1. Interface dermatitis as an indicator of hepatic involvement in drug reaction with eosinophilia and systemic symptoms (DRESS)
- Author
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Anuradha Thalian Chathoth, Aparna Govindan, Sarita Sasidharanpillai, Anza Khader, Effeena Merin David, Ruba Farsha, Olassery Kalathingal Reena Mariyath, Kidanghazhiyathmana Ajithkumar, and Najiya Sherin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Histology ,Biopsy ,Dermatitis ,Dermatology ,Drug reaction with eosinophilia and systemic symptoms ,Pathology and Forensic Medicine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Eosinophilia ,medicine ,Humans ,Transaminases ,Hyperbilirubinemia ,integumentary system ,medicine.diagnostic_test ,business.industry ,Exanthema ,Middle Aged ,medicine.disease ,Rash ,Hepatic Involvement ,Cross-Sectional Studies ,Liver ,030220 oncology & carcinogenesis ,Drug Hypersensitivity Syndrome ,Histopathology ,Female ,medicine.symptom ,business ,Interface dermatitis - Abstract
Background There are conflicting reports on the association between interface dermatitis and hepatic involvement in DRESS. Methods A cross-sectional analysis of the clinical and the histopathology features of DRESS was performed to study the association between the histopathology of the skin rash and hepatic involvement. Results The clinical and the histopathology findings were evaluated in forty cases of DRESS. Thirty patients (75%) had a hepatic involvement. Thirty (75%) biopsy specimens showed a combination of different inflammatory patterns. The interface dermatitis was noted in 24 specimens (60%). Twenty-one patients with the interface dermatitis had a hepatic involvement (P = 0.04). Conclusions The skin rash of DRESS often shows the coexistence of different inflammatory patterns. The interface dermatitis showed a statistically significant association with the hepatic involvement in DRESS.
- Published
- 2020