127 results on '"Killerby, Marie E."'
Search Results
2. The role and limitations of electronic medical records versus patient interviews for determining symptoms, underlying comorbidities, and medication usage for patients with COVID-19
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Soto, Raymond A, primary, Vahey, Grace M, additional, Marshall, Kristen E, additional, McDonald, Emily, additional, Herlihy, Rachel, additional, Chun, Helen M, additional, Killerby, Marie E, additional, Kawasaki, Breanna, additional, Midgley, Claire M, additional, Alden, Nisha B, additional, Tate, Jacqueline E, additional, Staples, J Erin, additional, and Investigation Team, Colorado, additional
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- 2024
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3. Behaviors Associated With Household Transmission of SARS-CoV-2 in California and Colorado, January 2021–April 2021
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Namageyo-Funa, Apophia, Ruffin, Jasmine D., Killerby, Marie E., Jalloh, Mohamed F., Scott, Colleen, Lindell, Kristine, Silver, Margaret, Matanock, Almea, Soto, Raymond A., Donnelly, Marisa A.P., Schwartz, Noah G., Chuey, Meagan R., Chu, Victoria T., Beatty, Mark E., Totten, Sarah Elizabeth, Hudziec, Meghan M., Tate, Jacqueline E., Kirking, Hannah L., and Hsu, Christopher H.
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- 2022
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4. Association of Shared Living Spaces and COVID-19 in University Students, Wisconsin, USA, 2020
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Bigouette, John Paul, Ford, Laura, Segaloff, Hannah E., Langolf, Kimberly, Kahrs, Juliana, Zochert, Tara, Tate, Jacqueline E., Gieryn, Douglas, Kirking, Hannah L., Westergaard, Ryan P., and Killerby, Marie E.
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Wisconsin -- Health aspects ,Epidemics -- Statistics -- Risk factors -- United States ,College students -- Statistics -- Health aspects -- Homes and haunts ,Student housing -- Statistics -- Health aspects ,Health - Abstract
In 2020, multiple outbreaks of coronavirus disease (COVID-19), the disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were documented in institutions of higher education (IHEs; e.g., [...]
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- 2021
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5. Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA, August-October 2020
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Currie, Dustin W., Moreno, Gage K., Delahoy, Miranda J., Pray, Ian W., Jovaag, Amanda, Braun, Katarina M., Cole, Devlin, Shechter, Todd, Fajardo, Geroncio C., Griggs, Carol, Yandell, Brian S., Goldstein, Steve, Bushman, Dena, Segaloff, Hannah E., Kelly, G. Patrick, Pitts, Collin, Lee, Christine, Grande, Katarina M., Kita-Yarbro, Amanda, Grogan, Brittany, Mader, Sara, Baggott, Jake, Bateman, Allen C., Westergaard, Ryan P., Tate, Jacqueline E., Friedrich, Thomas C., Kirking, Hannah L., O'Connor, David H., and Killerby, Marie E.
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Wisconsin -- Health aspects ,Epidemics -- Control -- Statistics -- United States ,Public universities and colleges -- Safety and security measures -- Health aspects ,Disease transmission -- Control ,Health ,University of Wisconsin -- Safety and security measures -- Health aspects - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), can spread rapidly within congregate settings, including institutions of higher education (IHEs) (1,2). During August-December 2020, as IHEs [...]
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- 2021
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6. Patterns of Virus Exposure and Presumed Household Transmission among Persons with Coronavirus Disease, United States, January--April 2020
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Burke, Rachel M., Calderwood, Laura, Killerby, Marie E., Ashworth, Candace E., Berns, Abby L., Brennan, Skyler, Bressler, Jonathan M., Morano, Laurel Harduar, Lewis, Nathaniel M., Markus, Tiffanie M., Newton, Suzanne M., Read, Jennifer S., Rissman, Tamara, Taylor, Joanne, Tate, Jacqueline E., and Midgley, Claire M.
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Households -- Statistics -- Health aspects ,Disease transmission -- Statistics -- Risk factors ,Health - Abstract
Coronavirus disease (COVID-19) was first identified in Wuhan, China, in December 2019 (1). The first reported case in the United States was identified in January 2020 (2); by mid-March, cases [...]
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- 2021
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7. Symptom Profiles of a Convenience Sample of Patients with COVID-19 — United States, January–April 2020
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Case Investigation Form Working Group, Burke, Rachel M., Killerby, Marie E., Newton, Suzanne, Ashworth, Candace E., Berns, Abby L., Brennan, Skyler, Bressler, Jonathan M., Bye, Erica, Crawford, Richard, Morano, Laurel Harduar, Lewis, Nathaniel M., Markus, Tiffanie M., Read, Jennifer S., Rissman, Tamara, Taylor, Joanne, Tate, Jacqueline E., and Midgley, Claire M.
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- 2020
8. Exposures Before Issuance of Stay-at-Home Orders Among Persons with Laboratory-Confirmed COVID-19 — Colorado, March 2020
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Colorado Investigation Team, Marshall, Kristen, Vahey, Grace M., McDonald, Emily, Tate, Jacqueline E., Herlihy, Rachel, Midgley, Claire M., Kawasaki, Breanna, Killerby, Marie E., Alden, Nisha B., and Staples, J. Erin
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- 2020
9. Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020
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CDC COVID-19 Response Clinical Team, Killerby, Marie E., Link-Gelles, Ruth, Haight, Sarah C., Schrodt, Caroline A., England, Lucinda, Gomes, Danica J., Shamout, Mays, Pettrone, Kristen, O’Laughlin, Kevin, Kimball, Anne, Blau, Erin F., Burnett, Eleanor, Ladva, Chandresh N., Szablewski, Christine M., Tobin-D’Angelo, Melissa, Oosmanally, Nadine, Drenzek, Cherie, Murphy, David J., Blum, James M., Hollberg, Julie, Lefkove, Benjamin, Brown, Frank W., Shimabukuro, Tom, Midgley, Claire M., and Tate, Jacqueline E.
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- 2020
10. Characteristics and Risk Factors of Hospitalized and Nonhospitalized COVID-19 Patients, Atlanta, Georgia, USA, March-April 2020
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Pettrone, Kristen, Burnett, Eleanor, Link-Gelles, Ruth, Haight, Sarah C., Schrodt, Caroline, England, Lucinda, Gomes, Danica J., Shamout, Mays, O'Laughlin, Kevin, Kimball, Anne, Blau, Erin F., Ladva, Chandresh N., Szablewski, Christine M., Tobin-DAngelo, Melissa, Oosmanally, Nadine, Drenzek, Cherie, Browning, Sean D., Bruce, Beau B., Silva, Juliana da, Gold, Jeremy A.W., Jackson, Brendan R., Morris, Sapna Bamrah, Natarajan, Pavithra, Fanfair, Robyn Neblett, Patel, Priti R., Rogers- Brown, Jessica, Rossow, John, Wong, Karen K., Murphy, David J., Blum, James M., Hollberg, Julie, Lefkove, Benjamin, Brown, Frank W., Shimabukuro, Tom, Midgley, Claire M., Tate, Jacqueline E., and Killerby, Marie E.
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Epidemics -- Risk factors -- Patient outcomes -- Demographic aspects -- United States ,Health - Abstract
Information about care-seeking behavior, symptom duration, and risk factors for progression to severe illness in nonhospitalized patients with coronavirus disease (COVID-19) aids in resource planning, disease identification, risk stratification, and [...]
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- 2021
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11. Symptom Profiles and Progression in Hospitalized and Nonhospitalized Patients with Coronavirus Disease, Colorado, USA, 2020
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Vahey, Grace M., Marshall, Kristen E., McDonald, Emily, Martin, Stacey W., Tate, Jacqueline E., Midgley, Claire M., Killerby, Marie E., Kawasaki, Breanna, Herlihy, Rachel K., Alden, Nisha B., and Staples, J. Erin
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Epidemics -- Control -- United States ,Prevalence studies (Epidemiology) -- Management ,Public health administration -- Evaluation ,Company business management ,Health - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), was first detected in China in December 2019 (2,2). Within 1 month, COVID-19 cases were reported [...]
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- 2021
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12. Human parainfluenza virus circulation, United States, 2011–2019
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DeGroote, Nicholas P., Haynes, Amber K., Taylor, Calli, Killerby, Marie E., Dahl, Rebecca M., Mustaquim, Desiree, Gerber, Susan I., and Watson, John T.
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- 2020
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13. Severe Acute Respiratory Syndrome Coronavirus 2 Prevalence, Seroprevalence, and Exposure among Evacuees from Wuhan, China, 2020
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Hallowell, Benjamin D., Carlson, Christina M., Jacobs, Jesica R., Pomeroy, Mary, Steinberg, Jonathan, Tenforde, Mark W., McDonald, Emily, Foster, Loretta, Feldstein, Leora R., Rolfes, Melissa A., Haynes, Amber, Abedi, Glen R., Odongo, George S., Saruwatari, Kim, Rider, Errin C., Douville, Gina, Bhakta, Neenaben, Maniatis, Panagiotis, Lindstrom, Stephen, Thornburg, Natalie J., Lu, Xiaoyan, Whitaker, Brett L., Kamili, Shifaq, Sakthivel, Senthilkumar K., Wang, Lijuan, Malapati, Lakshmi, Murray, Janna R., Lynch, Brian, Cetron, Martin, Brown, Clive, Roohi, Shahrokh, Rotz, Lisa, Borntrager, Denise, Ishii, Kenta, Moser, Kathleen, Rasheed, Mohammad, Freeman, Brandi, Lester, Sandra, Corbett, Kizzmekia S., Abiona, Olubukola M., Hutchinson, Geoffrey B., Graham, Barney S., Pesik, Nicki, Mahon, Barbara, Braden, Christopher, Behravesh, Casey Barton, Stewart, Rebekah, Knight, Nancy, Hall, Aron J., and Killerby, Marie E.
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Quarantine -- Health aspects ,Severe acute respiratory syndrome -- Health aspects ,Coronaviruses -- Health aspects ,COVID-19 -- Health aspects ,Health - Abstract
On December 31, 2019, a cluster of severe pneumonia cases in Wuhan, Hubei Province, China, was reported (1). On January 7, 2020, a novel coronavirus, severe acute respiratory syndrome coronavirus [...]
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- 2020
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14. Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States
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Kujawski, Stephanie A., Wong, Karen K., Collins, Jennifer P., Epstein, Lauren, Killerby, Marie E., Midgley, Claire M., and Abedi, Glen R.
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Biological sciences ,Health - Abstract
Data on the detailed clinical progression of COVID-19 in conjunction with epidemiological and virological characteristics are limited. In this case series, we describe the first 12 US patients confirmed to have COVID-19 from 20 January to 5 February 2020, including 4 patients described previously.sup.1-3. Respiratory, stool, serum and urine specimens were submitted for SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) testing, viral culture and whole genome sequencing. Median age was 53 years (range: 21-68); 8 patients were male. Common symptoms at illness onset were cough (n = 8) and fever (n = 7). Patients had mild to moderately severe illness; seven were hospitalized and demonstrated clinical or laboratory signs of worsening during the second week of illness. No patients required mechanical ventilation and all recovered. All had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2-3 weeks after illness onset. Lowest real-time PCR with reverse transcription cycle threshold values in the upper respiratory tract were often detected in the first week and SARS-CoV-2 was cultured from early respiratory specimens. These data provide insight into the natural history of SARS-CoV-2. Although infectiousness is unclear, highest viral RNA levels were identified in the first week of illness. Clinicians should anticipate that some patients may worsen in the second week of illness. Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention., Author(s): Stephanie A. Kujawski [sup.1] [sup.1] , Karen K. Wong [sup.1] , Jennifer P. Collins [sup.1] , Lauren Epstein [sup.1] , Marie E. Killerby [sup.1] , Claire M. Midgley [sup.1] [...]
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- 2020
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15. Middle East Respiratory Syndrome Coronavirus Transmission
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Killerby, Marie E., Biggs, Holly M., Midgley, Claire M., Gerber, Susan I., and Watson, John T.
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Diseases -- Middle East -- Saudi Arabia -- United Arab Emirates ,Middle East respiratory syndrome ,Disease transmission ,Backup software ,Infection ,Public health ,Respiratory tract diseases ,Public health movements ,Health ,World Health Organization - Abstract
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) was first detected in Saudi Arabia in 2012 (1). To date, >2,400 cases globally have been reported to the World Health Organization (WHO), [...]
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- 2020
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16. Human coronavirus circulation in the United States 2014–2017
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Killerby, Marie E., Biggs, Holly M., Haynes, Amber, Dahl, Rebecca M., Mustaquim, Desiree, Gerber, Susan I., and Watson, John T.
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- 2018
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17. Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014-2017
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Khudhair, Ahmed, Killerby, Marie E., Mulla, Mariam Al, Elkheir, Kheir Abou, Ternanni, Wassim, Bandar, Zyad, Weber, Stefan, Khoury, Mary, Donnelly, George, Muhairi, Salama Al, Khalafalla, Abdelmalik I., Trivedi, Suvang, Tamin, Azaibi, Thornburg, Natalie J., Watson, John T., Gerber, Susan I., Hosani, Farida Al, and Hall, Aron J.
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United States. Centers for Disease Control and Prevention ,Meat industry -- International economic relations -- Health aspects ,Workers -- Surveys -- Health aspects ,Middle East respiratory syndrome -- Health aspects ,Slaughterhouses ,Beef cattle ,Infection ,Health ,World Health Organization - Abstract
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) was first identified as a cause of severe respiratory tract infections in Saudi Arabia in October 2012 (1). The clinical spectrum of MERS [...]
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- 2019
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18. Epidemic Keratoconjunctivitis Outbreak Associated with Human Adenovirus Type 8 — U.S. Virgin Islands, June–November 2016
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Killerby, Marie E., Stuckey, Matthew J., Guendel, Irene, Sakthivel, Senthilkumar, Lu, Xiaoyan, Erdman, Dean D., Schneider, Eileen, Fagan, Ryan, Davis, Michelle S., Watson, John T., Gerber, Susan I., Biggs, Holly M., and Ellis, Esther M.
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- 2017
19. Results from a Test-to-Release from Isolation Strategy Among Fully Vaccinated National Football League Players and Staff Members with COVID-19--United States, December 14-19, 2021
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Mack, Christina D., Wasserman, Erin B., Killerby, Marie E., Soelaeman, Rieza H., Hall, Aron J., MacNeil, Adam, Anderson, Deverick J., Walton, Patti, Pasha, Saamir, Myers, Emily, O'Neal, Catherine S., Hostler, Christopher J., Singh, Navdeep, Mayer, Thom, and Sills, Allen
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Vaccination -- Health aspects ,Football (Professional) -- Health aspects ,Health - Abstract
During December 2021, the United States experienced a surge in COVID-19 cases, coinciding with predominance of the SARS-CoV-2 B. 1.1.529 (Omicron) variant (1). During this surge, the National Football League [...]
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- 2022
20. 92. Incidence of Adenovirus Respiratory Infection and Coinfection in a Longitudinal Birth Cohort
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Gailani, Adam E, primary, Teoh, Zheyi, additional, Conrey, Shannon C, additional, Burke, Rachel M, additional, Cline, Allison R, additional, Killerby, Marie E, additional, Lu, Xiaoyan, additional, Mattison, Claire, additional, McNeal, Monica, additional, Morrow, Ardythe L, additional, Payne, Daniel C, additional, and Staat, Mary A, additional
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- 2022
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21. SARS-CoV-2 infection risk among vaccinated and unvaccinated household members during the Alpha variant surge – Denver, Colorado, and San Diego, California, January–April 2021
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McCormick, David W., primary, Konkle, Stacey L., additional, Magleby, Reed, additional, Chakrabarti, Ayan K., additional, Cherney, Blake, additional, Lindell, Kristine, additional, Namageyo-Funa, Apophia, additional, Visser, Susanna, additional, Soto, Raymond A., additional, Donnelly, Marisa A.P., additional, Stringer, Ginger, additional, Austin, Brett, additional, Beatty, Mark E., additional, Stous, Sarah, additional, Albanese, Bernadette A., additional, Chu, Victoria T., additional, Chuey, Meagan, additional, Dietrich, Elizabeth A., additional, Drobeniuc, Jan, additional, Folster, Jennifer M., additional, Killerby, Marie E., additional, Lehman, Jennifer A., additional, McDonald, Eric C., additional, Ruffin, Jasmine, additional, Schwartz, Noah G., additional, Sheldon, Sarah W., additional, Sleweon, Sadia, additional, Thornburg, Natalie J., additional, Hughes, Laura J., additional, Petway, Marla, additional, Tong, Suxiang, additional, Whaley, Melissa J., additional, Kirking, Hannah L., additional, Tate, Jacqueline E., additional, Hsu, Christopher H., additional, and Matanock, Almea, additional
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- 2022
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22. Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
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Waltenburg, Michelle A., primary, Whaley, Melissa J., additional, Chancey, Rebecca J., additional, Donnelly, Marisa A.P., additional, Chuey, Meagan R., additional, Soto, Raymond, additional, Schwartz, Noah G., additional, Chu, Victoria T., additional, Sleweon, Sadia, additional, McCormick, David W., additional, Uehara, Anna, additional, Retchless, Adam C., additional, Tong, Suxiang, additional, Folster, Jennifer M., additional, Petway, Marla, additional, Thornburg, Natalie J., additional, Drobeniuc, Jan, additional, Austin, Brett, additional, Hudziec, Meghan M., additional, Stringer, Ginger, additional, Albanese, Bernadette A., additional, Totten, Sarah E., additional, Matzinger, Shannon R., additional, Staples, J. Erin, additional, Killerby, Marie E., additional, Hughes, Laura J., additional, Matanock, Almea, additional, Beatty, Mark, additional, Tate, Jacqueline E., additional, Kirking, Hannah L., additional, Hsu, Christopher H., additional, Alford, Alexis, additional, Baird, Samuel, additional, Bankers, Laura, additional, Bello, Jazmin, additional, Bolcen, Shanna, additional, Browning, Peter, additional, Cook, Peter W., additional, David, Ebenezer, additional, Harcourt, Jennifer L., additional, Hareland, Geir, additional, Hetherington-Rauth, Molly C., additional, Ir, Diana, additional, Jain, Shilpi, additional, Jia, Tao Lily, additional, Johnson, Ralen, additional, Kelleher, Anna, additional, Kim, Gimin, additional, Li, Yan, additional, Lynch, Brian, additional, Mallal, Daniel, additional, Maniatis, Panagiotis, additional, Marine, Rachel, additional, Medrzycki, Magdalena, additional, Metz, John M., additional, Montmayeur, Anna Maria, additional, Moss, Kimberly M., additional, Justin Ng, Han Jia, additional, Nyugen, Van, additional, Ortiz, Kristina, additional, Paden, Clinton R., additional, Park, So Hee, additional, Queen, Krista, additional, Rossheim, Alexandria E.B., additional, Semenova, Vera, additional, Shepard, Samuel S., additional, Tamin, Azaibi, additional, Tao, Ying, additional, Tejada-Strop, Alexandra, additional, Wong, Phili, additional, Zellner, Briana, additional, and Zhang, Jing, additional
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- 2022
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23. Examination of Common Coronavirus Antibodies in SARS-CoV-2-Infected and Uninfected Participants in a Household Transmission Investigation
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Stumpf, Megan M, primary, Freeman, Brandi, additional, Mills, Lisa, additional, Lester, Sandra, additional, Chu, Victoria T, additional, Kirking, Hannah L, additional, Thornburg, Natalie J, additional, and Killerby, Marie E, additional
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- 2022
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24. Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection
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Chu, Victoria T., Schwartz, Noah G., Donnelly, Marisa A. P., Chuey, Meagan R., Soto, Raymond, Yousaf, Anna R., Schmitt-Matzen, Emily N., Sleweon, Sadia, Ruffin, Jasmine, Thornburg, Natalie, Harcourt, Jennifer L., Tamin, Azaibi, Kim, Gimin, Folster, Jennifer M., Hughes, Laura J., Tong, Suxiang, Stringer, Ginger, Albanese, Bernadette A., Totten, Sarah E., Hudziec, Meghan M., Matzinger, Shannon R., Dietrich, Elizabeth A., Sheldon, Sarah W., Stous, Sarah, McDonald, Eric C., Austin, Brett, Beatty, Mark E., Staples, J. Erin, Killerby, Marie E., Hsu, Christopher H., Tate, Jacqueline E., Kirking, Hannah L., and Matanock, Almea
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Adult ,Cohort Studies ,Reverse Transcriptase Polymerase Chain Reaction ,SARS-CoV-2 ,Internal Medicine ,COVID-19 ,Humans ,Female ,Prospective Studies ,Child ,Sensitivity and Specificity ,Original Investigation - Abstract
ImportanceAs self-collected home antigen tests become widely available, a better understanding of their performance during the course of SARS-CoV-2 infection is needed.ObjectiveTo evaluate the diagnostic performance of home antigen tests compared with reverse transcription–polymerase chain reaction (RT-PCR) and viral culture by days from illness onset, as well as user acceptability.Design, Setting, and ParticipantsThis prospective cohort study was conducted from January to May 2021 in San Diego County, California, and metropolitan Denver, Colorado. The convenience sample included adults and children with RT-PCR–confirmed infection who used self-collected home antigen tests for 15 days and underwent at least 1 nasopharyngeal swab for RT-PCR, viral culture, and sequencing.ExposuresSARS-CoV-2 infection.Main Outcomes and MeasuresThe primary outcome was the daily sensitivity of home antigen tests to detect RT-PCR–confirmed cases. Secondary outcomes included the daily percentage of antigen test, RT-PCR, and viral culture results that were positive, and antigen test sensitivity compared with same-day RT-PCR and cultures. Antigen test use errors and acceptability were assessed for a subset of participants.ResultsThis study enrolled 225 persons with RT-PCR–confirmed infection (median [range] age, 29 [1-83] years; 117 female participants [52%]; 10 [4%] Asian, 6 [3%] Black or African American, 50 [22%] Hispanic or Latino, 3 [1%] Native Hawaiian or Other Pacific Islander, 145 [64%] White, and 11 [5%] multiracial individuals) who completed 3044 antigen tests and 642 nasopharyngeal swabs. Antigen test sensitivity was 50% (95% CI, 45%-55%) during the infectious period, 64% (95% CI, 56%-70%) compared with same-day RT-PCR, and 84% (95% CI, 75%-90%) compared with same-day cultures. Antigen test sensitivity peaked 4 days after illness onset at 77% (95% CI, 69%-83%). Antigen test sensitivity improved with a second antigen test 1 to 2 days later, particularly early in the infection. Six days after illness onset, antigen test result positivity was 61% (95% CI, 53%-68%). Almost all (216 [96%]) surveyed individuals reported that they would be more likely to get tested for SARS-CoV-2 infection if home antigen tests were available over the counter.Conclusions and RelevanceThe results of this cohort study of home antigen tests suggest that sensitivity for SARS-CoV-2 was moderate compared with RT-PCR and high compared with viral culture. The results also suggest that symptomatic individuals with an initial negative home antigen test result for SARS-CoV-2 infection should test again 1 to 2 days later because test sensitivity peaked several days after illness onset and improved with repeated testing.
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- 2022
25. Seasonality of Common Human Coronaviruses in the United States, 2014-2021
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Shah, Melisa M., primary, Winn, Amber, additional, Dahl, Rebecca M., additional, Kniss, Krista L., additional, Silk, Benjamin J., additional, and Killerby, Marie E., additional
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- 2022
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26. Twelve-month Follow-up of Early COVID-19 Cases in the United States: Cellular and Humoral Immune Longevity
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Shah, Melisa M, primary, Rasheed, Mohammad Ata Ur, additional, Harcourt, Jennifer L, additional, Abedi, Glen R, additional, Stumpf, Megan M, additional, Kirking, Hannah L, additional, Tamin, Azaibi, additional, Mills, Lisa, additional, Armstrong, Madeleine, additional, Salvatore, Phillip P, additional, Surasi, Krishna, additional, Scott, Sarah E, additional, Killerby, Marie E, additional, Briggs-Hagen, Melissa, additional, Saydah, Sharon, additional, Tate, Jacqueline E, additional, Fry, Alicia M, additional, Hall, Aron J, additional, Thornburg, Natalie J, additional, and Midgley, Claire M, additional
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- 2022
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27. Symptom Profiles of a Convenience Sample of Patients with COVID-19 — United States, January–April 2020
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Burke, Rachel M., Killerby, Marie E., Newton, Suzanne, Ashworth, Candace E., Berns, Abby L., Brennan, Skyler, Bressler, Jonathan M., Bye, Erica, Crawford, Richard, Harduar Morano, Laurel, Lewis, Nathaniel M., Markus, Tiffanie M., Read, Jennifer S., Rissman, Tamara, Taylor, Joanne, Tate, Jacqueline E., Midgley, Claire M., Balachandran, Neha, Dahl, Rebecca M., Dott, Mary, Gilani, Zunera, Grober, Aaron, Leung, Jessica, O’Hegarty, Michelle, Person, John, Ricaldi, Jessica N., Roth, Nicole M., Sejvar, James J., Shimabukuro, Tom, Tran, Cuc H., Watson, John T., Whitham, Hilary, Chiou, Howard, Clogher, Paula, Duca, Lindsey M., Dratch, Alissa, Feldpausch, Amanda, Fill, Mary-Margaret, Ghinai, Isaac, Holshue, Michelle, Scott, Sarah, and Westergaard, Ryan
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myalgia ,Male ,Pediatrics ,Health (social science) ,Epidemiology ,Health, Toxicology and Mutagenesis ,01 natural sciences ,Severity of Illness Index ,0302 clinical medicine ,Health Information Management ,Pandemic ,030212 general & internal medicine ,Full Report ,Young adult ,Child ,Aged, 80 and over ,General Medicine ,Middle Aged ,Hospitalization ,Child, Preschool ,Chills ,Female ,medicine.symptom ,Symptom Assessment ,Coronavirus Infections ,Adult ,medicine.medical_specialty ,Adolescent ,Fever ,Pneumonia, Viral ,MEDLINE ,03 medical and health sciences ,Betacoronavirus ,Young Adult ,Severity of illness ,medicine ,Humans ,0101 mathematics ,Pandemics ,Aged ,business.industry ,SARS-CoV-2 ,Public health ,010102 general mathematics ,COVID-19 ,Infant ,medicine.disease ,United States ,Pneumonia ,Dyspnea ,Cough ,business - Abstract
Coronavirus disease 2019 (COVID-19) was first detected in the United States in January 2020 (1), and by mid-July, approximately 3.4 million cases had been reported in the United States (2). Information about symptoms among U.S. COVID-19 patients is limited, especially among nonhospitalized patients. To better understand symptom profiles of patients with laboratory-confirmed COVID-19 in the United States, CDC used an optional questionnaire to collect detailed information on a convenience sample of COVID-19 patients from participating states. Symptom data were analyzed by age group, sex, hospitalization status, and symptom onset date relative to expansion of testing guidelines on March 8, 2020 (3). Among 164 symptomatic patients with known onset during January 14-April 4, 2020, a total of 158 (96%) reported fever, cough, or shortness of breath. Among 57 hospitalized adult patients (aged ≥18 years), 39 (68%) reported all three of these symptoms, compared with 25 (31%) of the 81 nonhospitalized adult patients. Gastrointestinal (GI) symptoms and other symptoms, such as chills, myalgia, headache, and fatigue, also were commonly reported, especially after expansion of testing guidelines. To aid prompt recognition of COVID-19, clinicians and public health professionals should be aware that COVID-19 can cause a wide variety of symptoms.
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- 2020
28. Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020
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Killerby, Marie E., Link-Gelles, Ruth, Haight, Sarah C., Schrodt, Caroline A., England, Lucinda, Gomes, Danica J., Shamout, Mays, Pettrone, Kristen, O'Laughlin, Kevin, Kimball, Anne, Blau, Erin F., Burnett, Eleanor, Ladva, Chandresh N., Szablewski, Christine M., Tobin-D’Angelo, Melissa, Oosmanally, Nadine, Drenzek, Cherie, Murphy, David J., Blum, James M., Hollberg, Julie, Lefkove, Benjamin, Brown, Frank W., Shimabukuro, Tom, Midgley, Claire M., Tate, Jacqueline E., Browning, Sean D., Bruce, Beau B., da Silva, Juliana, Gold, Jeremy A.W., Jackson, Brendan R., Bamrah Morris, Sapna, Natarajan, Pavithra, Neblett Fanfair, Robyn, Patel, Priti R., Rogers-Brown, Jessica, Rossow, John, and Wong, Karen K.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Health (social science) ,Georgia ,Adolescent ,Epidemiology ,Health, Toxicology and Mutagenesis ,Pneumonia, Viral ,Disease ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Health Information Management ,Risk Factors ,030225 pediatrics ,Acute care ,Diabetes mellitus ,medicine ,Outpatient clinic ,Humans ,030212 general & internal medicine ,Full Report ,Young adult ,Cities ,Pandemics ,Aged ,business.industry ,Medical record ,COVID-19 ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Hospitalization ,Emergency medicine ,Female ,business ,Coronavirus Infections ,Kidney disease - Abstract
The first reported U.S. case of coronavirus disease 2019 (COVID-19) was detected in January 2020 (1). As of June 15, 2020, approximately 2 million cases and 115,000 COVID-19-associated deaths have been reported in the United States.* Reports of U.S. patients hospitalized with SARS-CoV-2 infection (the virus that causes COVID-19) describe high proportions of older, male, and black persons (2-4). Similarly, when comparing hospitalized patients with catchment area populations or nonhospitalized COVID-19 patients, high proportions have underlying conditions, including diabetes mellitus, hypertension, obesity, cardiovascular disease, chronic kidney disease, or chronic respiratory disease (3,4). For this report, data were abstracted from the medical records of 220 hospitalized and 311 nonhospitalized patients aged ≥18 years with laboratory-confirmed COVID-19 from six acute care hospitals and associated outpatient clinics in metropolitan Atlanta, Georgia. Multivariable analyses were performed to identify patient characteristics associated with hospitalization. The following characteristics were independently associated with hospitalization: age ≥65 years (adjusted odds ratio [aOR] = 3.4), black race (aOR = 3.2), having diabetes mellitus (aOR = 3.1), lack of insurance (aOR = 2.8), male sex (aOR = 2.4), smoking (aOR = 2.3), and obesity (aOR = 1.9). Infection with SARS-CoV-2 can lead to severe outcomes, including death, and measures to protect persons from infection, such as staying at home, social distancing (5), and awareness and management of underlying conditions should be emphasized for those at highest risk for hospitalization with COVID-19. Measures that prevent the spread of infection to others, such as wearing cloth face coverings (6), should be used whenever possible to protect groups at high risk. Potential barriers to the ability to adhere to these measures need to be addressed.
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- 2020
29. 1331. Seasonality of Common Human Coronaviruses in the United States, 2014-2021
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Shah, Melisa, primary, Haynes, Amber K, additional, Dahl, Rebecca M, additional, Kniss, Krista, additional, Silk, Benjamin, additional, and Killerby, Marie E, additional
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- 2021
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30. 373. Household transmission of SARS-CoV-2 B.1.1.7 lineage –2 U.S. States, 2021
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Soto, Raymond, primary, Hsu, Christoper, additional, Chuey, Meagan, additional, Donnelly, Marisa, additional, Chu, Victoria T, additional, Schwartz, Noah G, additional, Tong, Suxiang, additional, Thornburg, Natalie J, additional, Killerby, Marie E, additional, Staples, J Erin, additional, Kirking, Hannah L, additional, Tate, Jacqueline, additional, Matanock, Almea, additional, Stringer, Ginger, additional, Albanese, Bernadette, additional, Beatty, Mark, additional, and Hughes, Laura J, additional
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- 2021
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31. Seasonality of Common Human Coronaviruses, United States, 2014-20211.
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Shah, Melisa M., Winn, Amber, Dahl, Rebecca M., Kniss, Krista L., Silk, Benjamin J., and Killerby, Marie E.
- Abstract
The 4 common types of human coronaviruses (HCoVs)-2 alpha (HCoV-NL63 and HCoV-229E) and 2 beta (HCoV-HKU1 and HCoV-OC43)-generally cause mild upper respiratory illness. Seasonal patterns and annual variation in predominant types of HCoVs are known, but parameters of expected seasonality have not been defined. We defined seasonality of HCoVs during July 2014-November 2021 in the United States by using a retrospective method applied to National Respiratory and Enteric Virus Surveillance System data. In the 6 HCoV seasons before 2020-21, season onsets occurred October 21-November 12, peaks January 6-February 13, and offsets April 18-June 27; most (>93%) HCoV detection was within the defined seasonal onsets and offsets. The 2020-21 HCoV season onset was 11 weeks later than in prior seasons, probably associated with COVID-19 mitigation efforts. Better definitions of HCoV seasonality can be used for clinical preparedness and for determining expected patterns of emerging coronaviruses. [ABSTRACT FROM AUTHOR]
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- 2022
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32. Application of a Serial Antigen-Based Testing Strategy for Severe Acute Respiratory Syndrome Coronavirus 2 and Student Adherence in a University Setting: Wisconsin, October–November 2020
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Bigouette, John Paul, primary, Ford, Laura, additional, Pray, Ian, additional, Langolf, Kimberly, additional, Kahrs, Juliana, additional, Zochert, Tara, additional, Tate, Jacqueline E, additional, Gieryn, Douglas, additional, Kirking, Hannah L, additional, Westergaard, Ryan, additional, and Killerby, Marie E, additional
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- 2021
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33. Exposures Before Issuance of Stay-at-Home Orders Among Persons with Laboratory-Confirmed COVID-19 — Colorado, March 2020
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Marshall, Kristen, Vahey, Grace M., McDonald, Emily, Tate, Jacqueline E., Herlihy, Rachel, Midgley, Claire M., Kawasaki, Breanna, Killerby, Marie E., Alden, Nisha B., Staples, J. Erin, Basile, Alison J., Beck, Alyssa R., Boroughs, Karen L., Burns, Paul L., Buschmeier, Cathy L., Byers, Nathaniel M., Calvert, Amanda E., Chambers, Trudy V., Dennis, David T., Fernandez, Mary Ellen, Ficalora, Katherine T., Fitzpatrick, Kelly A., Fleck-Derderian, Shannon, Foster, Erik S., Goodman, Christin H., Heck, Garrett, Huang, Claire Y-H., Lambert, Amy J., Lehane, Aine, Lehman, Jennifer A., Lindell, Kristine, Lindsey, Nicole P., Maes, Sarah E., Nawrocki, Courtney, Nay, Nancy H., Orloski, Kathleen A., Osikowicz, Lynn, Parise, Christina, Perinet, Lara C., Pilgard, Mark A., Powers, Jordan A., Rizzo, María F., Russell, Brandy J., Semcer, Tracey M., Skinner, Benjamin, and Spillane, Melanie
- Subjects
Adult ,Male ,medicine.medical_specialty ,Colorado ,Health (social science) ,Electronic data capture ,Coronavirus disease 2019 (COVID-19) ,Epidemiology ,Health, Toxicology and Mutagenesis ,Pneumonia, Viral ,Population ,01 natural sciences ,Proxy (climate) ,03 medical and health sciences ,0302 clinical medicine ,Health Information Management ,medicine ,Humans ,Full Report ,030212 general & internal medicine ,0101 mathematics ,education ,Pandemics ,Disease surveillance ,education.field_of_study ,Data collection ,business.industry ,Public health ,010102 general mathematics ,COVID-19 ,Environmental Exposure ,General Medicine ,Environmental exposure ,Middle Aged ,Social Isolation ,Family medicine ,Female ,Public Health ,Coronavirus Infections ,Laboratories ,business - Abstract
On March 26, 2020, Colorado instituted stay-at-home orders to reduce community transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). To inform public health messaging and measures that could be used after reopening, persons with laboratory-confirmed COVID-19 during March 9-26 from nine Colorado counties comprising approximately 80% of the state's population† (Adams, Arapahoe, Boulder, Denver, Douglas, El Paso, Jefferson, Larimer, and Weld) were asked about possible exposures to SARS-CoV-2 before implementation of stay-at-home orders. Among 1,738 persons meeting the inclusion criteria§ in the Colorado Electronic Disease Surveillance System, 600 were randomly selected and interviewed using a standardized questionnaire by telephone. Data collection during April 10-30 included information about demographic characteristics, occupations, and selected activities in the 2 weeks preceding symptom onset. During the period examined, SARS-CoV-2 molecular testing was widely available in Colorado; community transmission was documented before implementation of the stay-at-home order. At least three attempts were made to contact all selected patients or their proxy (for deceased patients, minors, and persons unable to be interviewed [e.g., those with dementia]) on at least 2 separate days, at different times of day. Data were entered into a Research Electronic Data Capture (version 9.5.13; Vanderbilt University) database, and descriptive analyses used R statistical software (version 3.6.3; The R Foundation).
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- 2020
34. Shedding of culturable virus, seroconversion, and 6-month follow-up antibody responses in the first 14 confirmed cases of COVID-19 in the United States
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Killerby, Marie E, Ata Ur Rasheed, Mohammad, Tamin, Azaibi, Harcourt, Jennifer L, Abedi, Glen R, Lu, Xiaoyan, Kujawski, Stephanie, Shah, Melisa M, Kirking, Hannah L, Gold, Jeremy A W, Salvatore, Phillip P, Coughlin, Melissa M, Whitaker, Brett, Tate, Jacqueline E, Watson, John T, Lindstrom, Stephen, Hall, Aron J, Fry, Alicia M, Gerber, Susan I, Midgley, Claire M, and Thornburg, Natalie J
- Subjects
AcademicSubjects/MED00290 ,SARS-CoV-2 ,Seroconversion ,Brief Report ,Immunoglobulin G ,Antibody Formation ,Spike Glycoprotein, Coronavirus ,COVID-19 ,Humans ,Antibodies, Viral ,Antibodies, Neutralizing ,United States ,Follow-Up Studies - Abstract
We aimed to characterize presence of culturable virus in clinical specimens during acute illness, and antibody kinetics up to 6 months after symptom onset, among 14 early patients with coronavirus disease 2019 in the United States. We isolated viable severe acute respiratory syndrome coronavirus 2 from real-time reverse-transcription polymerase chain reaction-positive respiratory specimens collected during days 0-8 after onset, but not after. All 13 patients with 2 or more serum specimens developed anti-spike antibodies; 12 developed detectable neutralizing antibodies. We did not isolate virus after detection of neutralizing antibodies. Eight participants provided serum at 6 months after onset; all retained detectable anti-spike immunoglobulin G, and half had detectable neutralizing antibodies. Two participants reported not feeling fully recovered at 6 months.
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- 2021
35. Description of a University COVID-19 Outbreak and Interventions to Disrupt Transmission, Wisconsin, August – October 2020
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Currie, Dustin W., primary, Moreno, Gage K., additional, Delahoy, Miranda J., additional, Pray, Ian W., additional, Jovaag, Amanda, additional, Braun, Katarina M., additional, Cole, Devlin, additional, Shechter, Todd, additional, Fajardo, Geroncio C., additional, Griggs, Carol, additional, Yandell, Brian S., additional, Goldstein, Steve, additional, Bushman, Dena, additional, Segaloff, Hannah E., additional, Kelly, G. Patrick, additional, Pitts, Collin, additional, Lee, Christine, additional, Grande, Katarina M., additional, Kita-Yarbro, Amanda, additional, Grogan, Brittany, additional, Mader, Sara, additional, Baggott, Jake, additional, Bateman, Allen C., additional, Westergaard, Ryan P., additional, Tate, Jacqueline E., additional, Friedrich, Thomas C., additional, Kirking, Hannah L., additional, O’Connor, David H., additional, and Killerby, Marie E., additional
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- 2021
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36. Shedding of Culturable Virus, Seroconversion, and 6-Month Follow-up Antibody Responses in the First 14 Confirmed Cases of Coronavirus Disease 2019 in the United States
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Killerby, Marie E, primary, Ata Ur Rasheed, Mohammed, additional, Tamin, Azaibi, additional, Harcourt, Jennifer L, additional, Abedi, Glen R, additional, Lu, Xiaoyan, additional, Kujawski, Stephanie, additional, Shah, Melisa M, additional, Kirking, Hannah L, additional, Gold, Jeremy A W, additional, Salvatore, Phillip P, additional, Coughlin, Melissa M, additional, Whitaker, Brett, additional, Tate, Jacqueline E, additional, Watson, John T, additional, Lindstrom, Stephen, additional, Hall, Aron J, additional, Fry, Alicia M, additional, Gerber, Susan I, additional, Midgley, Claire M, additional, and Thornburg, Natalie J, additional
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- 2021
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37. First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA
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Ghinai, Isaac, primary, McPherson, Tristan D, additional, Hunter, Jennifer C, additional, Kirking, Hannah L, additional, Christiansen, Demian, additional, Joshi, Kiran, additional, Rubin, Rachel, additional, Morales-Estrada, Shirley, additional, Black, Stephanie R, additional, Pacilli, Massimo, additional, Fricchione, Marielle J, additional, Chugh, Rashmi K, additional, Walblay, Kelly A, additional, Ahmed, N Seema, additional, Stoecker, William C, additional, Hasan, Nausheen F, additional, Burdsall, Deborah P, additional, Reese, Heather E, additional, Wallace, Megan, additional, Wang, Chen, additional, Moeller, Darcie, additional, Korpics, Jacqueline, additional, Novosad, Shannon A, additional, Benowitz, Isaac, additional, Jacobs, Max W, additional, Dasari, Vishal S, additional, Patel, Megan T, additional, Kauerauf, Judy, additional, Charles, E Matt, additional, Ezike, Ngozi O, additional, Chu, Victoria, additional, Midgley, Claire M, additional, Rolfes, Melissa A, additional, Gerber, Susan I, additional, Lu, Xiaoyan, additional, Lindstrom, Stephen, additional, Verani, Jennifer R, additional, Layden, Jennifer E, additional, Brister, Sarah, additional, Goldesberry, Kristin, additional, Hoferka, Stacey, additional, Jovanov, Dejan, additional, Nims, Dawn, additional, Saathoff-Huber, Lori, additional, Hoskin Snelling, Chantel, additional, Adil, Hira, additional, Ali, Raabiah, additional, Andreychak, Elaina, additional, Bemis, Kelley, additional, Frias, Mabel, additional, Quartey-Kumapley, Pearl, additional, Baskerville, Kristin, additional, Murphy, Elizabeth, additional, Murskyj, Emily, additional, Noffsinger, Zach, additional, Vercillo, Janice, additional, Elliott, Apryll, additional, Onwuta, Uche S., additional, Burck, Danielle, additional, Abedi, Glen, additional, Burke, Rachel M., additional, Fagan, Ryan, additional, Farrar, Jennifer, additional, Fry, Alicia M., additional, Hall, Aron J., additional, Haynes, Amber, additional, Hoff, Connor, additional, Kamili, Shifaq, additional, Killerby, Marie E., additional, Kim, Lindsay, additional, Kujawski, Stephanie A., additional, Kuhar, David T., additional, Lynch, Brian, additional, Malapati, Lakshmi, additional, Marlow, Mariel, additional, Murray, Janná R., additional, Rha, Brian, additional, Sakthivel, Senthil Kumar K., additional, Smith-Jeffcoat, Sarah E., additional, Soda, Elizabeth, additional, Wang, Lijuan, additional, Whitaker, Brett L., additional, and Uyeki, Timothy M., additional
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- 2020
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38. Risk factors for hospitalization among persons with COVID-19—Colorado.
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Vahey, Grace M., McDonald, Emily, Marshall, Kristen, Martin, Stacey W., Chun, Helen, Herlihy, Rachel, Tate, Jacqueline E., Kawasaki, Breanna, Midgley, Claire M., Alden, Nisha, Killerby, Marie E., and Staples, J. Erin
- Subjects
COVID-19 ,COVID-19 pandemic ,ELECTRONIC health records ,HOSPITAL care - Abstract
Background: Most current evidence on risk factors for hospitalization because of coronavirus disease 2019 (COVID-19) comes from studies using data abstracted primarily from electronic health records, limited to specific populations, or that fail to capture over-the-counter medications and adjust for potential confounding factors. Properly understanding risk factors for hospitalization will help improve clinical management and facilitate targeted prevention messaging and forecasting and prioritization of clinical and public health resource needs. Objectives: To identify risk factors for hospitalization using patient questionnaires and chart abstraction. Methods: We randomly selected 600 of 1,738 laboratory-confirmed Colorado COVID-19 cases with known hospitalization status and illness onset during March 9–31, 2020. In April 2020, we collected demographics, social history, and medications taken in the 30 days before illness onset via telephone questionnaire and collected underlying medical conditions in patient questionnaires and medical record abstraction. Results: Overall, 364 patients participated; 128 were hospitalized and 236 were non-hospitalized. In multivariable analysis, chronic hypoxemic respiratory failure with oxygen requirement (adjusted odds ratio [aOR] 14.64; 95% confidence interval [CI] 1.45–147.93), taking opioids (aOR 8.05; CI 1.16–55.77), metabolic syndrome (aOR 5.71; CI 1.18–27.54), obesity (aOR 3.35; CI 1.58–7.09), age ≥65 years (aOR 3.22; CI 1.20–7.97), hypertension (aOR 3.14; CI 1.47–6.71), arrhythmia (aOR 2.95; CI 1.00–8.68), and male sex (aOR 2.65; CI 1.44–4.88), were significantly associated with hospitalization. Conclusion: We identified patient characteristics, medications, and medical conditions, including some novel ones, associated with hospitalization. These data can be used to inform clinical and public health resource needs. [ABSTRACT FROM AUTHOR]
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- 2021
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39. Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016–2017
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Killerby, Marie E, primary, Rozwadowski, Faye, additional, Lu, Xiaoyan, additional, Caulcrick-Grimes, Mardea, additional, McHugh, Lisa, additional, Haldeman, Ann Marie, additional, Fulton, Tara, additional, Schneider, Eileen, additional, Sakthivel, Senthilkumar K, additional, Bhatnagar, Julu, additional, Rabeneck, Demi B, additional, Zaki, Sherif, additional, Gerber, Susan I, additional, and Watson, John T, additional
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- 2019
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40. Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017
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Alanazi, Khalid H., primary, Killerby, Marie E., additional, Biggs, Holly M., additional, Abedi, Glen R., additional, Jokhdar, Hani, additional, Alsharef, Ali A., additional, Mohammed, Mutaz, additional, Abdalla, Osman, additional, Almari, Aref, additional, Bereagesh, Samar, additional, Tawfik, Sameh, additional, Alresheedi, Husain, additional, Alhakeem, Raafat F., additional, Hakawi, Ahmed, additional, Alfalah, Haitham, additional, Amer, Hala, additional, Thornburg, Natalie J., additional, Tamin, Azaibi, additional, Trivedi, Suvang, additional, Tong, Suxiang, additional, Lu, Xiaoyan, additional, Queen, Krista, additional, Li, Yan, additional, Sakthivel, Senthilkumar K., additional, Tao, Ying, additional, Zhang, Jing, additional, Paden, Clinton R., additional, Al-Abdely, Hail M., additional, Assiri, Abdullah M., additional, Gerber, Susan I., additional, and Watson, John T., additional
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- 2018
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41. Notes from the Field: Epidemic Keratoconjunctivitis Outbreak Associated with Human Adenovirus Type 8 — U.S. Virgin Islands, June–November 2016
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Killerby,, Marie E., primary, Stuckey,, Matthew J., additional, Guendel,, Irene, additional, Sakthivel,, Senthilkumar, additional, Lu,, Xiaoyan, additional, Erdman,, Dean D., additional, Schneider,, Eileen, additional, Fagan,, Ryan, additional, Davis,, Michelle S., additional, Watson,, John T., additional, Gerber,, Susan I., additional, Biggs,, Holly M., additional, and Ellis,, Esther M., additional
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- 2017
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42. Human Coronavirus Circulation in the USA, 2014‒2017
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Biggs, Holly M, primary, Killerby, Marie E, additional, Haynes, Amber K, additional, Dahl, Rebecca M, additional, Gerber, Susan I, additional, and Watson, John T, additional
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- 2017
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43. Outbreak of Acute Respiratory Illness Associated with Adenovirus Type 4 at the U.S. Naval Academy, 2016.
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Rogers, Amy E., Xiaoyan Lu, Killerby, Marie E., Campbell, Elizabeth, Gallus, Linda, Kamau, Edwin, Froh, Irma B., Nowak, Gosia, Erdman, Dean D., Sakthivel, Senthilkumar K., Gerber, Susan I., Schneider, Eileen, Watson, John T., and Johnson, Lucas A.
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- 2019
44. Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017
- Author
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Alanazi, Khalid H., Killerby, Marie E., Biggs, Holly M., Abedi, Glen R., Jokhdar, Hani, Alsharef, Ali A., Mohammed, Mutaz, Abdalla, Osman, Almari, Aref, Bereagesh, Samar, Tawfik, Sameh, Alresheedi, Husain, Alhakeem, Raafat F., Hakawi, Ahmed, Alfalah, Haitham, Amer, Hala, Thornburg, Natalie J., Tamin, Azaibi, Trivedi, Suvang, Tong, Suxiang, Lu, Xiaoyan, Queen, Krista, Li, Yan, Sakthivel, Senthilkumar K., Tao, Ying, Zhang, Jing, Paden, Clinton R., Al-Abdely, Hail M., Assiri, Abdullah M., Gerber, Susan I., and Watson, John T.
- Abstract
AbstractObjectiveTo investigate a Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak event involving multiple healthcare facilities in Riyadh, Saudi Arabia; to characterize transmission; and to explore infection control implications.DesignOutbreak investigation.SettingCases presented in 4 healthcare facilities in Riyadh, Saudi Arabia: a tertiary-care hospital, a specialty pulmonary hospital, an outpatient clinic, and an outpatient dialysis unit.MethodsContact tracing and testing were performed following reports of cases at 2 hospitals. Laboratory results were confirmed by real-time reverse transcription polymerase chain reaction (rRT-PCR) and/or genome sequencing. We assessed exposures and determined seropositivity among available healthcare personnel (HCP) cases and HCP contacts of cases.ResultsIn total, 48 cases were identified, involving patients, HCP, and family members across 2 hospitals, an outpatient clinic, and a dialysis clinic. At each hospital, transmission was linked to a unique index case. Moreover, 4 cases were associated with superspreading events (any interaction where a case patient transmitted to ≥5 subsequent case patients). All 4 of these patients were severely ill, were initially not recognized as MERS-CoV cases, and subsequently died. Genomic sequences clustered separately, suggesting 2 distinct outbreaks. Overall, 4 (24%) of 17 HCP cases and 3 (3%) of 114 HCP contacts of cases were seropositive.ConclusionsWe describe 2 distinct healthcare-associated outbreaks, each initiated by a unique index case and characterized by multiple superspreading events. Delays in recognition and in subsequent implementation of control measures contributed to secondary transmission. Prompt contact tracing, repeated testing, HCP furloughing, and implementation of recommended transmission-based precautions for suspected cases ultimately halted transmission.
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- 2019
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45. Seasonality of Common Human Coronaviruses, United States, 2014-20211.
- Author
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Shah, Melisa M., Winn, Amber, Dahl, Rebecca M., Kniss, Krista L., Silk, Benjamin J., and Killerby, Marie E.
- Abstract
The 4 common types of human coronaviruses (HCoVs)-2 alpha (HCoV-NL63 and HCoV-229E) and 2 beta (HCoV-HKU1 and HCoV-OC43)-generally cause mild upper respiratory illness. Seasonal patterns and annual variation in predominant types of HCoVs are known, but parameters of expected seasonality have not been defined. We defined seasonality of HCoVs during July 2014-November 2021 in the United States by using a retrospective method applied to National Respiratory and Enteric Virus Surveillance System data. In the 6 HCoV seasons before 2020-21, season onsets occurred October 21-November 12, peaks January 6-February 13, and offsets April 18-June 27; most (>93%) HCoV detection was within the defined seasonal onsets and offsets. The 2020-21 HCoV season onset was 11 weeks later than in prior seasons, probably associated with COVID-19 mitigation efforts. Better definitions of HCoV seasonality can be used for clinical preparedness and for determining expected patterns of emerging coronaviruses. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
46. Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Alpha Variant-United States, 2021.
- Author
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Donnelly MAP, Chuey MR, Soto R, Schwartz NG, Chu VT, Konkle SL, Sleweon S, Ruffin J, Haberling DL, Guagliardo SAJ, Stoddard RA, Anderson RD, Morgan CN, Rossetti R, McCormick DW, Magleby R, Sheldon SW, Dietrich EA, Uehara A, Retchless AC, Tong S, Folster JM, Drobeniuc J, Petway ME, Austin B, Stous S, McDonald E, Jain S, Hudziec MM, Stringer G, Albanese BA, Totten SE, Staples JE, Killerby ME, Hughes L, Matanock A, Beatty M, Tate JE, Kirking HL, and Hsu CH
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- Family Characteristics, Humans, United States epidemiology, COVID-19 epidemiology, SARS-CoV-2 genetics
- Abstract
Background: In Spring 2021, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.7 (Alpha) became the predominant variant in the United States. Research suggests that Alpha has increased transmissibility compared with non-Alpha lineages. We estimated household secondary infection risk (SIR), assessed characteristics associated with transmission, and compared symptoms of persons with Alpha and non-Alpha infections., Methods: We followed households with SARS-CoV-2 infection for 2 weeks in San Diego County and metropolitan Denver, January to April 2021. We collected epidemiologic information and biospecimens for serology, reverse transcription-polymerase chain reaction (RT-PCR), and whole-genome sequencing. We stratified SIR and symptoms by lineage and identified characteristics associated with transmission using generalized estimating equations., Results: We investigated 127 households with 322 household contacts; 72 households (56.7%) had member(s) with secondary infections. SIRs were not significantly higher for Alpha (61.0% [95% confidence interval, 52.4-69.0%]) than non-Alpha (55.6% [44.7-65.9%], P = .49). In households with Alpha, persons who identified as Asian or Hispanic/Latino had significantly higher SIRs than those who identified as White (P = .01 and .03, respectively). Close contact (eg, kissing, hugging) with primary cases was associated with increased transmission for all lineages. Persons with Alpha infection were more likely to report constitutional symptoms than persons with non-Alpha (86.9% vs 76.8%, P = .05)., Conclusions: Household SIRs were similar for Alpha and non-Alpha. Comparable SIRs may be due to saturation of transmission risk in households due to extensive close contact, or true lack of difference in transmission rates. Avoiding close contact within households may reduce SARS-CoV-2 transmission for all lineages among household members., (Published by Oxford University Press for the Infectious Diseases Society of America 2022.)
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- 2022
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47. Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection.
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Chu VT, Schwartz NG, Donnelly MAP, Chuey MR, Soto R, Yousaf AR, Schmitt-Matzen EN, Sleweon S, Ruffin J, Thornburg N, Harcourt JL, Tamin A, Kim G, Folster JM, Hughes LJ, Tong S, Stringer G, Albanese BA, Totten SE, Hudziec MM, Matzinger SR, Dietrich EA, Sheldon SW, Stous S, McDonald EC, Austin B, Beatty ME, Staples JE, Killerby ME, Hsu CH, Tate JE, Kirking HL, and Matanock A
- Subjects
- Adult, Child, Cohort Studies, Female, Humans, Prospective Studies, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2 genetics, Sensitivity and Specificity, COVID-19 diagnosis
- Abstract
Importance: As self-collected home antigen tests become widely available, a better understanding of their performance during the course of SARS-CoV-2 infection is needed., Objective: To evaluate the diagnostic performance of home antigen tests compared with reverse transcription-polymerase chain reaction (RT-PCR) and viral culture by days from illness onset, as well as user acceptability., Design, Setting, and Participants: This prospective cohort study was conducted from January to May 2021 in San Diego County, California, and metropolitan Denver, Colorado. The convenience sample included adults and children with RT-PCR-confirmed infection who used self-collected home antigen tests for 15 days and underwent at least 1 nasopharyngeal swab for RT-PCR, viral culture, and sequencing., Exposures: SARS-CoV-2 infection., Main Outcomes and Measures: The primary outcome was the daily sensitivity of home antigen tests to detect RT-PCR-confirmed cases. Secondary outcomes included the daily percentage of antigen test, RT-PCR, and viral culture results that were positive, and antigen test sensitivity compared with same-day RT-PCR and cultures. Antigen test use errors and acceptability were assessed for a subset of participants., Results: This study enrolled 225 persons with RT-PCR-confirmed infection (median [range] age, 29 [1-83] years; 117 female participants [52%]; 10 [4%] Asian, 6 [3%] Black or African American, 50 [22%] Hispanic or Latino, 3 [1%] Native Hawaiian or Other Pacific Islander, 145 [64%] White, and 11 [5%] multiracial individuals) who completed 3044 antigen tests and 642 nasopharyngeal swabs. Antigen test sensitivity was 50% (95% CI, 45%-55%) during the infectious period, 64% (95% CI, 56%-70%) compared with same-day RT-PCR, and 84% (95% CI, 75%-90%) compared with same-day cultures. Antigen test sensitivity peaked 4 days after illness onset at 77% (95% CI, 69%-83%). Antigen test sensitivity improved with a second antigen test 1 to 2 days later, particularly early in the infection. Six days after illness onset, antigen test result positivity was 61% (95% CI, 53%-68%). Almost all (216 [96%]) surveyed individuals reported that they would be more likely to get tested for SARS-CoV-2 infection if home antigen tests were available over the counter., Conclusions and Relevance: The results of this cohort study of home antigen tests suggest that sensitivity for SARS-CoV-2 was moderate compared with RT-PCR and high compared with viral culture. The results also suggest that symptomatic individuals with an initial negative home antigen test result for SARS-CoV-2 infection should test again 1 to 2 days later because test sensitivity peaked several days after illness onset and improved with repeated testing.
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- 2022
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48. Results from a Test-to-Release from Isolation Strategy Among Fully Vaccinated National Football League Players and Staff Members with COVID-19 - United States, December 14-19, 2021.
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Mack CD, Wasserman EB, Killerby ME, Soelaeman RH, Hall AJ, MacNeil A, Anderson DJ, Walton P, Pasha S, Myers E, O'Neal CS, Hostler CJ, Singh N, Mayer T, and Sills A
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- Adult, Athletes, COVID-19 prevention & control, Football, Humans, Male, United States epidemiology, COVID-19 diagnosis, COVID-19 Testing methods, Quarantine, Return to Sport, Return to Work, SARS-CoV-2
- Abstract
During December 2021, the United States experienced a surge in COVID-19 cases, coinciding with predominance of the SARS-CoV-2 B.1.1.529 (Omicron) variant (1). During this surge, the National Football League (NFL) and NFL Players Association (NFLPA) adjusted their protocols for test-to-release from COVID-19 isolation on December 16, 2021, based on analytic assessments of their 2021 test-to-release data. Fully vaccinated* persons with COVID-19 were permitted to return to work once they were asymptomatic or fever-free and experiencing improving symptoms for ≥24 hours, and after two negative or high cycle-threshold (Ct) results (Ct≥35) from either of two reverse transcription-polymerase chain reaction (RT-PCR) tests
† (2). This report describes data from NFL's SARS-CoV-2 testing program (3) and time to first negative or Ct≥35 result based on serial COVID-19 patient testing during isolation. Among this occupational cohort of 173 fully vaccinated adults with confirmed COVID-19 during December 14-19, 2021, a period of Omicron variant predominance, 46% received negative test results or had a subsequent RT-PCR test result with a Ct≥35 by day 6 postdiagnosis (i.e., concluding 5 days of isolation) and 84% before day 10. The proportion of persons with positive test results decreased with time, with approximately one half receiving positive RT-PCR test results after postdiagnosis day 5. Although this test result does not necessarily mean these persons are infectious (RT-PCR tests might continue to return positive results long after an initial positive result) (4), these findings indicate that persons with COVID-19 should continue taking precautions, including correct and consistent mask use, for a full 10 days after symptom onset or initial positive test result if they are asymptomatic., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Christina D. Mack, Erin B. Wasserman, and Saamir Pasha report full-time employment by IQVIA. Deverick J. Anderson reports receipt of royalties for authorship from UpToDate Online, LLC and co-ownership of Infection Control Education for Major Sports, LLC. Patti Walton reports consulting fees from NFL, honoraria for presentation from Ortho Clinical Diagnostics, payment as an expert witness regarding laboratory practices, support for travel to meetings from the American Society for Clinical Pathology (ASCP), serving on the Board of Directors of the Clinical Laboratory Management Association (2019–2021), membership on the ASCP Board of Governors (2019–current), and Chairmanship of the Tennessee Medical Laboratory Licensing Board (2019–2021). Catherine O’Neal reports consulting fees from NFL. Christopher J. Hostler reports co-ownership of Infection Control Education for Major Sports, LLC. Allen Sills and Emily Myers report employment by NFL. Navdeep Singh reports receipt of consulting fees from NFL and the Las Vegas Raiders. No other potential conflicts of interest were disclosed.- Published
- 2022
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- View/download PDF
49. Epidemiologic Characteristics Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigen-Based Test Results, Real-Time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) Cycle Threshold Values, Subgenomic RNA, and Viral Culture Results From University Testing.
- Author
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Ford L, Lee C, Pray IW, Cole D, Bigouette JP, Abedi GR, Bushman D, Delahoy MJ, Currie DW, Cherney B, Kirby MK, Fajardo GC, Caudill M, Langolf K, Kahrs J, Zochert T, Kelly P, Pitts C, Lim A, Aulik N, Tamin A, Harcourt JL, Queen K, Zhang J, Whitaker B, Browne H, Medrzycki M, Shewmaker PL, Bonenfant G, Zhou B, Folster JM, Bankamp B, Bowen MD, Thornburg NJ, Goffard K, Limbago B, Bateman A, Tate JE, Gieryn D, Kirking HL, Westergaard RP, and Killerby ME
- Subjects
- Antigens, Viral, Humans, RNA, Reverse Transcriptase Polymerase Chain Reaction, Reverse Transcription, Sensitivity and Specificity, Universities, COVID-19, SARS-CoV-2
- Abstract
Background: Real-time reverse transcription polymerase chain reaction (rRT-PCR) and antigen tests are important diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sensitivity of antigen tests has been shown to be lower than that of rRT-PCR; however, data to evaluate epidemiologic characteristics that affect test performance are limited., Methods: Paired mid-turbinate nasal swabs were collected from university students and staff and tested for SARS-CoV-2 using both Quidel Sofia SARS Antigen Fluorescent Immunoassay (FIA) and rRT-PCR assay. Specimens positive by either rRT-PCR or antigen FIA were placed in viral culture and tested for subgenomic RNA (sgRNA). Logistic regression models were used to evaluate characteristics associated with antigen results, rRT-PCR cycle threshold (Ct) values, sgRNA, and viral culture., Results: Antigen FIA sensitivity was 78.9% and 43.8% among symptomatic and asymptomatic participants, respectively. Among rRT-PCR positive participants, negative antigen results were more likely among asymptomatic participants (odds ratio [OR] 4.6, 95% confidence interval [CI]: 1.3-15.4) and less likely among participants reporting nasal congestion (OR 0.1, 95% CI: .03-.8). rRT-PCR-positive specimens with higher Ct values (OR 0.5, 95% CI: .4-.8) were less likely, and specimens positive for sgRNA (OR 10.2, 95% CI: 1.6-65.0) more likely, to yield positive virus isolation. Antigen testing was >90% positive in specimens with Ct values < 29. Positive predictive value of antigen test for positive viral culture (57.7%) was similar to that of rRT-PCR (59.3%)., Conclusions: SARS-CoV-2 antigen test advantages include low cost, wide availability and rapid turnaround time, making them important screening tests. The performance of antigen tests may vary with patient characteristics, so performance characteristics should be accounted for when designing testing strategies and interpreting results., (Published by Oxford University Press for the Infectious Diseases Society of America 2021.)
- Published
- 2021
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50. Symptom Profiles of a Convenience Sample of Patients with COVID-19 - United States, January-April 2020.
- Author
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Burke RM, Killerby ME, Newton S, Ashworth CE, Berns AL, Brennan S, Bressler JM, Bye E, Crawford R, Harduar Morano L, Lewis NM, Markus TM, Read JS, Rissman T, Taylor J, Tate JE, and Midgley CM
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Betacoronavirus isolation & purification, COVID-19, Child, Child, Preschool, Coronavirus Infections epidemiology, Coronavirus Infections therapy, Cough virology, Dyspnea virology, Female, Fever virology, Hospitalization statistics & numerical data, Humans, Infant, Male, Middle Aged, Pandemics, Pneumonia, Viral epidemiology, Pneumonia, Viral therapy, SARS-CoV-2, Severity of Illness Index, United States epidemiology, Young Adult, Coronavirus Infections complications, Coronavirus Infections diagnosis, Pneumonia, Viral complications, Pneumonia, Viral diagnosis, Symptom Assessment
- Abstract
Coronavirus disease 2019 (COVID-19) was first detected in the United States in January 2020 (1), and by mid-July, approximately 3.4 million cases had been reported in the United States (2). Information about symptoms among U.S. COVID-19 patients is limited, especially among nonhospitalized patients. To better understand symptom profiles of patients with laboratory-confirmed COVID-19 in the United States, CDC used an optional questionnaire to collect detailed information on a convenience sample of COVID-19 patients from participating states. Symptom data were analyzed by age group, sex, hospitalization status, and symptom onset date relative to expansion of testing guidelines on March 8, 2020 (3). Among 164 symptomatic patients with known onset during January 14-April 4, 2020, a total of 158 (96%) reported fever, cough, or shortness of breath. Among 57 hospitalized adult patients (aged ≥18 years), 39 (68%) reported all three of these symptoms, compared with 25 (31%) of the 81 nonhospitalized adult patients. Gastrointestinal (GI) symptoms and other symptoms, such as chills, myalgia, headache, and fatigue, also were commonly reported, especially after expansion of testing guidelines. To aid prompt recognition of COVID-19, clinicians and public health professionals should be aware that COVID-19 can cause a wide variety of symptoms., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.
- Published
- 2020
- Full Text
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