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2,512 results on '"Kim, Min-Ju"'

30. Low- or standard-dose edoxaban versus antiplatelet therapy for leaflet thrombus and cerebral thromboembolism after TAVR: A prespecified analysis of randomized ADAPT-TAVR trial

Author

Kim, Mijin, Ahn, Jung-Min, Kang, Do-Yoon, Kim, Min-Ju, Kim, Kyung Won, Koo, Hyun Jung, Yang, Dong Hyun, Jung, Seung Chai, Kim, Byungjun, Wong, Yiu Tung Anthony, Lam, Cheung Chi Simon, Yin, Wei‐Hsian, Wei, Jeng, Lee, Yung-Tsai, Kao, Hsien-Li, Lin, Mao-Shin, Yu Ko, Tsung, Kim, Won-Jang, Kang, Se Hun, Lee, Seung-Ah, Ko, Euihong, Kim, Dae-Hee, Kang, Joon-Won, Lee, Jae-Hong, Lee, Jinho, Park, Jinsun, Kim, Hoyun, Choi, Yeonwoo, Park, Seung-Jung, and Park, Duk-Woo

Published
2024
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31. Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617

Author

Lee, Se-eun, Kim, Min-ju, Hillman, Prima F, Oh, Dong-Chan, Fenical, William, Nam, Sang-Jip, and Lim, Kyung-Min

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Physical Chemistry, Animals, Cell Line, Tumor, Down-Regulation, Humans, Melanins, Melanocytes, Melanoma, Melanoma, Experimental, Mice, Quinazolines, Skin, Streptomyces, Streptomyces sp, deoxyvasicinone, marine natural products, anti-melanogenic effect, Streptomyces sp., Physical Chemistry (incl. Structural), Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Physical chemistry
Abstract

The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marine-derived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by α-melanocyte-stimulating hormone (α-MSH). In addition, microscopic images of the cells showed that deoxyvasicinone attenuated melanocyte activation. Although, deoxyvasicinone did not directly inhibit tyrosinase (TYR) enzymatic activity, real-time PCR showed that it inhibited the mRNA expression of TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). In the artificial 3D pigmented skin model MelanodermTM, deoxyvasicinone brightened the skin significantly, as confirmed by histological examination. In conclusion, this study demonstrated that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect through downregulation of melanogenic enzymes.

Published
2022

45. Reducing the Model Variance of a Rectal Cancer Segmentation Network

Author

Lee, Joohyung, Oh, Ji Eun, Kim, Min Ju, Hur, Bo Yun, and Sohn, Dae Kyung

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

In preoperative imaging, the demarcation of rectal cancer with magnetic resonance images provides an important basis for cancer staging and treatment planning. Recently, deep learning has greatly improved the state-of-the-art method in automatic segmentation. However, limitations in data availability in the medical field can cause large variance and consequent overfitting to medical image segmentation networks. In this study, we propose methods to reduce the model variance of a rectal cancer segmentation network by adding a rectum segmentation task and performing data augmentation; the geometric correlation between the rectum and rectal cancer motivated the former approach. Moreover, we propose a method to perform a bias-variance analysis within an arbitrary region-of-interest (ROI) of a segmentation network, which we applied to assess the efficacy of our approaches in reducing model variance. As a result, adding a rectum segmentation task reduced the model variance of the rectal cancer segmentation network within tumor regions by a factor of 0.90; data augmentation further reduced the variance by a factor of 0.89. These approaches also reduced the training duration by a factor of 0.96 and a further factor of 0.78, respectively. Our approaches will improve the quality of rectal cancer staging by increasing the accuracy of its automatic demarcation and by providing rectum boundary information since rectal cancer staging requires the demarcation of both rectum and rectal cancer. Besides such clinical benefits, our method also enables segmentation networks to be assessed with bias-variance analysis within an arbitrary ROI, such as a cancerous region., Comment: published at IEEE ACCESS

Published
2019
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