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13 results on '"Kikhtyak, Zoya"'

4. Selective inhibition of CDK9 in triple negative breast cancer

Author

Mustafa, Ebtihal H., primary, Laven-Law, Geraldine, additional, Kikhtyak, Zoya, additional, Nguyen, Van, additional, Ali, Simak, additional, Pace, Alex A., additional, Iggo, Richard, additional, Kebede, Alemwork, additional, Noll, Ben, additional, Wang, Shudong, additional, Winter, Jean M., additional, Dwyer, Amy R., additional, Tilley, Wayne D., additional, and Hickey, Theresa E., additional

Published
2023
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6. Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Author

Valdés-Mora, Fátima, primary, Salomon, Robert, additional, Gloss, Brian Stewart, additional, Law, Andrew Man Kit, additional, Venhuizen, Jeron, additional, Castillo, Lesley, additional, Murphy, Kendelle Joan, additional, Magenau, Astrid, additional, Papanicolaou, Michael, additional, Rodriguez de la Fuente, Laura, additional, Roden, Daniel Lee, additional, Colino-Sanguino, Yolanda, additional, Kikhtyak, Zoya, additional, Farbehi, Nona, additional, Conway, James Ronald William, additional, Sikta, Neblina, additional, Oakes, Samantha Richelle, additional, Cox, Thomas Robert, additional, O’Donoghue, Seán Ignatius, additional, Timpson, Paul, additional, Ormandy, Christopher John, additional, and Gallego-Ortega, David, additional

Published
2021
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8. Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype

Author

Valdes-Mora, Fatima, primary, Salomon, Robert, additional, Gloss, Brian, additional, Law, Andrew MK, additional, Castillo, Lesley, additional, Murphy, Kendelle, additional, Venhuizen, Jeron, additional, Magenau, Astrid, additional, Papanicolau, Michael, additional, Rodriguez de la Fuente, Laura, additional, Roden, Daniel L., additional, Colino-Sanguino, Yolanda, additional, Kikhtyak, Zoya, additional, Farbehi, Nona, additional, Conway, James RW, additional, Oakes, Samantha R., additional, Sikta, Neblina, additional, O'Donoghue, Seán I., additional, Cox, Thomas R., additional, Timpson, Paul, additional, Ormandy, Christopher J., additional, and Gallego Ortega, David, additional

Published
2020
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9. Nuclear ErbB-2 activity modulates the interferon signaling pathway in breast cancer cells resistant to anti-ErbB-2 therapies

Author

Russo, Rosalia I Cordo, primary, Madera, Santiago, additional, Chervo, Maria F, additional, Ebrahimie, Esmaeil, additional, Selth, Luke, additional, Chiauzzi, Violeta A, additional, Kikhtyak, Zoya, additional, Proietti, Cecilia J, additional, Schillaci, Roxana, additional, Charreau, Eduardo H, additional, Hickey, Theresa E, additional, Tilley, Wayne D, additional, and Elizalde, Patricia V, additional

Published
2019
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10. Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Author

Valdes-Mora, Fatima, primary, Salomon, Robert, additional, Gloss, Brian, additional, Law, Andrew MK., additional, Castillo, Lesley, additional, Murphy, Kendelle J., additional, Venhuizen, Jeron, additional, Magenau, Astrid, additional, Papanicolau, Michael, additional, de la Fuente, Laura Rodriguez, additional, Roden, Daniel L., additional, Colino-Sanguino, Yolanda, additional, Kikhtyak, Zoya, additional, Farbehi, Nona, additional, Conway, James RW., additional, Oakes, Samantha R., additional, Sikta, Neblina, additional, O’Donoghue, Seán I., additional, Cox, Thomas R, additional, Timpson, Paul, additional, Ormandy, Christopher J., additional, and Gallego-Ortega, David, additional

Published
2019
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11. ELF5 drives lung metastasis in luminal breast cancer through recruitment of Gr1+ CD11b+ myeloid-derived suppressor cells

Author

Gallego-Ortega, David, Ledger, Anita, Roden, Daniel L., Law, Andrew M.K., Magenau, Astrid, Kikhtyak, Zoya, Cho, Christina, Allerdice, Stephanie L., Lee, Heather J., Valdes-Mora, Fatima, Herrmann, David, Salomon, Robert, Young, Adelaide I.J., Lee, Brian Y., Marcelo Sergio, C., Kaplan, Warren, Piggin, Catherine, Conway, James R.W., Rabinovich, Brian, Millar, Ewan K.A., Oakes, Samantha R., Chtanova, Tatyana, Swarbrick, Alexander, Naylor, Matthew J., Green, Andrew R., Timpson, Paul, Gee, Julia M.W., Ellis, Ian O., Clark, Susan J., and Ormandy, Christopher J.

Subjects
Nottingham Breast Cancer Research Centre
Abstract

During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subtype and has been implicated in the development of insensitivity to anti-estrogen therapy. In the mouse mammary tumor virus-Polyoma Middle T (MMTV-PyMT) model of luminal breast cancer, induction of ELF5 levels increased leukocyte infiltration, angiogenesis, and blood vessel permeability in primary tumors and greatly increased the size and number of lung metastasis. Myeloid-derived suppressor cells, a group of immature neutrophils recently identified as mediators of vasculogenesis and metastasis, were recruited to the tumor in response to ELF5. Depletion of these cells using specific Ly6G antibodies prevented ELF5 from driving vasculogenesis and metastasis. Expression signatures in luminal A breast cancers indicated that increased myeloid cell invasion and inflammation were correlated with ELF5 expression, and increased ELF5 immunohistochemical staining predicted much shorter metastasis–free and overall survival of luminal A patients, defining a group who experienced unexpectedly early disease progression. Thus, in the MMTV-PyMT mouse mammary model, increased ELF5 levels drive metastasis by co-opting the innate immune system. As ELF5 has been previously implicated in the development of antiestrogen resistance, this finding implicates ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.

Published
2015

12. A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

Author

Oakes, Samantha R., primary, Gallego-Ortega, David, additional, Stanford, Prudence M., additional, Junankar, Simon, additional, Au, Wendy Wing Yee, additional, Kikhtyak, Zoya, additional, von Korff, Anita, additional, Sergio, Claudio M., additional, Law, Andrew M. K., additional, Castillo, Lesley E., additional, Allerdice, Stephanie L., additional, Young, Adelaide I. J., additional, Piggin, Catherine, additional, Whittle, Belinda, additional, Bertram, Edward, additional, Naylor, Matthew J., additional, Roden, Daniel L., additional, Donovan, Jesse, additional, Korennykh, Alexei, additional, Goodnow, Christopher C., additional, O’Bryan, Moira K., additional, and Ormandy, Christopher J., additional

Published
2017
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13. ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.

Author

Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A, Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, and Ormandy CJ

Subjects
Animals, Breast Neoplasms immunology, Breast Neoplasms physiopathology, Breast Neoplasms virology, Capillary Permeability, Cell Proliferation, DNA-Binding Proteins, Female, Green Fluorescent Proteins genetics, Green Fluorescent Proteins metabolism, Hemorrhage etiology, Hemorrhage prevention & control, Humans, Leukocytes immunology, Leukocytes pathology, Lung blood supply, Lung immunology, Lung pathology, Lung Neoplasms blood supply, Lung Neoplasms pathology, Lung Neoplasms prevention & control, Lymphocyte Depletion, Mice, Transgenic, Myeloid Cells immunology, Myeloid Cells pathology, Neoplasm Proteins genetics, Neovascularization, Pathologic etiology, Neovascularization, Pathologic prevention & control, Neutrophil Infiltration, Polyomavirus pathogenicity, Proto-Oncogene Proteins c-ets genetics, Recombinant Fusion Proteins metabolism, Survival Analysis, Transcription Factors, Tumor Burden, Breast Neoplasms metabolism, Lung metabolism, Lung Neoplasms secondary, Neoplasm Proteins metabolism, Proto-Oncogene Proteins c-ets metabolism
Abstract

During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subtype and has been implicated in the development of insensitivity to anti-estrogen therapy. In the mouse mammary tumor virus-Polyoma Middle T (MMTV-PyMT) model of luminal breast cancer, induction of ELF5 levels increased leukocyte infiltration, angiogenesis, and blood vessel permeability in primary tumors and greatly increased the size and number of lung metastasis. Myeloid-derived suppressor cells, a group of immature neutrophils recently identified as mediators of vasculogenesis and metastasis, were recruited to the tumor in response to ELF5. Depletion of these cells using specific Ly6G antibodies prevented ELF5 from driving vasculogenesis and metastasis. Expression signatures in luminal A breast cancers indicated that increased myeloid cell invasion and inflammation were correlated with ELF5 expression, and increased ELF5 immunohistochemical staining predicted much shorter metastasis-free and overall survival of luminal A patients, defining a group who experienced unexpectedly early disease progression. Thus, in the MMTV-PyMT mouse mammary model, increased ELF5 levels drive metastasis by co-opting the innate immune system. As ELF5 has been previously implicated in the development of antiestrogen resistance, this finding implicates ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.

Published
2015
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