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33. Numerical Assessment of Flow Around Circular Cylinder

Author

Lekkala, Malakonda Reddy, Latheef, Mohamed, Kim, Do Kyun, Wahab, Mubarak Bin A., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Mohammed, Bashar S., editor, Shafiq, Nasir, editor, Rahman M. Kutty, Shamsul, editor, Mohamad, Hisham, editor, and Balogun, Abdul-Lateef, editor

Published
2021
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45. Time-Restricted Feeding Protects against Renal Ischemia-Reperfusion Injury in Mice.

Author

Kim, Do Kyun, Kim, Young Suk, Kim, Min Jeong, Kim, Seo Rin, Lee, Dong Won, Lee, Soo Bong, and Kim, Il Young

Subjects
*LOW-calorie diet, *REPERFUSION injury, *ACUTE kidney failure, *REPERFUSION, *LABORATORY mice
Abstract

Ischemia-reperfusion injury (IRI) in the kidneys is a major cause of acute kidney injury (AKI). Time-restricted feeding (TRF), known for its metabolic health benefits and alleviation of various chronic diseases without calorie restriction, was investigated for its potential protective effects against IRI-induced AKI. Male C57BL/6 mice underwent unilateral IRI, with their kidneys collected after two days. For two weeks before IRI induction, the TRF group had unlimited access to standard chow but within an 8-hour feeding window during the dark cycle. The study groups were Control, TRF, IRI, and TRF + IRI. In the TRF + IRI group, tubular damage scores significantly decreased compared to the IRI group. Furthermore, the TRF + IRI mice had lower levels of phosphorylated NF-κB and fewer F4/80-positive macrophages than the IRI group. Oxidative stress markers for lipids and proteins were also notably lower in the TRF + IRI group. Additionally, TUNEL-positive tubular cells and cleaved caspase-3 expression were reduced in the TRF + IRI group. Without calorie restriction, TRF mitigated renal damage by reducing inflammation, oxidative stress, and tubular apoptosis in renal IRI. This suggests that TRF could be a promising dietary strategy to prevent IRI-induced AKI. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Experimental Investigation of Stress Concentration and Fatigue Behavior in 9% Ni Steel Welded Joints under Cryogenic Conditions.

Author

Lin, Yu-Yao, Han, Sang-Woong, Park, Young-Hwan, and Kim, Do Kyun

Subjects
STRAINS & stresses (Mechanics), STRESS concentration, BENDING stresses, AXIAL stresses, ENGINEERING design
Abstract

This experimental study delves into the intricate mechanics of stress concentration and fatigue behavior exhibited by 9% Ni steel welded joints under cryogenic conditions. The study specifically examines butt-welded, fillet longitudinal, and fillet transverse specimens, comparing their fatigue properties under room and cryogenic temperatures. Notably, determining hot-spot stress presents a challenge, as it cannot be directly obtained through traditional means. To overcome this limitation, a method for predicting hot-spot stress is introduced, which considers the effects of misalignments and weld bead characteristics. The study also highlights the impact of grip-clamping-induced specimen deformation and the reduced middle section on stress concentration resulting from misalignments. Furthermore, it proposes separate consideration of the effects of the weld bead on the axial nominal stress and on the bending stress of the specimen. The accuracy of strain gauge measurements in cryogenic environments is addressed by suggesting a method to correct the output of 2-wire strain gauges using a fixed ratio derived from 2-wire and 3-wire strain gauges. By comparing predicted hot-spot stress with actual measurements, the study validates the reliability of the proposed predictive method. These findings contribute to a deeper understanding of the behavior of 9% Ni steel welded joints under cryogenic conditions and provide valuable insights for design and engineering in similar applications. [ABSTRACT FROM AUTHOR]

Published
2024
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