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142 results on '"Kim, Jai-Eun"'

3. Inhibiting AGS Cancer Cell Proliferation through the Combined Application of Aucklandiae Radix and Hyperthermia: Investigating the Roles of Heat Shock Proteins and Reactive Oxygen Species.

Author

Ahn, Chae Ryeong, Ha, In Jin, Kim, Jai-Eun, Ahn, Kwang Seok, Park, Jinbong, and Baek, Seung Ho

Subjects
HEAT shock proteins, CANCER cell proliferation, REACTIVE oxygen species, FEVER, CELL cycle
Abstract

Cancer is a major global health concern. To address this, the combination of traditional medicine and newly appreciated therapeutic modalities has been gaining considerable attention. This study explores the combined effects of Aucklandiae Radix (AR) and 43 °C hyperthermia (HT) on human gastric adenocarcinoma (AGS) cell proliferation and apoptosis. We investigated the synergistic effects of AR and HT on cell viability, apoptosis, cell cycle progression, and reactive oxygen species (ROS)-dependent mechanisms. Our findings suggest that the combined treatment led to a notable decrease in AGS cell viability and increased apoptosis. Furthermore, cell cycle arrest at the G2/M phase contributed to the inhibition of cancer cell proliferation. Notably, the roles of heat shock proteins (HSPs) were highlighted, particularly in the context of ROS regulation and the induction of apoptosis. Overexpression of HSPs was observed in cells subjected to HT, whereas their levels were markedly reduced following AR treatment. The suppression of HSPs and the subsequent increase in ROS levels appeared to contribute to the activation of apoptosis, suggesting a potential role for HSPs in the combined therapy's anti-cancer mechanisms. These findings provide valuable insights into the potential of integrating AR and HT in cancer and HSPs. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Special Issue Entitled "Immune Regulatory Properties of Natural Products".

Author

Kim, Jai-Eun and Park, Wansu

Subjects
NATURAL products, IDIOPATHIC pulmonary fibrosis, CYCLIC adenylic acid, PLANT extracts, RESPIRATORY diseases, DEEP brain stimulation
Abstract

This document is an editorial from the journal Processes, titled "Special Issue Entitled 'Immune Regulatory Properties of Natural Products'." It discusses ongoing research on the use of natural products in the treatment of immune-mediated inflammatory diseases, such as autoimmune diseases and chronic inflammatory diseases. The editorial highlights the traditional use of natural products in Asian countries and the development of analytical science to identify specific components and their pharmacological efficacy. The Special Issue presents five research papers, including in vivo and in vitro studies, systematic literature reviews, and a review of herbal medicine combined with pirfenidone for idiopathic pulmonary fibrosis. The papers explore the immunoregulatory effects of natural products and their potential in treating various diseases. [Extracted from the article]

Published
2024
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15. Special Issue on "Pharmacodynamics Modeling of Anti-Inflammatory Drugs".

Author

Kim, Jai-Eun, Oh, Myung Sook, and Park, Wansu

Subjects
MACROPHAGE colony-stimulating factor, ANTI-inflammatory agents, ENDOPLASMIC reticulum, INTRACELLULAR calcium, DISEASE risk factors, PHARMACODYNAMICS, GRANULOCYTE-macrophage colony-stimulating factor
Abstract

In addition, although animal experiments have not provided confirmation, ER stress signaling is modulated by the inhibition of intracellular calcium release through the regulation of p38 MAPK phosphorylation and the expression of the transcription factor CHOP. In respiratory infectious diseases such as COVID-19, cytokine overproduction, called "cytokine storms", is a problem, but the detailed mechanism of cytokine storms has not yet been fully identified. For example, the hyperinflammation caused by respiratory infections (e.g., cytokine storm) exacerbates lung damage and is associated with acute respiratory distress syndrome. [Extracted from the article]

Published
2023
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27. Activation of the Nrf2/HO-1 Pathway by Amomum villosum Extract Suppresses LPS-Induced Oxidative Stress In Vitro and Ex Vivo.

Author

Lim, Dong-Woo, Choi, Hee-Jin, Park, Sun-Dong, Kim, Hyuck, Yu, Ga-Ram, Kim, Jai-Eun, and Park, Won-Hwan

Subjects
ANIMAL experimentation, CELL lines, CELLULAR signal transduction, CYTOKINES, GENE expression, INFLAMMATORY mediators, LEUCINE, MACROPHAGES, MICE, NITRIC oxide, OXIDOREDUCTASES, PROSTAGLANDINS, PLANT extracts, OXIDATIVE stress, LIPOPOLYSACCHARIDES, IN vitro studies, PHARMACODYNAMICS
Abstract

Despite its deleterious effects on living cells, oxidative stress plays essential roles in normal physiological processes and provides signaling molecules for cell growth, differentiation, and inflammation. Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages. We investigated the effects of ethanol extract of A. villosum (AVEE) on lipopolysaccharide- (LPS-) stimulated inflammatory responses generated via the Nrf2/HO-1 signaling pathway in murine peritoneal macrophages and RAW 264.7 cells. AVEE was found to suppress the NF-κB signaling pathway, thus, to reduce proinflammatory cytokine, nitric oxide, and prostaglandin levels in peritoneal macrophages and Raw 264.7 cells treated with LPS, and to enhance HO-1 expression by activating Nrf2 signaling. Furthermore, these anti-inflammatory effects of AVEE were diminished when cells were pretreated with SnPP (a HO-1 inhibitor). HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway. These results show A. villosum ethanol extract exerts anti-inflammatory effects by activating the Nrf2/HO-1 pathway in LPS-stimulated macrophages. [ABSTRACT FROM AUTHOR]

Published
2020
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