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18 results on '"Khoueir, Paul"'

4. Effets des polyphénols du thé vert et de la radiothérapie sur la progression et la résistance tumorale dans un modèle in vivo de glioblastome

Author

Khoueir, Paul, Ferron, André, and Béliveau, Richard

Subjects
CNS-1, Barrière hémato-encéphalique, Invasion, Métalloprotéinases, Angiostatine, Cavéoline, P-glycoprotéine, Néovascularisation, Antiangiogénique, Cellule endothéliale
Abstract

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Published
2005

5. Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy

Author

Régina, Anthony, Jodoin, Julie, Khoueir, Paul, Rolland, Yannève, Berthelet, France, Moumdjian, Robert, Fenart, Laurence, Cecchelli, Roméo, Demeule, Michel, Béliveau, Richard, Laboratoire de Médecine Moléculaire Ste-Justine-UQAM, Centre de Cancérologie Charles-Bruneau, Hôpital Ste-Justine-Université du Québec à Montréal = University of Québec in Montréal (UQAM), Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UA), Service d'Hématologie-Oncologie, and Hôpital Ste-Justine

Subjects
Caveolin-1, Endothelial cells, Irradiation, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Angiogenesis, Brain tumors
Abstract

International audience; Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during tumoral progression would be an asset in understanding brain tumor biology. Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling, oncogenesis, and angiogenesis. In this work we investigated regulation of caveolin-1 expression in brain endothelial cells (ECs) under angiogenic conditions. In vitro, brain EC caveolin-1 is down-regulated by angiogenic factors treament and by hypoxia. Coculture of brain ECs with tumoral cells induced a similar downregulation. In addition, activation of the p42/44 MAP kinase is demonstrated. By using an in vivo brain tumor model, we purified ECs from gliomas as well as from normal brain to investigate possible regulation of caveolin-1 expression in tumoral brain vasculature. We show that caveolin-1 expression is strikingly down-regulated in glioma ECs, whereas an increase of phosphorylated caveolin-1 is observed. Whole-brain radiation treatment, a classical way in which GB is currently being treated, resulted in increased caveolin-1 expression in tumor isolated ECs. The level of tumor cells spreading around newly formed blood vessels was also elevated. The regulation of caveolin-1 expression in tumoral ECs may reflect the tumoral vasculature state and correlates with angiogenesis kinetics.

Published
2004

18. Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy.

Author

Régina A, Jodoin J, Khoueir P, Rolland Y, Berthelet F, Moumdjian R, Fenart L, Cecchelli R, Demeule M, and Béliveau R

Subjects
Angiogenic Proteins pharmacology, Animals, Brain Neoplasms metabolism, Brain Neoplasms radiotherapy, Caveolae drug effects, Caveolae metabolism, Caveolae radiation effects, Caveolin 1, Caveolins radiation effects, Cell Line, Tumor, Coculture Techniques, Disease Models, Animal, Down-Regulation drug effects, Down-Regulation physiology, Down-Regulation radiation effects, Endothelial Cells drug effects, Endothelial Cells radiation effects, Glioma metabolism, Glioma radiotherapy, Hypoxia metabolism, Hypoxia physiopathology, Male, Mice, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 1 radiation effects, Neoplasm Metastasis physiopathology, Neoplasm Metastasis radiotherapy, Neovascularization, Pathologic physiopathology, Neovascularization, Pathologic radiotherapy, Phosphorylation radiation effects, Rats, Rats, Inbred Lew, Brain Neoplasms blood supply, Caveolins metabolism, Endothelial Cells metabolism, Glioma blood supply, Neovascularization, Pathologic metabolism
Abstract

Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during tumoral progression would be an asset in understanding brain tumor biology. Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling, oncogenesis, and angiogenesis. In this work we investigated regulation of caveolin-1 expression in brain endothelial cells (ECs) under angiogenic conditions. In vitro, brain EC caveolin-1 is down-regulated by angiogenic factors treament and by hypoxia. Coculture of brain ECs with tumoral cells induced a similar down-regulation. In addition, activation of the p42/44 MAP kinase is demonstrated. By using an in vivo brain tumor model, we purified ECs from gliomas as well as from normal brain to investigate possible regulation of caveolin-1 expression in tumoral brain vasculature. We show that caveolin-1 expression is strikingly down-regulated in glioma ECs, whereas an increase of phosphorylated caveolin-1 is observed. Whole-brain radiation treatment, a classical way in which GB is currently being treated, resulted in increased caveolin-1 expression in tumor isolated ECs. The level of tumor cells spreading around newly formed blood vessels was also elevated. The regulation of caveolin-1 expression in tumoral ECs may reflect the tumoral vasculature state and correlates with angiogenesis kinetics., (Copyright 2003 Wiley-Liss, Inc.)

Published
2004
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