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1,388 results on '"Kim, Myeong-Jin"'

12. Pitfalls and problems to be solved in the diagnostic CT/MRI Liver Imaging Reporting and Data System (LI-RADS)

Author

Kim, Yeun-Yoon, Choi, Jin-Young, Sirlin, Claude B, An, Chansik, and Kim, Myeong-Jin

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Liver Disease, Biomedical Imaging, Digestive Diseases, Liver Cancer, Rare Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Algorithms, Carcinoma, Hepatocellular, Data Systems, Humans, Liver Neoplasms, Magnetic Resonance Imaging, Research Design, Tomography, X-Ray Computed, Diagnosis, Liver cancer, Tomography, Magnetic resonance imaging, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

The 2017 Core of the computed tomography (CT)/magnetic resonance imaging (MRI) Liver Imaging Reporting and Data System (LI-RADS) provides clear definitions and concise explanations of the CT/MRI diagnostic algorithm. Nevertheless, there remain some practical and controversial issues that radiologists should be aware of when using the system. This article discusses pitfalls and problems which may be encountered when the version 2017 diagnostic algorithm is used for CT and MRI. The pitfalls include challenges in applying major features and assigning the LR-M category, as well as categorisation discrepancy between CT and MRI. The problems include imprecision of category codes, application of ancillary features, and regional practice variations in hepatocellular carcinoma (HCC) diagnosis. Potential solutions are presented along with these pitfalls and problems. KEY POINTS: • Although the diagnostic algorithm provides clear and detailed explanations, major feature evaluation can be subject to pitfalls and differentiation of HCC and non-HCC malignancy remains challenging. • Ancillary features are optional and equally weighted. However, features such as hepatobiliary phase hypointensity and restricted diffusion have greater impact on HCC diagnosis than other ancillary features and may merit greater emphasis or weighting. • LI-RADS was initially developed from a Western paradigm, which may limit its applicability in the East due to regional practice variations. In Eastern Asia, high sensitivity is prioritised over near-perfect specificity for HCC diagnosis in order to detect tumours at early stages.

Published
2019

15. Intraindividual comparison of prognostic imaging features of HCCs between MRIs with extracellular and hepatobiliary contrast agents.

Author

Yoon, Ja Kyung, Han, Dai Hoon, Lee, Sunyoung, Choi, Jin‐Young, Choi, Gi Hong, Kim, Do Young, and Kim, Myeong‐Jin

Subjects
LOGISTIC regression analysis, MAGNETIC resonance imaging, CONTRAST media, PROGNOSIS, HEPATOCELLULAR carcinoma
Abstract

Background & Aims: Accumulating evidence suggests that certain imaging features of hepatocellular carcinoma (HCC) may have prognostic implications. This study aimed to intraindividually compare MRIs with extracellular contrast agent (ECA‐MRI) and hepatobiliary agent (HBA‐MRI) for prognostic imaging features of HCC and to compare the prediction of microvascular invasion (MVI) and early recurrence between the two MRIs. Methods: The present study included 102 prospectively enrolled at‐risk patients (median age, 61.0 years; 83 men) with surgically resected single HCC with both preoperative ECA‐MRI and HBA‐MRI between July 2019 and June 2023. The McNemar test was used to compare each prognostic imaging feature between the two MRIs. Significant imaging features associated with MVI were identified by multivariable logistic regression analysis, and early recurrence rates (<2 years) were compared between the two MRIs. Results: The frequencies of prognostic imaging features were not significantly different between the two MRIs (p =.07 to >.99). Non‐smooth tumour margin (ECA‐MRI, odds ratio [OR] = 5.30; HBA‐MRI, OR = 7.07) and peritumoral arterial phase hyperenhancement (ECA‐MRI, OR = 4.26; HBA‐MRI, OR = 4.43) were independent factors significantly associated with MVI on both MRIs. Two‐trait predictor of venous invasion (presence of internal arteries and absence of hypoattenuating halo) on ECA‐MRI (OR = 11.24) and peritumoral HBP hypointensity on HBA‐MRI (OR = 20.42) were other predictors of MVI. Early recurrence rates of any two or more significant imaging features (49.8% on ECA‐MRI vs 51.3% on HBA‐MRI, p =.75) were not significantly different between the two MRIs. Conclusion: Prognostic imaging features of HCC may be comparable between ECA‐MRI and HBA‐MRI. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer

Author

Kang, Hyeon Woong, primary, Kim, Ju Hyun, additional, Lee, Da Eun, additional, Lee, Yun Sun, additional, Kim, Myeong Jin, additional, Kim, Hyung Sun, additional, Fang, SungSoon, additional, Lee, Bo Eun, additional, Lee, Kyung Jin, additional, Yoo, Jongman, additional, Kim, Hyo Jung, additional, and Park, Joon Seong, additional

Published
2023
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40. Sargachromenol Attenuates Inflammatory Responses by Regulating NF-κB and Nrf2 Pathways in RAW 264.7 Cells and LPS-treated Mice

Author

Joung, Eun-Ji, primary, Lee, Min-Kyeong, primary, Lee, Minsup, additional, Gwon, Misung, additional, Shin, Taisun, additional, Ryu, Heeyeon, additional, Jeong, Hyeon Hak, additional, Kim, Myeong-Jin, additional, Van, Ji Yun, additional, Kim, Jae-Il, additional, Choi, Jinkyung, additional, Jung, Won-Kyo, additional, Kim, Hyeung-Rak, additional, and Lee, Bonggi, additional

Published
2023
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