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38. Analysis of Response and Progression Patterns of Tyrosine Kinase Inhibitors in Recurrent or Metastatic Adenoid Cystic Carcinoma: A Post Hoc Analysis of Two KCSG Phase II Trials.

Author

Kim, Youjin, Keam, Bhumsuk, Kang, Eun Joo, Kim, Jin-Soo, Kim, Hye Ryun, Lee, Keun-Wook, Kwon, Jung Hye, Lee, Kyoung Eun, Yang, Yaewon, Choi, Yoon Hee, Kim, Min Kyoung, Ji, Jun Ho, Yun, Tak, Choi, Moon Young, Lee, Ki Hyeong, Kim, Sung-Bae, and Ahn, Myung-Ju

Subjects
VASCULAR endothelial growth factor receptors, VASCULAR endothelial growth factor antagonists, PROTEIN-tyrosine kinase inhibitors, BONE metastasis, OVERALL survival, ADENOID cystic carcinoma
Abstract

Purpose: In this study, we evaluated 66 patients diagnosed with adenoid cystic carcinoma (ACC) enrolled in two Korean Cancer Study Group trials to investigate the response and progression patterns in recurrent and/or metastatic ACC treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs). Materials and Methods: We evaluated 66 patients diagnosed with ACC who were enrolled in the Korean Cancer Study Group trials. The tumor measurements, clinical data, treatment outcomes, and progression patterns of therapy were analyzed. Results: In the 66 patients (53 receiving axitinib and 13 receiving nintedanib), the disease control rate was 61%, and three patients achieved partial response. The median follow-up, median progression-free survival (PFS), overall survival, and 6-month PFS rate were 27.6%, 12.4%, and 18.1% months and 62.1%, respectively. Among 42 patients who experienced progression, 27 (64.3%) showed target lesion progression. Bone metastasis was an independent poor prognostic factor. Conclusion: Overall, most patients demonstrated stable disease with prolonged PFS; however, prominent target lesion progression occurred in some patients. Thus, PFS may capture VEGFR-TKI efficacy better than the objective response rate. [ABSTRACT FROM AUTHOR]

Published
2024
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44. A phase II study of ibrutinib in combination with rituximab-cyclophosphamide-doxorubicin hydrochloride-vincristine sulfate-prednisone therapy in Epstein-Barr virus-positive, diffuse large B cell lymphoma (54179060LYM2003: IVORY study): results of the final analysis

Author

Yoon, Sang Eun, Kim, Seok Jin, Yoon, Dok Hyun, Koh, Youngil, Mun, Yeung-Chul, Do, Young Rok, Choi, Yoon Seok, Yang, Deok Hwan, Kim, Min Kyoung, Lee, Gyeong-Won, Suh, Cheolwon, Ko, Young Hyeh, and Kim, Won Seog

Published
2020
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45. Sentiment Analysis of Korean Teenagers’ Language Based on Sentiment Dictionary Construction

Author

Kim, Jason, Kim, Min Kyoung, Park, Yeoeun, Kim, Eomji, Lee, Junhee, Kim, Dongho, Kim, Seonho, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Hung, Jason C., editor, Yen, Neil Y., editor, and Hui, Lin, editor

Published
2019
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