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490 results on '"Kidd, K. K."'

5. Genome-wide association study of Tourette's syndrome

Author

Scharf, J M, Yu, D, Mathews, C A, Neale, B M, Stewart, S E, Fagerness, J A, Evans, P, Gamazon, E, Edlund, C K, Service, S K, Tikhomirov, A, Osiecki, L, Illmann, C, Pluzhnikov, A, Konkashbaev, A, Davis, L K, Han, B, Crane, J, Moorjani, P, Crenshaw, A T, Parkin, M A, Reus, V I, Lowe, T L, Rangel-Lugo, M, Chouinard, S, Dion, Y, Girard, S, Cath, D C, Smit, J H, King, R A, Fernandez, T V, Leckman, J F, Kidd, K K, Kidd, J R, Pakstis, A J, State, M W, Herrera, L D, Romero, R, Fournier, E, Sandor, P, Barr, C L, Phan, N, Gross-Tsur, V, Benarroch, F, Pollak, Y, Budman, C L, Bruun, R D, Erenberg, G, Naarden, A L, Lee, P C, Weiss, N, Kremeyer, B, Berrío, G B, Campbell, D D, Cardona Silgado, J C, Ochoa, W C, Mesa Restrepo, S C, Muller, H, Valencia Duarte, A V, Lyon, G J, Leppert, M, Morgan, J, Weiss, R, Grados, M A, Anderson, K, Davarya, S, Singer, H, Walkup, J, Jankovic, J, Tischfield, J A, Heiman, G A, Gilbert, D L, Hoekstra, P J, Robertson, M M, Kurlan, R, Liu, C, Gibbs, J R, Singleton, A, Hardy, J, Strengman, E, Ophoff, R A, Wagner, M, Moessner, R, Mirel, D B, Posthuma, D, Sabatti, C, Eskin, E, Conti, D V, Knowles, J A, Ruiz-Linares, A, Rouleau, G A, Purcell, S, Heutink, P, Oostra, B A, McMahon, W M, Freimer, N B, Cox, N J, and Pauls, D L

Published
2013
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15. MAPlex - A massively parallel sequencing ancestry analysis multiplex for Asia-Pacific populations

Author

Phillips, C., McNevin, D., Kidd, K. K., Lagace, R., Wootton, S., de la Puente, M., Freire-Aradas, A., Mosquera-Miguel, A., Eduardoff, M., Gross, T., Dagostino, L., Power, D., Olson, S., Hashiyada, M., Oz, C., Parson, W., Schneider, P. M., Lareu, M., V, Daniel, R., Phillips, C., McNevin, D., Kidd, K. K., Lagace, R., Wootton, S., de la Puente, M., Freire-Aradas, A., Mosquera-Miguel, A., Eduardoff, M., Gross, T., Dagostino, L., Power, D., Olson, S., Hashiyada, M., Oz, C., Parson, W., Schneider, P. M., Lareu, M., V, and Daniel, R.

Abstract

Current forensic ancestry-informative panels are limited in their ability to differentiate populations in the Asia-Pacific region. MAPlex (Multiplex for the Asia-Pacific), a massively parallel sequencing (MPS) assay, was developed to improve differentiation of East Asian, South Asian and Near Oceanian populations found in the extensive cross-continental Asian region that shows complex patterns of admixture at its margins. This study reports the development of MAPlex; the selection of SNPs in combination with microhaplotype markers; assay design considerations for reducing the lengths of microhaplotypes while preserving their ancestry-informativeness; adoption of new population-informative multiple-allele SNPs; compilation of South Asian-informative SNPs suitable for forensic AIMs panels; and the compilation of extensive reference and test population genotypes from online whole-genome-sequence data for MAPlex markers. STRUCTURE genetic clustering software was used to gauge the ability of MAPlex to differentiate a broad set of populations from South and East Asia, the West Pacific regions of Near Oceania, as well as the other globally distributed population groups. Preliminary assessment of MAPlex indicates enhanced South Asian differentiation with increased divergence between West Eurasian, South Asian and East Asian populations, compared to previous forensic SNP panels of comparable scale. In addition, MAPlex shows efficient differentiation of Middle Eastern individuals from Europeans. MAPlex is the first forensic AIM assay to combine binary and multiple-allele SNPs with microhaplotypes, adding the potential to detect and analyze mixed source forensic DNA.

Published
2019

17. ALFRED: the ALelle FREquency Database. Update

Author

Rajeevan, H., Osier, M. V., Cheung, K.-H., Deng, H., Druskin, L., Heinzen, R., Kidd, J. R., Stein, S., Pakstis, A. J., Tosches, N. P., Yeh, C.-C., Miller, P. L., and Kidd, K. K.

Published
2003

19. Modern African ape populations as genetic and demographic models of the last common ancestor of humans, chimpanzees, and gorillas

Author

Jensen-Seaman, M. I., Deinard, A. S., and Kidd, K. K.

Subjects
Population genetics -- Research, Nucleotides -- Research, Apes -- Genetic aspects, Apes -- Research, Genetic research, Biological sciences
Abstract

Estimates of nucleotide diversity and effective population size of modern African ape species is provided. These estimates are useful to make predictions about the nature of the ancestral population, which give rise to the living species of African apes, including humans.

Published
2001

25. Γενετική των πελοποννησιακών πληθυσμών και η θεωρία της εξαφάνισης των Πελοποννήσιων Ελλήνων της μεσαιωνικής περιόδου.

Author

Σταματογιαννόπουλος, Γ., Bose, A., Θεοδοσιάδης, Α., Τσέτσος, Φ., Plantinga, A., Ψαθά, Ν., Ζώγας, Ν., Γιαννάκη, Ε., Zalloua, P., Kidd, K. K., Browning, B. L., Σταματογιαννόπουλος, Ι. Α., Πάσχου, Π., and Δρινέας, Π.

Abstract

The Peloponnese is one of the cradles of the Classical European civilization and an important contributor to the ancient history of Europe. It has also been the subject of a controversy about the ancestry of its present population. In a theory hotly debated by scholars for over 170 years, the German historian Jacob Philipp Fallmerayer proposed that the medieval Peloponneseans were totally extinguished by Slavic and Avar invaders and replaced by Slavic settlers during the 6th century AD. In this study, 2.5 million single-nucleotide polymorphisms were used to investigate the genetic structure of the present Peloponnesean population in a sample of 241 individuals originating in all districts of the peninsula, and to examine predictions of the theory of replacement of the medieval Peloponneseans by Slavs. We found considerable heterogeneity in the Peloponnesean populations, exemplified by genetically distinct subpopulations and by gene flow gradients within the Peloponnese. By principal component analysis (PCA) and ADMIXTURE analysis we demonstrated that the pattern of the Peloponneseans is clearly distinguishable from the populations of the Slavic homeland and is very similar to that of Sicilians and Italians. Using a novel method of quantitative analysis of ADMIXTURE output we found that the Slavic ancestry of Peloponnesean subpopulations ranges from 0.2% to 14.4%. Subpopulations considered by Fallmerayer to be Slavic tribes or to have Near Eastern origin, have no significant ancestry of either. This study rejects the theory of extinction of medieval Peloponneseans and illustrates how genetics can clarify important aspects of the history of a human population. [ABSTRACT FROM AUTHOR]

Published
2017
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27. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism

Author

Osier, M, Pakstis, A J, Kidd, J R, Lee, J F, Yin, S J, Ko, H C, Edenberg, H J, Lu, R B, and Kidd, K K

Subjects
Research Article
Abstract

Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode known functional variants that act on alcohol with different efficiencies. Variants at both these genes have been implicated in alcoholism in some populations because allele frequencies differ between alcoholics and controls. Specifically, controls have higher frequencies of the variants with higher Vmax (ADH2*2 and ADH3*1). In samples both of alcoholics and of controls from three Taiwanese populations (Chinese, Ami, and Atayal) we found significant pairwise disequilibrium for all comparisons of the two functional polymorphisms and a third, presumably neutral, intronic polymorphism in ADH2. The class I ADH genes all lie within 80 kb on chromosome 4; thus, variants are not inherited independently, and haplotypes must be analyzed when evaluating the risk of alcoholism. In the Taiwanese Chinese we found that, only among those chromosomes containing the ADH3*1 variant (high Vmax), the proportions of chromosomes with ADH2*1 (low Vmax) and those with ADH2*2 (high Vmax) are significantly different between alcoholics and controls (P

Published
1999

29. Evolution of Haplotypes at the DRD2 Locus

Author

Castiglione, C. M., Deinard, A. S., Speed, W. C., Sirugo, G., Rosenbaum, H. C., Zhang, Y., Grandy, D. K., Grigorenko, E. L., Bonne-Tamir, B., Pakstis, A. J., Kidd, J. R., and Kidd, K. K.

Subjects
Genetics, Population, Polymorphism, Genetic, Base Sequence, Haplotypes, Receptors, Dopamine D2, Molecular Sequence Data, Chromosome Mapping, Humans, Original Articles, Biological Evolution, Linkage Disequilibrium, Polymorphism, Restriction Fragment Length, Repetitive Sequences, Nucleic Acid
Abstract

We present here the first evolutionary perspective on haplotypes at DRD2, the locus for the dopamine D2 receptor. The dopamine D2 receptor plays a critical role in the functioning of many neural circuits in the human brain. If functionally relevant variation at the DRD2 locus exists, understanding the evolution of haplotypes on the basis of polymorphic sites encompassing the gene should provide a powerful framework for identifying that variation. Three DRD2 polymorphisms (TaqI “A” and “B” RFLPs and the (CA)n short tandem repeat polymorphism) encompassing the coding sequences have been studied in 15 populations; these markers are polymorphic in all the populations studied, and they display strong and significant linkage disequilibria with each other. The common haplotypes for the two TaqI RFLPs are separately derived from the ancestral haplotype but predate the spread of modern humans around the world. The knowledge of how the various haplotypes have evolved, the allele frequencies of the haplotypes in human populations, and the physical relationships of the polymorphisms to each other and to the functional parts of the gene should now allow proper design and interpretation of association studies.

Published
1995

31. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma

Author

Godshalk, S E, primary, Paranjape, T, additional, Nallur, S, additional, Speed, W, additional, Chan, E, additional, Molinaro, A M, additional, Bacchiocchi, A, additional, Hoyt, K, additional, Tworkoski, K, additional, Stern, D F, additional, Sznol, M, additional, Ariyan, S, additional, Lazova, R, additional, Halaban, R, additional, Kidd, K K, additional, Weidhaas, J B, additional, and Slack, F J, additional

Published
2010
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34. Motoneuron-specific NR3B gene

Author

Niemann, S., primary, Landers, J. E., additional, Churchill, M. J., additional, Hosler, B., additional, Sapp, P., additional, Speed, W. C., additional, Lahn, B. T., additional, Kidd, K. K., additional, Brown, R. H., additional, and Hayashi, Y., additional

Published
2008
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35. Modeling uncertainty in a database for physical gene mapping data

Author

Miller, P. L., Shifman, M. A., and Kidd, K. K.

Subjects
Databases, Factual, Models, Genetic, Chromosome Mapping, Software, Research Article, Probability
Abstract

We are building a database for the storage, retrieval, and graphical display of physical gene mapping data. To allow this information to be analyzed robustly, such a database must confront the inherent uncertainty of the data as a central design issue. The paper describes the overall database design, the types of gene mapping data which the system will contain, the types of uncertainty in the data, and certain of the design issues involved in allowing the database to handle uncertainty in a comprehensive fashion. Only if a full appreciation of uncertainty is built into the system from its inception will a physical gene mapping database be truly robust and successful.

Published
1991

43. Y-chromosome specific YCAII, DYS19 and YAP polymorphisms in human populations: a comparative study

Author

QUINTANA-MURCI, L., primary, SEMINO, O., additional, POLONI, E. S., additional, LIU, A., additional, GIJN, M., additional, PASSARINO, G., additional, BREGA, A., additional, NASIDZE, I. S., additional, MACCIONI, L., additional, COSSU, G., additional, AL-ZAHERY, N., additional, KIDD, J. R., additional, KIDD, K. K., additional, and SANTACHIARA-BENERECETTI, A. S., additional

Published
1999
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44. A Novel, Heritable, Expanding CTG Repeat in an Intron of the SEF2-1 Gene on Chromosome 18q21.1

Author

Breschel, T. S., primary, McInnis, M. G., additional, Margolis, R. L., additional, Sirugo, G., additional, Corneliussen, B., additional, Simpson, S. G., additional, McMahon, F. J., additional, MacKinnon, D. F., additional, Xu, J. F., additional, Pleasant, N., additional, Huo, Y., additional, Ashworth, R. G., additional, Grundstrom, C., additional, Grundstrom, T., additional, Kidd, K. K., additional, DePaulo, J. R., additional, and Ross, C. A., additional

Published
1997
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