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7. Effect of Severe Fever With Thrombocytopenia Syndrome Virus Genotype on Disease Severity, Viral Load, and Cytokines in South Korea.

Author

Kwon, Ji-Soo, Kim, Ji Yeun, Jang, Choi Young, Son, Ju Yeon, Kim, Woori, Kim, Taeeun, Park, Se Yoon, Kim, Min-Chul, Park, Seong Yeon, Cha, Hye Hee, Jang, Hyeon Mu, Kim, Min-Jae, Chong, Yong Pil, Lee, Sang-Oh, Choi, Sang-Ho, Kim, Yang Soo, and Kim, Sung-Han

Subjects
*VIRAL genomes, *VIRAL load, *TICK-borne diseases, *INTENSIVE care units, *POLYMERASE chain reaction
Abstract

Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by Bandavirus dabieense (SFTS virus [SFTSV]). Recently, at least 6 different genotypes of SFTSV have been identified, with genotypes A, D, and F dominant in China and B dominant in Japan and Korea. This study investigated the effect of SFTSV genotypes circulating in South Korea on disease severity, viral load, and cytokine profile. Methods We prospectively enrolled 70 patients with SFTS from July 2015 to June 2022. Serial plasma samples were obtained during hospitalization and analyzed. Viral load was measured by real-time reverse-transcription polymerase chain reaction. Partial sequences of the viral genome were analyzed for genotyping. Plasma concentrations of 17 cytokines were measured by multiplex-bead immunoassay. Results Of 70 samples, 51 could be genotyped. Genotype B was predominant (80.4%) and other genotypes were uncommon. Intensive care unit admission rates (51.2% vs 50.0%) and mortality rates (26.8% vs 40.0%) did not show any significant differences between genotype B and non-B genotypes. The initial viral load did not show any significant differences (3.59 vs 3.64 log copies/μL), whereas viral load measured at hospital day 3–4 tended to be higher in genotype B than non-B genotypes (3.83 vs 1.83 log copies/μL, P =.07). Additionally, the plasma concentrations of interferon-α, interleukin 10, and interferon-γ–induced protein 10, which are closely related to mortality in cases of SFTS, did not show any significant differences. Conclusions SFTSV genotype B was the prevalent genotype in South Korea, with no genotype-specific difference in clinical outcomes, initial viral load, or cytokine profiles. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Aspergillosis coinfection in patients with proven mucormycosis.

Author

Ra, Sang Hyun, Kim, Ji Yeun, Song, Joon Seon, Jang, Hyeon Mu, Chang, Euijin, Bae, Seongman, Jung, Jiwon, Kim, Min Jae, Chong, Yong Pil, Lee, Sang-Oh, Choi, Sang-Ho, Kim, Yang Soo, and Kim, Sung-Han

Abstract

Although research on aspergillosis and mucormycosis confection is important to optimize antifungal therapy, data on this issue is scarce. Thus, we systematically investigated aspergillosis coinfection in patients with proven mucormycosis. Medical records of adult patients with proven mucormycosis whose formalin-fixed paraffin-embedded (FFPE) tissue sections were available, in a tertiary hospital from August 2007 to July 2023 were retrospectively reviewed to assess coinfection with aspergillosis. We noted cultures of fungi from sterile and non-sterile sites and performed polymerase chain reaction (PCR) assays on FFPE tissues to detect Aspergillus - and Mucorales-specific DNA. Sixty-seven patients with proven mucormycosis, including 12 (18%) with a positive culture of the mucormycosis agent from sterile site cultures, were enrolled. Fungal cultures from sterile and non-sterile sites revealed Aspergillus spp. growth in nine (13%) of the 67 patients, including two sterile and seven non-sterile cultures. The fungal PCR analysis from the FFPE sections was positive for Aspergillus -specific PCR in five (7%) and positive for both Aspergillus - and Mucorales-specific PCR results in eight (12%). Overall, 21 (31%) of the 67 patients with proven mucormycosis had microbiologic and/or molecular evidence of aspergillosis coinfection. Positive blood or bronchoalveolar lavage fluid galactomannan results were more common in the coinfection group (67% [14/21]) than in the mucormycosis group (37% [17/46], P  = .024). No significant difference in mortality between the two groups was observed. Approximately one-third of patients with proven mucormycosis exhibited molecular and/or microbiologic evidence of aspergillosis coinfection. Further research is needed to identify patients with aspergillosis and mucormycosis coinfections, for optimal antifungal therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The Association Between Antibody Responses and Prolonged Viable Severe Acute Respiratory Syndrome Coronavirus 2 Shedding in Immunocompromised Patients: A Prospective Cohort Study.

Author

Lim, So Yun, Kim, Jun-Won, Kim, Ji Yeun, Kang, Sung-Woon, Jang, Choi-Young, Chang, Euijin, Yang, Jeong-Sun, Kim, Kyung-Chang, Jang, Hee-Chang, Kim, Da Sol, Shin, Younmin, Lee, Joo-Yeon, and Kim, Sung-Han

Subjects
SARS-CoV-2, ANTIBODY formation, IMMUNOCOMPROMISED patients, COVID-19, IMMUNOGLOBULIN G
Abstract

Immunocompromised patients with coronavirus disease 2019 were prospectively enrolled from March to November 2022 to understand the association between antibody responses and severe acute respiratory syndrome coronavirus 2 shedding. A total of 62 patients were analyzed, and the results indicated a faster decline in genomic and subgenomic viral RNA in patients with higher neutralizing and S1-specific immunoglobulin G (IgG) antibodies (both P <.001). Notably, high neutralizing antibody levels were associated with a significantly faster decrease in viable virus cultures (P =.04). Our observations suggest the role of neutralizing antibodies in prolonged virus shedding in immunocompromised patients, highlighting the potential benefits of enhancing their humoral immune response through vaccination or monoclonal antibody treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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12. 1361. The association between antibody responses and prolonged viable SARS-CoV-2 shedding in immunocompromised patients: a prospective cohort study

Author

Lim, So Yun, primary, Kim, Jun-Won, additional, Kim, Ji Yeun, additional, Kang, Sung-Woon, additional, Jang, Choi-Young, additional, Chang, Eui Jin, additional, Yun, Sung-Cheol, additional, Yang, Jeong-Sun, additional, Kim, Kyung-Chang, additional, Jang, Hee-Chang, additional, Kim, Dasol, additional, Shin, Younmin, additional, Lee, Joo-Yeon, additional, and Kim, Sung-Han, additional

Published
2023
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13. Virological characteristics and the rapid antigen test as deisolation criteria in immunocompromised patients with COVID‐19: A prospective cohort study

Author

Kang, Sung‐Woon, primary, Kim, Jun‐Won, additional, Kim, Ji Yeun, additional, Lim, So Yun, additional, Jang, Choi‐Young, additional, Chang, Euijin, additional, Yang, Jeong‐Sun, additional, Kim, Kyung‐Chang, additional, Jang, Hee‐Chang, additional, Kim, Dasol, additional, Shin, Younmin, additional, Lee, Joo‐Yeon, additional, and Kim, Sung‐Han, additional

Published
2023
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14. Mutational analysis of severe acute respiratory syndrome coronavirus 2 in immunocompromised patients with persistent viral detection using whole genome sequencing

Author

Chang, Euijin, primary, Lee, Jungmin, additional, Kim, Jun‐Won, additional, Seok, Jong Hyeon, additional, Bae, Joon‐Yong, additional, Kim, Jeonghun, additional, Park, Heedo, additional, Jang, Choi‐Young, additional, Kang, Sung‐Woon, additional, Lim, So Yun, additional, Kim, Ji Yeun, additional, Yang, Jeong‐Sun, additional, Kim, Kyung‐Chang, additional, Lee, Joo‐Yeon, additional, Park, Man‐Seong, additional, and Kim, Sung‐Han, additional

Published
2023
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18. Waning of humoral immunity depending on the types of COVID-19 vaccine

Author

Lim, So Yun, Kim, Ji Yeun, Jung, Jiwon, Yun, Sung-Cheol, and Kim, Sung-Han

Subjects
Microbiology (medical), Infectious Diseases, General Immunology and Microbiology, General Medicine
Abstract

There are limited data on the rates of the waning of antibody levels after two-dose and booster vaccination according to the different platforms of COVID-19 vaccines. We enrolled healthcare workers (HCWs) in a tertiary care hospital who received homologous two-dose vaccination, followed by a homologous or heterologous booster mRNA vaccine. SARS-CoV-2 S1-specific IgG was measured using ELISA. A linear mixed regression model was used to compare the slope from the peak antibody titre to the lowest antibody titres 3 months after vaccination. A total of 113 HCWs (BNT162b2 (n = 48 [42%]), ChAdOx1 nCoV-19 (n = 52 [46%]) or mRNA-1273 (n = 13 [12%])) were enrolled in this prospective cohort study. More gradual antibody waning was observed over 3 months with the two-dose ChAdOx1 nCoV-19 (ChAdOx1) than with the two-dose BNT162b2 or mRNA-1273 (p < 0.001 and p = 0.001, respectively). In addition, homologous mRNA-1273 booster induced a more durable antibody response than homologous BNT162b2 booster (p < 0.001) or heterologous ChAdOx1-BNT162b2 booster (p < 0.001). Two-dose homologous ChAdOx1 vaccination or homologous mRNA-1273 booster appears to induce more-durable antibody responses than 2-dose homologous mRNA vaccination, homologous BNT162b2 booster, or 2-dose ChAdOx1 followed by BNT62b2 booster, although our findings are based on the relatively short term (3-month) follow-up after the vaccinations and the evaluation of the slopes from different antibody peak levels. Further studies on long-term durability depending on the types of vaccines are needed.

Published
2023
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20. Letter to the Editor with # CTM2‐2023‐10‐2488 entitled 'Antibody responses as correlates of protection against SARS‐CoV‐2 in the Omicron era: A 5‐month prospective cohort study in Korean healthcare workers'.

Author

Lim, So Yun, Kim, Jineui, Kwon, Ji‐Soo, Kang, Sung‐Woon, Kim, Seung‐Beom, Kim, Woori, Son, Ju Yeon, Jang, Choi Young, Park, Heedo, Kim, Jeonghun, Lee, Sohyun, Kim, Kyung Taek, Choi, Jaeuk, Kim, Ji Yeun, Lim, Joon Seo, Chang, Euijin, Bae, Seongman, Jung, Jiwon, Kim, Min Jae, and Chong, Yong Pil

Subjects
MEDICAL personnel, COVID-19, SARS-CoV-2 Omicron variant, ANTIBODY formation, SARS-CoV-2
Abstract

The letter to the editor discusses a study conducted in South Korea that examined the immune response to COVID-19 in healthcare workers. The study found that individuals with hybrid immunity, meaning they had both natural infection and vaccination, and higher levels of certain antibodies had a lower risk of subsequent infection. The study suggests that these antibody levels can be used as an indicator of protection against infection. However, baseline saliva IgA antibodies did not show a protective role. The study concludes that further research is needed to fully understand the mechanisms involved. [Extracted from the article]

Published
2024
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22. Corrigendum to “Comparison of outward transmission potential between vaccinated and partially vaccinated or unvaccinated individuals with the SARS-CoV-2 delta variant infection” [J Infect 85 (2022) e69–e71]

Author

Kang, Sung Woon, primary, Kim, Ji Yeun, additional, Park, Heedo, additional, Lim, So Yun, additional, Kim, Jeonghun, additional, Bae, Seongman, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang-Oh, additional, Choi, Sang-Ho, additional, Kim, Yang Soo, additional, Park, Man-Seong, additional, and Kim, Sung-Han, additional

Published
2023
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24. Comparison of the clinical and virological characteristics of SARS-CoV-2 Omicron BA.1/BA.2 and omicron BA.5 variants: A prospective cohort study

Author

Kang, Sung-Woon, primary, Park, Heedo, additional, Kim, Ji Yeun, additional, Lim, So Yun, additional, Lee, Sohyun, additional, Bae, Joon-Yong, additional, Kim, Jeonghun, additional, Chang, Euijin, additional, Bae, Seongman, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang-Oh, additional, Choi, Sang-Ho, additional, Kim, Yang Soo, additional, Park, Man-Seong, additional, and Kim, Sung-Han, additional

Published
2023
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25. Characteristics and risk factors of prolonged viable virus shedding in immunocompromised patients with COVID-19: a prospective cohort study

Author

Kang, Sung-Woon, primary, Kim, Jun-Won, additional, Kim, Ji Yeun, additional, Lim, So Yun, additional, Jang, Choi-Young, additional, Chang, Euijin, additional, Yang, Jeong-Sun, additional, Kim, Kyung-Chang, additional, Jang, Hee-Chang, additional, Kim, Dasol, additional, Shin, Younmin, additional, Lee, Joo-Yeon, additional, and Kim, Sung-Han, additional

Published
2023
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26. Combining CRF and Multi-hypothesis Detection for Accurate Lesion Segmentation in Breast Sonograms

Author

Hao, Zhihui, Wang, Qiang, Seong, Yeong Kyeong, Lee, Jong-Ha, Ren, Haibing, Kim, Ji-yeun, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ayache, Nicholas, editor, Delingette, Hervé, editor, Golland, Polina, editor, and Mori, Kensaku, editor

Published
2012
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28. Comparison of secondary attack rate and viable virus shedding between patients with SARS‐CoV‐2 Delta and Omicron variants: A prospective cohort study

Author

Kang, Sung‐Woon, primary, Kim, Ji Yeun, additional, Park, Heedo, additional, Lim, So Yun, additional, Kim, Jeonghun, additional, Chang, Euijin, additional, Bae, Seongman, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang‐Oh, additional, Choi, Sang‐Ho, additional, Kim, Yang Soo, additional, Park, Man‐Seong, additional, and Kim, Sung‐Han, additional

Published
2022
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29. No correlation of neutralizing antibody titers against the Omicron variant after a booster dose of COVID-19 vaccines with subsequent breakthrough Omicron infections among healthcare workers

Author

Lee, Jeongjae, primary, Park, Soonju, additional, Kim, Ji Yeun, additional, Lim, So Yun, additional, Chang, Euijin, additional, Bae, Seongman, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang-Oh, additional, Choi, Sang-Ho, additional, Kim, Yang Soo, additional, Lee, Nakyung, additional, Shum, David, additional, Kim, Seungtaek, additional, Jee, Youngmee, additional, and Kim, Sung-Han, additional

Published
2022
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33. Daily, self-test rapid antigen test to assess SARS-CoV-2 viability in de-isolation of patients with COVID-19

Author

Bae, Seongman, primary, Park, Heedo, additional, Kim, Ji Yeun, additional, Park, Sunghee, additional, Lim, So Yun, additional, Bae, Joon-Yong, additional, Kim, Jeonghun, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang-Oh, additional, Choi, Sang-Ho, additional, Kim, Yang Soo, additional, Park, Man-Seong, additional, and Kim, Sung-Han, additional

Published
2022
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34. A Video Summarization Method for Basketball Game

Author

Kim, Eui-Jin, Lee, Gwang-Gook, Jung, Cheolkon, Kim, Sang-Kyun, Kim, Ji-Yeun, Kim, Whoi-Yul, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ho, Yo-Sung, editor, and Kim, Hyoung Joong, editor

Published
2005
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35. An Effective News Anchorperson Shot Detection Method Based on Adaptive Audio/Visual Model Generation

Author

Kim, Sang-Kyun, Hwang, Doo Sun, Kim, Ji-Yeun, Seo, Yang-Seock, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Leow, Wee-Kheng, editor, Lew, Michael S., editor, Chua, Tat-Seng, editor, Ma, Wei-Ying, editor, Chaisorn, Lekha, editor, and Bakker, Erwin M., editor

Published
2005
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36. Consideration of Illuminant Independence in MPEG-7 Color Descriptors

Author

Kim, Sang-Kyun, Choi, Yanglim, Choe, Wonhee, Park, Du-Sik, Kim, Ji-Yeun, Seo, Yang-Seock, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Aizawa, Kiyoharu, editor, Nakamura, Yuichi, editor, and Satoh, Shin’ichi, editor

Published
2005
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37. An Effective Anchorperson Shot Extraction Method Robust to False Alarms

Author

Kim, Sang-Kyun, Hwang, Doo Sun, Kim, Ji-Yeun, Seo, Yang-Seock, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Aizawa, Kiyoharu, editor, Nakamura, Yuichi, editor, and Satoh, Shin’ichi, editor

Published
2005
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38. Comparison of outward transmission potential between vaccinated and partially vaccinated or unvaccinated individuals with the SARS-CoV-2 delta variant infection

Author

Kang, Sung Woon, primary, Kim, Ji Yeun, additional, Park, Heedo, additional, Lim, So Yun, additional, Kim, Jeonghun, additional, Bae, Seongman, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang-Oh, additional, Choi, Sang-Ho, additional, Kim, Yang Soo, additional, Park, Man-Seong, additional, and Kim, Sung-Han, additional

Published
2022
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39. The relationship between organising pneumonia and invasive mould disease in patients with haematologic malignancy.

Author

Bae, Moonsuk, Song, Joon Seon, Kim, Ji Yeun, Bae, Seongman, Jung, Jiwon, Kim, Min Jae, Chong, Yong Pil, Lee, Sang‐Oh, Choi, Sang‐Ho, Kim, Yang Soo, and Kim, Sung‐Han

Subjects
ORGANIZING pneumonia, PULMONARY aspergillosis, HEMATOPOIETIC stem cell transplantation, NEUROENDOCRINE cells
Abstract

Background: Organising pneumonia (OP) is reported in patients with haematologic malignancy suspected of having invasive mould disease, yet little is known about this relationship. Objective: To investigate molecular evidence of invasive mould pneumonia in paraffin‐embedded lung tissues from histologically diagnosed OP patients with suspected invasive mould pneumonia. Patients/Methods: Patients with haematologic malignancy suspected to have invasive pulmonary mould disease who underwent lung biopsy at a tertiary hospital, Seoul, South Korea, between 2008 and 2020, were retrospectively reviewed. To find molecular evidence of fungal infection, PCR assay was used to detect Aspergillus‐ and Mucorales‐specific DNA within OP lung tissue sections. Results: Forty‐seven patients with suspected invasive mould pneumonia underwent lung biopsy and 15 (32%) were histologically diagnosed as OP without any evidence of fungal hyphae. Of these 15 patients, 3 (20%) received allogenic haematopoietic stem cell transplantation prior to developing OP. Before biopsy, 2 and 13 patients had probably and possible invasive mould disease, respectively. The median antifungal treatment length was 81 [8–114] days, and the median steroid treatment dosage was 0.35 mg/kg/day for 36 days (methylprednisolone equivalent doses), respectively. After biopsy, three patients with possible invasive mould infection revealed probable invasive pulmonary aspergillosis. From the 15 paraffin‐embedded lung tissues, 6 (40%) exhibited positive PCR assay results for detecting Aspergillus‐ and Mucorales‐specific DNA. Conclusions: More than one third of OP cases in patients with suspected invasive mould pneumonia exhibited molecular evidence of invasive mould infection by fungus‐specific PCR in lung tissues, likely associated with concurrent or prior fungal infection. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Clinical and Virological Characteristics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta) Variant: A Prospective Cohort Study

Author

Park, Sunghee, primary, Lim, So Yun, additional, Kim, Ji Yeun, additional, Park, Heedo, additional, Lim, Joon Seo, additional, Bae, Seongman, additional, Kim, Jeonghun, additional, Jung, Jiwon, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Choi, Sang Ho, additional, Lee, Sang Oh, additional, Kim, Yang Soo, additional, Park, Man Seong, additional, and Kim, Sung Han, additional

Published
2022
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43. Breakthrough infections and waning immune responses with ChAdOx1 nCoV‐19 or mRNA vaccine in healthcare workers

Author

Lim, So Yun, primary, Jung, Jiwon, additional, Kim, Ji Yeun, additional, Park, Soonju, additional, Kwon, Ji‐Soo, additional, Park, So Yeon, additional, Kim, Sun‐Kyung, additional, Lim, Young‐Ju, additional, Kim, Eun Ok, additional, Bae, Seongman, additional, Kim, Min Jae, additional, Chong, Yong Pil, additional, Lee, Sang‐Oh, additional, Choi, Sang‐Ho, additional, Kim, Yang Soo, additional, Lee, Nakyung, additional, Kim, Kideok, additional, Shum, David, additional, Jee, Youngmee, additional, and Kim, Sung‐Han, additional

Published
2022
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44. Factors Associated with Body Weight Gain among Korean Adults during the COVID-19 Pandemic

Author

Hur, Yang-Im, primary, Huh, Youn, additional, Lee, Jae Hyuk, additional, Lee, Chang Beom, additional, Kim, Bo-Yeon, additional, Yu, Sung Hoon, additional, Kim, Jung Hwan, additional, Kim, Jin-Wook, additional, Kim, Hyun Min, additional, Lee, Min-Kyung, additional, Hong, Jun Hwa, additional, Choi, Dughyun, additional, Bae, Jaehyun, additional, Lee, Kun Ho, additional, and Kim, Ji Yeun, additional

Published
2022
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49. Immune responses and reactogenicity after ChAdOx1 in individuals with past SARS-CoV-2 infection and those without

Author

Lim, So Yun, primary, Kim, Ji Yeun, additional, Lee, Jin Ah, additional, Kwon, Ji-Soo, additional, Park, Ji Young, additional, Cha, Hye Hee, additional, Suh, Mi Hyun, additional, Lee, Hyun Jung, additional, Kim, Hyeonju, additional, Kim, Seungtaek, additional, Bae, Seongman, additional, Jung, Jiwon, additional, Kim, Eui Ho, additional, Jee, Youngmee, additional, and Kim, Sung-Han, additional

Published
2022
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50. Immune responses to the ChAdOx1 nCoV-19 and BNT162b2 vaccines and to natural COVID-19 infections over a three-month period

Author

Kim, Ji Yeun, Lim, So Yun, Park, Soonju, Kwon, Ji-Soo, Bae, Seongman, Park, Ji Young, Cha, Hye Hee, Seo, Mi Hyun, Lee, Hyun Jung, Lee, Nakyung, Kim, Kideok, Shum, David, Jee, Youngmee, and Kim, Sung-Han

Subjects
Adult, Male, SARS-CoV-2, Vaccination, T cells, COVID-19, 2 nd dose, Middle Aged, Antibodies, Neutralizing, AcademicSubjects/MED00290, ChAdOx1 nCoV-19, antibody, Immunoglobulin G, Antibody Formation, Major Article, Humans, BNT162b2, Female, BNT162 Vaccine, Aged
Abstract

There are limited data directly comparing immune responses to vaccines and to natural infections with coronavirus disease 2019 (COVID-19). This study assessed the immunogenicity of the BNT162b2 and ChAdOx1 nCoV-19 vaccines over a 3-month period and compared the immune responses with those to natural infections.We enrolled healthcare workers who received BNT162b2 or ChAdOx1 nCoV-19 vaccines and patients with confirmed COVID-19 and then measured S1 immunoglobulin (Ig) G and neutralizing antibodies and T-cell responses.A total of 121 vaccinees and 26 patients with confirmed COVID-19 were analyzed. After the second dose, the BNT162b2 vaccine yielded S1 IgG antibody responses similar to those achieved with natural infections (mean IgG titer [standard deviation], 2241 [899] vs 2601 [5039]; P = .68) but significantly stronger than responses to the ChAdOx1 vaccine (174 [96]; P .001). The neutralizing antibody titer generated by BNT162b2 was 6-fold higher than that generated by ChAdOx1 but lower than that by natural infection. T-cell responses persisted for 3 months with BNT162b2 and natural infection but decreased with ChAdOx1.Antibody responses after the second dose of BNT162b2 are higher than after the second dose of ChAdOx1 and like those occurring after natural infection. T-cell responses are maintained longer in BNT162b2 vaccinees than in ChAdOx1 vaccinees.

Published
2021

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