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Cholera is a major public health problem in developing countries of the world. Relative resistance to antibiotics is difficult to treat cholera patients leading to spread of microbial drug resistance as a global public health challenge that results in increased illness and death rate. Newer antimicrobials or agents are urgently required to overcome this problem. The present study was conducted to investigate the antimicrobial potential of four types of honey against clinical isolates of Vibrio cholerae O1 and O139 sero groups Disc Diffusion method using Karanja (Pongamia glabra), Mango (Mangifera indica), Neem (Azardirachta indiaca) and Mustard (Brassica campestris) honey were employed for their antibacterial activity. All Vibrio cholerae strains were highly susceptible to almost all five concentration of Karanja honey in comparison to other three types of honey. From the antibiogram profile it was observed that the susceptibility pattern of total strains were tetracycline > gentamicin > norfloxacin > ciprofloxacin. The present findings indicated that different types of monofloral honey exhibited different antibacterial activity against V.cholerae strains which were almost dose dependent. These results suggest the possibility of using honey as an alternative to antibiotics to overcome the growing problem of antimicrobial resistance among V.cholerae strains. [ABSTRACT FROM AUTHOR]

The article discusses the clinical manifestation of cholera which caused by cholera toxin, the major virulence factor. Topics discussed samples which were transported to the ICMR-Regional Medical Research Center; emergence of Haitian variant, tempted researchers to investigate its incidence; and the presence of hypervirulent Haitian variant in Puri has significance in connection to the spread of cholera.

Background: As undernutrition and anemia persist to be prevalent in India, the socioeconomically disadvantaged groups continue to take the greater brunt. Odisha is home to the largest number of particularly vulnerable tribal groups (PVTGs) in India. The study aimed to provide a comprehensive report on the undernutrition and anemia status of all the PVTGs of Odisha., Methods: A community-based cross-sectional study was conducted among (N = 1461, 683 males and 779 females) 13 PVTGs spread across 12 districts of Odisha from August 2018 to February 2019., Results: Among the under-five children, the prevalence of underweight was observed in 75.26%, stunting in 55.42%, and wasting in 60.00% and all forms of undernutrition were higher among girls. Among children and adolescents belonging to the age group of 5 to 19 years, the prevalence of thinness was 46.7%. In individuals above the age of 20, the prevalence of underweight among males was 37.7% and females was 44.3% and severe anemia was present in 36.5% of females and 35.8% of males. Women in the reproductive age have a higher prevalence of anemia., Conclusion: The study shows that undernutrition and anemia remain high in the PVTGs, especially among the under-five children and women in the reproductive age. As the country heads toward fulfilling Sustainable Development Goals (SDG) by 2030, national and state health policies need to be designed and implemented, giving special focus to these vulnerable groups., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Indian Journal of Community Medicine.)