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535 results on '"Kikuchi,Shin-Ichi"'

6. Nocturnal Leg Cramps and Lumbar Spinal Stenosis: A Cross-Sectional Study in the Community

Author

Handa,Junichi, Otani,Koji, Nikaido,Takuya, Kikuchi,Shin-ichi, Konno,Shin-ichi, Handa,Junichi, Otani,Koji, Nikaido,Takuya, Kikuchi,Shin-ichi, and Konno,Shin-ichi

Abstract

Junichi Handa, Koji Otani, Takuya Nikaido, Shin-ichi Kikuchi ,†Shin-ichi Konno Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan†Shin-ichi Kikuchi passed away on February 22th, 2022Correspondence: Junichi Handa, Tel +81-24-547-1276, Fax +81-24-548-5505, Email hanhan@fmu.ac.jpPurpose: Nocturnal leg cramps are considered to be a symptom of lumbar spinal stenosis (LSS). However, the relationship between LSS and nocturnal leg cramps in the general population remains unclear. The purpose of this study was to investigate the prevalence and characteristics of nocturnal leg cramps in LSS in the community.Patients and Methods: 328 voluntary participants were enrolled in this study. The presence of LSS was assessed by a validated and self-administered diagnostic support tool. The presence of nocturnal leg cramps and neurological findings were evaluated by one experienced spine surgeon. To investigate the relationship between leg cramps and anatomical factors, the participants underwent an MRI scan, and the dural sac cross-sectional area (DCSA) at each lumbar intervertebral disc level was measured.Results: A total of 214 participants (65.2%) had nocturnal leg cramps, and 94 of 328 participants (28.7%) showed typical LSS symptoms. In the typical LSS symptom group, 31 participants (33.0%) had nocturnal leg cramps. In the atypical LSS symptom group, 83 participants (35.5%) had nocturnal leg cramps. There was no statistically significant difference in the prevalence of nocturnal leg cramps between the two groups. The narrowest DCSA (< 25 mm2 and 25– 49.4mm2) was statistically related to the presence of nocturnal leg cramp. Statistically significant differences in sensory disturbance and motor weakness were not observed between the subjects with and those without nocturnal leg cramps. Moreover, impaired PTR was statistically related to the presence of nocturnal leg cramp.Conclusion: The prevalence of nocturnal leg cramps

Published
2022

10. Generalization of a clinical diagnosis support tool for lumbar spinal stenosis: Can the ankle brachial pressure index be replaced by palpation of the posterior tibial artery in the lumbar spinal stenosis diagnostic support tool? (DISTO project)

Author

Nikaido, Takuya, primary, Sekiguchi, Miho, additional, Yonemoto, Koji, additional, Kakuma, Tatsuyuki, additional, Watanabe, Kazuyuki, additional, Kato, Kinshi, additional, Kobayashi, Hiroshi, additional, Tominaga, Ryoji, additional, Otani, Koji, additional, Yabuki, Shoji, additional, Kikuchi, Shin-ichi, additional, and Konno, Shin-ichi, additional

Published
2022
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25. Ossification of the ligamentum flavum in the thoracic spine mimicking sciatica in a young baseball pitcher: a case report

Author

Kato, Kinshi, Yabuki, Shoji, Otani, Koji, Nikaido, Takuya, Otoshi, Ken-Ichi, Watanabe, Kazuyuki, Kikuchi, Shin-Ichi, Konno, Shin-Ichi, Kato, Kinshi, Yabuki, Shoji, Otani, Koji, Nikaido, Takuya, Otoshi, Ken-Ichi, Watanabe, Kazuyuki, Kikuchi, Shin-Ichi, and Konno, Shin-Ichi

Abstract

type:Text, Thoracic ossification of the ligamentum flavum (OLF) is a pathological condition that causes myelopathy, with unilateral lower extremity pain rarely a feature in the presenting complaint. Moreover, most symptomatic cases of thoracic OLF occur in middle-aged men, with younger individuals rarely affected. We present a rare case of severe and chronic unilateral buttock and leg pain mimicking sciatica due to thoracic OLF in a professional baseball pitcher. A 28-year-old, right-handed, Japanese professional baseball pitcher experienced intractable left leg pain with numbness and spasticity. After the initial presentation, extensive testing focusing on lumbar, hip, and pelvis lesions failed to identify a cause for the pain. One year after onset, careful neurological examination showed signs of upper motor neuron disturbance, and thoracic computed tomography and magnetic resonance imaging revealed thoracic OLF at the level of the thoracolumbar junction. After resection of the thoracic OLF, the pain, numbness, and spasticity completely resolved. He resumed full training and was pitching in top condition within four months after surgery. Though rare, thoracic OLF should be considered in the differential diagnosis of lower extremity pain in young athletes, especially amongst high-level baseball pitchers.

Published
2021

28. Locomotor dysfunction and risk of cardiovascular disease, quality of life, and medical costs: design of the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) and baseline characteristics of the study population

Author

Otani, Koji, Takegami, Misa, Fukumori, Norio, Sekiguchi, Miho, Onishi, Yoshihiro, Yamazaki, Shin, Ono, Rei, Otoshi, Kenichi, Hayashino, Yasuaki, Fukuhara, Shunichi, Kikuchi, Shin-ichi, Konno, Shin-ichi, and The LOHAS Research Group

Published
2012
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37. Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 3. Validity study and establishment of the measurement scale: Subcommittee on Low Back Pain and Cervical Myelopathy Evaluation of the Clinical Outcome Committee of the Japanese Orthopaedic Association, Japan

Author

Fukui, Mitsuru, Chiba, Kazuhiro, Kawakami, Mamoru, Kikuchi, Shin-Ichi, Konno, Shin-Ichi, Miyamoto, Masabumi, Seichi, Atsushi, Shimamura, Tadashi, Shirado, Osamu, Taguchi, Toshihiko, Takahashi, Kazuhisa, Takeshita, Katsushi, Tani, Toshikazu, Toyama, Yoshiaki, Wada, Eiji, Yonenobu, Kazuo, Tanaka, Takashi, and Hirota, Yoshio

Published
2008
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39. Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis

Author

Kitamura, Takuya, Kabuyama, Yukihito, Kamataki, Akihisa, Homma, Miwako K., Kobayashi, Hideo, Aota, Shigeo, Kikuchi, Shin-ichi, and Homma, Yoshimi

Subjects
Lymphocytes -- Physiological aspects, Cell migration -- Research, Cytokines -- Measurement, Rheumatoid arthritis -- Physiological aspects, Biological sciences
Abstract

Although the etiology of early events in rheumatoid arthritis (RA) remains undefined, an anomaly in T cell homeostasis and hyperproliferation of synovial-lining cells are involved in the disease process. Since it has been reported that the ephrin/Eph receptor system plays important signaling roles in inflammation processes, we attempted to examine ephrinB molecules in T cells and synovial cells derived from RA in this study. The expression level of ephrinB1 was significantly high in synovial fibroblasts and CD3-positive exudate lymphocytes in synovial tissues derived from patients with RA compared with those in osteoarthritis (OA). Protein and mRNA levels of ephrinB1 were also higher in peripheral blood lymphocytes (PBLs) prepared from patients with RA than those from normal controls. Similar results were obtained from an animal model of human RA, collagen antibody-induced arthritis mice. Moreover, a recombinant ephrinB1/Fc fusion protein stimulated normal PBLs to exhibit enhanced migration and production of TNF-[alpha]. EphrinB1/Fc also activated synovial cells established from patients with RA to produce IL-6. Tyrosine phosphorylation of EphB1 was induced in these cells by ephrinB1/Fc. The CpG islands in the 5' upstream regulatory region of the ephrinB1 gene were hypomethylated in RA patients compared with those of normal donors. These results suggest that ephrinB1 and EphB1 receptors play an important role in the inflammatory states of RA, especially by affecting the population and function of T cells. Inhibition of the ephrinB/EphB system might be a novel target for the treatment of RA. synovial cells; T cells; cytokine; DNA methylation

Published
2008

40. An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 1

Author

Fukui, Mitsuru, Chiba, Kazuhiro, Kawakami, Mamoru, Kikuchi, Shin-ichi, Konno, Shin-ichi, Miyamoto, Masabumi, Seichi, Atsushi, Shimamura, Tadashi, Shirado, Osamu, Taguchi, Toshihiko, Takahashi, Kazuhisa, Takeshita, Katsushi, Tani, Toshikazu, Toyama, Yoshiaki, Wada, Eiji, Yonenobu, Kazuo, Tanaka, Takashi, and Hirota, Yoshio

Published
2007
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41. Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 2. Endorsement of the alternative item

Author

Fukui, Mitsuru, Chiba, Kazuhiro, Kawakami, Mamoru, Kikuchi, Shin-ichi, Konno, Shin-ichi, Miyamoto, Masabumi, Seichi, Atsushi, Shimamura, Tadashi, Shirado, Osamu, Taguchi, Toshihiko, Takahashi, Kazuhisa, Takeshita, Katsushi, Tani, Toshikazu, Toyama, Yoshiaki, Wada, Eiji, Yonenobu, Kazuo, Tanaka, Takashi, and Hirota, Yoshio

Published
2007
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44. Involvement of poly(ADP-ribose) polymerase 1 in ERBB2 expression in rheumatoid synovial cells

Author

Kitamura, Takuya, Sekimata, Masayuki, Kikuchi, Shin-ichi, and Homma, Yoshimi

Subjects
Synovial membranes, Rheumatoid arthritis, Hyperplasia, Biological sciences
Abstract

Hyperplasia of synovial lining cells is one of the main features of rheumatoid arthritis (RA). We previously reported that ERBB2 is highly expressed in RA synovial cells and that it plays an important role in their hyperproliferative growth. Recent findings have suggested that poly(ADP-ribose) polymerase-1 (PARP-1) is involved in the transactivation of NF-[kappa]B-dependent genes such as ERBB2. In the present study, we investigated the role of PARP-1 in ERBB2 transcription in RA synovial cells. The expression level of PARP-1 was significantly high in synovial cells derived from three patients with RA, compared with three patients with osteoarthritis (OA). Luciferase assays revealed that PARP-1 augments the transcription of the ERBB2 gene and that a region between -404 and -368 is responsible for this activation. A protein with an apparent molecular mass of 115 kDa was isolated mainly from nuclear extracts of RA synovial cells with an affinity matrix harboring a DNA fragment identical to the above region. Mass spectrometric analysis demonstrated this protein to be PARP-1. Southwestern blot analysis showed that PARP-1 binds to this region, but not to adjacent regions. PARP-1 associates directly with NF-[kappa]B, and a chromatin immunoprecipitation assay indicated that these proteins interact with this enhancer region in the ERBB2 gene. Treatment of RA synovial cells with PARP-I small interfering RNA attenuated their ERBB2 expression, while an inhibitor of the polymerase activity of PARP-1 had no effect. PARP-1 DNA binding is not required for transcriptional activation. These findings suggest that PARP-1 is involved in the expression of ERBB2 in concert with NF-[kappa]B, which might be associated with the proliferation of RA synovial cells. nuclear factor-[kappa]B; rheumatoid arthritis; joint lining cell; hyperproliferation

Published
2005

46. Sagittal imbalance and symptoms of depression in adults: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study (LOHAS)

Author

Watanabe, Kazuyuki, primary, Otani, Koji, additional, Tominaga, Ryoji, additional, Kokubun, Yoshiyuki, additional, Sekiguchi, Miho, additional, Fukuma, Shingo, additional, Kamitani, Tsukasa, additional, Nikaido, Takuya, additional, Kato, Kinshi, additional, Kobayashi, Hiroshi, additional, Yabuki, Shoji, additional, Kikuchi, Shin-ichi, additional, and Konno, Shin-ichi, additional

Published
2020
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48. Synthesis and reactions of optically active seconday dialkylphosphine-boranes

Author

Miura, Tomoya, Yamada, Hironari, Kikuchi, Shin-ichi, and Imamoto, Tsuneo

Subjects
Organic compounds -- Synthesis, Borane -- Research, Alkylation -- Analysis, Biological sciences, Chemistry
Abstract

A synthetic route to P-chirogenic trialkylphosphine-boranes involves an optically active secondary dialkylphosphine-borane as an intemediate. Research shows that the methodology is applicable for the synthesis of analogous phosphine-boranes and phosphine ligands.

Published
2000

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