186 results on '"Kilty, Iain"'
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2. The development of differentiated cell lines using a thermolabile form of SV40 Large T Antigen
3. Corrigendum to “Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling” [International Journal of Cardiology 167 (2013) 2630–2637]
4. The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial
5. TAK1 selective inhibition: state of the art and future opportunities
6. Cigarette smoke induces proinflammatory cytokine release by activation of NF-[kappa]B and posttranslational modifications of histone deacetylase in macrophages
7. TAK1 Inhibition in the DFG-Out Conformation
8. LPS challenge in healthy subjects: An investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2
9. Chronic Obstructive Pulmonary Disease-Specific Gene Expression Signatures of Alveolar Macrophages as well as Peripheral Blood Monocytes Overlap and Correlate with Lung Function
10. Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects
11. MOESM1 of Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects
12. Gene Expression and Immunolocalization of 15-Lipoxygenase Isozymes in the Airway Mucosa of Smokers with Chronic Bronchitis
13. Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages
14. PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor
15. The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition
16. Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study
17. The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures
18. Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline
19. Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists
20. Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function
21. Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function
22. The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro
23. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
24. Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid
25. Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis
26. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
27. Glycogen synthase kinase-3 beta modulation of glucocorticoid responsiveness in COPD
28. The role of phosphodiesterase 4 in the pathophysiology of atopic dermatitis and the perspective for its inhibition.
29. Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction
30. A novel flow cytometric based method to measure kinase inhibition in sputum from COPD subjects
31. Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium
32. Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD
33. 18F-Fluorodeoxyglucose (18FDG) PET pulmonary imaging: Role in detecting vascular inflammation
34. 18F-fluorodeoxyglucose (18FDG) PET pulmonary imaging in COPD
35. Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects
36. JAK–STAT pathway activation in COPD
37. Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells
38. Fragment based discovery of a novel and selective PI3 kinase inhibitor
39. Kinases as Anti-Inflammatory Targets for Respiratory Disease
40. Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling
41. Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling
42. Mitochondrial Superoxide Generation Enhances P2X7R-Mediated Loss of Cell Surface CD62L on Naive Human CD4+ T Lymphocytes
43. Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling
44. Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.
45. Effects Of Oral And Inhaled P38 Inhibitors On Sputum Inflammatory Markers Following Whole Lung Lipopolysaccharide (LPS) Challenge In Healthy Subjects
46. The Role Of The JAK/STAT Pathway In A Lipopolysaccharide-Induced Mouse Model Of Acute Lung Injury
47. The Effect Of A Novel Chemical Probe For BET Bromodomains (JQ1/SGCBD01) Upon Inflammation And Proliferation In Human ASM Cells
48. NF-kappaB/IKK-2 Signalling Is Not Required For Cigarette Smoke-Induced Airway Inflammation
49. Potential Role Of Sphingosine Mono-Phosphate In Corticosteroid Resistant Airway Inflammation
50. Activation Of The JAK/STAT Pathway In The Lungs Of COPD Patients
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