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3. EVpedia: a community web portal for extracellular vesicles research

Author

Kim, Dae-Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong-Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si-Hyun, Park, Kyong-Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, van Balkom, Bas WM, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E, Buée, Luc, Buzás, Edit I, Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S, Desiderio, Dominic M, Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M, Gardiner, Chris, Giebel, Bernd, Greening, David W, Gross, Julia Christina, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F, Hill, Michelle M, Nolte-'t Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V, Jayachandran, Muthuvel, Jee, Young-Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon-Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, van Leeuwen, Johannes, Lener, Thomas, Liu, Ming-Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, François, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N, Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I, Rodrigues, Marcio L, Roh, Tae-Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J, Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stępień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J, Wai, Sun Nyunt, Witwer, Kenneth, Yáñez-Mó, María, Youn, Hyewon, Zeidler, Reinhard, and Gho, Yong Song

Subjects
Biomedical Research, Computational Biology, Database Management Systems, Databases, Factual, Exosomes, Extracellular Space, Humans, Software, User-Computer Interface, Mathematical Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

MotivationExtracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging.ResultsWe present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.Availability and implementationThe web site was implemented in PHP, Java, MySQL and Apache, and is freely available at http://evpedia.info.

Published
2015

5. Extrapulmonary clinical manifestations of COVID-19: an umbrella review of meta-analysis

Author

Han, Young Joo, primary, Lee, Keum Hwa, additional, Lee, Jae-Young, additional, Kim, Oh Youn, additional, Moon, Seungeon, additional, Kim, Sunghyuk, additional, Ryu, Seokhyeon, additional, Lee, Dongsu, additional, Kim, Jae yun, additional, Kim, Taeyeon, additional, Lee, Song, additional, Bae, Seok-Joo, additional, Lee, Minho, additional, So, Jaewon, additional, and Shin, Jae Il, additional

Published
2022
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11. EVpedia: a community web portal for extracellular vesicles research

Author

Kim, Dae-Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong-Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si-Hyun, Park, Kyong-Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E, Buée, Luc, Buzás, Edit I, Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S, Desiderio, Dominic M, Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M, Gardiner, Chris, Giebel, Bernd, Greening, David W, Gross, Julia Christina, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F, Hill, Michelle M, Nolte-'t Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V, Jayachandran, Muthuvel, Jee, Young-Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon-Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, van Leeuwen, Johannes, Lener, Thomas, Liu, Ming-Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, François, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N, Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I, Rodrigues, Marcio L, Roh, Tae-Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J, Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stępień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J, Wai, Sun Nyunt, Witwer, Kenneth, Yáñez-Mó, María, Youn, Hyewon, Zeidler, Reinhard, Gho, Yong Song, Nolte - t Hoen, Esther, Biology of Reproductive Cells, Strategic Infection Biology, Sub General Pharmaceutics, LS Celbiologie-Algemeen, and B&C BRC-SIB

Abstract

MOTIVATION: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. RESULTS: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research. Availability and implementation: The web site was implemented in PHP, Java, MySQL and Apache, and is freely available at http://evpedia.info. CONTACT: ysgho@postech.ac.kr.

Published
2014

14. EVpedia : A community web portal for extracellular vesicles research

Author

Kim, Dae Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si Hyun, Park, Kyong Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, Van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E., Buée, Luc, Buzás, Edit I., Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S., Desiderio, Dominic M., Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M., Gardiner, Chris, Giebel, Bernd, Greening, David W., Christina Gross, Julia, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F., Hill, Michelle M., Nolte-'T Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V., Jayachandran, Muthuvel, Jee, Young Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, Van Leeuwen, Johannes, Lener, Thomas, Liu, Ming Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, Francois, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N., Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I., Rodrigues, Marcio L., Roh, Tae Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J., Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stepień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J., Wai, Sun Nyunt, Witwer, Kenneth, Yánez-Mó, Maria, Youn, Hyewon, Zeidler, Reinhard, Gho, Yong Song, Kim, Dae Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si Hyun, Park, Kyong Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, Van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E., Buée, Luc, Buzás, Edit I., Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S., Desiderio, Dominic M., Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M., Gardiner, Chris, Giebel, Bernd, Greening, David W., Christina Gross, Julia, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F., Hill, Michelle M., Nolte-'T Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V., Jayachandran, Muthuvel, Jee, Young Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, Van Leeuwen, Johannes, Lener, Thomas, Liu, Ming Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, Francois, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N., Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I., Rodrigues, Marcio L., Roh, Tae Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J., Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stepień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J., Wai, Sun Nyunt, Witwer, Kenneth, Yánez-Mó, Maria, Youn, Hyewon, Zeidler, Reinhard, and Gho, Yong Song

Published
2015

15. EVpedia: A community web portal for extracellular vesicles research

Author

MS Nefrologie, Circulatory Health, CDL Staf Research, Kim, Dae Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si Hyun, Park, Kyong Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, Van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E., Buée, Luc, Buzás, Edit I., Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S., Desiderio, Dominic M., Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M., Gardiner, Chris, Giebel, Bernd, Greening, David W., Christina Gross, Julia, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F., Hill, Michelle M., Nolte-'T Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V., Jayachandran, Muthuvel, Jee, Young Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, Van Leeuwen, Johannes, Lener, Thomas, Liu, Ming Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, Francois, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N., Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I., Rodrigues, Marcio L., Roh, Tae Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J., Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stepień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J., Wai, Sun Nyunt, Witwer, Kenneth, Yánez-Mó, Maria, Youn, Hyewon, Zeidler, Reinhard, Gho, Yong Song, MS Nefrologie, Circulatory Health, CDL Staf Research, Kim, Dae Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si Hyun, Park, Kyong Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, Van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E., Buée, Luc, Buzás, Edit I., Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S., Desiderio, Dominic M., Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M., Gardiner, Chris, Giebel, Bernd, Greening, David W., Christina Gross, Julia, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F., Hill, Michelle M., Nolte-'T Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V., Jayachandran, Muthuvel, Jee, Young Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, Van Leeuwen, Johannes, Lener, Thomas, Liu, Ming Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, Francois, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N., Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I., Rodrigues, Marcio L., Roh, Tae Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J., Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stepień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J., Wai, Sun Nyunt, Witwer, Kenneth, Yánez-Mó, Maria, Youn, Hyewon, Zeidler, Reinhard, and Gho, Yong Song

Published
2015

16. Sepsis-Like Systemic Inflammation Induced by Nano-Sized Extracellular Vesicles From Feces.

Author

Lee, Jaewook, Lee, Changjin, Park, Hyun Taek, Kim, Jung-Wook, Kim, Oh Youn, Kim, Sae Rom, Gho, Yong Song, Park, Kyong-Su, Rådinger, Madeleine, Lötvall, Jan, Jung, Hoe-Yune, and Park, Jaesung

Subjects
EXOSOMES, FECES, VESICLES (Cytology)
Abstract

Nano-sized extracellular vesicles (EVs), including exosomes, microvesicles, and other types of vesicles, are released by most mammalian cells and bacteria. We here ask whether feces contain EVs of mammalian and/or bacterial origin, and whether these EVs induce systemic inflammation. Fecal extracellular vesicles (fEVs) were isolated from mice and humans. The presence of EVs from Gram-negative and Gram-positive bacteria was detected by enzyme-linked immunosorbent assay using anti-lipid A and anti-lipoteichoic acid antibodies, whereas Western blot using anti-beta-actin antibody was employed to detect host-derived EVs in the fEVs. Further, fEVs were administered into mice by intraperitoneal injection, and inflammatory responses were investigated in the peritoneum, blood, and lungs. The role of TLR2 and TLR4 were studied using knockout mice. Significant quantities of EVs were present in feces from mice as well as humans, and derived from Gram-negative and Gram-positive bacteria, as well as the host. Bacteria-free fEVs introduced into the peritoneum induced local and systemic inflammation (including in the lungs), but fEVs from germ-free animals had weaker effects. This pronounced local and systemic inflammatory responses seemed to be induced by EVs from both Gram-negative and Gram-positive bacteria, and was attenuated in mice lacking TLR2 or TLR4. Our findings show that fEVs cause sepsis-like systemic inflammation, when introduced intraperitoneally, a process regulated by TLR2 and TLR4. [ABSTRACT FROM AUTHOR]

Published
2018
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17. Active Immunization with Extracellular Vesicles Derived from Staphylococcus aureus Effectively Protects against Staphylococcal Lung Infections, Mainly via Th1 Cell-Mediated Immunity

Author

Choi, Seng Jin, primary, Kim, Min-Hye, additional, Jeon, Jinseong, additional, Kim, Oh Youn, additional, Choi, Youngwoo, additional, Seo, Jihye, additional, Hong, Sung-Wook, additional, Lee, Won-Hee, additional, Jeon, Seong Gyu, additional, Gho, Yong Song, additional, Jee, Young-Koo, additional, and Kim, Yoon-Keun, additional

Published
2015
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18. Outer Membrane Vesicles: In vivo Kinetic Biodistribution of Nano-Sized Outer Membrane Vesicles Derived from Bacteria (Small 4/2015)

Author

Jang, Su Chul, primary, Kim, Sae Rom, additional, Yoon, Yae Jin, additional, Park, Kyong-Su, additional, Kim, Ji Hyun, additional, Lee, Jaewook, additional, Kim, Oh Youn, additional, Choi, Eun-Jeong, additional, Kim, Dae-Kyum, additional, Choi, Dong-Sic, additional, Kim, Yoon-Keun, additional, Park, Jaesung, additional, Di Vizio, Dolores, additional, and Gho, Yong Song, additional

Published
2015
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19. EVpedia: a community web portal for extracellular vesicles research

Author

Biology of Reproductive Cells, Strategic Infection Biology, Sub General Pharmaceutics, LS Celbiologie-Algemeen, B&C BRC-SIB, Kim, Dae-Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong-Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si-Hyun, Park, Kyong-Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E, Buée, Luc, Buzás, Edit I, Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S, Desiderio, Dominic M, Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M, Gardiner, Chris, Giebel, Bernd, Greening, David W, Gross, Julia Christina, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F, Hill, Michelle M, Nolte-'t Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V, Jayachandran, Muthuvel, Jee, Young-Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon-Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, van Leeuwen, Johannes, Lener, Thomas, Liu, Ming-Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, François, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N, Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I, Rodrigues, Marcio L, Roh, Tae-Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J, Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stępień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J, Wai, Sun Nyunt, Witwer, Kenneth, Yáñez-Mó, María, Youn, Hyewon, Zeidler, Reinhard, Gho, Yong Song, Nolte - t Hoen, Esther, Biology of Reproductive Cells, Strategic Infection Biology, Sub General Pharmaceutics, LS Celbiologie-Algemeen, B&C BRC-SIB, Kim, Dae-Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong-Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si-Hyun, Park, Kyong-Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, van Balkom, Bas W M, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E, Buée, Luc, Buzás, Edit I, Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S, Desiderio, Dominic M, Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M, Gardiner, Chris, Giebel, Bernd, Greening, David W, Gross, Julia Christina, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F, Hill, Michelle M, Nolte-'t Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V, Jayachandran, Muthuvel, Jee, Young-Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon-Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, van Leeuwen, Johannes, Lener, Thomas, Liu, Ming-Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, François, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N, Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I, Rodrigues, Marcio L, Roh, Tae-Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J, Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stępień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J, Wai, Sun Nyunt, Witwer, Kenneth, Yáñez-Mó, María, Youn, Hyewon, Zeidler, Reinhard, Gho, Yong Song, and Nolte - t Hoen, Esther

Published
2014

20. Bacterial Protoplast-Derived Nanovesicles as Vaccine Delivery System against Bacterial Infection

Author

Kim, Oh Youn, primary, Choi, Seng Jin, additional, Jang, Su Chul, additional, Park, Kyong-Su, additional, Kim, Sae Rom, additional, Choi, Jun Pyo, additional, Lim, Ji Hwan, additional, Lee, Seung-Woo, additional, Park, Jaesung, additional, Di Vizio, Dolores, additional, Lötvall, Jan, additional, Kim, Yoon-Keun, additional, and Gho, Yong Song, additional

Published
2014
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21. EVpedia: a community web portal for extracellular vesicles research

Author

Kim, Dae-Kyum, primary, Lee, Jaewook, additional, Kim, Sae Rom, additional, Choi, Dong-Sic, additional, Yoon, Yae Jin, additional, Kim, Ji Hyun, additional, Go, Gyeongyun, additional, Nhung, Dinh, additional, Hong, Kahye, additional, Jang, Su Chul, additional, Kim, Si-Hyun, additional, Park, Kyong-Su, additional, Kim, Oh Youn, additional, Park, Hyun Taek, additional, Seo, Ji Hye, additional, Aikawa, Elena, additional, Baj-Krzyworzeka, Monika, additional, van Balkom, Bas W. M., additional, Belting, Mattias, additional, Blanc, Lionel, additional, Bond, Vincent, additional, Bongiovanni, Antonella, additional, Borràs, Francesc E., additional, Buée, Luc, additional, Buzás, Edit I., additional, Cheng, Lesley, additional, Clayton, Aled, additional, Cocucci, Emanuele, additional, Dela Cruz, Charles S., additional, Desiderio, Dominic M., additional, Di Vizio, Dolores, additional, Ekström, Karin, additional, Falcon-Perez, Juan M., additional, Gardiner, Chris, additional, Giebel, Bernd, additional, Greening, David W., additional, Gross, Julia Christina, additional, Gupta, Dwijendra, additional, Hendrix, An, additional, Hill, Andrew F., additional, Hill, Michelle M., additional, Nolte-'t Hoen, Esther, additional, Hwang, Do Won, additional, Inal, Jameel, additional, Jagannadham, Medicharla V., additional, Jayachandran, Muthuvel, additional, Jee, Young-Koo, additional, Jørgensen, Malene, additional, Kim, Kwang Pyo, additional, Kim, Yoon-Keun, additional, Kislinger, Thomas, additional, Lässer, Cecilia, additional, Lee, Dong Soo, additional, Lee, Hakmo, additional, van Leeuwen, Johannes, additional, Lener, Thomas, additional, Liu, Ming-Lin, additional, Lötvall, Jan, additional, Marcilla, Antonio, additional, Mathivanan, Suresh, additional, Möller, Andreas, additional, Morhayim, Jess, additional, Mullier, François, additional, Nazarenko, Irina, additional, Nieuwland, Rienk, additional, Nunes, Diana N., additional, Pang, Ken, additional, Park, Jaesung, additional, Patel, Tushar, additional, Pocsfalvi, Gabriella, additional, del Portillo, Hernando, additional, Putz, Ulrich, additional, Ramirez, Marcel I., additional, Rodrigues, Marcio L., additional, Roh, Tae-Young, additional, Royo, Felix, additional, Sahoo, Susmita, additional, Schiffelers, Raymond, additional, Sharma, Shivani, additional, Siljander, Pia, additional, Simpson, Richard J., additional, Soekmadji, Carolina, additional, Stahl, Philip, additional, Stensballe, Allan, additional, Stępień, Ewa, additional, Tahara, Hidetoshi, additional, Trummer, Arne, additional, Valadi, Hadi, additional, Vella, Laura J., additional, Wai, Sun Nyunt, additional, Witwer, Kenneth, additional, Yáñez-Mó, María, additional, Youn, Hyewon, additional, Zeidler, Reinhard, additional, and Gho, Yong Song, additional

Published
2014
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23. In vivo Kinetic Biodistribution of Nano-Sized Outer Membrane Vesicles Derived from Bacteria

Author

Jang, Su Chul, primary, Kim, Sae Rom, additional, Yoon, Yae Jin, additional, Park, Kyong-Su, additional, Kim, Ji Hyun, additional, Lee, Jaewook, additional, Kim, Oh Youn, additional, Choi, Eun-Jeong, additional, Kim, Dae-Kyum, additional, Choi, Dong-Sic, additional, Kim, Yoon-Keun, additional, Park, Jaesung, additional, Di Vizio, Dolores, additional, and Gho, Yong Song, additional

Published
2014
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28. EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles

Author

Kim, Dae-Kyum, primary, Kang, Byeongsoo, additional, Kim, Oh Youn, additional, Choi, Dong-sic, additional, Lee, Jaewook, additional, Kim, Sae Rom, additional, Go, Gyeongyun, additional, Yoon, Yae Jin, additional, Kim, Ji Hyun, additional, Jang, Su Chul, additional, Park, Kyong-Su, additional, Choi, Eun-Jeong, additional, Kim, Kwang Pyo, additional, Desiderio, Dominic M., additional, Kim, Yoon-Keun, additional, Lötvall, Jan, additional, Hwang, Daehee, additional, and Gho, Yong Song, additional

Published
2013
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33. Bacterial Protoplast-DerivedNanovesicles as VaccineDelivery System against Bacterial Infection.

Author

Kim, Oh Youn, Choi, Seng Jin, Jang, Su Chul, Park, Kyong-Su, Kim, Sae Rom, Choi, Jun Pyo, Lim, Ji Hwan, Lee, Seung-Woo, Park, Jaesung, Di Vizio, Dolores, Lötvall, Jan, Kim, Yoon-Keun, and Gho, Yong Song

Subjects
*BACTERIAL protoplasts, *BACTERIAL diseases, *DRUG delivery systems, *IMMUNIZATION, *PREVENTION of communicable diseases
Abstract

The notion that widespread infectiousdiseases could be best managedby developing potent, adjuvant-free vaccines has resulted in the useof various biological immune-stimulating components as new vaccinecandidates. Recently, extracellular vesicles, also known as exosomesand microvesicles in mammalian cells and outer membrane vesicles inGram-negative bacteria, have gained attention for the next generationvaccine. However, the more invasive and effective the vaccine is indelivery, the more risk it holds for severe immune toxicity. Here,in optimizing the current vaccine delivery system, we designed bacterialprotoplast-derived nanovesicles (PDNVs), depleted of toxic outer membranecomponents to generate a universal adjuvant-free vaccine deliverysystem. These PDNVs exhibited significantly higher productivity andsafety than the currently used vaccine delivery vehicles and inducedstrong antigen-specific humoral and cellular immune responses. Moreover,immunization with PDNVs loaded with bacterial antigens conferred effectiveprotection against bacterial sepsis in mice. These nonliving nanovesiclesderived from bacterial protoplast open up a new avenue for the creationof next generation, adjuvant-free, less toxic vaccines to be usedto prevent infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2015
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35. Proteomic profiling of Gram-negative bacterial outer membrane vesicles: Current perspectives.

Author

Lee J, Kim OY, and Gho YS

Subjects
Bacterial Proteins metabolism, Gram-Negative Bacteria cytology, Cell Membrane metabolism, Gram-Negative Bacteria metabolism, Proteomics methods
Abstract

Outer membrane vesicles (OMVs) are extracellular vesicles derived from Gram-negative bacteria. Recent progress in the studies of Gram-negative bacterial extracellular vesicles implies that OMVs may function as intercellular communicasomes in bacteria-bacteria and bacteria-host interactions. Current MS-based high-throughput proteomic analyses of Gram-negative bacterial OMVs have identified thousands of vesicular proteins and provided clues to reveal the biogenesis and pathophysiological functions of Gram-negative bacterial OMVs. The future directions of proteomics of Gram-negative bacterial OMVs may include the isolation strategy of Gram-negative bacterial OMVs to thoroughly exclude nonvesicular contaminants and proteomics of Gram-negative bacterial OMVs derived from diverse conditions as well as body fluids of bacterium-infected hosts. We hope this review will shed light on future research in this emerging field of proteomics of extracellular vesicles derived from Gram-negative bacteria and contribute to the development of OMV-based diagnostic tools and effective vaccines., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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