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3. Accuracy and Reproducibility of Myocardial Blood Flow Quantification by Single Photon Emission Computed Tomography Imaging in Patients With Known or Suspected Coronary Artery Disease

Author

de Souza, Ana Carolina do AH, Harms, Hendrik J, Martell, Laurel, Bibbo, Courtney, Harrington, Meagan, Sullivan, Kyle, Hainer, Jon, Dorbala, Sharmila, Blankstein, Ron, Taqueti, Viviany R, Kijewski, Marie Foley, Park, Mi-Ae, Meretta, Alejandro, Breault, Christopher, Roth, Nathaniel, Poitrasson-Rivière, Alexis, Soman, Prem, Gullberg, Grant T, and Di Carli, Marcelo F

Subjects
Heart Disease - Coronary Heart Disease, Cardiovascular, Biomedical Imaging, Clinical Research, Heart Disease, Prevention, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Ammonia, Cadmium, Coronary Artery Disease, Coronary Circulation, Humans, Myocardial Perfusion Imaging, Positron-Emission Tomography, Reproducibility of Results, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon, Zinc, myocardial blood flow, myocardial flow reserve, positron emission tomography, tomography, emission-computed, single-photon, tomography, emission-computed, single-photon, Clinical Sciences, Cardiovascular System & Hematology
Abstract

BackgroundSingle photon emission computed tomography (SPECT) has limited ability to identify multivessel and microvascular coronary artery disease. Gamma cameras with cadmium zinc telluride detectors allow the quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR). However, evidence of its accuracy is limited, and of its reproducibility is lacking. We aimed to validate 99mTc-sestamibi SPECT MBF and MFR using standard and spline-fitted reconstruction algorithms compared with 13N-ammonia positron emission tomography in a cohort of patients with known or suspected coronary artery disease and to evaluate the reproducibility of this technique.MethodsAccuracy was assessed in 34 participants who underwent dynamic 99mTc-sestamibi SPECT and 13N-ammonia positron emission tomography and reproducibility in 14 participants who underwent 2 99mTc-sestamibi SPECT studies, all within 2 weeks. A rest/pharmacological stress single-day SPECT protocol was performed. SPECT images were reconstructed using a standard ordered subset expectation maximization (OSEM) algorithm with (N=21) and without (N=30) application of spline fitting. SPECT MBF was quantified using a net retention kinetic model' and MFR was derived as the stress/rest MBF ratio.ResultsSPECT global MBF with splines showed good correlation with 13N-ammonia positron emission tomography (r=0.81, P0.05 for all).ConclusionsMBF and MFR quantification using 99mTc-sestamibi cadmium zinc telluride SPECT with spatiotemporal spline fitting improved the correlation with 13N-ammonia positron emission tomography flow estimates and test/retest reproducibility. The use of splines may represent an important step toward the standardization of SPECT flow estimation.

Published
2022

9. Contributors

Author

Baehring, Joachim M., primary, Bastos, Dhiego C.A., additional, Beegle, Richard, additional, Bi, Wenya Linda, additional, Blackburn, Kyle M., additional, Blumenthal, Deborah T., additional, Bourekas, Eric C., additional, Bovi, Joseph A., additional, Brennan, Nicole Petrovich, additional, Brown, Alyssa, additional, Budhu, Joshua A., additional, Burt Nabors, L., additional, Bussiere, Marc, additional, Chakravarti, Arnab, additional, Chamberlain, Marc C., additional, Chao, Samuel T., additional, Chapman, Paul H., additional, Chen, Clark C., additional, Chi, Susan, additional, Choi, Serah, additional, Christoforidis, Gregory A., additional, Clarke, Jennifer L., additional, Corrêa, Diogo Goulart, additional, da Cruz, Luiz Celso Hygino, additional, Diaz, Maria, additional, Dixit, Karan S., additional, Dodson, Sean, additional, Edwards, Ryan M., additional, Ellika, Shehanaz, additional, Ellithi, Moataz, additional, Elsamadicy, Aladine A., additional, Fecci, Peter E., additional, Ferrante, Mark A., additional, Ferraro, Nicholas C., additional, Field, Melvin, additional, Fisicaro, Ryan, additional, Fonkem, Ekokobe, additional, Fulbright, Robert K., additional, Gerstner, Elizabeth R., additional, Golby, Alexandra J., additional, Goulart, Carlos R., additional, Guenette, Jeffrey P., additional, Guiou, Michael, additional, Gupta, Nilendu, additional, Halima, Ahmed, additional, Hatef, Angel L., additional, Heverhagen, Johannes T., additional, Holodny, Andrei, additional, Hughes, Tudor Hesketh, additional, Huie, David, additional, Ilica, Ahmet Turan, additional, Ina Ly, K., additional, Ivan, Michael E., additional, Jain, Rajan, additional, Johansson, Jens, additional, Johnson, Michele H., additional, Jolesz, Ferenc A., additional, Jung, Edward W., additional, Kangarlu, Alayar, additional, Kardan, Arash, additional, Karschnia, Philipp, additional, Kaur, Gurvinder, additional, Kijewski, Marie Foley, additional, Kim, Jinsuh, additional, Kocher, Madison, additional, Komotar, Ricardo J., additional, Krol, George, additional, Kurz, Sylvia C., additional, Kwofie, Michael, additional, Lantos, Joshua, additional, Lee, Eudocia Quant, additional, Le Rhun, Emilie, additional, Lerner, Emily C., additional, Liu, Benjamin P., additional, Lo, Simon S., additional, Lobbous, Mina, additional, Loeffler, Jay S., additional, Lowe, Stephen R., additional, Luther, Evan, additional, Maier, Stephan E., additional, Majithia, Lonika, additional, Makary, Mina S., additional, Mattei, Tobias A., additional, Mayo, Zachary S., additional, Mendel, Ehud, additional, Mikkelsen, Tom, additional, Miranda, Pedro C., additional, Moffat, Bradford A., additional, Murphy, Erin S., additional, Murray, John Vincent, additional, Muzic, Raymond F., additional, Nagpal, Prashant, additional, Naidich, Michelle J., additional, Newton, Herbert B., additional, Nine, Erik B., additional, Nisnboym, Michal, additional, Noujaim, Daniel, additional, Oberheim Bush, Nancy Ann, additional, Olubiyi, Olutayo, additional, Omay, Sacit Bulent, additional, Paleologos, Nina A., additional, Patel, Kunal S., additional, Pena Pino, Isabela, additional, Poussaint, Tina Young, additional, Prabhu, Sanjay P., additional, Qin, Lei, additional, Qu, Jinrong, additional, Rebeiz, Karim, additional, Reddy, Haricharan, additional, Reeves, Benjamin C., additional, Rogers, Lisa R., additional, Satter, Martin, additional, Sattur, Mithun G., additional, Schmainda, Kathleen M., additional, Shams, Mana, additional, Shams, Sara, additional, Silvera, V. Michelle, additional, Sloan, Andrew, additional, Slone, H. Wayne, additional, Snyder, James, additional, Sodickson, Daniel K., additional, Sodickson, Aaron D., additional, Solnes, Lilja Bjork, additional, Spampinato, Maria Vittoria, additional, Srinivasan, Ethan S., additional, Suh, John H., additional, Sun, Yanping, additional, Sutton, Nicholas A., additional, Tadipatri, Ramya, additional, Tharin, Suzanne, additional, Thompson, Ryan, additional, Turner, Tia H., additional, Vaios, Eugene J., additional, Vernino, Steven, additional, Vogelbaum, Michael A., additional, Walston, Steve, additional, Waltz, Jeffrey, additional, Weicker, Michael A., additional, Welling, D. Bradley, additional, Wen, Patrick Y., additional, Wenger, Cornelia, additional, Wintermark, Max, additional, Wong, Eric T., additional, Yang, Edward, additional, Yeh, Randy, additional, Yildirim, Onur, additional, Young, Geoffrey S., additional, Young, Robert J., additional, Zaman, Rujman U., additional, and Zukas, Alicia M., additional

Published
2022
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12. Quantification of right ventricular amyloid burden with 18F-florbetapir positron emission tomography/computed tomography and its association with right ventricular dysfunction and outcomes in light-chain amyloidosis.

Author

Datar, Yesh, Clerc, Olivier F, Cuddy, Sarah A M, Kim, Sirwoo, Taylor, Alexandra, Neri, Jocelyn Canseco, Benz, Dominik C, Bianchi, Giada, Yee, Andrew J, Sanchorawala, Vaishali, Ruberg, Frederick L, Landau, Heather, Liao, Ronglih, Kijewski, Marie Foley, Jerosch-Herold, Michael, Kwong, Raymond Y, Carli, Marcelo F Di, Falk, Rodney H, and Dorbala, Sharmila

Subjects
CARDIAC amyloidosis, IMMUNOGLOBULIN light chains, CARDIOMYOPATHIES, RESEARCH funding, COMPUTED tomography, TREATMENT effectiveness, DESCRIPTIVE statistics, PEPTIDE hormones, MULTIVARIATE analysis, AMYLOIDOSIS, LUNGS, LONGITUDINAL method, RIGHT ventricular dysfunction, EMISSION-computed tomography, RIGHT heart ventricle, ECHOCARDIOGRAPHY, EVALUATION
Abstract

Aims In systemic light-chain (AL) amyloidosis, quantification of right ventricular (RV) amyloid burden has been limited and the pathogenesis of RV dysfunction is poorly understood. Using 18F-florbetapir positron emission tomography/computed tomography (PET/CT), we aimed to quantify RV amyloid; correlate RV amyloid with RV structure and function; determine the independent contributions of RV, left ventricular (LV), and lung amyloid to RV function; and associate RV amyloid with major adverse cardiac events (MACE: death, heart failure hospitalization, cardiac transplantation). Methods and results We prospectively enrolled 106 participants with AL amyloidosis (median age 62 years, 55% males) who underwent 18F-florbetapir PET/CT, magnetic resonance imaging, and echocardiography. 18F-florbetapir PET/CT identified RV amyloid in 63% of those with and 40% of those without cardiac involvement by conventional criteria. RV amyloid burden correlated with RV ejection fraction (EF), RV free wall longitudinal strain (FWLS), RV wall thickness, RV mass index, N-terminal pro-brain natriuretic peptide, troponin T, LV amyloid, and lung amyloid (each P < 0.001). In multivariable analysis, RV amyloid burden, but not LV or lung amyloid burden, predicted RV dysfunction (EF P = 0.014; FWLS P < 0.001). During a median follow-up of 28 months, RV amyloid burden predicted MACE (P < 0.001). Conclusion This study shows for the first time that 18F-florbetapir PET/CT identifies early RV amyloid in systemic AL amyloidosis prior to alterations in RV structure and function. Increasing RV amyloid on 18F-florbetapir PET/CT is associated with worse RV structure and function, predicts RV dysfunction, and predicts MACE. These results imply a central role for RV amyloid in the pathogenesis of RV dysfunction. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Quantification of Right Ventricular Amyloid Burden with 18F-florbetapir PET/CT and its Association with Right Ventricular Dysfunction and Outcomes in Light-Chain Amyloidosis

Author

Datar, Yesh, primary, Clerc, Olivier F, additional, Cuddy, Sarah A M, additional, Kim, Sirwoo, additional, Taylor, Alexandra, additional, Neri, Jocelyn Canseco, additional, Benz, Dominik C, additional, Bianchi, Giada, additional, Yee, Andrew J, additional, Sanchorawala, Vaishali, additional, Ruberg, Frederick L, additional, Landau, Heather, additional, Liao, Ronglih, additional, Kijewski, Marie Foley, additional, Jerosch-Herold, Michael, additional, Kwong, Raymond Y, additional, Di Carli, Marcelo F, additional, Falk, Rodney H, additional, and Dorbala, Sharmila, additional

Published
2024
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19. Myocardial Characterization for Early Diagnosis, Treatment Response Monitoring, and Risk Assessment in Systemic Light-Chain Amyloidosis

Author

Clerc, Olivier F., primary, Cuddy, Sarah A. M., additional, Jerosch-Herold, Michael, additional, Benz, Dominik C, additional, Katznelson, Ethan, additional, Canseco Neri, Jocelyn, additional, Taylor, Alexandra, additional, Kijewski, Marie Foley, additional, Bianchi, Giada, additional, Ruberg, Frederick L., additional, Di Carli, Marcelo F., additional, Liao, Ronglih, additional, Kwong, Raymond Y., additional, Falk, Rodney H., additional, and Dorbala, Sharmila, additional

Published
2023
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23. Accuracy and Reproducibility of Myocardial Blood Flow Quantification by SPECT Imaging in Patients With Known or Suspected Coronary Artery Disease

Author

de Souza, Ana Carolina do A. H., Harms, Hendrik J., Martell, Laurel, Bibbo, Courtney, Harrington, Meagan, Sullivan, Kyle, Hainer, Jon, Dorbala, Sharmila, Blankstein, Ron, Taqueti, Viviany R., Kijewski, Marie Foley, Park, Mi-Ae, Meretta, Alejandro, Breault, Christopher, Roth, Nathaniel, Poitrasson-Rivière, Alexis, Soman, Prem, Gullberg, Grant T., and Di Carli, Marcelo F.

Subjects
Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon, Zinc, Ammonia, Coronary Circulation, Positron-Emission Tomography, Myocardial Perfusion Imaging, Humans, Reproducibility of Results, Coronary Artery Disease, Article, Cadmium
Abstract

BACKGROUND: Single photon emission computed tomography (SPECT) has limited ability to identify multivessel and microvascular coronary artery disease (CAD). Gamma cameras with cadmium zinc telluride (CZT) detectors allow the quantification of absolute myocardial blood flow (MBF) and flow reserve (MFR). However, evidence of its accuracy is limited and of its reproducibility is lacking. We aimed to validate (99m)Tc-sestamibi SPECT MBF and MFR using standard and spline-fitted reconstruction algorithms compared to (13)N-ammonia PET in a cohort of patients with known or suspected CAD and to evaluate the reproducibility of this technique. METHODS: Accuracy was assessed in thirty four participants who underwent dynamic (99m)Tc-sestamibi SPECT and (13)N-ammonia PET and reproducibility in fourteen participants who underwent two (99m)Tc-sestamibi SPECT studies, all within two weeks. A rest/pharmacological stress single-day SPECT protocol was performed. SPECT images were reconstructed using a standard ordered subset expectation maximization (OSEM) algorithm with (N=21) and without (N=30) application of spline fitting. SPECT MBF was quantified using a net retention kinetic model and MFR was derived as the stress/rest MBF ratio. RESULTS: SPECT global MBF with splines showed good correlation with (13)N-ammonia PET (r=0.81, p0.05 for all). CONCLUSIONS: MBF and MFR quantification using (99m)Tc-sestamibi CZT SPECT with spatiotemporal spline fitting improved the correlation with (13)N-ammonia PET flow estimates and test/re-test reproducibility. The use of splines may represent an important step towards standardization of SPECT flow estimation.

Published
2022

24. List of Contributors

Author

Ankenbrandt, William, primary, Arrillaga-Romany, Isabel, additional, Atsina, K.K., additional, Badve, Chaitra A., additional, Baehring, J.M., additional, Baldassarre, Randall Lawrence, additional, Bi, Wenya Linda, additional, Black, Peter M., additional, Boehm, Ingrid B., additional, Bolles, Genevieve, additional, Bourekas, Eric C., additional, Brennan, Nicole Petrovich, additional, Bussiere, Marc, additional, Cha, Soonmee, additional, Chakravarti, Arnab, additional, Chamberlain, Marc C., additional, Chang, Susan M., additional, Chapman, Paul H., additional, Chen, Clark C., additional, Chi, Susan N., additional, Chourmouzi, D., additional, Christoforidis, Gregory A., additional, Chukwueke, Ugonma, additional, Clarke, Jennifer L., additional, Collins, John M., additional, da Cruz, L. Celso Hygino, additional, Dolati, Parviz, additional, Drevelegas, A., additional, Drevelegas, K., additional, Eisele, Sylvia, additional, Ellika, Shehanaz, additional, Ferrante, Mark A., additional, Ferraro, Nicholas C., additional, Fisicaro, Ryan, additional, Golby, Alexandra J., additional, Goulart, Carlos R., additional, Guiou, Michael, additional, Gupta, Nilendu, additional, Hata, Nobuhiko, additional, Hearshen, David, additional, Henson, John W., additional, Heverhagen, Johannes T., additional, Holodny, Andrei, additional, Hughes, Tudor Hesketh, additional, Ichise, Masanori, additional, Ivan, Michael E., additional, Jain, Rajan, additional, Jolesz, Ferenc A., additional, Jordan, Justin T., additional, Daniel, Kacher, additional, Kangarlu, Alayar, additional, Kardan, Arash, additional, Kijewski, Marie Foley, additional, Kimura, Margareth, additional, Kissel, John T., additional, Komotar, Ricardo J., additional, Krol, George, additional, Kumthekar, Priya, additional, Lantos, Joshua, additional, Le Rhun, Emilie, additional, Lev, Michael H., additional, Loeffler, Jay S., additional, Maier, Stephan E., additional, Majithia, Lonika, additional, Mattei, Tobias A., additional, McCullough, Brendan J., additional, Mendel, Ehud, additional, Mikkelsen, Tom, additional, Miloushev, Vesselin Z., additional, Miranda, Pedro C., additional, Monje, Michelle, additional, Nagpal, Prashant, additional, Nakanote, Ken Alexander, additional, Newton, Herbert B., additional, Nine, Erik B., additional, Oberheim Bush, Nancy Ann, additional, Olubiyi, Olutayo, additional, Omay, S.B., additional, Paleologos, Nina, additional, Papanicolaou, N., additional, Patel, Kunal S., additional, Poussaint, Tina Young, additional, Prabhu, Sanjay P., additional, Qu, Jinrong, additional, Raizer, Jeffrey J., additional, Reddy, Haricharan, additional, Rizvi, Tanvir, additional, Rogers, Lisa R., additional, Satter, Martin, additional, Sattur, Mithun G., additional, Schiff, David, additional, Schmainda, Kathleen, additional, Schweitzer, Andrew D., additional, Silvera, Victoria Michelle, additional, Slone, H. Wayne, additional, Snyder, James, additional, Sodickson, Aaron D., additional, Sodickson, Daniel K., additional, Solnes, Lilja Bjork, additional, Spampinato, Maria Vittoria, additional, Sun, Yanping, additional, Taillibert, Sophie, additional, Talos, Ion-Florin, additional, Tharin, Suzanne, additional, Vagal, Achala, additional, Vernino, Steven, additional, Vogelbaum, Michael A., additional, Vossough, Arastoo, additional, Walston, Steve, additional, Warfield, Simon K., additional, Weicker, Michael A., additional, Welling, D. Bradley, additional, Wenger, Cornelia, additional, Wen, Patrick Y., additional, Wintermark, Max, additional, Wong, Eric T., additional, Xinou, E., additional, Yang, Edward, additional, Yeh, Randy, additional, Young, Geoffrey S., additional, Young, Robert J., additional, and Zukas, Alicia M., additional

Published
2016
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31. The design and manufacture of an annular variable-focusing collimator for highsensitivity brain SPECT

Author

Ouyang, Jinsong, El Fakhri, Georges, Xia, Weishi, Kijewski, Marie Foley, and Genna, Sebastian

Subjects
SPECT imaging -- Equipment and supplies, Collimators (Optical instrument) -- Design and construction, Brain mapping -- Methods, Business, Electronics, Electronics and electrical industries
Abstract

Sensitivity near the center of the brain is critical for some clinical applications of brain SPECT, especially for those applications which require dynamic imaging. We have designed and built a novel collimator for the CeraSPECT dedicated brain SPECT system which uses variable focusing to increase the sensitivity for central regions of its field of view. The sensitivity at the center of the field of view is increased by a factor of two compared to the standard three-segment parallel-hole collimator; this sensitivity gain is achieved without compromising spatial resolution. Index Terms--Annular brain SPECT, CeraSPECT, SensOgrade collimator, variable-focusing collimator.

Published
2006

32. Collimator optimization for detection and quantitation tasks: application to gallium-67 imaging

Author

Moore, Stephen C., Kijewski, Marie Foley, and El Fakhri, Georges

Subjects
Radioisotope scanning -- Research, Business, Electronics, Electronics and electrical industries, Health care industry
Abstract

We describe a new approach to the problem of collimator optimization in nuclear medicine; our methodology is illustrated for the challenging case of gallium-67 imaging. Collimator-design methods based on empirical rules, such as specification of an allowable level of single-septal penetration (SSP) at a fixed energy, are especially inappropriate for radionuclides characterized by an abundance of high-energy contaminant photons that scatter in the patient, collimator, and/or detector before detection within one of a few photopeak energy windows. Lead X-rays produced in the collimator are an additional source of contamination. We designed optimal collimation for [sup.67]Ga based on relevant clinical imaging tasks and a realistic simulation of photon transport in a phantom, collimator, and detector. Collimator designs were compared on the basis of performance in lesion detection, as predicted by a three-channel Hotelling observer (CHO), as well as in tumor and background activity estimation (EST), quantified by task-specific signal-to-noise ratios (SNRs). The optimal values of collimator lead content were 22.0 and 23.8 g/[cm.sup.2], respectively, for CHO and EST, while the optimal geometric resolution values were 1.8 and 1.6 cm full-width at half-maximum (FWHM), respectively, at a distance of 23.5 cm. The resolution of a commercially available medium-energy low-penetration collimator (MELP) is 1.9 cm FWHM at this distance. The optimal values for SSP at 300 keV were 7.3% and 5.8% based on CHO and EST, respectively, compared to 5.2% for the MELP collimator. Compared with the commercial MELP collimator, the [sup.67]Ga collimator optimized for tumor detection or activity estimation tasks provided improved geometric spatial resolution with reduced geometric efficiency and, surprisingly, allowed an increased level of single-septal penetration. Index Terms--Collimator, detection, estimation, Ga-67, scintigraphy, SPECT.

Published
2005

34. Contributors

Author

Ankenbrandt, William, primary, Bajwa, Harman P.S., additional, Black, Peter M., additional, Bourekas, Eric C., additional, Brennan, Nicole Petrovich, additional, Bussiere, Marc, additional, Chamberlain, Marc C., additional, Chapman, Paul H., additional, Chen, Clark C., additional, Chourmouzi, D., additional, Christoforidis, Gregory A., additional, Cruz, L. Celso Hygino, additional, Davis, Eric, additional, Domingues, Romeu C., additional, Drevelegas, A., additional, Ellika, Shehanaz, additional, Ferrante, Mark A., additional, Figiel, Jens H., additional, Golby, Alexandra, additional, Gonzalez, R. Gilberto, additional, Gordon, Jonathan P., additional, Harris, Gordon J., additional, Hata, Nobuhiko, additional, Hearshen, D., additional, Henson, John W., additional, Heverhagen, Johannes T., additional, Holodny, Andrei, additional, Hsu, Liangge, additional, Hughes, Tudor H., additional, Ichise, Masanori, additional, Jain, Rajan, additional, Jolesz, Ferenc A., additional, Kacher, Daniel, additional, Kangarlu, Alayar, additional, Keil, Boris R., additional, Kijewski, Marie Foley, additional, Kissel, John T., additional, Knopp, Michael V., additional, Krol, George, additional, Lev, Michael H., additional, Lindell, E. Paul, additional, Loeffler, Jay S., additional, Maier, Stephan E., additional, Malkin, Mark G., additional, Mamata, Hatsuho, additional, Mikkelsen, T., additional, Monje, Michelle, additional, Mulkern, Robert V., additional, Naidich, Michelle J., additional, Newton, Herbert B., additional, Nine, Erik B., additional, Packard, Alan B., additional, Paleologos, Nina A., additional, Papanicolaou, N., additional, Phillips, C. Douglas, additional, Provenzale, James M., additional, Raizer, Jeffrey J., additional, Ray-Chaudhury, Abhik, additional, Reddy, Haricharan, additional, Robertson, Richard L., additional, Rogers, Lisa R., additional, Schaefer, Pamela W., additional, Schiff, David, additional, Schmainda, Kathleen, additional, Schmidt, Karl F., additional, Shah, Lubdha M., additional, Shuang, Xia, additional, Silvera, V. Michelle, additional, Sivapatham, Thinesh, additional, Slone, H. Wayne, additional, Sodickson, Aaron, additional, Solnes, Lilja, additional, Sorensen, A. Gregory, additional, Sun, Yanping, additional, Talos, Ion-Florin, additional, Tharin, Suzanne, additional, Ulmer, Stephan, additional, Van Heertum, Ronald L., additional, Vernino, Steven, additional, Vossough, Arastoo, additional, Warfield, Simon K., additional, Wen, Patrick Y., additional, Xinou, E., additional, Young, Geoffrey S., additional, Poussaint, Tina Young, additional, and Zamani, Amir A., additional

Published
2008
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38. Reproducibility and Repeatability of Assessment of Myocardial Light Chain Amyloidosis Burden Using 18F-Florbetapir PET/CT.

Author

Nodoushani, Ariana, El-Sady, Mohammed Samir, Park, Mi-Ae, Castilloveitia, Gloria L., Falk, Rodney H., Di Carli, Marcelo F., Kijewski, Marie Foley, and Dorbala, Sharmila

Abstract

Background: 18F-florbetapir PET is emerging as an excellent quantitative tool to quantify cardiac light chain (AL) amyloidosis burden. The primary aim of this study was to determine interobserver reproducibility and intraobserver repeatability, defined per the recommendations of the Quantitative Imaging Biomarker Alliance technical performance group, of PET 18F-florbetapir retention index (RI) in patients with cardiac AL amyloidosis.Methods: The study cohort comprised 37 subjects with systemic AL amyloidosis enrolled in the prospective study: Molecular Imaging of Primary Amyloid Cardiomyopathy (clinical trials.gov NCT: 02641145). Using 10 mCi of 18F-florbetapir, a 60-minute dynamic cardiac scan was acquired. Global and segmental left ventricular estimates of retention index (RI) of 18F-florbetapir were calculated (Carimas 2.9 software, Turku, Finland). RI was analyzed twice, at least 24 hours apart, by two independent observers. Intraobserver repeatability and interobserver reproducibility were evaluated using Bland-Altman plots and scatter plots with fitted linear regression curves.Results: All reproducibility (interobserver, r = 0.98) and repeatability (intraobserver, R=0.99 for each observer) measures of 18F-florbetapir RI are excellent. On the Bland-Altman plots, the agreement limits for global 18F-florbetapir RI were high and ranged for reproducibility (interobserver) from - 9.3 to + 9.4% (Fig. 1), and for repeatability (observer 1 from - 10.8 to + 10.7% and from - 9.2 to + 11.4%, for observer 2).Conclusions: The present study showed excellent interobserver reproducibility and intraobserver repeatability of 18F-florbetapir PET retention index in patients with cardiac AL amyloidosis. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Contributors

Author

Aghayev, Ayaz, Aguadé-Bruix, Santiago, Al-Mallah, Mouaz H., Bajaj, Navkaranbir S., Bateman, Timothy M., Beanlands, Rob S., Bengel, Frank M., Blankstein, Ron, Bokhari, Sabahat, Borges-Neto, Salvador, Bourque, Jamieson M., Bravo, Paco E., Brenande, Juliana, Case, James A., Chareonthaitawee, Panithaya, Cuddy-Walsh, Sarah G., Daaboul, Yazan, Dalgaard, Frederik, deKemp, Robert A., Di Carli, Marcelo Fernando, Diekmann, Johanna, Divakaran, Sanjay, Dorbala, Sharmila, Dweck, Marc R., Fayad, Zahi A., Fudim, Marat, Gimelli, Alessia, Groarke, John D., Gropler, Robert J., Hachamovitch, Rory, Hendel, Robert, Kijewski, Marie Foley, Lamacie, Mariana, Mahmarian, John, Malhotra, Saurabh, Gonzalez, Carola Maraboto, Meadows, Judith, Mielniczuk, Lisa M., Miller, Edward, Neglia, Danilo, Newby, David E., Nohria, Anju, Osborne, Michael T., Panhwar, Muhammad, Park, Mi-Ae, Patel, Krishna K., Peterson, Linda R., Pizzi, María Nazarena, Roque, Albert, Rudd, James H.F., Ruddy, Terrence David, Sanghani, Rupa M., Schwartz, Ronald G., Shaw, Leslee J., Sinusas, Albert J., Skali, Hicham, Slomka, Piotr J., Small, Gary R., Soman, Prem, Steigner, Michael, Taqueti, Viviany R., Tarkin, Jason M., Tawakol, Ahmed, Thackeray, James T., Travin, Mark I., Udelson, James E., Wells, R. Glenn, Werner, Rudolf A., Wilber, Michael, Liga, Riccardo, Schindler, Thomas H., Isgum, Ivana, Dey, Damini, Miller, Robert H., and Tzolos, Evangelos

Published
2022
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44. Relative Apical Sparing of Myocardial Longitudinal Strain Is Explained by Regional Differences in Total Amyloid Mass Rather Than the Proportion of Amyloid Deposits

Author

Bravo, Paco E., primary, Fujikura, Kana, additional, Kijewski, Marie Foley, additional, Jerosch-Herold, Michael, additional, Jacob, Sophia, additional, El-Sady, Mohamed Samir, additional, Sticka, William, additional, Dubey, Shipra, additional, Belanger, Anthony, additional, Park, Mi-Ae, additional, Di Carli, Marcelo F., additional, Kwong, Raymond Y., additional, Falk, Rodney H., additional, and Dorbala, Sharmila, additional

Published
2019
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46. Introduction of a novel ultrahigh sensitivity collimator for brain SPECT imaging

Author

Park, Mi-Ae, Kijewski, Marie Foley, Keijzers, Ronnie, Keijzers, Mark, Lyon, Morgan C., Horky, Laura, and Moore, Stephen C.

Subjects
Tomography, Emission-Computed, Single-Photon, DIAGNOSTIC IMAGING (IONIZING AND NON-IONIZING), Phantoms, Imaging, Brain, Signal-To-Noise Ratio
Abstract

Noise levels of brain SPECT images are highest in central regions, due to preferential attenuation of photons emitted from deep structures. To address this problem, the authors have designed a novel collimator for brain SPECT imaging that yields greatly increased sensitivity near the center of the brain without loss of resolution. This hybrid collimator consisted of ultrashort cone-beam holes in the central regions and slant-holes in the periphery (USCB). We evaluated this collimator for quantitative brain imaging tasks.Owing to the uniqueness of the USCB collimation, the hole pattern required substantial variations in collimator parameters. To utilize the lead-casting technique, the authors designed two supporting plates to position about 37 000 hexagonal, slightly tapered pins. The holes in the supporting plates were modeled to yield the desired focal length, hole length, and septal thickness. To determine the properties of the manufactured collimator and to compute the system matrix, the authors prepared an array of point sources that covered the entire detector area. Each point source contained 32 μCi of Tc-99m at the first scan time. The array was imaged for 5 min at each of the 64 shifted locations to yield a 2-mm sampling distance, and hole parameters were calculated. The sensitivity was also measured using a point source placed along the central ray at several distances from the collimator face. High-count projection data from a five-compartment brain phantom were acquired with the three collimators on a dual-head SPECT/CT system. The authors calculated Cramer-Rao bounds on the precision of estimates of striatal and background activity concentration. In order to assess the new collimation system to detect changes in striatal activity, the authors evaluated the precision of measuring a 5% decrease in right putamen activity. The authors also reconstructed images of projection data obtained by summing data from the individual phantom compartments.The sensitivity of the novel cone-beam collimator varied with distance from the detector face; it was higher than that of the fan-beam collimator by factors ranging from 2.7 to 162. Examination of the projections of the point sources revealed that only a few holes were distorted or partially blocked, indicating that the intensive manual fabrication process was very successful. Better reconstructed phantom images were obtained from the USCB+FAN collimator pair than from either LEHR or FAN collimation. For the left caudate, located near the center of the brain, the detected counts were 9.8 (8.3) times higher for UCSB compared with LEHR (FAN), averaged over 60 views. The task-specific SNR for detecting a 5% decrease in putamen uptake was 7.4 for USCB and 3.2 for LEHR.The authors have designed and manufactured a novel collimator for brain SPECT imaging. The sensitivity is much higher than that of a fan-beam collimator. Because of differences between the manufactured collimator and its design, reconstruction of the data requires a measured system matrix. The authors have demonstrated the potential of USCB collimation for improved precision in estimating striatal uptake. The novel collimator may be useful for early detection of Parkinson's disease, and for monitoring therapy response and disease progression.

Published
2016

47. Effects of SPECT Collimation and System Geometry on Classification Tasks Related to Parkinson's Disease

Author

Kijewski, Marie Foley, Moore, Stephen C., Jadvar, Hossein, Zimmerman, Robert E., and Muller, Stefan P.

Subjects
Parkinson's disease -- Diagnosis, CT imaging -- Usage, Business, Electronics, Electronics and electrical industries
Abstract

We assessed the potential performance of three commercial SPECT systems in simulated, but realistic, imaging tasks related to the diagnosis and management of Parkinson's disease (PD). Images of I-123 altropane activity distributions in normal and PD brains were modeled assuming values from the literature for striatal sizes and activity concentrations, as well as for nonspecific activity. Imaging characteristics of the three systems were determined by phantom studies. The expected distributions of estimates of activity concentration and striatal volume were based on covariance matrices determined by the Cramer-Rao lower bounds calculated for a simultaneous estimation of these two parameters, as well as background activity concentration. Potential performance in several binary classification tasks was assessed by fitting ROC curves to simulated likelihood ratios for 5000 'subjects' in each category. For all conditions studied, ROC areas were similar for the higher resolution instruments and lower for the lower resolution system. These results imply a diagnostic advantage for higher resolution systems in imaging tasks related to PD.

Published
2001

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