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197 results on '"Kikic, I."'

18. Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and time

Author

Marizza, Paolo, Pontoni, L., Rindzevicius, Tomas, Alopaeus, J.F., Su, K., Zeitler, J.A., Keller, Stephan Sylvest, Kikic, I., Moneghini, M., De Zordi, N., Solinas, D., Cortesi, A., Boisen, Anja, Marizza, Paolo, Pontoni, L., Rindzevicius, Tomas, Alopaeus, J.F., Su, K., Zeitler, J.A., Keller, Stephan Sylvest, Kikic, I., Moneghini, M., De Zordi, N., Solinas, D., Cortesi, A., and Boisen, Anja

Abstract

The present study is aimed to enhance the oral bioavailability of ketoprofen by inserting it into the matrixof poly(vinylpyrrolidone) (PVP) K10 spatially confined into microcontainers, by means of supercriticalCO2-aided impregnation. Microcontainers are cylindrical reservoirs, with typical sizes in the micrometerrange, with a cavity open on one side, where the drug formulation is loaded. Differently to traditionaltablets, microcontainers have a higher surface area per unit volume, and release the drug only in onedirection. This design is meant to enhance the absorption of problematic drugs, like those with poor sol-ubility in water. In a previous study we introduced a novel technique for drug loading of microcontainers,based on inkjet printing and supercritical impregnation (SCI). We showed that SCI produces accurate andreproducible drug loading for large arrays of microcontainers. In the attempt of enhancing the throughputof the loading methods, we propose the replacement of polymer inkjet printing with an easier man-ual compression of the PVP powder into the microcontainers. As the second step, the polymer powderfilled-microcontainers were submitted to SCI. The separate role of different impregnation parameters(temperature, pressure, time, drug concentration in the supercritical phase) was elucidated with respectto the loading capacity. The microcontainer filling was observed by means of optical macroimaging, X-ray microtomography and scanning electron microscopy. The physical state of the drug was investigatedby means of Raman spectroscopy and compared with selected representative PVP-ketoprofen physicalmixtures. Finally, the drug loading was estimated by means of in vitro dissolution tests.The characterization study shows that the present loading method is a valuable alternative to the onepreviously described. The drug loading can be controlled with high accuracy and reproducibility andthe impregnated drug is in amorphous state. These results demonstrate that SC

Published
2016

20. Pharmaceutical and Nutraceutical Applications of Supercritical Carbon Dioxide

Author

Zordi, N., Angelo Cortesi, Kikic, I., Moneghini, M., Solinas, D., Jane Osborne, DE ZORDI, Nicola, Cortesi, Angelo, Kikic, Ireneo, Moneghini, Mariarosa, and Solinas, Dario

Subjects
Food science, Particle design, Supercritical CO2 (SC-CO2), Pharmaceutical, Pharmaceuticals
Abstract

The main objective of this chapter is to review and highlight the main applications of Supercritical Carbon Dioxide (SCO2) techniques in several fields such as food science, pharmaceuticals, chemical residues, biofuel, and polymers. In particular supercritical processes such as particle design, impregnation and extraction processes will be investigated. Supercritical Fluid Particle Design (SCFPD), through different processes, allows to increase the solubility and dissolution rate of poorly water-soluble drugs and to improve the molecular properties of Active Pharmaceutical Ingredients (API) and Drug Delivery System (DDS). The chapter will be focused on the most recent developments of these processes covering the fundamental concept of SCO2 and the principle of SCFPD processes that are typically used to control both particle size and polymorphic form of the treated substances. Extraction with supercritical fluids arises in the last three decades as a promising alternative to conventional analytical methods for lipid extraction, and currently has consolidated its application in extraction processes of raw materials of plant and animal origin. Its advantages, over conventional techniques, are many and well known, but this technology stands out mainly by environmental factors and products quality. The aspects related to the use of SCO2 for extraction and fractionation of lipids, with special emphasis in triglycerols and fatty acids (in particular Polyunsaturated Fatty Acids –PUFA) will be investigated. A brief overview on the separation procedures involving supercritical technology, as supercritical fluid chromatography, will be also presented.

Published
2014

24. Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

Author

Paolo Marizza, Stephan Sylvest Keller, Rades, T., Müllertz, A., Kikic, I., Moneghini, M., Zordi, N., Solinas, D., Anja Boisen, CRS, P., Marizza, S. S., Keller, T., Rade, A., Müllertz, Kikic, Ireneo, Moneghini, Mariarosa, DE ZORDI, Nicola, Solinas, Dario, and A., Boisen

Subjects
Supercritical CO2 (SC-CO2), polymer, Impregnation
Abstract

In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

Published
2013

26. Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

Author

Marizza, Paolo, Keller, Stephan Sylvest, Rades, T., Müllertz, A., Kikic, I., Moneghini, M., De Zordi, N., Solinas, D., and Boisen, Anja

Abstract

In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

Published
2013

37. Determination and Correlation of Solubility of Pharmaceutical Products in Supercritical Carbon Dioxide

Author

Alessi, P., Cortesi, A., Kikic, I., NEIL FOSTER, Alessi, Paolo, Cortesi, Angelo, Kikic, Ireneo, and Foster, R. N.

Subjects
Solid supercritical solubility, Correlation, Prediction
Abstract

Aim of this work is to evaluate and to compare different methodologies for the correlation and prediction of solubility data of heavy solid compounds in supercritical fluids. This evaluation will allow a more useful use of the predictive methods combined with the reduction of the experimental work.

Published
1997

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