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2,105 results on '"Kikuchi, Takashi"'

5. Excess mortality in COVID-19-affected solid organ transplant recipients across the pandemic

Author

Unagami, Kohei, Ishida, Hideki, Omoto, Kazuya, Kasahara, Mureo, Uchida, Hajime, Sakamoto, Seisuke, Futamura, Kenta, Nishikawa, Kenta, Imamura, Ryoichi, Nakazawa, Shigeaki, Hatano, Etsuro, Ito, Takashi, Masano, Yuki, Nishihira, Morikuni, Hirata, Yuta, Sakuma, Yasunaru, Onishi, Yasuharu, Yokoyama, Naoki, Yamamoto, Shingo, Yamada, Yusuke, Ogura, Yasuhiro, Kurata, Nobuhiko, Uchida, Junji, Kabei, Kazuya, Iwamoto, Hitoshi, Ikeda, Chie, Shinoda, Kazunobu, Yoshiike, Miki, Hotta, Kiyohiko, Hidaka, Yuji, Iwami, Daiki, Ishii, Yasuo, Kamiyama, Manabu, Yoshizumi, Tomoharu, Kosai-Fujimoto, Yukiko, Kobayashi, Takaaki, Motoyama, Kentaro, Yamamoto, Megumi, Asai, Toshihiro, Tasaki, Masayuki, Kenmochi, Takashi, Ito, Taihei, Tokodai, Kazuaki, Fujio, Atsushi, Tsukamoto, Yasumasa, Watanabe, Takuya, Akamatsu, Nobuhisa, Yamashina, Sachi, Ishii, Daisuke, Kitajima, Kazuki, Yamada, Yasutoshi, Mitsuke, Akihiko, Sakaguchi, Takashi, Nakamura, Michio, Tomita, Yusuke, Nakamura, Yuki, Ishimoto, Tatsuro, Ohdan, Hideki, Tanimine, Naoki, Fujiwara, Takuzo, Yanagihara, Mitsuki, Hatakeyama, Shingo, Takai, Manabu, Nose, Kazuhiro, Kikuchi, Takashi, Mori, Yasunori, Araki, Motoo, Sekito, Takanori, Nishimura, Shingo, Tanabe, Tatsu, Igarashi, Yuto, Hidaka, Sumi, Watanabe, Masaaki, Ariyoshi, Yuichi, Hasegawa, Yasushi, Kamiyama, Masato, Yoneda, Tatsuo, Shimizu, Tomokazu, Nishikawa, Kouhei, Fukumoto, Takumi, Kuramitsu, Kaoru, Kato, Masashi, Saito, Mitsuru, Shinkai, Makoto, Usui, Hidehito, Sato, Masaaki, Eguchi, Hidetoshi, Imamura, Hiroki, Kobayashi, Shogo, Soejima, Yuji, Mita, Atsuyoshi, Kobayashi, Takashi, Nakamura, Kenji, Ohtsuka, Masayuki, Nakada, Shinichiro, Yagi, Takahito, Yasui, Kazuya, Matsuno, Naoto, Mizuno, Chiharu, Sugimoto, Mikio, Ueda, Nobufumi, Okada, Yoshinori, Hirama, Takashi, Toyooka, Shinichi, Sugimoto, Seiichiro, Matsubara, Kei, Ikegami, Toru, Furukawa, Kenei, Nitta, Hiroyuki, Katagiri, Hirokatsu, Onita, Toru, Shiraishi, Takeshi, Mizuno, Shugo, Amiya, Eisuke, Shintani, Yasushi, Kanou, Takashi, Funaki, Soichiro, Miura, Yoshifumi, Nakajima, Daisuke, Urahashi, Taizen, Matsumiya, Goro, Watanabe, Michiko, Ebisu, Yosuke, Osawa, Ryosuke, Ono, Minoru, Sogawa, Hiroshi, Gomi, Harumi, Chen-Yoshikawa, Toyofumi, Yoshida, Kazunari, Ogawa, Naoko, Yamanaga, Shigeyoshi, Shimata, Keita, Ohfuji, Satoko, Yoshikawa, Mikiko, Natori, Yoichiro, Hibi, Taizo, Yuzawa, Kenji, and Egawa, Hiroto

Published
2024
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8. MONITORING ALASKAN ARCTIC SHELF ECOSYSTEMS THROUGH COLLABORATIVE OBSERVATION NETWORKS

Author

Danielson, Seth L., Grebmeier, Jacqueline M., Iken, Katrin, Berchok, Catherine, Britt, Lyle, Dunton, Kenneth H., Eisner, Lisa, Farley, Edward V., Fujiwara, Amane, Hauser, Donna D.W., Itoh, Motoyo, Kikuchi, Takashi, Kotwicki, Stan, Kuletz, Kathy J., Mordy, Calvin W., Nishino, Shigeto, Peralta-Ferriz, Cecilia, Pickart, Robert S., Stabeno, Phyllis S., Stafford, Kathleen M., Whiting, Alex V., and Woodgate, Rebecca

Published
2022

11. Trimodality Therapy With Iodine-125 Brachytherapy, External Beam Radiation Therapy, and Short- or Long-Term Androgen Deprivation Therapy for High-Risk Localized Prostate Cancer: Results of a Multicenter, Randomized Phase 3 Trial (TRIP/TRIGU0907)

Author

Yorozu, Atsunori, Namiki, Mikio, Saito, Shiro, Egawa, Shin, Yaegashi, Hiroshi, Konaka, Hiroyuki, Momma, Tetsuo, Fukagai, Takashi, Tanaka, Nobumichi, Ohashi, Toshio, Takahashi, Hiroyuki, Nakagawa, Yoko, Kikuchi, Takashi, Mizokami, Atsushi, and Stone, Nelson N.

Published
2024
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13. Ten-Year Outcomes of a Phase 3, Multicenter, Randomized Controlled Trial (SHIP0804) With 3-Month Neoadjuvant Androgen Deprivation Prior to 125I-Seed Transperineal Prostate Brachytherapy Followed by Nil Versus 9-Month Adjuvant Hormonal Therapy in Patients With Intermediate-Risk Prostate Cancer

Author

Momma, Tetsuo, Tsumura, Hideyasu, Fukagai, Takashi, Karasawa, Kumiko, Masui, Koji, Hashine, Katsuyoshi, Tanaka, Nobumichi, Katayama, Satoshi, Kusuhara, Yoshito, Eto, Masatoshi, Iinuma, Koji, Hayashi, Narihiko, Sugimoto, Mikio, Suzuki, Kazuhiro, Imamura, Ryoichi, Yonese, Junji, Fukuokaya, Wataru, Miki, Kenta, Aoki, Manabu, Takahashi, Hiroyuki, Saito, Shiro, Yorozu, Atsunori, Kikuchi, Takashi, Dokiya, Takushi, and Egawa, Shin

Published
2024
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17. The Pacific water flow branches in the eastern Chukchi Sea

Author

Pickart, Robert S., Lin, Peigen, Bahr, Frank, McRaven, Leah T., Huang, Jie, Pacini, Astrid, Arrigo, Kevin R., Ashjian, Carin J., Berchok, Catherine, Baumgartner, Mark F., Cho, Kyoung-Ho, Cooper, Lee W., Danielson, Seth L., Dasher, Douglas, Fuiwara, Amane, Gann, Jeanette, Grebmeier, Jacqueline M., He, Jianfeng, Hirawake, Toru, Itoh, Motoyo, Juranek, Lauren, Kikuchi, Takashi, Moore, G.W.K., Napp, Jeff, John Nelson, R., Nishino, Shigeto, Statscewich, Hank, Stabeno, Phyllis, Stafford, Kathleen M., Ueno, Hiromichi, Vagle, Svein, Weingartner, Thomas J., Williams, Bill, and Zimmermann, Sarah

Published
2023
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21. Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids

Author

Mitsuhashi, Takaaki, Barra, Lena, Powers, Zachary, Kojasoy, Volga, Cheng, Andrea, Yang, Feng, Taniguchi, Yoshimasa, Kikuchi, Takashi, Fujita, Makoto, Tantillo, Dean J, Porco, John A, and Abe, Ikuro

Subjects
Medicinal and Biomolecular Chemistry, Chemical Sciences, Biosynthetic Pathways, Fungi, Terpenes, chemoenzymatic synthesis, combinatorial biosynthesis, crystalline-sponge x-ray diffraction, meroterpenoid cyclase, meroterpenoids, Organic Chemistry, Chemical sciences
Abstract

Fungal meroterpenoids are a diverse group of hybrid natural products with impressive structural complexity and high potential as drug candidates. In this work, we evaluate the promiscuity of the early structure diversity-generating step in fungal meroterpenoid biosynthetic pathways: the multibond-forming polyene cyclizations catalyzed by the yet poorly understood family of fungal meroterpenoid cyclases. In total, 12 unnatural meroterpenoids were accessed chemoenzymatically using synthetic substrates. Their complex structures were determined by 2D NMR studies as well as crystalline-sponge-based X-ray diffraction analyses. The results obtained revealed a high degree of enzyme promiscuity and experimental results which together with quantum chemical calculations provided a deeper insight into the catalytic activity of this new family of non-canonical, terpene cyclases. The knowledge obtained paves the way to design and engineer artificial pathways towards second generation meroterpenoids with valuable bioactivities based on combinatorial biosynthetic strategies.

Published
2020

26. Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model.

Author

Miyake, Kentaro, Murata, Takuya, Murakami, Takashi, Zhao, Ming, Kiyuna, Tasuku, Kawaguchi, Kei, Igarashi, Kentaro, Miyake, Masuyo, Lwin, Thinzar, Hozumi, Chihiro, Komatsu, Shin, Kikuchi, Takashi, Shimoya, Koichiro, Singh, Shree, Endo, Itaru, Bouvet, Michael, and Hoffman, Robert

Subjects
Bacterial therapy, Cervical cancer, Nude mice, Patient-derived orthotopic xenograft, S. typhimurium A1-R, Albumins, Animals, Disease Models, Animal, Doxorubicin, Female, Humans, Mice, Mice, Nude, Oligopeptides, Paclitaxel, Salmonella typhimurium, Uterine Cervical Neoplasms, Xenograft Model Antitumor Assays
Abstract

PURPOSE: Cervical cancer is a recalcitrant disease. To help overcome this problem, we previously established a patient-derived orthotopic xenograft (PDOX) model of cervical cancer. In the previous study, we found the tumor to be resistant to nab-paclitaxal (nab-PTX). We also previously developed the tumor-targeting bacteria Salmonella typhimurium A1-R (S. typhimurium A1-R). The aim of the present study was to investigate the efficacy of S. typhimurium A1-R to overcome nab-PTX resistance in the cervical cancer PDOX model. METHODS: Cervical-cancer tumor fragments were implanted orthotopically into the neck of the uterus of nude mice. The cervical-cancer PDOX models were randomized into the following four groups after the tumor volume reached 60 mm3: G1: untreated group; G2: nab-PTX (i.v., 10 mg/kg, biweekly, 3 weeks); G3: Salmonella typhimurium A1-R (i.v., 5 × 107 CFU/body, weekly, 3 weeks); G4: nab-PTX combined with Salmonella typhimurium A1-R (nab-PTX, 10 mg/kg, i.v., biweekly, 3 weeks; S. typhimurium A1-R, 5 × 107 CFU/body, i.v., weekly, 3 weeks). Each group comprised eight mice. All mice were sacrificed on day 22. Tumor volume was measured on day 0 and day 22. Body weight was measured twice a week. RESULTS: Nab-PTX and Salmonella typhimurium A1-R did not show significant efficacy as monotherapy compared to the control group (P = 0.564 and P = 0.120, respectively). In contrast, nab-PTX combined with Salmonella typhimurium A1-R significantly suppressed tumor growth compared to the untreated control group and nab-PTX group (P

Published
2019

30. Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan

Author

Masui, Toshihiko, Ito, Tetsuhide, Komoto, Izumi, Kojima, Shinsuke, Kasai, Yosuke, Tanabe, Minoru, Hara, Kazuo, Hirano, Satoshi, Okusaka, Takuji, Ichikawa, Yasushi, Kinugasa, Yusuke, Kokudo, Norihiro, Kudo, Atsushi, Sakurai, Akihiro, Sugihara, Kenichi, Date, Hiroshi, Haruma, Ken, Hijioka, Susumu, Hirata, Koichi, Yamano, Hiroo, Sakamine, Motohiro, Kikuchi, Takashi, Fukushima, Masanori, Imamura, Masayuki, and Uemoto, Shinji

Published
2022
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32. New workflow for the structure elucidation of trace amount natural products with microgram-scale crystalline sponge method: a scaled-down genome-mining study.

Author

Park, Chieon, Mitsuhashi, Takaaki, Wada, Naoki, Kikuchi, Takashi, and Fujita, Makoto

Abstract

Genome mining, an effective approach to natural product discovery, often requires large-scale cultivation (several to dozens of liters). Here, we demonstrate that the crystalline sponge method significantly reduces the cultivation scale as the method requires only a microgram quantity of an analyte. Prior to the NMR study, we directly addressed the X-ray structure of a natural product from a terpene synthase, which was heterologously expressed by only a 25-mL scale cultivation. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Stereospecific Ring Contraction of Bromocycloheptenes through Dyotropic Rearrangements via Nonclassical Carbocation–Anion Pairs

Author

Goh, Shermin S, Champagne, Pier Alexandre, Guduguntla, Sureshbabu, Kikuchi, Takashi, Fujita, Makoto, Houk, KN, and Feringa, Ben L

Subjects
Chemical Sciences, General Chemistry
Abstract

Experimental and theoretical evidence is reported for a rare type I dyotropic rearrangement involving a [1,2]-alkene shift, leading to the regio- and stereospecific ring contraction of bromocycloheptenes. This reaction occurs under mild conditions, with or without a Lewis acid catalyst. DFT calculations show that the reaction proceeds through a nonclassical carbocation-anion pair, which is crucial for the low activation barrier and enantiospecificity. The chiral cyclopropylcarbinyl cation may be a transition state or an intermediate, depending on the reaction conditions.

Published
2018

34. Enzalutamide in patients with non-metastatic castration-resistant prostate cancer after combined androgen blockade for recurrence following radical treatment in Japan (Japanese research for patients with non-metastatic castration-resistant prostate cancer-enzalutamide: JCASTRE-zero)—a prospective single-arm interventional study

Author

Sugimoto, Mikio, Kato, Takuma, Tohi, Yoichiro, Shimizu, Yosuke, Matsumoto, Ryuji, Inoue, Takahiro, Takezawa, Yutaka, Masui, Kimihiko, Sasaki, Hiroshi, Hirama, Hiromi, Saito, Shiro, Egawa, Shin, Kamoto, Toshiyuki, Teramukai, Satoshi, Kojima, Shinsuke, Kikuchi, Takashi, and Kakehi, Yoshiyuki

Published
2022
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37. Mechanical Properties of Modulative Undulating Layers in Two-Dimensional Metal–Organic Frameworks

Author

Iwai, Yuudai, primary, Kusumoto, Sotaro, additional, Suzuki, Ryo, additional, Tachibana, Masaru, additional, Komatsu, Kazuki, additional, Kikuchi, Takashi, additional, Kawaguchi, Saori I., additional, Kadobayashi, Hirokazu, additional, Masubuchi, Yuji, additional, Yamamoto, Yuzuki, additional, Ozawa, Yoshiki, additional, Abe, Masaaki, additional, Hirai, Kenji, additional, Le Ouay, Benjamin, additional, Ohba, Masaaki, additional, and Ohtani, Ryo, additional

Published
2024
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45. Cervical Cancer Patient-Derived Orthotopic Xenograft (PDOX) Is Sensitive to Cisplatinum and Resistant to Nab-paclitaxel.

Author

Murakami, Takashi, Murata, Takuya, Kawaguchi, Kei, Kiyuna, Tasuku, Igarashi, Kentaro, Hwang, Ho Kyoung, Hiroshima, Yukihiko, Hozumi, Chihiro, Komatsu, Shin, Kikuchi, Takashi, Lwin, Thinzar M, Delong, Jonathan C, Miyake, Kentaro, Zhang, Yong, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, and Hoffman, Robert M

Subjects
Cancer, Albumins, Animals, Antinematodal Agents, Cisplatin, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm, Female, Humans, Mice, Nude, Paclitaxel, Time Factors, Tumor Burden, Uterine Cervical Neoplasms, Xenograft Model Antitumor Assays, Cervical cancer, patient-derived othotopic xenograft, PDOX, nude mice, drug response, cispatinum, nab-paclitaxel, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundCervical cancer is a world-wide problem that requires transformative therapeutic strategies. We have previously developed patient-derived orthotopic xenograft (PDOX) nude-mouse models of this disease. In the present report, we demonstrate that the standard drug, cisplatinum (CDDP), is highly-effective while the new, highly-touted agent, nab-paclitaxel (NAB-PTX) is ineffective.Materials and methodsCervical PDOX tumors were grown on the cervix of nude mice for 4 weeks after surgical orthotopic implantation (SOI). Tumors were treated with CDDP or NAB-PTX.ResultsH&E staining demonstrated that the PDOX tumor recapitulated the original patient tumor. CDDP was highly-effective. One tumor that was treated with CDDP completely regressed. CDDP-treated tumors were smaller (tumor volume ratio: 0.42±0.36) than the control group (tumor volume ratio: 3.47±1.66) (p

Published
2017

46. Synthesis of Zeolites via Dehydrative Condensation of Preorganized Composite Building Units

Author

Nishitoba, Toshiki, Matsumoto, Tomohiro, Yagihashi, Fujio, Satou, Junichi, Kikuchi, Takashi, Sato, Kazuhiko, and Igarashi, Masayasu

Abstract

The synthesis of high-performance zeolites with precisely controlled structures has led to the development of high-efficiency industrial catalysts, adsorbents, and separation membranes. Consequently, intense research efforts have been devoted to the development of novel high-performance zeolites. Although most zeolites are synthesized via hydrothermal synthesis, the formation mechanism is unclear, and a reasonable design has not yet been realized. Herein, a novel method for the synthesis of zeolites involving the stacking of composite building units (CBUs) is introduced. Using a hydrogen-bonded inorganic framework as a preorganized CBU, the zeolite was prepared via dehydrative condensation reactions under acidic conditions. Crystallization occurred throughout this process, while the CBU structure was maintained, leading to a novel zeolite with an eight-membered ring. Notably, by using this synthetic method, a large-sized zeolite that can be analyzed by conventional single-crystal X-ray diffraction techniques was obtained. The single-crystal X-ray diffraction analysis in combination with optimum-bright-field–scanning-transmission-electron-microscopy measurements confirmed the formation of the zeolite framework. This novel method for the synthesis of zeolites involving the assembly of CBUs provides a new platform for the development of unprecedented high-performance zeolites with arbitrary pore structures and active species.

Published
2024
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