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579 results on '"Kim, June Myung"'

1. Short Communication: HIV-1 Transmission Networks Across South Korea

Author

Ahn, Mi Young, Wertheim, Joel O, Kim, Woo Joo, Kim, Shin-Woo, Lee, Jin Soo, Ann, Hea Won, Jeon, Yongduk, Ahn, Jin Young, Song, Je Eun, Oh, Dong Hyun, Kim, Yong Chan, Kim, Eun Jin, Jung, In Young, Kim, Moo Hyun, Jeong, Wooyoung, Jeong, Su Jin, Ku, Nam Su, Kim, June Myung, Smith, Davey M, and Choi, Jun Yong

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Prevention, HIV/AIDS, Health Disparities, Sexually Transmitted Infections, Infectious Diseases, Minority Health, 2.5 Research design and methodologies (aetiology), 2.2 Factors relating to the physical environment, Infection, Adult, Aged, Cities, Cluster Analysis, Disease Transmission, Infectious, Female, Genotyping Techniques, HIV Infections, HIV-1, Humans, Male, Middle Aged, Molecular Epidemiology, Prospective Studies, Republic of Korea, Risk Factors, Young Adult, HIV transmission network, HIV-1 env V3 sequence, South Korea, Virology, Clinical sciences
Abstract

Molecular epidemiology can help clarify the properties and dynamics of HIV-1 transmission networks in both global and regional scales. We studied 143 HIV-1-infected individuals recruited from four medical centers of three cities in South Korea between April 2013 and May 2014. HIV-1 env V3 sequence data were generated (337-793 bp) and analyzed using a pairwise distance-based clustering approach to infer putative transmission networks. Participants whose viruses were ≤2.0% divergent according to Tamura-Nei 93 genetic distance were defined as clustering. We collected demographic, risk, and clinical data and analyzed these data in relation to clustering. Among 143 participants, we identified nine putative transmission clusters of different sizes (range 2-4 participants). The reported risk factor of participants were concordant in only one network involving two participants, that is, both individuals reported homosexual sex as their risk factor. The participants in the other eight networks did not report concordant risk factors, although they were phylogenetically linked. About half of the participants refused to report their risk factor. Overall, molecular epidemiology provides more information to understand local transmission networks and the risks associated with these networks.

Published
2017

3. HIV migration between blood plasma and cellular subsets before and after HIV therapy

Author

Choi, Jun Yong, Chaillon, Antoine, Oh, Jin Ok, Ahn, Jin Young, Ann, Hae Won, Jung, In Young, Ahn, Mi-Young, Jeon, Yong Duk, Ku, Nam Su, Smith, Davey M, and Kim, June Myung

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Clinical Research, HIV/AIDS, Health Disparities, Sexually Transmitted Infections, Infectious Diseases, Genetics, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Adult, Anti-Retroviral Agents, DNA, Viral, HIV Infections, HIV-1, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Plasma, RNA, Viral, Sequence Analysis, DNA, env Gene Products, Human Immunodeficiency Virus, HIV, compartmentalization, reservoir, viremia, antiretroviral therapy, cladistics analysis, Microbiology, Virology, Clinical sciences, Medical microbiology
Abstract

The cellular source of HIV RNA circulating in blood plasma remains unclear. Here, we investigated whether sequence analysis of HIV RNA populations circulating before combination antiretroviral therapy (cART) and HIV DNA populations in cellular subsets (CS) after cART could identify the cellular sources of circulating HIV RNA. Blood was collected from five subjects at cART initiation and again 6 months later. Naïve CD4+ T cells, resting central memory and effector memory CD4+ T cells, activated CD4+ T cells, monocytes, and natural killer cells were sorted using a fluorescence-activated cell sorter. HIV-1 env C2V3 sequences from HIV RNA in blood plasma and HIV DNA in CSs were generated using single genome sequencing. Sequences were evaluated for viral compartmentalization (Fst test) and migration events (MEs; Slatkin Maddison and cladistic measures) between blood plasma and each CS. Viral compartmentalization was observed in 88% of all cellular subset comparisons (range: 77-100% for each subject). Most observed MEs were directed from blood plasma to CSs (52 MEs, 85.2%). In particular, there was only viral movement from plasma to NK cells (15 MEs), monocytes (seven MEs), and naïve cells (five ME). We observed a total of nine MEs from activated CD4 cells (2/9 MEs), central memory T cells (3/9 MEs), and effector memory T cells (4/9 MEs) to blood plasma. Our results revealed that the HIV RNA population in blood plasma plays an important role in seeding various cellular reservoirs and that the cellular source of the HIV RNA population is activated central memory and effector memory T cells.

Published
2016

7. Short Communication: Prospective Comparison of Qualitative Versus Quantitative Polymerase Chain Reaction for Monitoring Virologic Treatment Failure in HIV-Infected Patients

Author

Jeong, Su Jin, Kim, Min Hyung, Song, Je Eun, Ahn, Jin Young, Kim, Sun Bean, Ann, Hea Won, Kim, Jae Kyung, Choi, Heun, Ku, Nam Su, Han, Sang Hoon, Kim, June Myung, Smith, Davey M, Kim, Hyon-Suk, and Choi, Jun Yong

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Sexually Transmitted Infections, Infectious Diseases, Infection, Adult, Aged, Aged, 80 and over, Anti-HIV Agents, Drug Monitoring, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, Polymerase Chain Reaction, Prospective Studies, Republic of Korea, Sensitivity and Specificity, Treatment Failure, Viral Load, Young Adult, Clinical Sciences, Virology, Clinical sciences
Abstract

Less costly but still accurate methods for monitoring HIV treatment response are needed. We prospectively evaluated if a qualitative polymerase chain reaction (PCR) amplification assay for virologic monitoring could maintain accuracy while reducing costs in Seoul, South Korea. We conducted the first prospective study comparing a qualitative PCR amplification of HIV-1 reverse transcriptase (RT) versus a commercial real time PCR assay (i.e., viral load) for virologic monitoring of 150 patients receiving antiretroviral therapy (ART) between November 2011 and August 2012 at an urban hospital in Seoul, South Korea. A total of 215 blood plasma samples from 150 patients receiving ART for more than 6 months were evaluated. Using the individual viral load assay, 12 of 215 (5.6%) plasma samples had more than 500 HIV RNA copies/ml. The qualitative PCR amplification assay detected individual samples with ≥500 HIV RNA copies/ml with 100% sensitivity. The specificities of the qualitative PCR amplification of the HIV-1 RT assay were 94.1%, 93.6%, and 93.2% compared to the real time PCR at 500, 1,000, and 5,000 threshold of HIV RNA copies/ml, respectively, and $24,940 USD would have been saved for 150 patients during 10 months. The qualitative PCR amplification of the HIV-1 RT assay might be a useful approach to effectively monitor patients receiving ART and save resources.

Published
2014

8. Pooled nucleic acid testing to identify antiretroviral treatment failure during HIV infection in Seoul, South Korea

Author

Kim, Sun Bean, Kim, Hye Won, Kim, Hyon-Suk, Ann, Hea Won, Kim, Jae Kyoung, Choi, Heun, Kim, Min Hyung, Song, Je Eun, Ahn, Jin Young, Ku, Nam Su, Oh, Dong Hyun, Kim, Yong Chan, Jeong, Su Jin, Han, Sang Hoon, Kim, June Myung, Smith, Davey M, and Choi, Jun Yong

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, 4.2 Evaluation of markers and technologies, Infection, Adult, Aged, Aged, 80 and over, Anti-Retroviral Agents, Drug Monitoring, Female, HIV, HIV Infections, Health Care Costs, Humans, Male, Middle Aged, Nucleic Acids, Republic of Korea, Specimen Handling, Treatment Failure, Viral Load, Young Adult, pooling, antiretroviral therapy, viral load, virologic failure, Clinical sciences, Medical microbiology, Epidemiology
Abstract

BackgroundThere have been various efforts to identify less costly but still accurate methods for monitoring the response to HIV treatment. We evaluated a pooling method to determine if this could improve screening efficiency and reduce costs while maintaining accuracy in Seoul, South Korea.MethodsWe conducted the first prospective study of pooled nucleic acid testing (NAT) using a 5 minipool + algorithm strategy versus individual viral load testing for patients receiving antiretroviral therapy (ART) between November 2011 and August 2012 at an urban hospital in Seoul, South Korea. The viral load assay used has a lower level of detection of 20 HIV RNA copies/ml, and the cost per assay is US$ 136. The 5 minipool +algorithm strategy was applied and 43 pooled samples were evaluated. The relative efficiency and accuracy of the pooled NAT were compared with those of individual testing.ResultsUsing the individual viral load assay, 15 of 215 (7%) plasma samples had more than 200 HIV RNA copies/ml. The pooled NAT using the 5 minipool + algorithm strategy was applied to 43 pooled samples; 111 tests were needed to test all samples when virologic failure was defined at HIV RNA ≥ 200 copies/ml. Therefore, 104 tests were saved over individual testing, with a relative efficiency of 0.48. When evaluating costs, a total of US$ 14,144 was saved for 215 individual samples during 10 months. The negative predictive value was 99.5% for all samples with HIV RNA ≥ 200 copies/ml.ConclusionsThe pooled NAT with 5 minipool + algorithm strategy seems to be a very promising approach to effectively monitor patients receiving ART and to save resources.

Published
2014

19. Impact of matrix-assisted laser desorption/ionization time of flight mass spectrometric evaluation on the clinical outcomes of patients with bacteremia and fungemia in clinical settings lacking an antimicrobial stewardship program: a pre-post quasi experimental study

Author

Jeon, Yong Duk, Seong, Hye, Kim, Dokyun, Ahn, Mi Young, Jung, In Young, Jeong, Su Jin, Choi, Jun Yong, Song, Young Goo, Yong, Dongeun, Lee, Kyungwon, Kim, June Myung, and Ku, Nam Su

Published
2018
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22. Trend of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in an institution with a high rate of MRSA after the reinforcement of antibiotic stewardship and hand hygiene

Author

Kim, Yong Chan, Kim, Min Hyung, Song, Je Eun, Ahn, Jin Young, Oh, Dong Hyun, Kweon, Oh Mee, Lee, Dongsuk, Kim, Sun Bean, Kim, Hye-won, Jeong, Su Jin, Ku, Nam Su, Han, Sang Hoon, Park, Eun Suk, Yong, Dongeun, Song, Young Goo, Lee, Kyungwon, Kim, June Myung, and Choi, Jun Yong

Published
2013
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24. Differences in the Risk Factors for Surgical Site Infection between Total Hip Arthroplasty and Total Knee Arthroplasty in the Korean Nosocomial Infections Surveillance System (KONIS)

Author

Song, Kyoung-Ho, Kim, Eu Suk, Kim, Young Keun, Jin, Hye Young, Jeong, Sun Young, Kwak, Yee Gyung, Cho, Yong Kyun, Sung, Joohon, Lee, Yeong-Seon, Oh, Hee-Bok, Kim, Tae Kyun, Koo, Kyung-Hoi, Kim, Eui-Chong, Kim, June Myung, Choi, Tae Yeol, Kim, Hyo Youl, Choi, Hee Jung, and Kim, Hong Bin

Published
2012
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28. HOSPITAL-BASED SURVEILLANCE OF INFECTION-RELATED MORTALITY IN SOUTH KOREA

Author

Choi, Jun Yong, Cheong, Hee-Jin, Chun, Byung Chul, Park, Hye Kyung, Lee, Han Sung, Lee, Hagyung, Kim, Sang IL, Kim, Min Ja, Kim, Sung Soo, Chang, Hyun-Ha, Lee, Sun Hee, Park, Kyung Hwa, Chung, Doo Ryeon, Chung, Jin-Won, Park, Dae Won, Choi, Young Hwa, Choo, Eun Ju, Jeong, Hye Won, Yoon, Hee Jung, Jeon, Min-Hyuk, Kim, Young Keun, Kim, Hyo Youl, Shin, Sang Yop, and Kim, June Myung

Published
2009

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