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4,406 results on '"Kim, Eun-Kyung"'

35. Role of dynamic contrast‐enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER‐positive, HER2‐negative, node‐negative invasive breast cancer

Author

Shin, Gi Won, Zhang, Yang, Kim, Min Jung, Su, Min‐Ying, Kim, Eun‐Kyung, Moon, Hee Jung, Yoon, Jung Hyun, and Park, Vivian Youngjean

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Biomedical Imaging, Women's Health, Cancer, Adult, Aged, Aged, 80 and over, Breast, Breast Neoplasms, Contrast Media, Disease-Free Survival, Estrogen Receptor alpha, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Magnetic Resonance Imaging, Mastectomy, Menstrual Cycle, Middle Aged, Multivariate Analysis, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Recurrence, Local, Observer Variation, Proportional Hazards Models, Receptors, Progesterone, Regression Analysis, Retrospective Studies, breast cancer, breast neoplasm, magnetic resonance imaging, recurrence, prognosis, Physical Sciences, Engineering, Medical and Health Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

BackgroundBackground parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments.PurposeTo investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer.Study typeRetrospective.PopulationIn all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm.Field strength/sequence3T, T1 -weighted DCE sequence.AssessmentBPE of the contralateral breast was assessed qualitatively by two dedicated radiologists and quantitatively (using region-of-interest and automatic breast segmentation).Statistical testsCox regression analysis was used to determine associations with recurrence-free survival (RFS) and distant metastasis-free survival (DFS). Interobserver variability for parenchymal enhancement was assessed using kappa statistics and intraclass correlation coefficient (ICC).ResultsThe median follow-up time was 75.8 months. Multivariate analysis showed receipt of total mastectomy (hazard ratio [HR]: 5.497) and high Ki-67 expression level (HR: 5.956) were independent factors associated with worse RFS (P

Published
2018

46. Charge Transfer Induced Molecular Hole Doping into Thin Film of Metal-Organic-Frameworks

Author

Lee, Deok Yeon, Kim, Eun-Kyung, Shrestha, Nabeen K., Boukhvalov, Danil W., Lee, Joong Kee, and Han, Sung-Hwan

Subjects
Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

Despite the highly porous nature with significantly large surface area, metal organic frameworks (MOFs) can be hardly used in electronic, and optoelectronic devices due to their extremely poor electrical conductivity. Therefore, the study of MOF thin films that require electron transport or conductivity in combination with the everlasting porosity is highly desirable. In the present work, thin films of Co3(NDC)3DMF4 MOFs with improved electronic conductivity are synthesized using layer-by-layer and doctor blade coating techniques followed by iodine doping. The as-prepared and doped films are characterized using FE-SEM, EDX, UV/Visible spectroscopy, XPS, current-voltage measurement, photoluminescence spectroscopy, cyclic voltammetry, and incident photon to current efficiency measurements. In addition, the electronic and semiconductor property of the MOF films are characterized using Hall Effect measurement, which reveals that in contrast to the insulator behavior of the as-prepared MOFs, the iodine doped MOFs behave as a p-type semiconductor. This is caused by charge transfer induced hole doping into the frameworks. The observed charge transfer induced hole doping phenomenon is also confirmed by calculating the densities of states of the as-prepared and iodine doped MOFs based on density functional theory. Photoluminescence spectroscopy demonstrate an efficient interfacial charge transfer between TiO2 and iodine doped MOFs, which can be applied to harvest solar radiations., Comment: Main paper (19 pages, 6 figures) and supplementary information (15 pages, 10 figures), accepted in ACS Appl. Materials & Interfaces

Published
2015
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48. Transcriptomic analysis of cellular senescence induced by ectopic expression of ATF6α in human breast cancer cells.

Author

Kim, Ju Won, Bae, So-Hyun, Moon, Yesol, Kim, Eun Kyung, Kim, Yongjin, Park, Yun Gyu, Han, Mi-Ryung, and Sohn, Jeongwon

Subjects
CONNECTIVE tissue cells, UNFOLDED protein response, SMALL interfering RNA, GENE expression, RNA interference
Abstract

Background: The transcriptomic profile of cellular senescence is strongly associated with distinct cell types, the specific stressors triggering senescence, and temporal progression through senescence stages. This implies the potential necessity of conducting separate investigations for each cell type and a stressor inducing senescence. To elucidate the molecular mechanism that drives endoplasmic reticulum (ER) stress-induced cellular senescence in MCF-7 breast cancer cells, with a particular emphasis on the ATF6α branch of the unfolded protein response. We conducted transcriptomic analysis on MCF-7 cells by ectopic expression of ATF6α. Methods: Transcriptomic sequencing was conducted on MCF-7 cells at 6 and 9 hours post senescence induction through ATF6α ectopic expression. Comprehensive analyses encompassing enriched functional annotation, canonical pathway analysis, gene network analysis, upstream regulator analysis and gene set enrichment analysis were performed on Differentially Expressed Genes (DEGs) at 6 and 9 hours as well as time-related DEGs. Regulators and their targets identified from the upstream regulator analysis were validated through RNA interference, and their impact on cellular senescence was assessed by senescence-associated β-galactosidase staining. Results: ATF6α ectopic expression resulted in the identification of 12 and 79 DEGs at 6 and 9 hours, respectively, employing criteria of a false discovery rate < 0.05 and a lower fold change (FC) cutoff |log2FC| > 1. Various analyses highlighted the involvement of the UPR and/or ER Stress Pathway. Upstream regulator analysis of 9 hour-DEGs identified six regulators and eleven target genes associated with processes related to cytostasis and 'cell viability and cell death of connective tissue cells.' Validation confirmed the significance of MAP2K1/2, GPAT4, and PDGF-BB among the regulators and DDIT3, PPP1R15A, and IL6 among the targets. Conclusion: Transcriptomic analyses and validation reveal the importance of the MAP2K1/2/GPAT4-DDIT3 pathway in driving cellular senescence following ATF6α ectopic expression in MCF-7 cells. This study contributes to our understanding of the initial molecular events underlying ER stress-induced cellular senescence in breast cancer cells, providing a foundation for exploring cell type- and stressor-specific responses in cellular senescence induction. [ABSTRACT FROM AUTHOR]

Published
2024
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