Tretyak, V. I., Veresnikova, A. V., Wirawan, R., Yakimenko, S. P., Yershov, N. V., Yoon, W. S., Yoon, Y. S., and Yue, Q.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The AMoRE (Advanced Mo-based Rare process Experiment) project is a series of experiments that use advanced cryogenic techniques to search for the neutrinoless double-beta decay of \mohundred. The work is being carried out by an international collaboration of researchers from eight countries. These searches involve high precision measurements of radiation-induced temperature changes and scintillation light produced in ultra-pure \Mo[100]-enriched and \Ca[48]-depleted calcium molybdate ($\mathrm{^{48depl}Ca^{100}MoO_4}$) crystals that are located in a deep underground laboratory in Korea. The \mohundred nuclide was chosen for this \zeronubb decay search because of its high $Q$-value and favorable nuclear matrix element. Tests have demonstrated that \camo crystals produce the brightest scintillation light among all of the molybdate crystals, both at room and at cryogenic temperatures. $\mathrm{^{48depl}Ca^{100}MoO_4}$ crystals are being operated at milli-Kelvin temperatures and read out via specially developed metallic-magnetic-calorimeter (MMC) temperature sensors that have excellent energy resolution and relatively fast response times. The excellent energy resolution provides good discrimination of signal from backgrounds, and the fast response time is important for minimizing the irreducible background caused by random coincidence of two-neutrino double-beta decay events of \mohundred nuclei. Comparisons of the scintillating-light and phonon yields and pulse shape discrimination of the phonon signals will be used to provide redundant rejection of alpha-ray-induced backgrounds. An effective Majorana neutrino mass sensitivity that reaches the expected range of the inverted neutrino mass hierarchy, i.e., 20-50 meV, could be achieved with a 200~kg array of $\mathrm{^{48depl}Ca^{100}MoO_4}$ crystals operating for three years., Comment: 93 pages

Published
2015

18. Large Area Light Detectors With MMC Readouts

Author

Kim, M. B., primary, Chung, J. S., additional, Jeon, J. A., additional, Kang, C. S., additional, Kim, H. B., additional, Kim, H. L., additional, Kim, S. C., additional, Kim, S. G., additional, Kim, S. R., additional, Kim, W. T., additional, Kim, Y. H., additional, Kwon, D. H., additional, Lee, D. Y., additional, Lee, H. J., additional, Lee, M. K., additional, Lee, S. H., additional, Lee, Y. C., additional, Lim, H. S., additional, and Woo, K. R., additional

Published
2023
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24. Status and Performance of the AMoRE-I Experiment on Neutrinoless Double Beta Decay

Author

Kim, H. B., primary, Ha, D. H., additional, Jeon, E. J., additional, Jeon, J. A., additional, Jo, H. S., additional, Kang, C. S., additional, Kang, W. G., additional, Kim, H. S., additional, Kim, S. C., additional, Kim, S. G., additional, Kim, S. K., additional, Kim, S. R., additional, Kim, W. T., additional, Kim, Y. D., additional, Kim, Y. H., additional, Kwon, D. H., additional, Lee, E. S., additional, Lee, H. J., additional, Lee, H. S., additional, Lee, J. S., additional, Lee, M. H., additional, Lee, S. W., additional, Lee, Y. C., additional, Leonard, D. S., additional, Lim, H. S., additional, Mailyan, B., additional, Nyanda, P. B., additional, Oh, Y. M., additional, Sari, M. B., additional, Seo, J. W., additional, Seo, K. M., additional, Seo, S. H., additional, So, J. H., additional, Woo, K. R., additional, and Yoon, Y. S., additional

Published
2022
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31. Analysis of Pier Contact Accident in Busan New Port of South Korea by System-Theoretic Accident Model and Processes (STAMP).

Author

Kim, S. R., Wangui, W. J., Camliyurt, G., Kim, D. W., and Park, Y. S.

Subjects
*ACCIDENT investigation, *MARINE accidents, *PIERS, *BRIDGE foundations & piers, *PUNISHMENT
Abstract

Marine accidents are caused by complex and diverse causes. Therefore, it is necessary to analyse accidents from the perspective of the whole system rather than the existing analysis models that focus on cause-effect. The STAMP analysis is a constraint-based model that focuses on improper management or enforcement of safety-related constraints in system operation. Thus, as a case study of the application of the STAMP technique in marine accident analysis, the Milano Bridge pier contact accident that occurred on April 6, 2020 in Busan New Port of South Korea was analysed by the STAMP technique in this study. Through this study, it was proposed to break away from the domestic accident investigation, which focused only on the punishment of the ship operator, and to suggest improvements that enable organizations related to the marine accidents to take initiative to take efforts for safety. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Prototype Design of Mobile Emergency Telemedicine System

Author

Yoo, Sun K., Jung, S. M., Kim, B. S., Yun, H. Y., Kim, S. R., Kim, D. K., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Gervasi, Osvaldo, editor, Gavrilova, Marina L., editor, Kumar, Vipin, editor, Laganà, Antonio, editor, Lee, Heow Pueh, editor, Mun, Youngsong, editor, Taniar, David, editor, and Tan, Chih Jeng Kenneth, editor

Published
2005
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36. Development and evaluation of introgression lines with yield enhancing genes of the Indian mega-variety of rice, MTU1010.

Author

Punniakotti, E., Kousik, MBVN., Chaitra, K., Harika, G., Kumar, T. Dilip, Vivek, G., Balachandran, S. M., Rekha, G., Aleena, D., Anila, M., Hajira, S. K., Mastanbee, S. K., Ayyappadass, M., Sinha, Pragya, Kale, Ravindra, Swapnil, K., Prasanna, B. Laxmi, Senguttuvel, P., Fiyaz, Abdul, and Kim, S. R.

Subjects
RICE, CROP improvement, PLANT yields, GENES, GRAIN yields, GENETIC transformation
Abstract

MTU 1010 is an early maturing and high-yielding mega rice variety widely grown in an area of 3 Mha. It is characterised by limited grain number and panicle branching. To improve the grain number in MTU 1010, an IRRI breeding line, IR121055-2-10-5 was utilized as donor to transfer yield-enhancing genes Gn1a and OsSPL14 (associated with increased grain number and better panicle branching, respectively) into MTU1010 by Marker-Assisted Backcross Breeding (MABB). At each backcross generation, foreground selection was carried out with Gn1a and OsSPL14- specific molecular markers, whilst background selection was done with a set of SSR markers polymorphic between the IR121055-2-10-5 and MTU1010. With the use of a gene-specific marker, homozygous BC2F2 plants carrying the yield-enhancing gene were identified and advanced through pedigree-method of selection till BC2F6 and best performing ten lines were selected and evaluated in replicated station trials for yield contributing traits, where grain number and brancing per panicle exhibited high significant and positive correlation with single plant yield. Three promising lines namely RP6353-5-8-13-24, RP6353-26-13-39-5 and RP6353-32-12-8-16 with higher grain number and yield than MTU1010 were identified and nominated for evaluation in Initial Varietal Trial-Aerobic (IVT-Aerobic) of All India Crop Improvement Programme on Rice (AICRP), of which RP6353-26-13-39-5 (IET28674), was promoted for further testing. [ABSTRACT FROM AUTHOR]

Published
2023
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38. The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Author

El Bairi, K., Haynes, H. R., Blackley, E., Fineberg, S., Shear, J., Turner, S., de Freitas, J. R., Sur, D., Amendola, L. C., Gharib, M., Kallala, A., Arun, I., Azmoudeh-Ardalan, F., Fujimoto, L., Sua, L. F., Liu, S. -W., Lien, H. -C., Kirtani, P., Balancin, M., El Attar, H., Guleria, P., Yang, W., Shash, E., Chen, I. -C., Bautista, V., Do Prado Moura, J. F., Rapoport, B. L., Castaneda, C., Spengler, E., Acosta-Haab, G., Frahm, I., Sanchez, J., Castillo, M., Bouchmaa, N., Md Zin, R. R., Shui, R., Onyuma, T., Husain, Z., Willard-Gallo, K., Coosemans, A., Perez, E. A., Provenzano, E., Ericsson, P. G., Richardet, E., Mehrotra, R., Sarancone, S., Ehinger, A., Rimm, D. L., Bartlett, J. M. S., Viale, G., Denkert, C., Hida, A. I., Sotiriou, C., Loibl, S., Hewitt, S. M., Badve, S., Symmans, W. F., Kim, R. S., Pruneri, G., Goel, S., Francis, P. A., Inurrigarro, G., Yamaguchi, R., Garcia-Rivello, H., Horlings, H., Afqir, S., Salgado, R., Adams, S., Kok, M., Dieci, M. V., Michiels, S., Demaria, S., Loi, S., Schelfhout, V., Arbzadeh, E., Bondanar, A., Reyes, S. A. G., Ruz, J. R., Kang, J., Xiang, L., Zimovjanova, M., Togores, P., Ozturk, T., Patil, A., Corpa, M., Whitehouse, A., Tan, B., de Paula, A., Rossetti, C., Lang-Schwarz, C., Mahon, S., Giacometti, C., Linderholm, B., Deman, F., Montagna, G., Gong, G., Pavcovich, M., Chaer, Y., Cabrero, I. A., de Brito, M. L., Ilieva, N., Fulop, A., Souza, M., Bilancia, D., Idowu, M., Johri, R., Szpor, J., Bachani, L., Schmitt, F., Giannotti, M., Kurebayashi, Y., Ramirez, B. E. A., Salido, E., Bortesi, L., Bonetto, S., Elomina, K., Lopez, P., Sharma, V., Edirisinghe, A., Mathur, D., Sahay, A., Mouloud, M. A., Giang, C. H., Mukolwe, E., Kiruka, E., Samberg, N., Abe, N., Brown, M., Millar, E., X. B., Li, Yuan, Z., Pasupathy, A., Miele, R., Luff, R., e Porfirio, M. M. A., Ajemba, O., Soni, R., Orvieto, E., Dimaio, M., Thomas, J., Merard, R., Subramaniam, M. M., Apolinario, T., Preda, O., Preda, R., Makanga, A., Maior, M. S., Li, L., Saghatchian, M., Saurine, T., Janssen, E., Cochran, J., Vlada, N., Cappellesso, R., Elfer, K., Hollick, M., Desai, S., Oner, G., Schreurs, A., Liu, S., Perera, R., Mercurio, P., Garcia, F., Hosny, K., Matsumoto, H., van Deurzen, C., Bianchini, G., Coban, I., Jahangir, A., Rahman, A., Stover, D., Luz, P., Martel, A., Waumans, Y., Stenzinger, A., Cortes, J., Dimitrova, P., Nauwelaers, I., Velasco, M., Fan, F., Akturk, G., Firer, M., Roxanis, I., Schneck, M., Wen, H., Cockenpot, V., Konstantinov, A., Calatrava, A., Vidya, M. N., Choi, H. J., Jank, P., Ciinen, A. H., Sabanathan, D., Floris, G., Hoeflmayer, D., Hamada, T., Laudus, N., Grigoriadis, A., Porcellato, I., Acs, B., Miglietta, F., Parrodi, J., Clunie, D., Calhoun, B., F. -I., Lu, Lefevre, A., Tabbarah, S., Tran, W., Garcia-murillas, I., Jelinic, P., Boeckx, C., Souza, S., Cebollero, M. C., Felip, E., Rendon, J. L. S., El Gabry, E., Saltz, J., Bria, E., Garufi, G., Hartman, J., Sebastian, M., Olofsson, H., Kooreman, L., Cucherousset, J., Mathieu, M. -C., Ballesteros-Merino, C., Siziopikou, P., Fong, J., Klein, M., Qulis, I. R. I., Wesseling, J., Bellolio, E., Araya, J. C., Naber, S., Cheang, M., Castellano, I., Ales, A., Laenkholm, A. -V., Kulka, J., Quinn, C., Sapino, A., Amendoeira, I., Marchio, C., Braybrooke, J., Vincent-Salomon, A., Korski, K. P., Sofopoulos, M., Stovgaard, E. I. S., Bianchi, S., Bago-Horvath, Z., Yu, C., Regitnig, P., Hall, S., Kos, Z., Sant, S., Tille, J. -C., Gallas, B., Bethmann, D., Savas, P., Mendes, L., Soler, T., van Seijen, M., Gruosso, T., Quintana, A., Giltnane, J., Van den Eynden, G., Duregon, E., de Cabo, R., Recamo, P. C., Gaboury, L., Zimmerman, J., Pop, C. S., Wernicke, A., Williams, D., Gill, A., Solomon, B., Thapa, B., Farshid, G., Gilham, L., Christie, M., O'Toole, S., Hendry, S., Fox, S. B., Luen, S. J., Lakhani, S. R., Fuchs, T., John, T., Brcic, I., Hainfellner, J., Sigurd, L., Preusser, M., Poortmans, P., Decaluwe, A., Carey, C., Colpaert, C., Larsimont, D., Peeters, D., Broeckx, G., van de Vijver, K., Buisseret, L., Dirix, L., Hertoghs, M., Piccart, M., Ignatiadis, M., Van Bockstal, M., Sirtaine, N., Vermeulen, P., de Wind, R., Declercq, S., Gevaert, T., Haibe-Kans, B., Nelson, B. H., Watson, P. H., Leung, S., Nielsen, T., Shi, L., Balslev, E., Thagaard, J., Almangush, A., Makitie, A., Joensuu, H., Lundin, J., Drubay, D., Roblin, E., Andre, F., Penault-Llorca, F., Lemonnier, J., Adam, J., Lacroix-Triki, M., Ternes, N., Radosevic-Robin, N., Klaushen, F., Weber, K., Harbeck, N., Gluz, O., Wienert, S., Cserni, G., Vingiani, A., Criscitiello, C., Solinas, C., Curigliano, G., Konishi, E., Suzuki, E., Yoshikawa, K., Kawaguchi, K., Takada, M., Toi, M., Ishida, M., Shibata, N., Saji, S., Kogawa, T., Sakatani, T., Okamoto, T., Moriya, T., Kataoka, T., Shimoi, T., Sugie, T., Mukohara, T., Shu, Y., Kikawa, Y., Kozuka, Y., Sayed, S., Rahayu, R., Ramsaroop, R., Senkus-Konefka, E., Chmielik, E., Cardoso, F., Ribeiro, J., Chan, J., Dent, R., Martin, M., Hagen, C., Guerrero, A., Rojo, F., Comerma, L., Nuciforo, P., Serrano, V. V., Camaea, V. P., Steenbruggen, T., Ciompi, F., Nederlof, I., Jan, Hudecek, van der Laak, J., van den Berg, J., Voorwerk, L., van de Vijver, M., de Maaker, M., Linn, S., Mckenzie, H., Somaiah, N., Tutt, A., Swanton, C., Hiley, C., Moore, D. A., Hall, J. A., Le Quesne, J., Jabbar, K. A., al Bakir, M., Hills, R., Irshad, S., Yuan, Y., Li, Z., Liu, M., Klein, J., Fadare, O., Thompson, A., Lazar, A. J., Gown, A., Lo, A., Garrido Castro, A. C., Madabhushi, A., Moreira, A., Richardson, A., Beck, A. H., Bellizzi, A. M., Wolff, A., Harbhajanka, A., Sharma, A., Cimino-Mathews, A., Srinivasan, A., Singh, B., Chennubhotla, C. S., Chauhan, C., Dillon, D. A., Zardavas, D., Johnson, D. B., Thompson, A. E., Brogi, E., Reisenbichler, E., Huang, E., Hirsch, F. R., Mcarthur, H., Ziai, J., Brock, J., Kerner, J., Zha, J., Lennerz, J. K., Carter, J. M., Reis-Filho, J., Sparano, J., Balko, J. M., Pogue-Geile, K., Steele, K. E., Blenman, K. R. M., Allison, K. H., Pusztai, L., Cooper, L., Estrada, V. M., Flowers, M., Robson, M., Rebelatto, M. C., Hanna, M. G., Goetz, M. P., Khojasteh, M., Sanders, M. E., Regan, M. M., Misialek, M., Amgad, M., Tung, N., Singh, R., Huang, R., Pierce, R. H., Leon-Ferre, R., Swain, S., Ely, S., Kim, S. -R., Bedri, S., Paik, S., Schnitt, S., D'Alfons, T., Kurkure, U., Bossuyt, V., Tong, W., Wang, Y., Dos Anjos, C. H., Gaire, F., Van Diest, P. J., El Bairi, Khalid [0000-0002-8414-4145], de Freitas, Juliana Ribeiro [0000-0003-4978-7273], Sur, Daniel [0000-0002-0926-4614], Amendola, Luis Claudio [0000-0002-6404-450X], Azmoudeh-Ardalan, Farid [0000-0003-4701-0532], Kirtani, Pawan [0000-0002-2343-7016], Yang, Wenxian [0000-0002-5349-9680], Castillo, Miluska [0000-0002-0111-3176], Provenzano, Elena [0000-0003-3345-3965], Mehrotra, Ravi [0000-0001-9453-1408], Ehinger, Anna [0000-0001-9225-7396], Rimm, David L [0000-0001-5820-4397], Bartlett, John MS [0000-0002-0347-3888], Denkert, Carsten [0000-0002-2249-0982], Hida, Akira I [0000-0002-4486-8819], Sotiriou, Christos [0000-0002-5745-9977], Hewitt, Stephen M [0000-0001-8283-1788], Badve, Sunil [0000-0001-8861-9980], Symmans, William Fraser [0000-0002-1526-184X], Goel, Shom [0000-0001-8329-9084], Francis, Prudence A [0000-0002-7207-9286], Horlings, Hugo [0000-0003-4782-8828], Salgado, Roberto [0000-0002-1110-3801], Demaria, Sandra [0000-0003-4426-0499], Loi, Sherene [0000-0001-6137-9171], Apollo - University of Cambridge Repository, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), and UNICANCER

Subjects
Oncology, medicine.medical_treatment, [SDV]Life Sciences [q-bio], TRASTUZUMAB, Improved survival, MICROENVIRONMENT, Review Article, SUBTYPES, NEOADJUVANT CHEMOTHERAPY, 0302 clinical medicine, Breast cancer, Ecology,Evolution & Ethology, PROGNOSTIC-SIGNIFICANCE, Medicine and Health Sciences, Pharmacology (medical), TUMOR-INFILTRATING LYMPHOCYTES, Stage (cooking), RC254-282, Chemical Biology & High Throughput, 0303 health sciences, Human Biology & Physiology, Genome Integrity & Repair, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ASSOCIATION, 3. Good health, 030220 oncology & carcinogenesis, Biomarker (medicine), Life Sciences & Biomedicine, Genetics & Genomics, medicine.medical_specialty, chemical and pharmacologic phenomena, International Immuno-Oncology Biomarker Working Group, Predictive markers, 03 medical and health sciences, Signalling & Oncogenes, SDG 3 - Good Health and Well-being, Internal medicine, 692/53/2423, medicine, Radiology, Nuclear Medicine and imaging, In patient, 030304 developmental biology, Computational & Systems Biology, Science & Technology, IDENTIFICATION, business.industry, review-article, Cancer, 03.01. Általános orvostudomány, Immunotherapy, Tumour Biology, medicine.disease, PREDICTIVE-VALUE, 692/4028/67/1347, Programmed death 1, business, FREE SURVIVAL
Abstract

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC. ispartof: NPJ BREAST CANCER vol:7 issue:1 ispartof: location:United States status: published

Published
2021

46. Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Author

Hudecek, J., Voorwerk, L., van Seijen, M., Nederlof, I., de Maaker, M., van den Berg, J., van de Vijver, K. K., Sikorska, K., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Michiels, S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S. M., Denkert, C., Loibl, S., Loi, S., Bartlett, J. M. S., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kos, Z., Salgado, R., Kok, M., Horlings, H. M., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Lazar, A. J., Gown, A., Lo, A., Sapino, A., Madabhushi, A., Moreira, A., Richardson, A., Vingiani, A., Beck, A. H., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Ehinger, A., Garrido-Castro, A., Vincent-Salomon, A., Laenkholm, A. -V., Sharma, A., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Gallas, B. D., Castaneda, C., Ballesteros-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Swanton, C., Solinas, C., Hiley, C., Drubay, D., Bethmann, D., Moore, D. A., Larsimont, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Brogi, E., Perez, E., Elgabry, E. A., Stovgaard, E. S., Blackley, E. F., Roblin, E., Reisenbichler, E., Bellolio, E., Balslev, E., Chmielik, E., Gaire, F., Andre, F., F. -I., Lu, Azmoudeh-Ardalan, F., Rojo, F., Gruosso, T., Ciompi, F., Peale, F., Hirsch, F. R., Klauschen, F., Penault-Llorca, F., Acosta Haab, G., Farshid, G., van den Eynden, G., Curigliano, G., Floris, G., Broeckx, G., Gonzalez-Ericsson, Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Lien, H. -C., Chen, I. -C., Cree, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Wesseling, J., Giltnane, J., Kerner, J. K., Thagaard, J., Braybrooke, J. P., van der Laak, J. A. W. M., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Saltz, J., Hartman, J., Hainfellner, J., Quesne, J. L., Juco, J. W., Reis-Filho, J., Sanchez, J., Sparano, J., Cucherousset, J., Araya, J. C., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Willard-Gallo, K., Weber, K., Pogue-Geile, K. L., Steele, K. E., Emancipator, K., Abduljabbar, K., El Bairi, K., Blenman, K. R. M., Allison, K. H., Korski, K., Pusztai, L., Comerma, L., Buisseret, L., Cooper, L. A. D., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Lacroix-Triki, M., Al Bakir, M., Sebastian, M. M., van de Vijver, M., Balancin, M. L., Dieci, M. V., Mathieu, M. -C., Rebelatto, M. C., Piccart, M., Hanna, M. G., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., van Bockstal, M., Castillo, M., Amgad, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Gonzalez-Ericsson, P., Kirtani, P., Jelinic, P., Watson, P. H., Savas, P., Francis, P. A., Russell, P. A., Singh, R., Kim, R. S., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., De Clercq, S., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Kim, S. -R., Bedri, S., Irshad, S., Liu, S. -W., Goel, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Wienert, S., Fox, S. B., Luen, S. J., Naber, S., Schnitt, S. J., Sua, L. F., Lakhani, S. R., Fineberg, S., Soler, T., Gevaert, T., D'Alfonso, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camara, V. P., Tong, W., Chen, W., Yang, W., Tran, W. T., Wang, Y., Yuan, Y., Allory, Y., Husain, Z., Bago-Horvath, Z., Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Hudeček, Jan [0000-0003-1071-5686], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, William Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Loi, Sherene [0000-0001-6137-9171], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], Apollo - University of Cambridge Repository, van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, German Breast Group (GBG), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, MEDLINE, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review Article, lcsh:RC254-282, 631/67/1857, Tumour biomarkers, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Breast cancer, 692/53, Internal medicine, Medicine and Health Sciences, medicine, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, 692/4028/67/580, Stromal tumor, Biomarkers, Tumour immunology, business.industry, Risk management framework, review-article, Médecine pathologie humaine, 631/67/1347, Immunotherapy, Sciences bio-médicales et agricoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], 3. Good health, Review article, Clinical trial, Cancérologie, 030104 developmental biology, 030220 oncology & carcinogenesis, Biomarker (medicine), business
Abstract

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting., info:eu-repo/semantics/published

Published
2020

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