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9 results on '"Khoyratty, Tariq E"'

2. Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

Author

Edgar, Laurienne, primary, Akbar, Naveed, additional, Braithwaite, Adam T., additional, Krausgruber, Thomas, additional, Gallart-Ayala, Héctor, additional, Bailey, Jade, additional, Corbin, Alastair L., additional, Khoyratty, Tariq E., additional, Chai, Joshua T., additional, Alkhalil, Mohammad, additional, Rendeiro, André F., additional, Ziberna, Klemen, additional, Arya, Ritu, additional, Cahill, Thomas J., additional, Bock, Christoph, additional, Laurencikiene, Jurga, additional, Crabtree, Mark J., additional, Lemieux, Madeleine E., additional, Riksen, Niels P., additional, Netea, Mihai G., additional, Wheelock, Craig E., additional, Channon, Keith M., additional, Rydén, Mikael, additional, Udalova, Irina A., additional, Carnicer, Ricardo, additional, and Choudhury, Robin P., additional

Published
2021
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3. The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation

Author

Xie, Bin, primary, Khoyratty, Tariq E., additional, Abu-Shah, Enas, additional, F. Cespedes, Pablo, additional, MacLean, Andrew J., additional, Pirgova, Gabriela, additional, Hu, Zhiyuan, additional, Ahmed, Ahmed A., additional, Dustin, Michael L., additional, Udalova, Irina A., additional, and Arnon, Tal I., additional

Published
2021
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4. Co-option of Neutrophil Fates by Tissue Environments

Author

Ballesteros, Iván, primary, Rubio-Ponce, Andrea, additional, Genua, Marco, additional, Lusito, Eleonora, additional, Kwok, Immanuel, additional, Fernández-Calvo, Gabriel, additional, Khoyratty, Tariq E., additional, van Grinsven, Erinke, additional, González-Hernández, Sara, additional, Nicolás-Ávila, José Ángel, additional, Vicanolo, Tommaso, additional, Maccataio, Antonio, additional, Benguría, Alberto, additional, Li, Jackson LiangYao, additional, Adrover, José M., additional, Aroca-Crevillen, Alejandra, additional, Quintana, Juan A., additional, Martín-Salamanca, Sandra, additional, Mayo, Francisco, additional, Ascher, Stefanie, additional, Barbiera, Giulia, additional, Soehnlein, Oliver, additional, Gunzer, Matthias, additional, Ginhoux, Florent, additional, Sánchez-Cabo, Fátima, additional, Nistal-Villán, Estanislao, additional, Schulz, Christian, additional, Dopazo, Ana, additional, Reinhardt, Christoph, additional, Udalova, Irina A., additional, Ng, Lai Guan, additional, Ostuni, Renato, additional, and Hidalgo, Andrés, additional

Published
2020
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5. Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis

Author

Bo, Marco, primary, Niegowska, Magdalena, additional, Eames, Hayley L., additional, Almuttaqi, Hannah, additional, Arru, Giannina, additional, Erre, Gian Luca, additional, Passiu, Giuseppe, additional, Khoyratty, Tariq E., additional, van Grinsven, Erinke, additional, Udalova, Irina A., additional, and Sechi, Leonardo A., additional

Published
2020
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6. The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.

Author

Bin Xie, Khoyratty, Tariq E., Abu-Shah, Enas, Cespedes, Pablo F., MacLean, Andrew J., Pirgova, Gabriela, Zhiyuan Hu, Ahmed, Ahmed A., Dustin, Michael L., Udalova, Irina A., and Arnon, Tal I.

Subjects
*ZINC-finger proteins, *PLASMA cells, *CELL differentiation, *B cells, *PROMOTERS (Genetics)
Abstract

The PI3K pathway plays a key role in B cell activation and is important for the differentiation of Ab producing plasma cells (PCs). Although much is known about the molecular mechanisms that modulate PI3K signaling in B cells, the transcriptional regulation of PI3K expression is poorly understood. In this study, we identify the zinc finger protein Zbtb18 as a transcriptional repressor that directly binds enhancer/promoter regions of genes encoding class I PI3K regulatory subunits, subsequently limiting their expression, dampening PI3K signaling and suppressing PC responses. Following activation, dividing B cells progressively downregulated Zbtb18, allowing gradual amplification of PI3K signals and enhanced development of PCs. Human Zbtb18 displayed similar expression patterns and function in human B cells, acting to inhibit development of PCs. Furthermore, a number of Zbtb18 mutants identified in cancer patients showed loss of suppressor activity, which was also accompanied by impaired regulation of PI3K genes. Taken together, our study identifies Zbtb18 as a repressor of PC differentiation and reveals its previously unappreciated function as a transcription modulator of the PI3K signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.

Author

Seneviratne, Anusha N, Edsfeldt, Andreas O, Cole, Jennifer E, Kassiteridi, Christina, Swart, Maarten, Park, Inhye, Green, Patricia, Khoyratty, Tariq E, Saliba, David G, Goddard, Michael E, Sansom, Stephen N, Goncalves, Isabel, Krams, Rob, Udalova, Irina A, Monaco, Claudia, Edsfeldt, Andreas, Khoyratty, Tariq, and Saliba, David

Published
2017
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