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1,041 results on '"Kim, Dae-Woo"'

28. Endotype and Phenotype Related Postoperative Effects of Bacterial Lysate in Chronic Rhinosinusitis.

Author

Hong, Seung-No, Yang, Seung Koo, Kim, Su Geun, Han, Sun A., Park, Jin-A, Cha, Hyunkyung, Kim, Joon Kon, Yoon, So Yeon, Eun, Kyoung Mi, and Kim, Dae Woo

Subjects
RESEARCH funding, CLINICAL trials, SINUSITIS, TREATMENT effectiveness, SEVERITY of illness index, CHRONIC diseases, POSTOPERATIVE period, CYTOKINES, INFLAMMATION, PHENOTYPES, IMMUNOMODULATORS, EOSINOPHILS, PHARMACODYNAMICS
Abstract

Objectives: Chronic rhinosinusitis (CRS) endotypes have demonstrated clinical value in guiding treatment decisions. Bacterial lysates are immunomodulators that have shown beneficial effects in various respiratory inflammatory diseases. This study aimed to evaluate the effect of postoperative bacterial lysate therapy on different CRS endotypes. Methods: Patients diagnosed with CRS who underwent endoscopic sinus surgery were recruited. Bacterial lysates were administered postoperatively for 10 days per month for 3 months to the experimental group comprising patients with a history of frequent upper respiratory infections without adverse reactions. The remaining participants were allocated to the control group. The results of the postoperative 3-, 6-, and 12-month assessments, including the modified Lund-Kennedy (mLK) endoscopic and Sinonasal Outcome Test (SNOT) 22 scores, for the groups were compared. The tissue samples obtained from the participants were evaluated to detect the presence of relevant inflammatory mediators. Results: Among the 92 participants, 47 started bacterial lysate therapy 2 weeks after the surgery. The tissue cytokine profiles and clinical parameters, such as the disease severity and blood eosinophil percentage, of the bacterial lysate and control groups were comparable before treatment. The mLK endoscopic and SNOT-22 scores did not differ after 3, 6, and 12 months of follow-up. The subgroup analysis revealed that the bacterial lysate group had significantly lower mLK endoscopic scores than the control group for CRS without nasal polyps, while there was a tendency toward significance for the interleukin (IL)-5 negative group after 6 months. Conclusion: Postoperative bacterial lysate therapy has some beneficial effects on the endoscopic findings of patients with CRS without nasal polyps or those who are negative for IL-5. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Improved Photovoltaic Performance and Stability of Perovskite Solar Cells by Adoption of an n-Type Zwitterionic Cathode Interlayer

Author

Noh, Young Wook, primary, Ha, Jung Min, additional, Son, Jung Geon, additional, Han, Jongmin, additional, Lee, Heunjeong, additional, Kim, Dae Woo, additional, Jee, Min Hun, additional, Shin, Woo Gyeong, additional, Cho, Shinuk, additional, Kim, Jin Young, additional, Song, Myoung Hoon, additional, and Woo, Han Young, additional

Published
2024
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36. Controlled Crystal Growth of All-Inorganic CsPbI2Br via Sequential Vacuum Deposition for Efficient Perovskite Solar Cells

Author

Lee, Min Hyeong, Kim, Dae Woo, Noh, Young Wook, Kim, Hye Seung, Han, Jongmin, Lee, Heunjeong, Choi, Kyoung Jin, Cho, Shinuk, and Song, Myoung Hoon

Abstract

Vacuum deposition of perovskites is a promising method for scale-up fabrication and uniform film growth. However, improvements in the photovoltaic performance of perovskites are limited by the fabrication of perovskite films, which are not optimized for high device efficiency in the vacuum evaporation process. Herein, we fabricate CsPbI2Br perovskite with high crystallinity and larger grain size by controlling the deposition sequence between PbI2and CsBr. The nucleation barrier for perovskite formation is significantly lowered by first evaporating CsBr and then PbI2(CsBr–PbI2), followed by the sequential evaporation of multiple layers. The results show that the reduced Gibbs free energy of CsBr–PbI2, compared with that of PbI2–CsBr, accelerates perovskite formation, resulting in larger grain size and reduced defect density. Furthermore, surface-modified homojunction perovskites are fabricated to efficiently extract charge carriers and enhance the efficiency of perovskite solar cells (PeSCs) by modulating the final PbI2thickness before thermal annealing. Using these strategies, the best PeSC exhibits a power conversion efficiency of 13.41% for a small area (0.135 cm2), the highest value among sequential thermal deposition inorganic PeSCs, and 11.10% for a large area PeSC (1 cm2). This study presents an effective way to understand the crystal growth of thermally deposited perovskites and improve their performance in optoelectronic devices.

Published
2024
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