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17 results on '"Kim, BongWoo"'

2. Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

Author

Yu, Yang, Chen, Ying, Kim, Bongwoo, Wang, Haibo, Zhao, Chuntao, He, Xuelian, Liu, Lei, Liu, Wei, Wu, Lai Man N, Mao, Meng, Chan, Jonah R, Wu, Jiang, and Lu, Q Richard

Subjects
Biochemistry and Cell Biology, Biological Sciences, Neurosciences, Genetics, Stem Cell Research, Neurodegenerative, Human Genome, Underpinning research, 1.1 Normal biological development and functioning, Animals, Basic Helix-Loop-Helix Transcription Factors, Brain, Cell Differentiation, Cells, Cultured, Chromatin Assembly and Disassembly, DNA Helicases, Enhancer Elements, Genetic, Gene Expression Regulation, Mice, Mice, Knockout, Nerve Tissue Proteins, Nuclear Proteins, Oligodendrocyte Transcription Factor 2, Oligodendroglia, Rats, Spinal Cord, Transcription Factors, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4/Brg1 to oligodendrocyte-specific enhancers. Recruitment of Smarca4/Brg1 to distinct subsets of myelination regulatory genes is developmentally regulated. Functional analyses of Smarca4/Brg1 and Olig2 co-occupancy relative to chromatin epigenetic marking uncover stage-specific cis-regulatory elements that predict sets of transcriptional regulators controlling oligodendrocyte differentiation. Together, our results demonstrate that regulation of the functional specificity and activity of a Smarca4/Brg1-dependent chromatin-remodeling complex by Olig2, coupled with transcriptionally linked chromatin modifications, is critical to precisely initiate and establish the transcriptional program that promotes oligodendrocyte differentiation and subsequent myelination of the CNS.

Published
2013

5. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Author

Wang, Yingfei, An, Ran, Umanah, George K., Park, Hyejin, Nambiar, Kalyani, Eacker, Stephen M., Kim, BongWoo, Bao, Lei, Harraz, Maged M., Chang, Calvin, Chen, Rong, Wang, Jennifer E., Kam, Tae-In, Jeong, Jun Seop, Xie, Zhi, Neifert, Stewart, Qian, Jiang, Andrabi, Shaida A., Blackshaw, Seth, Zhu, Heng, Song, Hongjun, Ming, Guo-li, Dawson, Valina L., and Dawson, Ted M.

Published
2016

11. Direct Visualization of Membrane Architecture of Myelinating Cells in Transgenic Mice Expressing Membrane-Anchored EGFP

Author

Deng, Yaqi, Kim, BongWoo, He, Xuelian, Kim, Sunja, Lu, Changqing, Wang, Haibo, Cho, Ssang-Goo, Hou, Yiping, Li, Jianrong, Zhao, Xianghui, and Lu, Q. Richard

Subjects
Male, Cell Membrane, Green Fluorescent Proteins, Gene Expression, Membrane Proteins, Mice, Transgenic, Satellite Cells, Perineuronal, Article, Oligodendroglia, nervous system, Microscopy, Fluorescence, Spinal Cord, 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, Peripheral Nervous System, Animals, Female, Myelin Sheath
Abstract

Myelinogenesis is a complex process that involves substantial and dynamic changes in plasma membrane architecture and myelin interaction with axons. Highly ramified processes of oligodendrocytes in the central nervous system (CNS) make axonal contact and then extrapolate to wrap around axons and form multilayer compact myelin sheathes. Currently, the mechanisms governing myelin sheath assembly and axon selection by myelinating cells are not fully understood. Here, we generated a transgenic mouse line expressing the membrane-anchored green fluorescent protein (mEGFP) in myelinating cells, which allow live imaging of details of myelinogenesis and cellular behaviors in the nervous systems. mEGFP expression is driven by the promoter of 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) that is expressed in the myelinating cell lineage. Robust mEGFP signals appear in the membrane processes of oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system (PNS), wherein mEGFP expression defines the inner layers of myelin sheaths and Schmidt-Lanterman incisures in adult sciatic nerves. In addition, mEGFP expression can be used to track the extent of remyelination after demyelinating injury in a toxin-induced demyelination animal model. Taken together, the membrane-anchored mEGFP expression in the new transgenic line would facilitate direct visualization of dynamic myelin membrane formation and assembly during development and process remodeling during remyelination after various demyelinating injuries.

Published
2014

12. Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination

Author

He, Danyang, primary, Marie, Corentine, additional, Zhao, Chuntao, additional, Kim, Bongwoo, additional, Wang, Jincheng, additional, Deng, Yaqi, additional, Clavairoly, Adrien, additional, Frah, Magali, additional, Wang, Haibo, additional, He, Xuelian, additional, Hmidan, Hatem, additional, Jones, Blaise V, additional, Witte, David, additional, Zalc, Bernard, additional, Zhou, Xin, additional, Choo, Daniel I, additional, Martin, Donna M, additional, Parras, Carlos, additional, and Lu, Q Richard, additional

Published
2016
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13. 3,2/-Dihydroxyflavone-Treated Pluripotent Stem Cells Show Enhanced Proliferation, Pluripotency Marker Expression, and Neuroprotective Properties

Author

Han, Dawoon, primary, Kim, Han Jun, additional, Choi, Hye Yeon, additional, Kim, Bongwoo, additional, Yang, Gwangmo, additional, Han, Jihae, additional, Dayem, Ahmed Abdal, additional, Lee, Hye-Rim, additional, Kim, Jin Hoi, additional, Lee, Kyung-Mi, additional, Jeong, Kyu-Shik, additional, Do, Sun Hee, additional, and Cho, Ssang-Goo, additional

Published
2015
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15. Biologically synthesized silver nanoparticles induce neuronal differentiation of SH-SY5Y cells via modulation of reactive oxygen species, phosphatases, and kinase signaling pathways

Author

Dayem, Ahmed Abdal, primary, Kim, BongWoo, additional, Gurunathan, Sangiliyandi, additional, Choi, Hye Yeon, additional, Yang, Gwangmo, additional, Saha, Subbroto Kumar, additional, Han, Dawoon, additional, Han, Jihae, additional, Kim, Kyeongseok, additional, Kim, Jin-Hoi, additional, and Cho, Ssang-Goo, additional

Published
2014
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16. Alpha-Fetoprotein, Identified as a Novel Marker for the Antioxidant Effect of Placental Extract, Exhibits Synergistic Antioxidant Activity in the Presence of Estradiol

Author

Choi, Hye Yeon, primary, Kim, Seung Woo, additional, Kim, BongWoo, additional, Lee, Hae Na, additional, Kim, Su-Jeong, additional, Song, Minjung, additional, Kim, Sol, additional, Kim, Jungho, additional, Kim, Young Bong, additional, Kim, Jin-Hoi, additional, and Cho, Ssang-Goo, additional

Published
2014
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