1. A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 1.5 Tesla field strength
- Author
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Shiroishi, Mark S, Weinert, Dane, Cen, Steven Y, Varghese, Bino, Dondlinger, Timothy, Prah, Melissa, Mendoza, Jesse, Nazemi, Sina, Ameli, Nima, Amini, Negin, Shohas, Salman, Chen, Shannon, Bigjahan, Bavrina, Zada, Gabriel, Chen, Thomas, Neman-Ebrahim, Josh, Chang, Eric L, Chow, Frances E, Fan, Zhaoyang, Yang, Wensha, Attenello, Frank J, Ye, Jason, Kim, Paul E, Patel, Vishal N, Lerner, Alexander, Acharya, Jay, Hu, Leland S, Quarles, C Chad, Boxerman, Jerrold L, Wu, Ona, and Schmainda, Kathleen M
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Neurosciences ,Biomedical Imaging ,Rare Diseases ,Brain Cancer ,Clinical Research ,Cancer ,Brain Disorders ,1.5 Tesla ,dynamic susceptibility contrast MRI ,flip angle ,glioma ,standardization ,Clinical sciences ,Oncology and carcinogenesis - Abstract
Introduction1.5 Tesla (1.5T) remain a significant field strength for brain imaging worldwide. Recent computer simulations and clinical studies at 3T MRI have suggested that dynamic susceptibility contrast (DSC) MRI using a 30° flip angle ("low-FA") with model-based leakage correction and no gadolinium-based contrast agent (GBCA) preload provides equivalent relative cerebral blood volume (rCBV) measurements to the reference-standard acquisition using a single-dose GBCA preload with a 60° flip angle ("intermediate-FA") and model-based leakage correction. However, it remains unclear whether this holds true at 1.5T. The purpose of this study was to test this at 1.5T in human high-grade glioma (HGG) patients.MethodsThis was a single-institution cross-sectional study of patients who had undergone 1.5T MRI for HGG. DSC-MRI consisted of gradient-echo echo-planar imaging (GRE-EPI) with a low-FA without preload (30°/P-); this then subsequently served as a preload for the standard intermediate-FA acquisition (60°/P+). Both normalized (nrCBV) and standardized relative cerebral blood volumes (srCBV) were calculated using model-based leakage correction (C+) with IBNeuro™ software. Whole-enhancing lesion mean and median nrCBV and srCBV from the low- and intermediate-FA methods were compared using the Pearson's, Spearman's and intraclass correlation coefficients (ICC).ResultsTwenty-three HGG patients composing a total of 31 scans were analyzed. The Pearson and Spearman correlations and ICCs between the 30°/P-/C+ and 60°/P+/C+ acquisitions demonstrated high correlations for both mean and median nrCBV and srCBV.ConclusionOur study provides preliminary evidence that for HGG patients at 1.5T MRI, a low FA, no preload DSC-MRI acquisition can be an appealing alternative to the reference standard higher FA acquisition that utilizes a preload.
- Published
- 2023