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16 results on '"Kiaee, Kiavash"'

1. A comprehensive library of human transcription factors for cell fate engineering

Author

Ng, Alex H. M., Khoshakhlagh, Parastoo, Rojo Arias, Jesus Eduardo, Pasquini, Giovanni, Wang, Kai, Swiersy, Anka, Shipman, Seth L., Appleton, Evan, Kiaee, Kiavash, Kohman, Richie E., Vernet, Andyna, Dysart, Matthew, Leeper, Kathleen, Saylor, Wren, Huang, Jeremy Y., Graveline, Amanda, Taipale, Jussi, Hill, David E., Vidal, Marc, Melero-Martin, Juan M., Busskamp, Volker, and Church, George M.

Published
2021
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2. Bionic Organs

Author

Kiaee, Kiavash, primary, Jodat, Yasamin A., additional, and Mannoor, Manu Sebastian, additional

Published
2020
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3. A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

Author

Harvard University--MIT Division of Health Sciences and Technology, Lee, Junmin, Mehrotra, Shreya, Zare‐Eelanjegh, Elaheh, Rodrigues, Raquel O., Akbarinejad, Alireza, Ge, David, Amato, Luca, Kiaee, Kiavash, Fang, YongCong, Rosenkranz, Aliza, Keung, Wendy, Mandal, Biman B., Li, Ronald A., Zhang, Ting, Lee, HeaYeon, Dokmeci, Mehmet Remzi, Zhang, Yu Shrike, Khademhosseini, Ali, Shin, Su Ryon, Harvard University--MIT Division of Health Sciences and Technology, Lee, Junmin, Mehrotra, Shreya, Zare‐Eelanjegh, Elaheh, Rodrigues, Raquel O., Akbarinejad, Alireza, Ge, David, Amato, Luca, Kiaee, Kiavash, Fang, YongCong, Rosenkranz, Aliza, Keung, Wendy, Mandal, Biman B., Li, Ronald A., Zhang, Ting, Lee, HeaYeon, Dokmeci, Mehmet Remzi, Zhang, Yu Shrike, Khademhosseini, Ali, and Shin, Su Ryon

Published
2022

7. hiPSC-derived 3D Bioprinted Skeletal Muscle Tissue Implants Regenerate Skeletal Muscle Following Volumetric Muscle Loss

Author

Jodat, Yasamin A., Zhang, Ting, Tanoury, Ziad Al, Kamperman, Tom, Shi, Kun, Huang, Yike, Panayi, Adriana, Endo, Yori, Wang, Xichi, Quint, Jacob, Arnaout, Adnan, Kiaee, Kiavash, Hassan, Shabir, Lee, Junmin, Martinez, Angel Flores Huidobro, Ochoa, Sofia Lara, Lee, KangJu, Calabrese, Michelle, Carlucci, Alessandro, Tamayol, Ali, Sinha, Indranil, Pourquié, Olivier, Ryon Shin, Su, Developmental BioEngineering, and TechMed Centre

Abstract

Engineering of biomimetic tissue implants provides an opportunity for repairing volumetric muscle loss (VML), beyond a tissue’s innate repair capacity. Here, we present thick, suturable, and pre-vascularized 3D muscle implants containing human induced pluripotent stem cell-derived myogenic precursor cells (hiPSC-MPCs), which can differentiate into skeletal muscle cells while maintaining a self-renewing pool. The formation of contractile myotubes and millimeter-long fibers from hiPSC-MPCs is achieved in chemically, mechanically, and structurally tailored extracellular matrix-based hydrogels, which can serve as scaffolds to ultimately organize the linear fusion of myoblasts. Embedded multi-material bioprinting is used to deposit complex patterns of perfusable vasculatures and aligned hiPSC-MPC channels within an endomysium-like supporting gel to recapitulate muscle architectural integrity in a facile yet highly rapid manner. Moreover, we demonstrate successful graft-host integration and de novo muscle formation upon in vivo implantation of pre-vascularized constructs within a VML model. This work pioneers the engineering of large pre-vascularized hiPSC-derived muscle tissues toward next generation VML regenerative therapies.

Published
2021

8. Organ‐on‐a‐Chip: A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy (Small 15/2021)

Author

Lee, Junmin, primary, Mehrotra, Shreya, additional, Zare‐Eelanjegh, Elaheh, additional, Rodrigues, Raquel O., additional, Akbarinejad, Alireza, additional, Ge, David, additional, Amato, Luca, additional, Kiaee, Kiavash, additional, Fang, YongCong, additional, Rosenkranz, Aliza, additional, Keung, Wendy, additional, Mandal, Biman B., additional, Li, Ronald A., additional, Zhang, Ting, additional, Lee, HeaYeon, additional, Dokmeci, Mehmet Remzi, additional, Zhang, Yu Shrike, additional, Khademhosseini, Ali, additional, and Shin, Su Ryon, additional

Published
2021
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9. hiPSC-derived 3D Bioprinted Skeletal Muscle Tissue Implants Regenerate Skeletal Muscle Following Volumetric Muscle Loss

Author

Jodat, Yasamin A., primary, Zhang, Ting, additional, Tanoury, Ziad Al, additional, Kamperman, Tom, additional, Shi, Kun, additional, Huang, Yike, additional, Panayi, Adriana, additional, Endo, Yori, additional, Wang, Xichi, additional, Quint, Jacob, additional, Arnaout, Adnan, additional, Kiaee, Kiavash, additional, Hassan, Shabir, additional, Lee, Junmin, additional, Martinez, Angel Flores Huidobro, additional, Ochoa, Sofia Lara, additional, Lee, KangJu, additional, Calabrese, Michelle, additional, Carlucci, Alessandro, additional, Tamayol, Ali, additional, Sinha, Indranil, additional, Pourquié, Olivier, additional, and Shin, Su Ryon, additional

Published
2021
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10. A comprehensive library of human transcription factors for cell fate engineering

Author

Ng, Alex H. M., primary, Khoshakhlagh, Parastoo, additional, Rojo Arias, Jesus Eduardo, additional, Pasquini, Giovanni, additional, Wang, Kai, additional, Swiersy, Anka, additional, Shipman, Seth L., additional, Appleton, Evan, additional, Kiaee, Kiavash, additional, Kohman, Richie E., additional, Vernet, Andyna, additional, Dysart, Matthew, additional, Leeper, Kathleen, additional, Saylor, Wren, additional, Huang, Jeremy Y., additional, Graveline, Amanda, additional, Taipale, Jussi, additional, Hill, David E., additional, Vidal, Marc, additional, Melero-Martin, Juan M., additional, Busskamp, Volker, additional, and Church, George M., additional

Published
2020
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11. A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

Author

Lee, Junmin, primary, Mehrotra, Shreya, additional, Zare‐Eelanjegh, Elaheh, additional, Rodrigues, Raquel O., additional, Akbarinejad, Alireza, additional, Ge, David, additional, Amato, Luca, additional, Kiaee, Kiavash, additional, Fang, YongCong, additional, Rosenkranz, Aliza, additional, Keung, Wendy, additional, Mandal, Biman B., additional, Li, Ronald A., additional, Zhang, Ting, additional, Lee, HeaYeon, additional, Dokmeci, Mehmet Remzi, additional, Zhang, Yu Shrike, additional, Khademhosseini, Ali, additional, and Shin, Su Ryon, additional

Published
2020
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12. A 3D‐Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction

Author

Jodat, Yasamin A., primary, Kiaee, Kiavash, additional, Vela Jarquin, Daniel, additional, De la Garza Hernández, Rosakaren Ludivina, additional, Wang, Ting, additional, Joshi, Sudeep, additional, Rezaei, Zahra, additional, Melo, Bruna Alice Gomes, additional, Ge, David, additional, Mannoor, Manu S., additional, and Shin, Su Ryon, additional

Published
2020
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14. A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy.

Author

Lee, Junmin, Mehrotra, Shreya, Zare‐Eelanjegh, Elaheh, Rodrigues, Raquel O., Akbarinejad, Alireza, Ge, David, Amato, Luca, Kiaee, Kiavash, Fang, YongCong, Rosenkranz, Aliza, Keung, Wendy, Mandal, Biman B., Li, Ronald A., Zhang, Ting, Lee, HeaYeon, Dokmeci, Mehmet Remzi, Zhang, Yu Shrike, Khademhosseini, Ali, and Shin, Su Ryon

Published
2021
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15. Human-Derived Organ-on-a-Chip for Personalized Drug Development

Author

Jodat, Yasamin A., Kang, Min G., Kiaee, Kiavash, Kim, Gyeong J., Martinez, Angel F.H., Rosenkranz, Aliza, Bae, Hojae, and Shin, Su R.

Abstract

To reduce the required capital and time investment in the development of new pharmaceutical agents, there is an urgent need for preclinical drug testing models that are predictive of drug response in human tissues or organs. Despite tremendous advancements and rigorous multistage screening of drug candidates involving computational models, traditional cell culture platforms, animal models and most recently humanized animals, there is still a large deficit in our ability to predict drug response in patient groups and overall attrition rates from phase 1 through phase 4 of clinical studies remain well above 90%. Organ-on-a-chip (OOC) platforms have proven potential in providing tremendous flexibility and robustness in drug screening and development by employing engineering techniques and materials. More importantly, in recent years, there is a clear upward trend in studies that utilize human-induced pluripotent stem cell (hiPSC) to develop personalized tissue or organ models. Additionally, integrated multiple organs on the single chip with increasingly more sophisticated representation of absorption, distribution, metabolism, excretion and toxicity (ADMET) process are being utilized to better understand drug interaction mechanisms in the human body and thus showing great potential to better predict drug efficacy and safety. In this review, we summarize these advances, highlighting studies that took the next step to clinical trials and research areas with the utmost potential and discuss the role of the OOCs in the overall drug discovery process at a preclinical and clinical stage, as well as outline remaining challenges.

Published
2018

16. Engineering large-scale hiPSC-derived vessel-integrated muscle-like lattices for enhanced volumetric muscle regeneration.

Author

Lee MC, Jodat YA, Endo Y, Rodríguez-delaRosa A, Zhang T, Karvar M, Al Tanoury Z, Quint J, Kamperman T, Kiaee K, Ochoa SL, Shi K, Huang Y, Rosales MP, Arnaout A, Lee H, Kim J, Ceron EL, Reyes IG, Panayi AC, Martinez AFH, Wang X, Kim KT, Moon JI, Park SG, Lee K, Calabrese MA, Hassan S, Lee J, Tamayol A, Lee L, Pourquié O, Kim WJ, Sinha I, and Shin SR

Abstract

Engineering biomimetic tissue implants with human induced pluripotent stem cells (hiPSCs) holds promise for repairing volumetric tissue loss. However, these implants face challenges in regenerative capability, survival, and geometric scalability at large-scale injury sites. Here, we present scalable vessel-integrated muscle-like lattices (VMLs), containing dense and aligned hiPSC-derived myofibers alongside passively perfusable vessel-like microchannels inside an endomysium-like supporting matrix using an embedded multimaterial bioprinting technology. The contractile and millimeter-long myofibers are created in mechanically tailored and nanofibrous extracellular matrix-based hydrogels. Incorporating vessel-like lattice enhances myofiber maturation in vitro and guides host vessel invasion in vivo, improving implant integration. Consequently, we demonstrate successful de novo muscle formation and muscle function restoration through a combinatorial effect between improved graft-host integration and its increased release of paracrine factors within volumetric muscle loss injury models. The proposed modular bioprinting technology enables scaling up to centimeter-sized prevascularized hiPSC-derived muscle tissues with custom geometries for next-generation muscle regenerative therapies., Competing Interests: Declaration of interests The authors declare no conflict of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2024
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