Search

Cerebral Microbleeds (CMBs) are chronic deposits of small blood products in the brain tissues, which have explicit relation to various cerebrovascular diseases depending on their anatomical location, including cognitive decline, intracerebral hemorrhage, and cerebral infarction. However, manual detection of CMBs is a time-consuming and error-prone process because of their sparse and tiny structural properties. The detection of CMBs is commonly affected by the presence of many CMB mimics that cause a high false-positive rate (FPR), such as calcification and pial vessels. This paper proposes a novel 3D deep learning framework that does not only detect CMBs but also inform their anatomical location in the brain (i.e., lobar, deep, and infratentorial regions). For the CMB detection task, we propose a single end-to-end model by leveraging the U-Net as a backbone with Region Proposal Network (RPN). To significantly reduce the FPs within the same single model, we develop a new scheme, containing Feature Fusion Module (FFM) that detects small candidates utilizing contextual information and Hard Sample Prototype Learning (HSPL) that mines CMB mimics and generates additional loss term called concentration loss using Convolutional Prototype Learning (CPL). The anatomical localization task does not only tell to which region the CMBs belong but also eliminate some FPs from the detection task by utilizing anatomical information. The results show that the proposed RPN that utilizes the FFM and HSPL outperforms the vanilla RPN and achieves a sensitivity of 94.66% vs. 93.33% and an average number of false positives per subject (FPavg) of 0.86 vs. 14.73. Also, the anatomical localization task further improves the detection performance by reducing the FPavg to 0.56 while maintaining the sensitivity of 94.66%., Comment: 16 pages, 10 figures,3 tables

X-ray computed tomography (CT) uses different filter kernels to highlight different structures. Since the raw sinogram data is usually removed after the reconstruction, in case there are additional need for other types of kernel images that were not previously generated, the patient may need to be scanned again. Accordingly, there exists increasing demand for post-hoc image domain conversion from one kernel to another without sacrificing the image quality. In this paper, we propose a novel unsupervised continuous kernel conversion method using cycle-consistent generative adversarial network (cycleGAN) with adaptive instance normalization (AdaIN). Even without paired training data, not only can our network translate the images between two different kernels, but it can also convert images along the interpolation path between the two kernel domains. We also show that the quality of generated images can be further improved if intermediate kernel domain images are available. Experimental results confirm that our method not only enables accurate kernel conversion that is comparable to supervised learning methods, but also generates intermediate kernel images in the unseen domain that are useful for hypopharyngeal cancer diagnosis.

Time-resolved MR angiography (tMRA) has been widely used for dynamic contrast enhanced MRI (DCE-MRI) due to its highly accelerated acquisition. In tMRA, the periphery of the k-space data are sparsely sampled so that neighbouring frames can be merged to construct one temporal frame. However, this view-sharing scheme fundamentally limits the temporal resolution, and it is not possible to change the view-sharing number to achieve different spatio-temporal resolution trade-off. Although many deep learning approaches have been recently proposed for MR reconstruction from sparse samples, the existing approaches usually require matched fully sampled k-space reference data for supervised training, which is not suitable for tMRA. This is because high spatio-temporal resolution ground-truth images are not available for tMRA. To address this problem, here we propose a novel unsupervised deep learning using optimal transport driven cycle-consistent generative adversarial network (cycleGAN). In contrast to the conventional cycleGAN with two pairs of generator and discriminator, the new architecture requires just a single pair of generator and discriminator, which makes the training much simpler and improves the performance. Reconstruction results using in vivo tMRA data set confirm that the proposed method can immediately generate high quality reconstruction results at various choices of view-sharing numbers, allowing us to exploit better trade-off between spatial and temporal resolution in time-resolved MR angiography.

Recently, deep neural network-powered quantitative susceptibility mapping (QSM), QSMnet, successfully performed ill conditioned dipole inversion in QSM and generated high-quality susceptibility maps. In this paper, the network, which was trained by healthy volunteer data, is evaluated for hemorrhagic lesions that have substantially higher susceptibility than healthy tissues in order to test linearity of QSMnet for susceptibility. The results show that QSMnet underestimates susceptibility in hemorrhagic lesions, revealing degraded linearity of the network for the untrained susceptibility range. To overcome this limitation, a data augmentation method is proposed to generalize the network for a wider range of susceptibility. The newly trained network, which is referred to as QSMnet+, is assessed in computer-simulated lesions with an extended susceptibility range (-1.4 ppm to +1.4 ppm) and also in twelve hemorrhagic patients. The simulation results demonstrate improved linearity of QSMnet+ over QSMnet (root mean square error of QSMnet+: 0.04 ppm vs. QSMnet: 0.36 ppm). When applied to patient data, QSMnet+ maps show less noticeable artifacts to those of conventional QSM maps. Moreover, the susceptibility values of QSMnet+ in hemorrhagic lesions are better matched to those of the conventional QSM method than those of QSMnet when analyzed using linear regression (QSMnet+: slope = 1.05, intercept = -0.03, R2 = 0.93; QSMnet: slope = 0.68, intercept = 0.06, R2 = 0.86), consolidating improved linearity in QSMnet+. This study demonstrates the importance of the trained data range in deep neural network-powered parametric mapping and suggests the data augmentation approach for generalization of network. The new network can be applicable for a wide range of susceptibility quantification., Comment: 22 pages

Time-resolved angiography with interleaved stochastic trajectories (TWIST) has been widely used for dynamic contrast enhanced MRI (DCE-MRI). To achieve highly accelerated acquisitions, TWIST combines the periphery of the k-space data from several adjacent frames to reconstruct one temporal frame. However, this view-sharing scheme limits the true temporal resolution of TWIST. Moreover, the k-space sampling patterns have been specially designed for a specific generalized autocalibrating partial parallel acquisition (GRAPPA) factor so that it is not possible to reduce the number of view-sharing once the k-data is acquired. To address these issues, this paper proposes a novel k-space deep learning approach for parallel MRI. In particular, we have designed our neural network so that accurate k-space interpolations are performed simultaneously for multiple coils by exploiting the redundancies along the coils and images. Reconstruction results using in vivo TWIST data set confirm that the proposed method can immediately generate high-quality reconstruction results with various choices of view- sharing, allowing us to exploit the trade-off between spatial and temporal resolution in time-resolved MR angiography.

Deep neural networks have demonstrated promising potential for the field of medical image reconstruction. In this work, an MRI reconstruction algorithm, which is referred to as quantitative susceptibility mapping (QSM), has been developed using a deep neural network in order to perform dipole deconvolution, which restores magnetic susceptibility source from an MRI field map. Previous approaches of QSM require multiple orientation data (e.g. Calculation of Susceptibility through Multiple Orientation Sampling or COSMOS) or regularization terms (e.g. Truncated K-space Division or TKD; Morphology Enabled Dipole Inversion or MEDI) to solve the ill-conditioned deconvolution problem. Unfortunately, they either require long multiple orientation scans or suffer from artifacts. To overcome these shortcomings, a deep neural network, QSMnet, is constructed to generate a high quality susceptibility map from single orientation data. The network has a modified U-net structure and is trained using gold-standard COSMOS QSM maps. 25 datasets from 5 subjects (5 orientation each) were applied for patch-wise training after doubling the data using augmentation. Two additional datasets of 5 orientation data were used for validation and test (one dataset each). The QSMnet maps of the test dataset were compared with those from TKD and MEDI for image quality and consistency in multiple head orientations. Quantitative and qualitative image quality comparisons demonstrate that the QSMnet results have superior image quality to those of TKD or MEDI and have comparable image quality to those of COSMOS. Additionally, QSMnet maps reveal substantially better consistency across the multiple orientations than those from TKD or MEDI. As a preliminary application, the network was tested for two patients. The QSMnet maps showed similar lesion contrasts with those from MEDI, demonstrating potential for future applications., Comment: This work is accepted in neuroimage on 8 June, 2018 and soon will be published. The pubmed link is https://www.ncbi.nlm.nih.gov/pubmed/29894829