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8. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author

Sartelli, Massimo, Labricciosa, Francesco M., Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M., Ansaloni, Luca, Al-Hasan, Majdi N., Ansari, Shamshul, Barie, Philip S., Caínzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A., Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E., Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andreas, Leppäniemi, Ari K., Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E., Memish, Ziad Ahmed, Kirkpatrick, Andrew W., Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E., Sawyer, Robert G., Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Araúz, Ana Belén, Argenio, Giulio, Atanasov, Boyko C., Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A., Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boumédiène, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J., Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D’Acapito, Fabrizio, Damaskos, Dimitrios, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S., Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N., Dogjani, Agron, D’Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M., Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M., Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y., Hecker, Matthias, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S., Kapoor, Garima, Karaiskos, Ilias, Kavalakat, Alfie J., Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M., Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantinos, Lohsiriwat, Varut, Lostoridis, Eftychios, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasios, Martines, Gennaro, Martínez-Pérez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, Gökhan, Miranda-Novales, María Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y., Mora-Guzmán, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H., Negoi, Ionut, Nita, Gabriela Elisa, O’Connor, Donal B., Ordoñez, Carlos Alberto, Pantalone, Desiré, Panyko, Arpád, Papadopoulos, Aristeidis, Pararas, Nikolaos, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynolds, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampos, Serradilla-Martín, Mario, Shelat, Vishal G., Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andras, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, AliIbrahim, Zachariah, Sanoop K., Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P., Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V., and Catena, Fausto

Published
2022
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12. A pandemic recap: lessons we have learned

Author

Coccolini, Federico, Cicuttin, Enrico, Cremonini, Camilla, Tartaglia, Dario, Viaggi, Bruno, Kuriyama, Akira, Picetti, Edoardo, Ball, Chad, Abu-Zidan, Fikri, Ceresoli, Marco, Turri, Bruno, Jain, Sumita, Palombo, Carlo, Guirao, Xavier, Rodrigues, Gabriel, Gachabayov, Mahir, Machado, Fernando, Eftychios, Lostoridis, Kanj, Souha S., Di Carlo, Isidoro, Di Saverio, Salomone, Khokha, Vladimir, Kirkpatrick, Andrew, Massalou, Damien, Forfori, Francesco, Corradi, Francesco, Delibegovic, Samir, Machain Vega, Gustavo M., Fantoni, Massimo, Demetriades, Demetrios, Kapoor, Garima, Kluger, Yoram, Ansari, Shamshul, Maier, Ron, Leppaniemi, Ari, Hardcastle, Timothy, Vereczkei, Andras, Karamagioli, Evika, Pikoulis, Emmanouil, Pistello, Mauro, Sakakushev, Boris E., Navsaria, Pradeep H., Galeiras, Rita, Yahya, Ali I., Osipov, Aleksei V., Dimitrov, Evgeni, Doklestić, Krstina, Pisano, Michele, Malacarne, Paolo, Carcoforo, Paolo, Sibilla, Maria Grazia, Kryvoruchko, Igor A., Bonavina, Luigi, Kim, Jae Il, Shelat, Vishal G., Czepiel, Jacek, Maseda, Emilio, Marwah, Sanjay, Chirica, Mircea, Biancofiore, Giandomenico, Podda, Mauro, Cobianchi, Lorenzo, Ansaloni, Luca, Fugazzola, Paola, Seretis, Charalampos, Gomez, Carlos Augusto, Tumietto, Fabio, Malbrain, Manu, Reichert, Martin, Augustin, Goran, Amato, Bruno, Puzziello, Alessandro, Hecker, Andreas, Gemignani, Angelo, Isik, Arda, Cucchetti, Alessandro, Nacoti, Mirco, Kopelman, Doron, Mesina, Cristian, Ghannam, Wagih, Ben-Ishay, Offir, Dhingra, Sameer, Coimbra, Raul, Moore, Ernest E., Cui, Yunfeng, Quiodettis, Martha A., Bala, Miklosh, Testini, Mario, Diaz, Jose, Girardis, Massimo, Biffl, Walter L., Hecker, Matthias, Sall, Ibrahima, Boggi, Ugo, Materazzi, Gabriele, Ghiadoni, Lorenzo, Matsumoto, Junichi, Zuidema, Wietse P., Ivatury, Rao, Enani, Mushira A., Litvin, Andrey, Al-Hasan, Majdi N., Demetrashvili, Zaza, Baraket, Oussama, Ordoñez, Carlos A., Negoi, Ionut, Kiguba, Ronald, Memish, Ziad A., Elmangory, Mutasim M., Tolonen, Matti, Das, Korey, Ribeiro, Julival, O’Connor, Donal B., Tan, Boun Kim, Van Goor, Harry, Baral, Suman, De Simone, Belinda, Corbella, Davide, Brambillasca, Pietro, Scaglione, Michelangelo, Basolo, Fulvio, De’Angelis, Nicola, Bendinelli, Cino, Weber, Dieter, Pagani, Leonardo, Monti, Cinzia, Baiocchi, Gianluca, Chiarugi, Massimo, Catena, Fausto, and Sartelli, Massimo

Published
2021
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18. Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks

Author

Mulindwa, Frank, primary, Schwarz, Jean-Marc, additional, Brusselaers, Nele, additional, Nabwana, Martin, additional, Bollinger, Robert, additional, Buzibye, Allan, additional, Amutuhaire, Willington, additional, Yendewa, George, additional, Laker, Eva, additional, Kiguba, Ronald, additional, and Castelnuovo, Barbara, additional

Published
2023
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23. Epidemiology of adverse drug reactions to antihypertensive, antithrombotic and antidiabetic medications among adult inpatients at a National Referral Hospital, Uganda

Author

Kuteesa, Jonathan, Nasasira, Marble, and Kiguba, Ronald

Abstract

ABSTRACTIntroductionTreatment for hypertension, thrombosis and type 2 diabetes mellitus is long term and usually requires a combination of drugs which increases the risk of adverse drug reactions (ADRs). This study aimed to establish the prevalence at admission, incidence during hospitalization and characteristics of ADRs linked to antihypertensive, antithrombotic and antidiabetic drugs among adult inpatients in Uganda.MethodsWe conducted a secondary analysis of data from a previously assembled prospective cohort study in Uganda’s Mulago National Referral Hospital. We reviewed the files of inpatients who received antihypertensive, antithrombotic and/or antidiabetic medications prior to and/or during hospitalization. The modified Schumock and Thornton Preventability Scale, the Division of AIDS Table for Grading the Severity of Adult and Paediatric Adverse Events and the World Health Organization – Uppsala Monitoring Centre seriousness criteria were used to characterize the ADRs.ResultsMore than a quarter (27%, 42/155) of the inpatients experienced an ADR at admission or during hospitalization. The point prevalence of ADRs at admission was 8% (13/155) and the incidence of ADRs during hospitalization was 23% (36/155). Forty-one percent (35/86) of the ADRs were serious and the majority (59%, 51/86) were preventable.ConclusionOne in 13 inpatients experienced an ADR on admission and one in four experienced an ADR that developed during hospitalization. Clinicians ought to prescribe medicines with lower ADR risk profile for cardiovascular and/or diabetic patients whenever possible.

Published
2024
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27. Effectiveness of the Med Safety mobile application in improving adverse drug reaction reporting by healthcare professionals in Uganda: a protocol for a pragmatic cluster-randomised controlled trial

Author

Kiguba, Ronald, primary, Mwebaza, Norah, additional, Ssenyonga, Ronald, additional, Ndagije, Helen Byomire, additional, Nambasa, Victoria, additional, Katureebe, Cordelia, additional, Katumba, Kenneth, additional, Tregunno, Phil, additional, Harrison, Kendal, additional, Karamagi, Charles, additional, Scott, Kathryn A, additional, and Pirmohamed, Munir, additional

Published
2022
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28. An Evaluation of Antibiotic Prescription Rationality at Lower Primary Healthcare Facilities in Three Districts of South-Western Uganda

Author

Nantongo,Hanifah, Kiguba,Ronald, Batwala,Vincent, Mukonzo,Jackson, Nantongo,Hanifah, Kiguba,Ronald, Batwala,Vincent, and Mukonzo,Jackson

Abstract

Hanifah Nantongo,1,2 Ronald Kiguba,2 Vincent Batwala,3,4 Jackson Mukonzo2 1Department of Nursing, Mbarara University of Science and Technology, Mbarara, Uganda; 2Department of Pharmacology and Therapeutics, Makerere University, Makerere, Uganda; 3Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda; 4Directorate of Research and Graduate Training, Mbarara University of Science and Technology, Mbarara, UgandaCorrespondence: Hanifah Nantongo, P.O Box 1410, Mbarara, Uganda, Tel +256 773 413926, Email hnantongo@must.ac.ugPurpose: Antimicrobial resistance is now one of the leading five causes of death globally. This study evaluated the rationality of antibiotic prescriptions at lower primary care levels in three districts of Southwestern Uganda.Methods: This prospective cross-sectional study reviewed 9899 antibiotic prescriptions at 39 health centers following a drug delivery cycle by National Medical Stores in three phases (19 days each on average). Phase 1 started 3 days after delivery, mid-way (Phase 2) and towards the end (Phase 3). The proportion of rationally prescribed antibiotics was determined using a modified criterion by Badar and in reference to Uganda Clinical Guidelines (UCG). Using multivariate logistic regression, the factors associated with rational prescription were determined with 95% confidence intervals.Results: Seven of every 10 antibiotic prescriptions were irrational. Half the prescriptions were made by unauthorized personnel (nurses) and many of the pediatric prescriptions (916, 46.5%) did not bear body weight measurements to guide appropriate dosing. Also, the proportion of rational prescriptions in reference to UCG, 2016 was very low (3387, 34.2%). However, a high proportion of antibiotic prescriptions were legibly written (9462, 95.7%), prescribed by generic names (9083, 91.8%) and had a diagnosis (9677, 97.8%) indicated. Multivariate logistic analysis showed that; availability of medicines (phase 1) (ph

Published
2022

30. Implementation of a peer support intervention to promote the detection, reporting and management of adverse drug reactions in people living with HIV in Uganda: a protocol for a quasi-experimental study

Author

Kiguba, Ronald, primary, Ndagije, Helen Byomire, additional, Nambasa, Victoria, additional, Katureebe, Cordelia, additional, Zakumumpa, Henry, additional, Nanyonga, Stella Maris, additional, Ssanyu, Jacquellyn Nambi, additional, Tregunno, Phil, additional, Harrison, Kendal, additional, Merle, Corinne S, additional, Raguenaud, Marie-Eve, additional, and Kitutu, Freddy Eric, additional

Published
2022
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33. Additional file 1 of It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author

Sartelli, Massimo, Labricciosa, Francesco M., Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M., Ansaloni, Luca, Al-Hasan, Majdi N., Ansari, Shamshul, Barie, Philip S., Ca��nzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A., Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E., Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andreas, Lepp��niemi, Ari K., Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E., Memish, Ziad Ahmed, Kirkpatrick, Andrew W., Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E., Sawyer, Robert G., Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Ara��z, Ana Bel��n, Argenio, Giulio, Atanasov, Boyko C., Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A., Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boum��di��ne, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J., Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D���Acapito, Fabrizio, Damaskos, Dimitrios, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S., Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N., Dogjani, Agron, D���Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M., Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M., Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y., Hecker, Matthias, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S., Kapoor, Garima, Karaiskos, Ilias, Kavalakat, Alfie J., Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M., Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantinos, Lohsiriwat, Varut, Lostoridis, Eftychios, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasios, Martines, Gennaro, Mart��nez-P��rez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, G��khan, Miranda-Novales, Mar��a Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y., Mora-Guzm��n, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H., Negoi, Ionut, Nita, Gabriela Elisa, O���Connor, Donal B., Ordo��ez, Carlos Alberto, Pantalone, Desir��, Panyko, Arp��d, Papadopoulos, Aristeidis, Pararas, Nikolaos, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynolds, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampos, Serradilla-Mart��n, Mario, Shelat, Vishal G., Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andras, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, AliIbrahim, Zachariah, Sanoop K., Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P., Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V., and Catena, Fausto

Abstract

Additional file 1. Questionnaire.

Published
2022
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36. Pharmacovigilance in low‐ and middle‐income countries: A review with particular focus on Africa.

Author

Kiguba, Ronald, Olsson, Sten, and Waitt, Catriona

Subjects
*MIDDLE-income countries, *MEDICAL personnel, *DRUG accessibility, *NEGLECTED diseases, *DRUG utilization, *COMMUNITIES
Abstract

Low‐ and middle‐income countries (LMIC) face unique challenges with regard to the establishment of robust pharmacovigilance systems capable of generating data to inform healthcare policy and practice. These include the limited integration and reliability of pharmacovigilance systems across LMIC despite recent efforts to harmonize pharmacovigilance rules and regulations in several regional economic communities. There are particular challenges relating to the need to translate reporting tools into numerous local languages and the low numbers of healthcare providers relative to number of patients, with very short consultation times. Additional factors frequent in LMIC include high uptake of herbal and traditional medication, mostly by self‐medication; disruptive political conflicts jeopardizing fragile systems; and little or no access to drug utilization data, which makes it difficult to reliably estimate the true risks of medicines use. Pharmacovigilance activities are hindered by the scarcity of well‐trained personnel with little or no budgetary support from national governments; high turnover of pharmacovigilance staff whose training involves a substantial amount of resources; and little awareness of pharmacovigilance among healthcare workers, decision makers and consumers. Furthermore, little collaboration between public health programmes and national medicines regulatory authorities coupled with limited investment in pharmacovigilance activities, especially during mass drug administration for neglected tropical diseases and mass vaccinations, produces major challenges in establishing a culture where pharmacovigilance is systematically embedded. Very low spontaneous reporting rates with poor quality reports hinders robust signal detection analyses. This review summarises the specific challenges and areas of progress in pharmacovigilance in LMIC with special focus on the situation in Africa. [ABSTRACT FROM AUTHOR]

Published
2023
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40. A pandemic recap: lessons we have learned

Author

Coccolini, Federico Cicuttin, Enrico Cremonini, Camilla and Tartaglia, Dario Viaggi, Bruno Kuriyama, Akira Picetti, Edoardo Ball, Chad Abu-Zidan, Fikri Ceresoli, Marco and Turri, Bruno Jain, Sumita Palombo, Carlo Guirao, Xavier and Rodrigues, Gabriel Gachabayov, Mahir Machado, Fernando and Eftychios, Lostoridis Kanj, Souha S. Di Carlo, Isidoro Di Saverio, Salomone Khokha, Vladimir Kirkpatrick, Andrew and Massalou, Damien Forfori, Francesco Corradi, Francesco and Delibegovic, Samir Machain Vega, Gustavo M. Fantoni, Massimo and Demetriades, Demetrios Kapoor, Garima Kluger, Yoram Ansari, Shamshul Maier, Ron Leppaniemi, Ari Hardcastle, Timothy and Vereczkei, Andras Karamagioli, Evika Pikoulis, Emmanouil and Pistello, Mauro Sakakushev, Boris E. Navsaria, Pradeep H. and Galeiras, Rita Yahya, Ali I. Osipov, Aleksei V. Dimitrov, Evgeni Doklestic, Krstina Pisano, Michele Malacarne, Paolo and Carcoforo, Paolo Sibilla, Maria Grazia Kryvoruchko, Igor A. and Bonavina, Luigi Kim, Jae Il Shelat, Vishal G. Czepiel, Jacek Maseda, Emilio Marwah, Sanjay Chirica, Mircea and Biancofiore, Giandomenico Podda, Mauro Cobianchi, Lorenzo and Ansaloni, Luca Fugazzola, Paola Seretis, Charalampos Gomez, Carlos Augusto Tumietto, Fabio Malbrain, Manu Reichert, Martin Augustin, Goran Amato, Bruno Puzziello, Alessandro and Hecker, Andreas Gemignani, Angelo Isik, Arda Cucchetti, Alessandro Nacoti, Mirco Kopelman, Doron Mesina, Cristian and Ghannam, Wagih Ben-Ishay, Offir Dhingra, Sameer Coimbra, Raul Moore, Ernest E. Cui, Yunfeng Quiodettis, Martha A. and Bala, Miklosh Testini, Mario Diaz, Jose Girardis, Massimo and Biffl, Walter L. Hecker, Matthias Sall, Ibrahima Boggi, Ugo Materazzi, Gabriele Ghiadoni, Lorenzo Matsumoto, Junichi and Zuidema, Wietse P. Ivatury, Rao Enani, Mushira A. and Litvin, Andrey Al-Hasan, Majdi N. Demetrashvili, Zaza and Baraket, Oussama Ordonez, Carlos A. Negoi, Ionut Kiguba, Ronald Memish, Ziad A. Elmangory, Mutasim M. Tolonen, Matti and Das, Korey Ribeiro, Julival O'Connor, Donal B. Tan, Boun Kim Van Goor, Harry Baral, Suman De Simone, Belinda and Corbella, Davide Brambillasca, Pietro Scaglione, Michelangelo and Basolo, Fulvio De'Angelis, Nicola Bendinelli, Cino and Weber, Dieter Pagani, Leonardo Monti, Cinzia Baiocchi, Gianluca Chiarugi, Massimo Catena, Fausto Sartelli, Massimo

Abstract

On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.

Published
2021

42. Additional file 1 of Healthcare professionals’ perspective can guide post-marketing surveillance of artemisinin-based combination therapy in Uganda

Author

Ndagije, Helen, Kiguba, Ronald, Manirakiza, Leonard, Kirabira, Elijah, Sserwanga, Allan, Nabirye, Leah, Mukonzo, Jackson, Olsson, Sten, Spinewine, Anne, D’Hoore, William, and Speybroeck, Niko

Abstract

Additional file 1: File S1. Study questionnaire to assess clinician-perceived failure rates of commonly used ACT medicines. This was the questionnaire used to collect data about the HCP perceived failure rates of commonly used ACTs. Healthcare professionals in the selected health facilities completed this self-administered formulated questionnaire.

Published
2020
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43. Additional file 2 of Healthcare professionals’ perspective can guide post-marketing surveillance of artemisinin-based combination therapy in Uganda

Author

Ndagije, Helen, Kiguba, Ronald, Manirakiza, Leonard, Kirabira, Elijah, Sserwanga, Allan, Nabirye, Leah, Mukonzo, Jackson, Olsson, Sten, Spinewine, Anne, D’Hoore, William, and Speybroeck, Niko

Abstract

Additional file 2: Figure S1. Profile of suspected ACT failure rates in health facilities. A graphical representation of the percentages of drugs that were perceived not to have had satisfactory patient outcomes.

Published
2020
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44. Discontinuation and modification of highly active antiretroviral therapy in HIV-infected Ugandans

Author

Kiguba, Ronald, Byakika-Tusiime, Jayne, Karamagi, Charles, Ssali, Francis, Mugyenyi, Peter, and Katabira, Elly

Subjects
Highly active antiretroviral therapy -- Health aspects, HIV infection -- Drug therapy, Health
Abstract

The prevalence discontinuation and modification of highly active antiretroviral therapy (HAART) among sub-Saharan African population is estimated and factors associated with these phenomena are identified. The major reason for discontinuation of HAART is the drug cost which also affects the antiretroviral therapy programs.

Published
2007

45. Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting

Author

UCL - SSS/IRSS - Institut de recherche santé et société, Kiguba, Ronald, Ndagije, Helen Byomire, Nambasa, Victoria, Manirakiza, Leonard, Kirabira, Elijah, Serwanga, Allan, Olsson, Sten, Speybroeck, Niko, Mukonzo, Jackson, UCL - SSS/IRSS - Institut de recherche santé et société, Kiguba, Ronald, Ndagije, Helen Byomire, Nambasa, Victoria, Manirakiza, Leonard, Kirabira, Elijah, Serwanga, Allan, Olsson, Sten, Speybroeck, Niko, and Mukonzo, Jackson

Abstract

Background: Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises healthcare costs. Yet, little has been done to promote the pharmacovigilance (PV) of ACT ineffectiveness in sub-Saharan Africa, particularly in Uganda. This study aimed to determine the extent and associated factors of the past 6 months reporting of suspected or confirmed ACT therapeutic ineffectiveness by healthcare professionals (HCPs), and difficulties and potential solutions to the PV of ACT therapeutic ineffectiveness. Methods: Survey of 685 HCPs conducted using a self-administered questionnaire from June to July 2018 in a nationally representative sample of public and private health facilities in Uganda. HCPs disclosed if they had spontaneously reported ACT therapeutic ineffectiveness to appropriate authorities in the previous 6 months. Multivariable logistic regression models were used to identify determinants of past 6-months, HCP-reported ACT therapeutic ineffectiveness. Results: One in five (20%, 137/685; 95% CI 17-23%) HCPs reported ACT therapeutic ineffectiveness to an appropriate authority in the previous 6 months. HCPs commonly reported ACT therapeutic ineffectiveness to immediate supervisors (72%, 106/147), mostly verbally only (80%, 109/137); none had ever submitted a written report of ACT therapeutic ineffectiveness to Uganda's National Pharmacovigilance Centre. Common difficulties of reporting ACT therapeutic ineffectiveness were: unavailability of reporting procedures (31%, 129/421), poor follow-up of treated patients (22%, 93/421) and absence of reporting tools (16%, 68/421). Factors associated with reporting ACT therapeutic ineffectiveness in the past 6 months were: hospital-status (vs other; OR = 2.4, 95% CI 1.41-4.21), HCPs aged under 25 years (OR = 2.2, 95% CI 1.29-3.76), suspicion of ACT therapeutic ineffectiveness in the past 4 weeks (OR = 2.3, 95% CI 1.29-3.92), receipt of patient

Published
2020

47. Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting

Author

Kiguba, Ronald, primary, Ndagije, Helen Byomire, additional, Nambasa, Victoria, additional, Manirakiza, Leonard, additional, Kirabira, Elijah, additional, Serwanga, Allan, additional, Olsson, Sten, additional, Speybroeck, Niko, additional, and Mukonzo, Jackson, additional

Published
2020
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50. Assessing the quality of informed consent in a resource-limited setting: A cross-sectional study

Author

Kiguba Ronald, Kutyabami Paul, Kiwuwa Stephen, Katabira Elly, and Sewankambo Nelson K

Subjects
Medical philosophy. Medical ethics, R723-726
Abstract

Abstract Background The process of obtaining informed consent continues to be a contentious issue in clinical and public health research carried out in resource-limited settings. We sought to evaluate this process among human research participants in randomly selected active research studies approved by the School of Medicine Research and Ethics Committee at the College of Health Sciences, Makerere University. Methods Data were collected using semi-structured interviewer-administered questionnaires on clinic days after initial or repeat informed consent procedures for the respective clinical studies had been administered to each study participant. Results Of the 600 participants interviewed, two thirds (64.2%, 385/600) were female. Overall mean age of study participants was 37.6 (SD = 7.7) years. Amongst all participants, less than a tenth (5.9%, 35/598) reported that they were not given enough information before making a decision to participate. A similar proportion (5.7%, 34/597) reported that they had not signed a consent form prior to making a decision to participate in the study. A third (33.7%, 201/596) of the participants were not aware that they could, at any time, voluntarily withdraw participation from these studies. Participants in clinical trials were 50% less likely than those in observational studies [clinical trial vs. observational; (odds ratio, OR = 0.5; 95% CI: 0.35-0.78)] to perceive that refusal to participate in the parent research project would affect their regular medical care. Conclusions Most of the participants signed informed consent forms and a vast majority felt that they received enough information before deciding to participate. On the contrary, several were not aware that they could voluntarily withdraw their participation. Participants in observational studies were more likely than those in clinical trials to perceive that refusal to participate in the parent study would affect their regular medical care.

Published
2012
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