1. From the midfacial destructive drama to the unfolding EBV story: a short history of EBV-positive NK-cell and T-cell lymphoproliferative diseases.
- Author
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Ng CS
- Subjects
- Humans, Lymphoproliferative Disorders virology, Lymphoproliferative Disorders pathology, Lymphoproliferative Disorders immunology, Epstein-Barr Virus Infections immunology, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections virology, Herpesvirus 4, Human immunology, Killer Cells, Natural immunology, Killer Cells, Natural pathology, Killer Cells, Natural virology, T-Lymphocytes immunology, T-Lymphocytes pathology
- Abstract
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that has been related to oncogenesis of lymphoid and epithelial malignancies. Although the mechanism of EBV infection of NK and T cells remains enigmatic, it plays a pathogenic role in various EBV
+ NK-cell and T-cell lymphoproliferative diseases (LPDs), through promotion of cell activation pathways, inhibition of cell apoptotic pathways, behaving as oncogenes, interacting with host oncogenes or acting epigenetically. The study of NK-cell LPDs, previously hampered by the lack of immunophenotypical and genotypical criteria of NK cells, has become feasible with the recently accepted criteria. EBV+ NK- and T-cell LPDs are mostly of poor prognosis. This review delivers a short history from primeval to recent EBV+ NK- and T-cell LPDs in non-immunocompromised subjects, coupled with increasing interest, and work on the biological and oncogenic roles of EBV., (Copyright © 2024 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
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