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Objectives: A cross-sectional study was conducted to investigate whether working hours mismatch is associated with workaholism.Material and Methods: This study used the data from the 17th wave (2014) of the nationwide Korean Labor and Income Panel Study. Workaholism was evaluated using the Workaholism Analysis Questionnaire. The final study involved 3157 subjects who answered questions regarding both workaholism and working hours mismatch. To identify the association between working hours mismatch and workaholism according to weekly working hours, a stratification analysis was conducted by dividing the number of working hours/week into 3 groups (≤40 h, 41-59 h, and ≥60 h). The odds ratios were calculated using a multiple logistic regression model, which was adjusted for potential confounders.Results: The workers working more hours than desired showed the greatest frequency of workaholism. As regards workaholism, in all weekly working hours groups, the odds ratios of the group working more hours than desired were 4.28, 95% CI: 2.29-7.99 (≥40 h), 2.14, 95% CI: 1.34-3.43 (41-59 h), 3.40, 95% CI: 1.60-7.21 (≤60 h), which were statistically significant compared to the reference (matched) group. There was no statistically significant relationship between working hours and workaholism when stratified according to the mismatch in working hours.Conclusions: The workers' working hours mismatch can be significantly related to workaholism. Int J Occup Med Environ Health. 2020;33(2):187-94. [ABSTRACT FROM AUTHOR]

Purpose: Radiation-induced pulmonary fibrosis (RIF) is a significant complication of radiotherapy for lung cancer. Despite the large number of studies, the molecular mechanisms of RIF are poorly understood. Therefore, the complex protein expression pattern in RIF was characterized by identifying the proteins with an altered expression level after thorax irradiation using two-dimensional electrophoresis (2-DE) and mass spectrometry., Materials and Methods: A mouse model of RIF was used to examine the alteration of the lung proteome because of availability of murine data related to human cases and the abundance of murine fibrotic lung samples. A mouse model of RIF was induced in radiosensitive C57BL/6 mice. Twenty-one weeks after 25 Gy irradiation, hematoxylin-eosin staining and hydroxyproline assay confirmed the early-phase pulmonary fibrosis., Results: Lung samples from the irradiated and age-matched control mice were used to generate 16 high quality 2-DE gels containing approximately 1,000 spots. Of the 31 significantly up- or down-regulated protein spots, 17 were identified by MALDI-TOF/MS., Conclusions: Two important upregulated proteins were found, the alpha1-protease inhibitor and galectin-1, which might be used as potential markers for the early phase of RIF.