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Your search keyword '"Kidney cancer -- Diagnosis -- Care and treatment -- Genetic aspects"' showing total 3 results
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3 results on '"Kidney cancer -- Diagnosis -- Care and treatment -- Genetic aspects"'

1. SALL4 and C-kit positive malignant extrarenal rhabdoid tumor of the pelvis in a child: A diagnostic and therapeutic challenge

Author

Pahwa, Saloni, Pasricha, Sunil, Kapoor, Gauri, Jajodia, Ankush, Koyyala, Venkata Pradeep Babu, and Mehta, Anurag

Subjects
Gene mutations -- Health aspects, Immunohistochemistry -- Research, Kidney cancer -- Diagnosis -- Care and treatment -- Genetic aspects, Tumors in children -- Diagnosis -- Care and treatment -- Genetic aspects, Biological markers -- Identification and classification -- Health aspects, Health
Abstract

Extrarenal rhabdoid tumors (ERRTs) are highly aggressive pediatric tumors with very few cases reported in the literature. These tumors, similar to their renal counterparts, are characterized by inactivating mutations of the SMARCB1/INI-1 gene, a member of the SWI/SNF chromatin remodeling pathway. Diagnosis of ERRTs appears challenging owing to its rarity, varied morphological profile with a higher tendency for rhabdoid differentiation, and overlapping features with other SMARCB-1 deficient tumors. Here, we report a case of ERRT in the pelvis of a three-year-old child with an unusual expression of SALL4 and C-kit on immunohistochemistry. A complete immunohistochemical workup might help in differentiating ERRTs from other SMARCB1/INI1-deficient soft tissue tumors. The expression of stem cell markers in the presented case also suggests that these tumors might originate from or share similarities with embryonic stem cells or germ cells. Keywords: Extrarenal rhabdoid tumor, pediatric tumors, SMARCB1, Author(s): Saloni Pahwa [1]; Sunil Pasricha (corresponding author) [1]; Gauri Kapoor [2]; Ankush Jajodia [3]; Venkata Pradeep Babu Koyyala [4]; Anurag Mehta [5] INTRODUCTION Malignant rhabdoid tumors (MRTs) are rare, [...]

Published
2024
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2. L-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models

Author

Kundu, Anirban, Brinkley, Garrett J., Nam, Hyeyoung, Karki, Suman, Kirkman, Richard, Shim, Madhuparna PandiEunHee, Widden, Hayley, Liu, Juan, Heidarian, Yasaman, Mahmoudzadeh, Nader H., Absher, Alexander J. FitDevin, Ding, Han-Fei, Crossman, David K., Placzek, William J., Locasale, Jason W., Rakheja, Dinesh, McConathy, Jonathan E., Ramachandran, Rekha, Bae, Sejong, Tennessen, Jason M., and Sudarshan, Sunil

Subjects
Gene expression -- Analysis, Kidney cancer -- Diagnosis -- Care and treatment -- Genetic aspects, Methylation -- Health aspects, Metabolites -- Analysis, Health care industry, Diagnosis, Care and treatment, Analysis, Genetic aspects, Health aspects
Abstract

Tumor cells are known to undergo considerable metabolic reprogramming to meet their unique demands and drive tumor growth. At the same time, this reprogramming may come at a cost with resultant metabolic vulnerabilities. The small molecule l-2-hydroxyglutarate (L-2HG) is elevated in the most common histology of renal cancer. Similarly to other oncometabolites, L-2HG has the potential to profoundly impact gene expression. Here, we demonstrate that L-2HG remodels amino acid metabolism in renal cancer cells through combined effects on histone methylation and RNA [N.sup.6]- methyladenosine. The combined effects of L-2HG result in a metabolic liability that renders tumors cells reliant on exogenous serine to support proliferation, redox homeostasis, and tumor growth. In concert with these data, high-L-2HG kidney cancers demonstrate reduced expression of multiple serine biosynthetic enzymes. Collectively, our data indicate that high-L-2HG renal tumors could be specifically targeted by strategies that limit serine availability to tumors., Introduction Oncometabolites are small molecules that aberrantly accumulate within tumor cells. These small molecules can have either tumor-promoting or -suppressive effects, indicating that their impact on tumor biology is highly [...]

Published
2024
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3. Reports Outline Kidney Cancer Research from Zhejiang University School of Medicine (LINC00941 Promotes Cell Malignant Behavior and Is One of Five Costimulatory Molecule-Related lncRNAs That Predict Prognosis in Renal Clear Cell Carcinoma)

Subjects
Nomography (Mathematics) -- Analysis, Kidney cancer -- Diagnosis -- Care and treatment -- Genetic aspects, Macrophages -- Analysis, Health
Abstract

2023 MAR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on kidney cancer have been presented. According to news reporting [...]

Published
2023

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