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26. Behavioral similarities and differences among alcohol preferring and nonpreferring rats: confirmation by factor analysis and extension to additional groups

Author

Overstreet, D. H., Halikas, J. A., Seredenin, S. B., Kampov-Polevoy, A. B., Viglinskaya, I. V., Kashevskaya, O., Badishtov, B. A., Knapp, D. J., Pierre Mormede, Kiianmaa, K., Li, T. K., Rezvani, A. H., Neurogénétique et Stress (NS), Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1997

27. POSTER SESSION 1: BASIC RESEARCH AND INTERNAL MEDICINE * BASIC RESEARCH * P01 * ASSOCIATION BETWEEN FOK I VITAMIN D RECEPTOR (VDR) GENE POLYMORPHISM AND IMPULSIVENESS IN ALCOHOL-DEPENDENT PATIENTS

Author

Wrzosek, M., primary, Lukaszkiewicz, J., additional, Jakubczyk, A., additional, Wrzosek, M., additional, Matsumoto, H., additional, Wojnar, M., additional, Lee, J., additional, Lee, B., additional, Choi, M., additional, Chai, Y., additional, Choi, I., additional, Janu, L., additional, Rackova, S., additional, Horacek, J., additional, Sanchez-Catalan, M., additional, Hipolito, L., additional, Marti-Prats, L., additional, Orrico, A., additional, Zornoza, T., additional, Granero, L., additional, Polache, A., additional, Milivojevic, V., additional, Kranzler, H. R., additional, Covault, J., additional, Glahn, A., additional, Wenzel, C., additional, Wilhelm, J., additional, Frieling, H., additional, Heberlein, A., additional, Bleich, S., additional, Hillemacher, T., additional, Colombo, G., additional, Lobina, C., additional, Carai, M. A. M., additional, Gessa, G., additional, Cacciaglia, R., additional, Loche, A., additional, Kuthcer, E., additional, Egorov, A., additional, Filatova, E., additional, Kulagina, K., additional, Filatova, E. V., additional, Kuther, E., additional, Egorov, A. Y., additional, Loi, B., additional, Maccioni, P., additional, Ledesma, J., additional, Aragon, C. M. G., additional, Quoilin, C., additional, Didone, V., additional, Quertemont, E., additional, Kemppainen, H., additional, Raivio, N., additional, Kiianmaa, K., additional, Pascual-Mora, M., additional, Couto, B. R. D., additional, Minarro, J., additional, Guerri, C., additional, Alfonso-Loeches, S., additional, Urena-Peralta, J., additional, Pascual-Lucas, M., additional, Morillo, M. J., additional, Renau-Piqueras, J., additional, Marin, M., additional, Esteban-Pretel, G., additional, Ponsoda, X., additional, Romero, A., additional, Ballestin, R., additional, Lopez, C., additional, Megias, L., additional, Timoneda, J., additional, Molowni, A., additional, Escrig, M. A., additional, Tiraboschi, E., additional, Saarikoski, S. T., additional, Castren, E., additional, Tarragon, E., additional, Balino, P., additional, Aragon, C. M., additional, Camarini, R., additional, Soares, S. L., additional, Carrara-Nascimento, P. F., additional, Godinho, R. O., additional, Scavone, C., additional, Kanuri, G., additional, Kreusch, F., additional, Quertement, E., additional, Closon, C., additional, Masson, S., additional, Seutin, V., additional, Durazzo, T. C., additional, Fryer, S. L., additional, Hutchison, K. E., additional, Mon, A., additional, Meyerhoff, D. J., additional, Nummi, K. P., additional, Salaspuro, M., additional, Vakevainen, S., additional, Ukai, W., additional, Shirasaka, T., additional, Hashimoto, E., additional, Yoshinaga, T., additional, Kaneta, H., additional, Kigawa, M., additional, Igarashi, T., additional, Watanabe, K., additional, Tateno, M., additional, Ishii, T., additional, Saito, T., additional, Lallemand, F., additional, Ward, R. J., additional, De Witte, P., additional, Verbank, P., additional, Fiore, M., additional, and Ceccanti, M., additional

Published
2011
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34. Neurobiological Processes in Alcohol Addiction

Author

L??, A. D., primary, Kiianmaa, K., additional, Cunningham, C. L., additional, Engel, J. A., additional, Ericson, M., additional, S??derpalm, B., additional, Koob, G. F., additional, Roberts, A. J., additional, Weiss, F., additional, Hyyti??, P., additional, Janhunen, S., additional, Mikkola, J., additional, B??ckstr??m, P., additional, Ponomarev, I., additional, and Crabbe, J. C., additional

Published
2001
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35. Neurobiological Processes in Alcohol Addiction

Author

Le, A. D., primary, Kiianmaa, K., additional, Cunningham, C. L., additional, Engel, J. A., additional, Ericson, M., additional, Soderpalm, B., additional, Koob, G. F., additional, Roberts, A. J., additional, Weiss, F., additional, Hyytia, P., additional, Janhunen, S., additional, Mikkola, J., additional, Backstrom, P., additional, Ponomarev, I., additional, and Crabbe, J. C., additional

Published
2001
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39. Drinking habits and prevalence of heavy drinking among primary health care outpatients and general population.

Author

Aalto, M, Seppä, K, Kiianmaa, K, and Sillanaukee, P

Abstract

To identify the target group for brief alcohol intervention in primary health care and to compare the prevalence of heavy drinking in two different primary health care populations and the general population in the same geographical area. Drinking data were collected from outpatients of primary health care by a questionnaire containing the CAGE test and quantity-frequency alcohol consumption questions and from a sample of the general population by a telephone survey, including the CAGE. The index of heavy drinking was for men three, and for women two, affirmative answers in CAGE which though not specifically a consumption questionnaire is a good marker of heavy drinking. Two different primary health care populations (primary health care clinic and occupational health care clinic) and the general population in a Finnish health care area. Consecutive 1861 primary health care clinic and 2942 occupational health care clinic outpatients and 544 randomly selected adults in the general population, contacted by telephone. The primary health care clinic patients drank significantly more per occasion than the patients of the occupational health care clinic (75 vs. 66 g. in men; 33 vs. 27 g. in women) and fewer times per week (0.8 vs. 0.9 in men; 0.5 vs. 0.6 in women). The patients in the primary health care clinic also reported drinking more per week (76 vs. 67 g. in men; 23 vs. 19 g. in women); among women the difference was significant. Among men the prevalences of heavy drinking in the primary health care clinic, occupational health care clinic and general population were 20%, 17% and 16%, respectively (p > or = 0.05). Among women the corresponding figures were 9%, 6% and 13% (p < 0.05). The high prevalence of heavy drinking found in the study confirms the importance of brief intervention by general practitioners. The study also indicates that prevalence and drinking habits depend on the type of clinic and heavy drinkers in general may not be over-represented in primary health care. This study raises the question, especially among women, of how to reach and to provide health advice to those heavy drinkers who do not attend primary health care facilities. [ABSTRACT FROM AUTHOR]

Published
1999
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40. Differences in the Brain and Pituitary β-Endorphin System between the Alcohol-Preferring AA and Alcohol-Avoiding ANA Rats.

Author

Gianoulakis, C., Waele, J. P., and Kiianmaa, K.

Abstract

The content of pro-opiomelanocortin (POMC) mRNA was determined in the hypothalamus, as well as in the anterior and intermediate lobes of the pituitary gland of the alcohol-preferring AA and alcoholavoiding ANA rats under basal conditions. In addition the content of β-endorphin-like immunoreactivity (β-EPLIR) was measured in nine brain regions, the anterior and intermediate lobes of the pituitary gland and the serum. The content of β-EPLIR was significantly higher in the septum and significantly lower in the amygdala, and periaqueductal gray matter of the AA rats, while there was no significant difference between the AA and ANA rats in the arcuate nucleus plus median eminence, nucleus accumbens, caudate, hippocampus, and cortex. HPLC analysis indicated no significant differences in the relative proportions of non-acetyl and acetyl forms of β-endorphin peptides in the hypothalamus, distinct brain regions, and anterior and neurointermediate lobes of the pituitary gland, between the AA and ANA rats. The content of POMC mRNA but not of β-EPLIR was significantly higher in the hypothalamus and neurointermediate lobe of the AA rats, while the content of both β-EPLIR and POMC mRNA were significantly higher in the anterior pituitary of the AA than of the ANA rats. Thus, there are genetically determined differences in the pituitary and brain β-endorphin system between the AA and ANA rats, which may be important in controlling the differences in the voluntary ethanol consumption exhibited by these animals. [ABSTRACT FROM AUTHOR]

Published
1992
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