89 results on '"Khoud, A"'
Search Results
2. Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
- Author
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Yassin Ben-Khoud, Chao-Sheng Chen, and Maruf M. U. Ali
- Subjects
Hsp70 ,eukaryotic chaperones ,BiP ,IRE1 ,Tim44 ,XIAP ,Biology (General) ,QH301-705.5 - Abstract
Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryotes there is a vast array of Hsp70 isoforms that may facilitate adaption to a particular cellular compartment and distinct biological role. Emerging data indicate a novel type of interaction between Hsp70 and client protein that does not fit with the classical Hsp70 ATP regulated substrate mechanism. In this review, we highlight Hsp70 ATPase domain interactions with binding partners from various biological systems that we refer to as Hsp70 ATPase alternative binding proteins or HAAB proteins. We identify common mechanistic features that may define how Hsp70 operates when associating with proteins in this alternative HAAB mode of action.
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- 2023
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3. Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2
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Alice Halliday, Anna E. Long, Holly E. Baum, Amy C. Thomas, Kathryn L. Shelley, Elizabeth Oliver, Kapil Gupta, Ore Francis, Maia Kavanagh Williamson, Natalie Di Bartolo, Matthew J. Randell, Yassin Ben-Khoud, Ilana Kelland, Georgina Mortimer, Olivia Ball, Charlie Plumptre, Kyla Chandler, Ulrike Obst, Massimiliano Secchi, Lorenzo Piemonti, Vito Lampasona, Joyce Smith, Michaela Gregorova, Lea Knezevic, Jane Metz, Rachael Barr, Begonia Morales-Aza, Jennifer Oliver, Lucy Collingwood, Benjamin Hitchings, Susan Ring, Linda Wooldridge, Laura Rivino, Nicholas Timpson, Jorgen McKernon, Peter Muir, Fergus Hamilton, David Arnold, Derek N. Woolfson, Anu Goenka, Andrew D. Davidson, Ashley M. Toye, Imre Berger, Mick Bailey, Kathleen M. Gillespie, Alistair J. K. Williams, and Adam Finn
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antibody ,diagnostic ,ELISA ,evaluation ,SARS-CoV-2 ,COVID-19 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings where active testing for virus is limited and remote sampling is optimal. We developed 12 ELISAs detecting total or antibody isotypes to SARS-CoV-2 nucleocapsid, spike protein or its receptor binding domain (RBD), 3 anti-RBD isotype specific luciferase immunoprecipitation system (LIPS) assays and a novel Spike-RBD bridging LIPS total-antibody assay. We utilized pre-pandemic (n=984) and confirmed/suspected recent COVID-19 sera taken pre-vaccination rollout in 2020 (n=269). Assays measuring total antibody discriminated best between pre-pandemic and COVID-19 sera and were selected for diagnostic evaluation. In the blind evaluation, two of these assays (Spike Pan ELISA and Spike-RBD Bridging LIPS assay) demonstrated >97% specificity and >92% sensitivity for samples from COVID-19 patients taken >21 days post symptom onset or PCR test. These assays offered better sensitivity for the detection of COVID-19 cases than a commercial assay which requires 100-fold larger serum volumes. This study demonstrates that low-volume in-house antibody assays can provide good diagnostic performance, and highlights the importance of using well-characterized samples and controls for all stages of assay development and evaluation. These cost-effective assays may be particularly useful for seroprevalence studies in low and middle-income countries.
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- 2022
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4. Detection of residual and chemoresistant leukemic cells in an immune-competent mouse model of acute myeloid leukemia: Potential for unravelling their interactions with immunity.
- Author
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Alexia Mopin, Frédéric Leprêtre, Shéhérazade Sebda, Céline Villenet, Meriem Ben Khoud, Martin Figeac, Bruno Quesnel, and Carine Brinster
- Subjects
Medicine ,Science - Abstract
Acute myeloid leukemia (AML) is characterized by blocked differentiation and extensive proliferation of hematopoietic progenitors/precursors. Relapse is often observed after chemotherapy due to the presence of residual leukemic cells, which is also called minimal residual disease (MRD). Subclonal heterogeneity at diagnosis was found to be responsible for MRD after treatment. Patient xenograft mouse models are valuable tools for studying MRD after chemotherapy; however, the contribution of the immune system in these models is usually missing. To evaluate its role in leukemic persistence, we generated an immune-competent AML mouse model of persistence after chemotherapy treatment. We used well-characterized (phenotypically and genetically) subclones of the murine C1498 cell line stably expressing the ZsGreen reporter gene and the WT1 protein, a valuable antigen. Accordingly, these subclones were also selected due to their in vitro aracytidine (Ara-c) sensitivity. A combination of 3 subclones (expressing or not expressing WT1) was found to lead to prolonged mouse survival after Ara-c treatment (as long as 150 days). The presence of residual leukemic cells in the blood and BM of surviving mice indicated their persistence. Thus, a new mouse model that may offer insights into immune contributions to leukemic persistence was developed.
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- 2022
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5. In vitro and in vivo biological properties of pea pods (Pisum sativum L.)
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Mejri, Faiza, Ben Khoud, Haifa, Njim, Leila, Baati, Tarek, Selmi, Slimen, Martins, Alice, Serralheiro, Maria L.M., Rauter, Amelia P., and Hosni, Karim
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- 2019
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6. Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor-Alpha Receptor 1 Signaling Pathway Leads to Thymocytes' Cell Death by Necroptosis in a Mouse Model of Acute Myeloid Leukemia
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Meriem Ben Khoud, Nathalie Jouy, Virginie Driss, Bruno Quesnel, and Carine Brinster
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Virology ,Immunology ,Cell Biology - Published
- 2023
7. Rapid control prototyping of a quad-tilt-wing unmanned aerial vehicle.
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Khaled Ben Khoud, Soufiene Bouallègue, and Mounir Ayadi
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- 2017
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8. Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor-Alpha Receptor 1 Signaling Pathway Leads to Thymocytes' Cell Death by Necroptosis in a Mouse Model of Acute Myeloid Leukemia
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Ben Khoud, Meriem, primary, Jouy, Nathalie, additional, Driss, Virginie, additional, Quesnel, Bruno, additional, and Brinster, Carine, additional
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- 2023
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9. Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
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Ben-Khoud, Yassin, primary, Chen, Chao-Sheng, additional, and Ali, Maruf M. U., additional
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- 2023
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10. 221P The role of TNF-alpha in thymus dysfunction during acute myeloid leukemia
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Ben Khoud, M., primary, Jouy, N., additional, Quesnel, B., additional, and Brinster, C., additional
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- 2022
- Full Text
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11. Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
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Florescu, S, Stanciu, D, Zaharia, M, Kosa, A, Codreanu, D, Kidwai, A, Masood, S, Kaye, C, Coutts, A, MacKay, L, Summers, C, Polgarova, P, Farahi, N, Fox, E, McWilliam, S, Hawcutt, D, Rad, L, O’Malley, L, Whitbread, J, Jones, D, Dore, R, Saunderson, P, Kelsall, O, Cowley, N, Wild, L, Thrush, J, Wood, H, Austin, K, Bélteczki, J, Magyar, I, Fazekas, Á, Kovács, S, Szőke, V, Donnelly, A, Kelly, M, Smyth, N, O’Kane, S, McClintock, D, Warnock, M, Campbell, R, McCallion, E, Azaiz, A, Charron, C, Godement, M, Geri, G, Vieillard-Baron, A, Johnson, P, McKenna, S, Hanley, J, Currie, A, Allen, B, McGoldrick, C, McMaster, M, Mani, A, Mathew, M, Kandeepan, R, Vignesh, C, TV, B, Ramakrishnan, N, James, A, Elvira, E, Jayakumar, D, Pratheema, R, Babu, S, Ebenezer, R, Krishnaoorthy, S, Ranganathan, L, Ganesan, M, Shree, M, Guilder, E, Butler, M, Cowdrey, K-A, Robertson, M, Ali, F, McMahon, E, Duffy, E, Chen, Y, Simmonds, C, McConnochie, R, O’Connor, C, El-Khawas, K, Richardson, A, Hill, D, Commons, R, Abdelkharim, H, Saxena, M, Muteithia, M, Dobell-Brown, K, Jha, R, Kalogirou, M, Ellis, C, Krishnamurthy, V, O’Connor, A, Thurairatnam, S, Mukherjee, D, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Maloney, G, Kittridge, L, Solesbury, A, Ramos, A, Collins, D, Brickell, K, Reid, L, Smyth, M, Breen, P, Spain, S, Curley, G, McEvoy, N, Geoghegan, P, Clarke, J, Silversides, J, McGuigan, P, Ward, K, O’Neill, A, Finn, S, Wright, C, Green, J, Collins, É, Knott, C, Smith, J, Boschert, C, Slieker, K, Ewalds, E, Sanders, A, Wittenberg, W, Geurts, H, Poojara, L, Sara, T, Nand, K, Reeve, B, Dechert, W, Phillips, B, Oritz-Ruiz de Gordoa, L, Affleck, J, Shaikh, A, Murray, A, Ramanan, M, Frakking, T, Pinnell, J, Robinson, M, Gledhill, L, Wood, T, Sanghavi, R, Bhonagiri, D, Ford, M, Parikh, HG, Avard, B, Nourse, M, McDonald, B, Edmunds, N, Hoiting, O, Peters, M, Rengers, E, Evers, M, Prinssen, A, Morgan, M, Cole, J, Hill, H, Davies, M, Williams, A, Thomas, E, Davies, R, Wise, M, Grimm, P, Soukup, J, Wetzold, R, Löbel, M, Starke, L, Lellouche, F, Lizotte, P, Declerq, P, Antoine, M, Stephanie, G, Jean-Pierre, E, François, B, Marion, B, Philippe, R, Pourcine, F, Monchi, M, Luis, D, Mercier, R, Sagnier, A, Verrier, N, Caplin, C, Richecoeu, J, Combaux, D, Siami, S, Aparicio, C, Vautier, S, Jeblaoui, A, Lemaire-Brunel, D, D'Aragon, F, Carbonneau, E, Leblond, J, Plantefeve, G, Leparco, C, Contou, D, Fartoukh, M, Courtin, L, Labbe, V, Voiriot, G, Salhi, S, Chassé, M, Carrier, F, Boumahni, D, Benettaib, F, Ghamraoui, A, Sement, A, Gachet, A, Hanisch, A, Haffiane, A, Boivin, A-H, Barreau, A, Guerineau, E, Poupblanc, S, Egreteau, P, Lefevre, M, Bocher, S, Le Loup, G, Le Guen, L, Carn, V, Bertel, M, Antcliffe, D, Templeton, M, Rojo, R, Coghlan, P, Smee, J, Barker, G, Finn, A, Kreb, G, Hoff, U, Hinrichs, C, Nee, J, Mackay, E, Cort, J, Whileman, A, Spencer, T, Spittle, N, Beavis, S, Padmakumar, A, Dale, K, Hawes, J, Moakes, E, Gascoyne, R, Pritchard, K, Stevenson, L, Cooke, J, Nemeth-Roszpopa, K, Gauli, B, Bastola, S, Muller, G, Nay, M-A, Kamel, T, Benzekri, D, Jacquier, S, Runge, I, Mathonnet, A, Barbier, F, Bretagnol, A, Carter, J, Van Der Heyden, K, Mehrtens, J, Morris, A, Morgan, S, Burke, T, Mercier, E, Chartier, D, Salmon, C, Dequin, P-F, Garot, D, Bellemare, D, Cloutier, È, Daher, R, Costerousse, O, Boulanger, M-C, Couillard-Chénard, É, Lauzier, F, Francoeur, C, Francois, B, Gay, A, Anne-Laure, F, Ramali, M, HC, O, Ghosh, A, Osagie, R, Arachchige, M, Hartley, M, Cheung, W, Wong, H, Seigne, P, Eustace, J, O'Callaghan, A-M, O'Brien, F, Bamford, P, Reid, A, Cawley, K, Faulkner, M, Pickering, C, Raj, A, Tsinaslanidis, G, Khade, R, Agha, G, Sekiwala, R, Smith, T, Brewer, C, Gregory, J, Limb, J, Cowton, A, O’Brien, J, Postlethwaite, K, Malakouti, S, Music, E, Ricketts, D, King, A, Clermont, G, Bart, R, Mayr, F, Schoenling, A, Andreae, M, Shetty, V, Brant, E, Malley, B, Donadee, C, Sackrowitz, R, Weissman, A, Yealy, D, Barton, D, Talia, N, Nikitas, N, Wells, C, Lankester, L, McMillan, H, Van den Oever, H, Kruisdijk-Gerritsen, A, Haidar, G, Bain, W, Barbash, I, Fitzpatrick, M, Franz, C, Kitsios, G, Moghbeli, K, Rosborough, B, Shah, F, Suber, T, Pulletz, M, Williams, P, Birch, J, Wiseman, S, Horton, S, Alegria, A, Turki, S, Elsefi, T, Crisp, N, Allen, L, Truman, N, Smith, M, Chukkambotla, S, Goddard, W, Duberley, S, Khan, M, Kazi, A, Simpson, J, Duke, G, Chan, P, Carter, B, Hunter, S, Voigt, I, Schueler, R, Blank, E, Hüning, V, Steffen, M, Goralski, P, Litton, E, Regli, A, Pellicano, S, Palermo, A, Eroglu, E, Bihari, S, Laver, RD, Jin, X, Brown, J, McIntyre, J, French, C, Bates, S, Towns, M, Yang, Y, McGain, F, McCullagh, I, Cairns, T, Hanson, H, Patel, B, Clement, I, Evetts, G, Touma, O, Holland, S, Hodge, C, Taylor, H, Alderman, M, Barnes, N, Da Rocha, J, Smith, C, Brooks, N, Weerasinghe, T, Sinclair, J-A, Abusamra, Y, Doherty, R, Cudlipp, J, Singh, R, Yu, H, Daebis, A, Ng, C, Kendrick, S, Saran, A, Makky, A, Greener, D, Rowe-Leete, L, Edwards, A, Bland, Y, Dolman, R, Foster, T, Laffey, J, McNicholas, B, Scully, M, Casey, S, Kernan, M, Brennan, A, Rangan, R, Tully, R, Corbett, S, McCarthy, A, Duffy, O, Burke, D, Linnett, V, Sanderson, A, Ritzema, J, Wild, H, Lucas, R, Marriott, Y, Andric, Z, Cviljevic, S, Br, R, Zapalac, M, Mirković, G, Khare, D, Pinder, M, Gopinath, A, Kannan, T, Dean, S, Vanmali, P, Depuydt, P, De Waele, J, De Bus, L, Fierens, J, Bracke, S, Vermassen, J, Vermeiren, D, Pugh, R, Lean, R, Qiu, X, Scanlan, J, Evans, A, Davies, G, Lewis, J, Plesnikova, Y, Khoud, A, Coetzee, S, Puxty, K, Cathcart, S, Rimmer, D, Bagot, C, Scott, K, Martin, L, Yusuff, H, Isgro, G, Brightling, C, Bourne, M, Craner, M, Boyles, R, Alexander, B, Roberts, T, Nelli, A, Rosenstein-Sisson, R, Speyer, R, Pech, Y, McCullough, J, Tallott, M, Vazquez-Grande, G, Marten, N, Liu, T, Siddiqui, A, Khanal, S, Amatya, S, Szakmany, T, Cherian, S, Williams, G, James, C, Waters, A, Prout, R, Stedman, R, Davies, L, Pegler, S, Kyeremeh, L, Moorhouse, L, Arbane, G, Marotti, M, Bociek, A, Campos, S, Van Nieuwkoop, K, Ottens, T, Visser, Y, Van den Berg, L, Van der Kraan-Donker, A, Brett, S, Arias, S, Hall, R, Paneru, H, Koirala, S, Paudel, P, Wilson, M, Vaara, S, Pettilä, L, Heinonen, J, Pettilä, V, Jain, S, Gupta, A, Holbrook, C, Antoine, P, Meziani, F, Allam, H, Cattelan, J, Clere-Jehl, R, Helms, J, Kummerlen, C, Merdji, H, Monnier, A, Rahmani, H, Studer, A, Schneider, F, Castelain, V, Morel, G, L’Hotellier, S, Ochin, E, Vanjak, C, Rouge, P, Bendjemar, L, Albert, M, Serri, K, Cavayas, A, Duplaix, M, Williams, V, Catorze, NJTADS, Pereira, TNAL, Ferreira, RMC, Bastos, JMPS, Batista, TMO, Badie, J, Berdaguer, F, Malfroy, S, Mezher, C, Bourgoin, C, Moneger, G, Bouvier, E, Muñoz-Bermúdez, R, Marin-Corral, J, Degracia, A, Gómez, F, López, M, Aceto, R, Aghemo, A, Badalamenti, S, Brunetta, E, Cecconi, M, Ciccarelli, M, Constantini, E, Greco, M, Folci, M, Selmi, C, Voza, A, Henning, J, Bonner, S, Hugill, K, Cirstea, E, Wilkinson, D, Jones, J, Altomy, M, Karlikowski, M, Sutherland, H, Wilhelmsen, E, Woods, J, North, J, Pletz, M, Hagel, S, Ankert, J, Kolanos, S, Bloos, F, Simons, K, Van Zuylen, T, Bouman, A, Kumar, N, Panwar, R, Poulter, A-L, Sunkara, K, Szigligeti, G, Leszkoven, J, Rochwerg, B, Karachi, T, Oczkowski, S, Centofanti, J, Millen, T, Sundaran, D, Hollos, L, Turns, M, Walsh, J, Al Qasim, E, Alswaidan, L, Hegazy, M, Arishi, H, Al Amri, A, AlQahtani, S, Naidu, B, Tlayjeh, H, Hussain, S, Al Enezi, F, Abdukahil, SA, Hopkins, P, Noble, H, O’Reilly, K, Mehta, R, Wong, O, Makanju, E, Rao, D, Sikondari, N, Saha, S, Corcoran, E, Pappa, E, Cockrell, M, Donegan, C, Balaie, M, Nickoleit-Bitzenberger, D, Schaaf, B, Meermeier, W, Prebeg, K, Azzaui, H, Hower, M, Brieger, K-G, Elender, C, Sabelhaus, T, Riepe, A, Akamp, C, Kremling, J, Klein, D, Landsiedel-Mechenbier, E, Laha, S, Verlander, M, Jha, A, Megarbane, B, Voicu, S, Deye, N, Malissin, I, Sutterlin, L, Mrad, A, Lehalleur, A, Naim, G, Nguyen, P, Ekhérian, J-M, Boué, Y, Sidéris, G, Vodovar, D, Guérin, E, Grant, C, Brain, M, Mineall, S, Paramasivam, E, Wilby, E, Ogg, B, Howcroft, C, Aspinwall, A, Charlton, S, Gould, R, Mistry, D, Awan, S, Bedford, C, Carr-Wilkinson, J, Hall, A, Gardiner-Hill, C, Maloney, C, Brunskill, N, Watchorn, O, Hardy, C, Qureshi, H, Flint, N, Nicholson, S, Southin, S, Ghattaoraya, A, Harding, D, O’Halloran, S, Collins, A, Smith, E, Trues, E, Borgatta, B, Turner-Bone, I, Reddy, A, Wilding, L, Wilson, C, Surti, Z, Aneman, A, Miller, J, White, H, Estensen, K, Morrison, L, Sutton, J, Cooper, M, Warnapura, L, Agno, R, Sathianathan, P, Shaw, D, Ijaz, N, Spong, A, Sabaretnam, S, Burns, D, Lang, E, Tate, M, Fischer, R, Biradar, V, Soar, N, Golden, D, Davey, M, Seaman, R, Osborne, A, Bannard-Smith, J, Clark, R, Birchall, K, Henry, J, Pomeroy, F, Quayle, R, Wylie, K, Sukuraman, A, John, M, Sibin, S, Leditschke, A, Finnis, M, Jongebloed, K, Khwaja, K, Campisi, J, Van Vonderen, M, Pietersma, M, Vrolijk, L, Kampschreur, L, Van Gulik, L, Makowski, A, Misztal, B, Haider, S, Liao, A, Squires, R, Oborska, A, Kayani, A, Kalchko-Veyssal, S, Prabakaran, R, Hadebe, B, KalchkoVeyssal, S, Williams, T, Song, R, Morpeth, S, Lai, V, Habraken, H, Stewart, R, Mwaura, E, Mew, L, Wren, L, Willams, F, Sutherland, S-B, Rebello, R, Shehabi, Y, Al-Bassam, W, Hulley, A, Kadam, U, Sathianathan, K, Innes, R, Doble, P, Graham, L, Shovelton, C, Dean, T, Salahuddin, N, Aryal, D, Koirala, K, Rai, N, Luitel, S, Seppelt, I, Whitehead, C, Lowrey, J, Gresham, R, Masters, K, Hamlyn, V, Hawkins, N, Roynon-Reed, A, Cutler, S, Lewis, S, Lazaro, J, Newman, T, Aravindan, L, Asghar, A, Bartholomew, J, Bayne, M, Beddows, S, Birch, C, Brend, M, Byrne, R, Campbell, D, Campbell, H, Chambers, E, Clinton, A, Collins, J, Crawshaw, S, Dawson, LA, Donaldson, K, Drake, C, Dyas, S, Ellis, Y, Gilmour, K, Goodwin, J, Halden, S, Hall, AS, Hanson, J, Harper, H, Harrison, S, Hayes, A, Hodgson, H, Hurford, S-A, Jackson, S, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, Marsh, E, Mguni, N, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, O'Kell, E, Oliver, A, O'Reilly, J, Pearson, K, Porter, D, Potter, A, Rook, C, Rounds, C, Sheffield, J, Shirley, K, Siewersk, C, Skinner, T, Speight, H, Sutu, M, Unsworth, A, Van’t Hoff, W, Walker, S, Williams, H, Williamson, D, Williamson, JD, Duan, E, Tsang, J, Patterson, L, Austin, P, Chapman, S, Cabrelli, L, Fletcher, S, Nortje, J, Fottrell-Gould, D, Randell, G, Stammers, K, Healey, G, Pinto, M, Borrill, Z, Duncan, T, Ustianowski, A, Uriel, A, Eltayeb, A, Alfonso, J, Hey, S, Shaw, J, Fox, C, Lindergard, G, Charles, B, Blackledge, B, Connolly, K, Harris, J, Cuesta, J, Xavier, K, Purohit, D, Elhassan, M, Haldeos, A, Vincent, R, Abdelrazik, M, Jenkins, S, Ganesan, A, Kumar, R, Carter, D, Bakthavatsalam, D, Frater, A, Saleem, M, Everitt, R, Hacking, D, Zaman, M, Elmahi, E, Jones, A, Hall, K, Phillips, M, Terrill, L, Mills, G, Raithatha, A, Bauchmuller, K, Ryalls, K, Harrington, K, Bowler, H, Sall, J, Bourne, R, Gross, J, Massey, N, Adebambo, O, Long, M, Tony, K, Juffermans, N, Koopmans, M, Dujardin, R, Alderink, B, Rowland, M, Hutton, P, Bashyal, A, Davidson, N, Hird, C, Chhablani, M, Phalod, G, Kirkby, A, Archer, S, Netherton, K, Reschreiter, H, Camsooksai, J, Patch, S, Humphrey, C, Flynn, G, Harrington, C, Kruger, P, Walsham, J, Meyer, J, Harward, M, Jones, C, Sathe, S, Roche, L, Davies, E, Skinner, D, Gaylard, J, Newman, J, Pogson, D, Rose, S, Daly, Z, Brimfield, L, Nown, A, Parekh, D, Bergin, C, Bates, M, McGhee, C, Lynch, D, Bhandal, K, Tsakiridou, K, Bamford, A, Cooper, L, Whitehouse, T, Veenith, T, Forster, E, O'Connell, M, Sim, M, Hay, S, Henderson, S, Nygren, M, Valentine, E, Katary, A, Bell, G, Wilcox, L, Mataliotakis, M, Smith, P, Ali, M, Isguzar, A, Phull, M-K, Zaidi, A, Pogreban, T, Rosaroso, L, Harvey, D, Lowe, B, Meredith, M, Ryan, L, Schouten, J, Pickkers, P, Roovers, N, Klop-Riehl, M, Van der Eng, H, Sloots-Cuppen, S, Preijers, L, Van Oosten, N, Moine, P, Heming, N, Maxime, V, Bossard, I, Nicholier, T, Clair, B, Orlikowski, D, Bounab, R, Abdeladim, L, Baker, S, Duroux, M, Ratcliffe, M, Sy, E, Mailman, J, Lee, S, Gupta, C, Kassir, S, López, R, Rodríguez-Gómez, J, Cárcel, S, Carmona, R, De la Fuente, C, Rodriguez, M, Jan Hassing, R, Greven, F, Huijbens, D, Roebers, L, Verheij, H, Miles, H, Attokaran, A, Buehner, U, Williams, E, Chapman, M, O’Connor, S, Glasby, K, Rivett, J, Brown, N, Kutsogiannis, D, Thompson, P, Rooney, K, Rodden, N, Thomson, N, McGlynn, D, Abel, L, Gemmell, L, Sundaram, R, Hornsby, J, Walden, A, Keating, L, Frise, M, Rai, S, Bartley, S, Schuster-Bruce, M, Pitts, S, Miln, R, Purandare, L, Vamplew, L, Dempster, D, Gummadi, M, Dormand, N, Wang, S, Spivey, M, Bean, S, Burt, K, Moore, L, Hammonds, F, Richards, C, Campbell, L, Smyth, K, Day, C, Zitter, L, Benyon, S, Singh, J, Lynch, C, Mikusek, J, Deacon, B, Turner, K, Baker, E, Hickey, J, Champanerkar, S, Aitken, L, LewisProsser, L, Ahmad, N, Wiles, M, Willson, J, Grecu, I, Martin, J, Wrey Brown, C, Arias, A-M, Bevan, E, Westlake, S, Craven, T, Hope, D, Singleton, J, Clark, S, McCulloch, C, Biddie, S, Welters, I, Hamilton, D, Williams, K, Waugh, V, Mulla, S, Waite, A, Roman, J, Martinez, M, Johnston, B, Puthucheary, Z, Martin, T, Santos, F, Uddin, R, Fernandez, M, Seidu, F, Somerville, A, Pakats, M-L, Begum, S, Shahid, T, Presneill, J, Barge, D, Byrne, K, Janin, P, Yarad, E, Bass, F, Hammond, N, Vuylsteke, A, Chan, C, Victor, S, Waterson, S, McNamara, R, Boardman, M, Gattas, D, Buhr, H, Coles, J, Matsa, R, Gellamucho, M, Creagh-Brown, B, Marriot, C, Salberg, A, Zouita, L, Stone, S, Michalak, N, Donlon, S, Mtuwa, S, Mayangao, I, Verula, J, Burda, D, Harris, C, Jones, E, Bradley, P, Tarr, E, Harden, L, Piercy, C, Nolan, J, Kerslake, I, Cook, T, Simpson, T, Dalton, J, Demetriou, C, Mitchard, S, Ramos, L, White, K, Johnson, T, Headdon, W, Spencer, S, White, A, Howie, L, Reay, M, Watts, A, Traverse, E, Jennings, S, Anumakonda, V, Tuckwell, C, Harrow, K, Matthews, J, McGarry, K, Moore, V, Smith, L, Summerfield, A, Dark, P, Harvey, A, Doonan, R, McMorrow, L, Knowles, K, Pendlebury, J, Perez, J, Marsden, T, Taylor, M, Michael, A, Collis, M, Claxton, A, Habeichi, W, Horner, D, Slaughter, M, Thomas, V, Proudfoot, N, Keatley, C, Donnison, P, Casey, R, Irving, B, Matimba-Mupaya, W, Reed, C, Anthony, A, Trim, F, Cambalova, L, Robertson, D, Wilson, A, Hulme, J, Kannan, S, Kinney, F, Senya, H, Ratnam, V, Gill, M, Kirk, J, Shelton, S, Schweikert, S, Wibrow, B, Anstey, M, Rauniyar, R, Khoso, N, Asif, N, Taqdees, H, Frey, C, Scano, R, McKee, M, Murphy, P, Thomas, M, Worner, R, Faulkner, B, Gendall, E, Hayes, K, Blakemore, H, Borislavova, B, Deshpande, K, Van Haren, F, Konecny, P, Inskip, D, Tung, R, Hayes, L, Murphy, L, Neill, A, Reidy, B, O’Dwyer, M, Ryan, D, Ainscough, K, Hamilton-Davies, C, Mfuko, C, Abbass, H, Mandadapu, V, Leaver, S, Patel, K, Farnell-Ward, S, Saluzzio, R, Rawlins, S, Sicat, C, De Keulenaer, B, Ferrier, J, Fysh, E, Davda, A, Mevavala, B, Cook, D, Clarke, F, Banach, D, Fernández de Pinedo Artaraz, Z, Cabreros, L, Latham, V, Kruisselbrink, R, Brochard, L, Burns, K, Sandhu, G, Khalid, I, White, I, Croft, M, Holland, N, Pereira, R, Nair, P, Buscher, H, Reynolds, C, Newman, S, Santamaria, J, Barbazza, L, Homes, J, Smith, R, Zaki, A, Johnson, D, Garrard, H, Juhaz, V, Brown, L, Pemberton, A, Roy, A, Rostron, A, Woods, L, Cornell, S, Fowler, R, Adhikari, N, Kamra, M, Marinoff, N, Garrett, P, Murray, L, Brailsford, J, Fennessy, G, Mulder, J, Morgan, R, Pillai, S, Harford, R, Ivatt, H, Evans, D, Richards, S, Roberts, E, Bowen, J, Ainsworth, J, Kuitunen, A, Karlsson, S, Vahtera, A, Kiiski, H, Ristimäki, S, Albrett, J, Jackson, C, Kirkham, S, Tamme, K, Reinhard, V, Ellervee, A, Põldots, L, Rennit, P, Svitškar, N, Browne, T, Grimwade, K, Goodson, J, Keet, O, Callender, O, Udy, A, McCracken, P, Young, M, Board, J, Martin, E, Kasipandian, V, Patel, A, Allibone, S, Mary-Genetu, R, English, S, Watpool, I, Porteous, R, Miezitis, S, McIntyre, L, Brady, K, Vale, C, Shekar, K, Lavana, J, Parmar, D, Peake, S, Kurenda, C, Hormis, A, Walker, R, Collier, D, Kimpton, S, Oakley, S, Bhagani, S, De Neef, M, Garcia, S, Maharajh, A, Nandani, A, Dobson, J, Fernando, G, Eastgate, C, Gomez, K, Abdi, Z, Tatham, K, Jhanji, S, Black, E, Dela Rosa, A, Howle, R, Baikady, R, Drummond, A, Dearden, J, Philbin, J, Munt, S, Gopal, S, Pooni, J-S, Ganguly, S, Smallwood, A, Metherell, S, Naeem, A, Fagan, L, Ryan, E, Mariappa, V, Foulds, A, Revill, A, Bhattarai, B, De Jonge, E, Wigbers, J, Del Prado, M, Cremer, O, Mulier, J, Peters, A, Romberg, B, Schutgens, R, Troeman, D, Van Opdorp, M, Besten, H, Brakké, K, Barber, R, Hilldrith, A, Kluge, S, Nierhaus, A, Jarczak, D, Roedl, K, Kochanek, M, Rueß-Paterno, G, Mc-Kenzie, J, Eichenauer, D, Shimabukuro-Vornhagen, A, Wilcox, E, Del Sorbo, L, Abdelhady, H, Romagnuolo, T, Simpson, S, Maiden, M, Horton, M, Trickey, J, Krajinovic, V, Kutleša, M, Kotarski, V, Brohi, F, Jagannathan, V, Clark, M, Purvis, S, Wetherill, B, Brajković, A, Babel, J, Sever, H, Dragija, L, Kušan, I, Dushianthan, A, Cusack, R, De Courcy-Golder, K, Salmon, K, Burnish, R, Smith, S, Ruiz, W, Duke, Z, Johns, M, Male, M, Gladas, K, Virdee, S, Swabe, J, Tomlinson, H, Rohde, G, Grünewaldt, A, Bojunga, J, Petros, S, Kunz, K, Schütze, B, Weismann, D, Frey, A, Drayss, M, Goebeler, ME, Flor, T, Fragner, G, Wahl, N, Totzke, J, Sayehli, C, Hakak, S, Altaf, W, O'Sullivan, M, Murphy, A, Walsh, L, Rega La Valle, A, Bewley, J, Sweet, K, Grimmer, L, Johnson, R, Wyatt, R, Morgan, K, Varghese, S, Willis, J, Stratton, E, Kyle, L, Putensen, D, Drury, K, Skorko, A, Bremmer, P, Ward, G, Bassford, C, Sligl, W, Baig, N, Rewa, O, Bagshaw, S, Basile, K, Stavor, D, Burbee, D, McNamara, A, Wunderley, R, Bensen, N, Adams, P, Vita, T, Buhay, M, Scholl, D, Gilliam, M, Winters, J, Doherty, K, Berryman, E, Ghaffari, M, Marroquin, O, Quinn, K, Garrard, W, Kalchthaler, K, Beard, G, Skrtich, A, Bagavathy, K, Drapola, D, Bryan-Morris, K, Arnold, J, Reynolds, B, Hussain, M, Dunsavage, J, Saiyed, S, Hernandez, E, Goldman, J, Brown, C, Comp, S, Raczek, J, Morris, J, Vargas Jr., J, Weiss, D, Hensley, J, Kochert, E, Wnuk, C, Nemeth, C, Mowery, B, Hutchinson, C, Winters, L, McAdams, D, Walker, G, Minnier, T, Wisniewski, M, Mayak, K, McCreary, E, Bariola, R, Viehman, A, Daley, J, Lopus, A, Schmidhofer, M, Ambrosino, R, Keen, S, Toffalo, S, Stambaugh, M, Trimmer, K, Perri, R, Casali, S, Medva, R, Massar, B, Beyerl, A, Burkey, J, Keeler, S, Lowery, M, Oncea, L, Daugherty, J, Sevilla, C, Woelke, A, Dice, J, Weber, L, Roth, J, Ferringer, C, Beer, D, Fesz, J, Carpio, L, Colin, G, Zinzoni, V, Maquigneau, N, Henri-Lagarrigue, M, Pouplet, C, Reill, L, Distler, M, Maselli, A, Martynoga, R, Trask, K, Butler, A, Attwood, B, Parsons, P, Campbell, B, Smith, A, Page, V, Zhao, X, Oza, D, Abrahamson, G, Sheath, B, Young, P, Young, C, Lesona, E, Navarra, L, Cruz, R, Delaney, K, Aguilar-Dano, A, Gojanovic, M, Rhodes, J, Anderson, T, Morris, S, Nayyar, V, Bowen, D, Kong, J, Joy, J, Fuchs, R, Lambert, B, Tai, C, Thomas, A, Keen, A, Tierney, C, Omer, N, Bacon, G, Tridente, A, Shuker, K, Anders, J, Greer, S, Scott, P, Millington, A, Buchanan, P, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Denmade, C, Sadera, G, Jacob, R, Hughes, D, Sterba, M, Geng, W, Digby, S, Southern, D, Reddy, H, Hulse, S, Campbell, A, Garton, M, Watkins, C, Smuts, S, Quinn, A, Simpson, B, McMillan, C, Finch, C, Hill, C, Cooper, J, Budd, J, Small, C, O’Leary, R, Collins, E, Holland, A, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Ward, L, Yates, D, Birkinshaw, I, Kell, K, Scott, Z, Pearson, H, Hashmi, M, Hassan, N, Panjwani, A, Umrani, Z, Shaikh, M, Ain, Q, Kanwal, D, Van Bree, S, Bouw-Ruiter, M, Osinga, M, Van Zanten, A, McEldrew, R, Rashan, S, Singh, V, Azergui, N, Bari, S, Beltran, M, Brugman, C, Groeneveld, E, Jafarzadeh, M, Keijzer-Timmers, N, Kester, E, Koelink, M, Kwakkenbos-Craanen, M, Okundaye, C, Parker, L, Peters, S, Post, S, Rietveld, I, Scheepstra-Beukers, I, Schreuder, G, Smit, A, Brillinger, N, Markgraf, R, Eichinger, F, Doran, P, Anjum, A, Best-Lane, J, Barton, F, Miller, L, Richards-Belle, A, Saull, M, Sprinckmoller, S, Wiley, D, Darnell, R, Au, C, Lindstrum, K, Cheng, A, Forbes, A, Heritier, S, Trapani, T, Cuthbertson, B, Manoharan, V, Dondrop, A, Tolppa, T, Ehrmann, S, Hullegie, S, Povoa, P, Beasley, R, Daneman, N, McGloughlin, S, Paterson, D, Venkatesh, B, De Jong, M, Uyeki, T, Baillie, K, Netea, M, Orr, K, Patanwala, A, Tong, S, Cooper, N, Galea, J, Leavis, H, Ogungbenro, K, Patawala, A, Rademaker, E, Youngstein, T, Carrier, M, Fergusson, D, Hunt, B, Kumar, A, Laffan, M, Lother, S, Middeldorp, S, Stanworth, S, De Man, A, Masse, M-H, Abraham, J, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, McDyer, J, Menon, D, Pridee, N, Roberts, D, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Burrell, A, Ferguson, N, Hodgson, C, Orford, N, Phua, J, Baron, R, Epelman, S, Frankfurter, C, Gommans, F, Kim, E, Leaf, D, Vaduganathan, M, Van Kimmenade, R, Sanil, A, Van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Attanayaka, U, Darshana, S, Ishani, P, Udayanga, I, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z, Mouncey, PR, Al-Beidh, F, Annane, D, Arabi, YM, Beane, A, Van Bentum-Puijk, W, Bhimani, Z, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Buzgau, A, Buxton, M, Charles, WN, Cove, M, Detry, MA, Estcourt, LJ, Fagbodun, EO, Fitzgerald, M, Girard, TD, Goligher, EC, Goossens, H, Haniffa, R, Hills, T, Horvat, CM, Huang, DT, Ichihara, N, Lamontagne, F, Marshall, JC, McAuley, DF, McGlothlin, A, McGuinness, SP, McVerry, BJ, Neal, MD, Nichol, AD, Parke, RL, Parker, JC, Parry-Billings, K, Peters, SEC, Reyes, LF, Rowan, KM, Saito, H, Santos, MS, Saunders, CT, Serpa-Neto, A, Seymour, CW, Shankar-Hari, M, Stronach, LM, Turgeon, AF, Turner, AM, Van de Veerdonk, FL, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, McArthur, CJ, Berry, S, Derde, LPG, Gordon, AC, Webb, SA, Lawler, PR, Comm REMAP-CAP Investigators, Apollo - University of Cambridge Repository, Intensive Care Medicine, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pittsburgh Foundation, PF, Amgen, Health Research Board, HRB: CTN 2014-012, Horizon 2020 Framework Programme, H2020: 101003589, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, Heart and Stroke Foundation of Canada, HSF, National Institute for Health and Care Research, NIHR, European Commission, EC, National Health and Medical Research Council, NHMRC: 1101719, APP194811, CS-2016-16-011, GNT2008447, RP-2015-06-18, Office of Health and Medical Research, OHMR, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, Funding/Support : The Platform for European Preparedness Against (Re-) emerging Epidemics (PREPARE) consortium by the European Union, FP7-HEALTH-2013-INNOVATION-1 (#602525), the Rapid European COVID-19 Emergency Research response (RECOVER) consortium by the European Union’s Horizon 2020 research and innovation programme (#101003589), the Australian National Health and Medical Research Council (#APP1101719), the Australian Medical Research Future Fund (#APP2002132), the Health Research Council of New Zealand (#16/631), the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant (#158584) and the Canadian Institute of Health Research COVID-19 Rapid Research Funding (#447335), the UK National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Wellcome Trust Innovations Project (215522), the Minderoo Foundation, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the Translational Breast Cancer Research Consortium, the NSW Office of Health and Medical Research, Amgen, Eisai, and the Pittsburgh Foundation. Dr Higgins is funded by an NHMRC Emerging Leadership Fellowship (GNT2008447). Dr McQuilten is funded by an NHMRC Emerging Leadership Fellowship (APP194811). Dr Gordon is funded by an NIHR Research Professorship (RP-2015-06-18) and Dr Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011). Dr Turgeon is the Chairholder of the Canada Research Chair in Critical Care Neurology and Trauma. Dr Lawler is supported by a career award from the Heart and Stroke Foundation of Canada., and European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014)
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Adult ,Male ,corticosteroid ,[SDV]Life Sciences [q-bio] ,Critical Illness ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,antiplatelet ,Lopinavir ,Adaptive platform trial randomized controlled trial intensive care, pneumonia COVID-19 antiplatelet immunoglobulin antiviral corticosteroid immune modulation anticoagulation ,All institutes and research themes of the Radboud University Medical Center ,Adrenal Cortex Hormones ,Humans ,anticoagulation ,intensive care, pneumonia ,COVID-19 Serotherapy ,Original Investigation ,Medicine(all) ,immune modulation ,Ritonavir ,SARS-CoV-2 ,COVID-19 ,Anticoagulants ,Bayes Theorem ,General Medicine ,Middle Aged ,antiviral ,Receptors, Interleukin-6 ,Adaptive platform trial ,randomized controlled trial ,Female ,Human medicine ,immunoglobulin ,Follow-Up Studies ,Hydroxychloroquine - Abstract
ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.
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- 2023
12. Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2
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Halliday, Alice, primary, Long, Anna E., additional, Baum, Holly E., additional, Thomas, Amy C., additional, Shelley, Kathryn L., additional, Oliver, Elizabeth, additional, Gupta, Kapil, additional, Francis, Ore, additional, Williamson, Maia Kavanagh, additional, Di Bartolo, Natalie, additional, Randell, Matthew J., additional, Ben-Khoud, Yassin, additional, Kelland, Ilana, additional, Mortimer, Georgina, additional, Ball, Olivia, additional, Plumptre, Charlie, additional, Chandler, Kyla, additional, Obst, Ulrike, additional, Secchi, Massimiliano, additional, Piemonti, Lorenzo, additional, Lampasona, Vito, additional, Smith, Joyce, additional, Gregorova, Michaela, additional, Knezevic, Lea, additional, Metz, Jane, additional, Barr, Rachael, additional, Morales-Aza, Begonia, additional, Oliver, Jennifer, additional, Collingwood, Lucy, additional, Hitchings, Benjamin, additional, Ring, Susan, additional, Wooldridge, Linda, additional, Rivino, Laura, additional, Timpson, Nicholas, additional, McKernon, Jorgen, additional, Muir, Peter, additional, Hamilton, Fergus, additional, Arnold, David, additional, Woolfson, Derek N., additional, Goenka, Anu, additional, Davidson, Andrew D., additional, Toye, Ashley M., additional, Berger, Imre, additional, Bailey, Mick, additional, Gillespie, Kathleen M., additional, Williams, Alistair J. K., additional, and Finn, Adam, additional
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- 2022
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13. Detection of residual and chemoresistant leukemic cells in an immune-competent mouse model of acute myeloid leukemia: Potential for unravelling their interactions with immunity
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Mopin, Alexia, primary, Leprêtre, Frédéric, additional, Sebda, Shéhérazade, additional, Villenet, Céline, additional, Ben Khoud, Meriem, additional, Figeac, Martin, additional, Quesnel, Bruno, additional, and Brinster, Carine, additional
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- 2022
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14. Detection of residual and chemoresistant leukemic cells in an immune-competent mouse model of acute myeloid leukemia: Potential for unravelling their interactions with immunity
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Alexia Mopin, Frédéric Leprêtre, Shéhérazade Sebda, Céline Villenet, Meriem Ben Khoud, Martin Figeac, Bruno Quesnel, and Carine Brinster
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Disease Models, Animal ,Leukemia, Myeloid, Acute ,Mice ,Multidisciplinary ,Neoplasm, Residual ,Cytarabine ,Disease Progression ,Animals ,Humans - Abstract
Acute myeloid leukemia (AML) is characterized by blocked differentiation and extensive proliferation of hematopoietic progenitors/precursors. Relapse is often observed after chemotherapy due to the presence of residual leukemic cells, which is also called minimal residual disease (MRD). Subclonal heterogeneity at diagnosis was found to be responsible for MRD after treatment. Patient xenograft mouse models are valuable tools for studying MRD after chemotherapy; however, the contribution of the immune system in these models is usually missing. To evaluate its role in leukemic persistence, we generated an immune-competent AML mouse model of persistence after chemotherapy treatment. We used well-characterized (phenotypically and genetically) subclones of the murine C1498 cell line stably expressing theZsGreenreporter gene and the WT1 protein, a valuable antigen. Accordingly, these subclones were also selected due to theirin vitroaracytidine (Ara-c) sensitivity. A combination of 3 subclones (expressing or not expressing WT1) was found to lead to prolonged mouse survival after Ara-c treatment (as long as 150 days). The presence of residual leukemic cells in the blood and BM of surviving mice indicated their persistence. Thus, a new mouse model that may offer insights into immune contributions to leukemic persistence was developed.
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- 2021
15. 221P The role of TNF-alpha in thymus dysfunction during acute myeloid leukemia
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M. Ben Khoud, N. Jouy, B. Quesnel, and C. Brinster
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Oncology ,Immunology and Allergy - Published
- 2022
16. Kyste solitaire maxillomandibulaire
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Ben Khoud, N., Orset, E., Lebeau, J., and Brix, M.
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- 2009
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17. Acute Myeloid Leukemia: Is It T Time?
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Tiziano Ingegnere, Carine Brinster, Meriem Ben Ben Khoud, Bruno Quesnel, and Suman Mitra
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0301 basic medicine ,Cancer Research ,thymus function ,Myeloid ,medicine.medical_treatment ,T cells ,Review ,acute myeloid leukemia ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,hemic and lymphatic diseases ,medicine ,RC254-282 ,Cytopenia ,business.industry ,Myeloid leukemia ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Immunotherapy ,Acquired immune system ,medicine.disease ,Haematopoiesis ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Bone marrow ,immunotherapy ,business - Abstract
Simple Summary Acute myeloid leukemia (AML) is a cancer characterized by impaired differentiation and excessive expansion of blood progenitor cells leading to their accumulation in the bone marrow and circulation. The aim of this review is to describe how these leukemic cells can influence the immune system, particularly T lymphocytes that originate from the thymus and are involved in cancers’ and infections’ eradication. We focus on the elderly population, as this disease mainly affects people over 60 years-old. We discuss how AML cells can modify T lymphocytes’ production and functions. We also highlight newly developed therapeutic strategies to improve the anti-leukemic immune response and the clinical outcome of patients. Abstract Acute myeloid leukemia (AML) is a heterogeneous disease driven by impaired differentiation of hematopoietic primitive cells toward myeloid lineages (monocytes, granulocytes, red blood cells, platelets), leading to expansion and accumulation of “stem” and/or “progenitor”-like or differentiated leukemic cells in the bone marrow and blood. AML progression alters the bone marrow microenvironment and inhibits hematopoiesis’ proper functioning, causing sustained cytopenia and immunodeficiency. This review describes how the AML microenvironment influences lymphoid lineages, particularly T lymphocytes that originate from the thymus and orchestrate adaptive immune response. We focus on the elderly population, which is mainly affected by this pathology. We discuss how a permissive AML microenvironment can alter and even worsen the thymic function, T cells’ peripheral homeostasis, phenotype, and functions. Based on the recent findings on the mechanisms supporting that AML induces quantitative and qualitative changes in T cells, we suggest and summarize current immunotherapeutic strategies and challenges to overcome these anomalies to improve the anti-leukemic immune response and the clinical outcome of patients.
- Published
- 2021
18. Manifestations bucco-dentaires de la sclérodermie systémique
- Author
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Bouomrani Salem, Bel Hadj Ali Rim, Ben Khoud Sihem, and Béji Maher
- Subjects
sclérodermie systémique ,microstomie ,parodontite ,Medicine - Abstract
Nous rapportons l'observation d'une jeune femme de 26 ans ayant une sclérodermie systémique diffuse présentant une atteinte bucco-dentaire complexe : microstomie, hyperplasie gingivale, parodontite, dépôts tartriques, caries multiples et chevauchement dentaire antéro-inférieur.
- Published
- 2013
- Full Text
- View/download PDF
19. Acute Myeloid Leukemia: Is It T Time?
- Author
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Ben Khoud, Meriem Ben, primary, Ingegnere, Tiziano, additional, Quesnel, Bruno, additional, Mitra, Suman, additional, and Brinster, Carine, additional
- Published
- 2021
- Full Text
- View/download PDF
20. Maladie des brides amniotiques et malformations faciales
- Author
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Bouguila, J., Ben Khoud, N., Ghrissi, A., Bellalah, Z., Belghith, A., Landolsi, E., Zairi, I., Mokhtar, M., and Adouani, A.
- Published
- 2007
- Full Text
- View/download PDF
21. Design and co-simulation of a fuzzy gain-scheduled PID controller based on particle swarm optimization algorithms for a quad tilt wing unmanned aerial vehicle
- Author
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Mounir Ayadi, Khaled Ben Khoud, and Soufiene Bouallègue
- Subjects
0209 industrial biotechnology ,Wing ,Computer science ,MathematicsofComputing_NUMERICALANALYSIS ,PID controller ,Particle swarm optimization ,02 engineering and technology ,Co-simulation ,Fuzzy logic ,020901 industrial engineering & automation ,Tilt (optics) ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Instrumentation - Abstract
This paper deals with the systematic design and hardware co-simulation of a fuzzy gain-scheduled proportional–integral–derivative (GS-PID) controller for a quad tilt wing (QTW) type of unmanned aerial vehicles (UAVs) based on different variants of the particle swarm optimization (PSO) algorithm. The fuzzy PID gains scheduling problem for the stabilization of the roll, pitch and yaw dynamics of the QTW vehicle is formulated as a constrained optimization problem and solved thanks to improved PSO algorithms. PSO algorithms with variable inertia weight (PSO-In), PSO with constriction factor (PSO-Co) and PSO with possibility updating strategies (PSO-gbest) are proposed. Such variants of the PSO algorithm aim further to improve the exploration and exploitation capabilities of such a stochastic algorithm as well as its convergence fastness. The robustness of the designed PSO-based fuzzy GS-PID controllers under actuators faults is shown on the non-linear model of the QTW. All optimized fuzzy GS-PID controllers are then co-simulated within a processor-in-the-loop (PIL) framework based on an embedded NI myRIO-1900 board and a host PC. Such a proposed software (SW) and hardware (HW) computer aided design (CAD) platform is based on the Control Design and Simulation (CDSim) module of the LabVIEW environment as well as a set-up Network Streams-based data communication protocol. Demonstrative simulation results are presented, compared and discussed in order to improve the effectiveness of the proposed PSO-based fuzzy gains scheduled PID controllers for the QTW’s attitude flight stabilization.
- Published
- 2018
22. Electrochemical synthesis of [1,2,4]oxadiazol-3-one derivatives: anodic oxidation of N-amidoimidates
- Author
-
Tapsoba, I., Adhoum, N., Khoud, M.L.Ben, and Boujlel, K.
- Published
- 2003
- Full Text
- View/download PDF
23. P38 Our experience of diversifying simulation
- Author
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Matthew Aldridge, Ahmed Ben Khoud, Jeremy Purdell-Lewis, and Oliver Owen
- Subjects
Learning styles ,medicine.medical_specialty ,Instructional design ,Medical simulation ,Applied psychology ,medicine ,Psychology ,Curriculum ,Session (web analytics) ,Likert scale ,Instructional simulation ,Task (project management) - Abstract
Background Medical simulation is widely used in both undergraduate and post graduate medical education. A number of established formats exist, including linear, branching, rapid cycle simulation and Live Die Repeat.1 2 There is literature supporting improved patient safety, technical and nontechnical skills following the use of educational simulation. However, simulation provision and its evaluation tends to be in terms of individual simulation formats, rather than including a number of formats within a multimodal session. A multimodal educational session has the benefit of reinforcing learning using different learning styles. We document our learner and faculty experience of multimodal simulation sessions, comparing them to standard single format simulation. Methods Learners attended either BST only simulation, or BST/LDR combined simulation sessions. Pre and post questionnaires were completed by the learners, recording their responses using seven-point Likert scores. Technical and non-technical task confidence was scored, as well as overall session feedback. The BST/LDR learners also completed a LDR white box survey. Results In total 16 FY1 and 14 FY2 doctors attended one of six simulation sessions (19 BST and 12 LDR/BST). Learners reported a positive experience for LDR/BST sessions, preferring them to BST only sessions. Combined sessions recorded improved scores for simulation enjoyment as well as confidence in non-technical skills compared to BST only sessions. Of the 12 LDR/BST learners, 11 preferred the LDR simulation format. One participant scored LDR and BST as equal. All 12 stated that LDR reinforced their learning and that they would attend another LDR simulation session. The delayed 3 month survey also recorded a change in clinical behaviour from one participant following the LDR/BST simulation session. Discussion and conclusion The combined LDR/BST sessions achieved higher scores for simulation enjoyment as well as improved confidence in non-technical tasks. This may represent the merits of diversifying simulation sessions to reinforce learning via different simulation formats with the same session. Alternatively, the improved scores may signify the specific benefits of LDR as a simulation format. Our institution plans to complete LDR only sessions, as well as combined simulation sessions to incorporate linear and rapid cycle simulation. Educational theory supports the potential benefits of reinforcing learning with a multimodal simulation approach. However, more research and practical work needs to be undertaken to explore the actual benefits for learners. References Cook DA, Hamstra SJ, Brydges R, Zendejas B, Szostek JH, Wang AT, et al. Comparative effectiveness of instructional design features in simulation-based education: Systematic review and meta-analysis. Med Teach2013;35(1):844–75. Sunga K, Sandefur B, Asirvatham U, et al.LIVE. DIE. REPEAT: A novel instructional method incorporating recursive objective-based gameplay in an emergency medicine simulation curriculum. BMJ Simulation and Technology Enhanced Learning 2016;2:124–126.
- Published
- 2018
24. In vitro and in vivo biological properties of pea pods (Pisum sativum L.)
- Author
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Slimen Selmi, Leila Njim, Faiza Mejri, Amélia P. Rauter, Haifa Ben Khoud, Tarek Baati, Alice Martins, Karim Hosni, and Maria Luísa Serralheiro
- Subjects
chemistry.chemical_classification ,0303 health sciences ,Antioxidant ,030309 nutrition & dietetics ,medicine.medical_treatment ,Fatty acid ,04 agricultural and veterinary sciences ,040401 food science ,Biochemistry ,Palmitic acid ,Lipid peroxidation ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,chemistry ,In vivo ,Lactate dehydrogenase ,medicine ,Urea ,Alkaline phosphatase ,Food science ,Food Science - Abstract
Pea pods, a food waste by-product, was studied for its chemical composition and evaluated for its in vitro antioxidant, protein denaturating and anti-acetylcholinesterase (anti-AChE) and in vivo antidiabetic, antihyperlipidemic and cytoprotective properties in alloxan-induced diabetic mice. The pea pods had 51% fiber, 28.2% carbohydrates, 14.2% crude protein, 4.5% lipids and 4.5% ash which consisted mainly of K, Mg, Ca, Na, Fe, Zn and Cu (in descending order). The fatty acid (FA) profile showed that linoleic, linolenic and palmitic acids were the main components. Although its lipids are highly oxidation susceptible, the lipid fraction showed good nutritional attributes as shown by its low atherogenic, thrombogenic and hypoholestrolemic values. The pea pods methanol extract (PPE) showed very low antioxidant activity but it had a strong inhibitory effect on heat-induced BSA denaturation suggesting its possible anti-inflammatory effects. Oral administration of PPE to diabetic mice decreased serum glucose levels, alanine aminotransferase, aspartate aminotransferase, urea, creatinine, alkaline phosphatase and lactate dehydrogenase activities. It reduced lipid peroxidation, and H2O2 and SH contents, but it significantly (p
- Published
- 2019
25. Médecin dentiste face aux maladies émergentes et réémergences à transmission aérienne
- Author
-
Zina Bennou, Asma Annabi, Asma Dridi, Sihem Ben Khoud, and Radhia Hayder
- Subjects
business.industry ,Medicine ,business ,Humanities - Abstract
Introduction : depuis deux decennies, on assiste a l’emergence et a la re emergence de nombreuses maladies infectieuses. L’augmentation de la morbidite et de la mortalite de ces maladies a des consequences importantes en pratique dentaire essentiellement en matiere de protection contre la transmission des agents infectieux lors des soins effectues sur des patients infectes.
- Published
- 2018
26. Electrogenerated base-promoted synthesis and antimicrobial activity of 2-(1,3-dithian-2-ylidene)-2-arylacetonitrile and 2-(1,3-dithiolan-2-ylidene)-2-arylacetonitrile
- Author
-
Khaled Boujlel, Mohamed Lamine Ben Khoud, Nariman El Abed, Sami Ben Hadj Ahmed, Taieb Saied, and Kaouthar Hamrouni
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,Carbon disulfide ,Base (chemistry) ,Chemistry ,Proton NMR ,Organic chemistry ,General Chemistry ,Carbon-13 NMR ,Antimicrobial ,Acetonitrile ,Medicinal chemistry - Abstract
The new preparation of 2-(1,3-dithian-2-ylidene)-2-arylacetonitrile and 2-(1,3-dithiol-2-ylidene)-2-arylacetonitrile is described. The electrogenerated cyanomethyl base/anion obtained from the electroreduction of acetonitrile promotes reactions between arylacetonitrile, carbon disulfide and 1-bromo-3-chloropropane or 1,2-dibromoethane. Obtained products have been identified according to their spectroscopic data (IR and 1H NMR and 13C NMR) and elemental analysis. The possible antibacterial activities of some of these compounds were investigated. Promising results were found against few types of bacteria.
- Published
- 2015
27. W12 Live die repeat: our experience
- Author
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Purdell-lewis, Jeremy, primary, Aldridge, Matthew, additional, Khoud, Ahmed Ben, additional, and Owen, Oliver, additional
- Published
- 2018
- Full Text
- View/download PDF
28. P38 Our experience of diversifying simulation
- Author
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Purdell-Lewis, Jeremy, primary, Aldridge, Matthew, additional, Khoud, Ahmed Ben, additional, and Owen, Oliver, additional
- Published
- 2018
- Full Text
- View/download PDF
29. P8 The anaesthetic taster course: our experience of running a simulation taster course with near-peer tutors
- Author
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Khoud, Ahmed Amin Ben, primary, Aldridge, Matthew, additional, and Purdell-Lewis, Jeremy, additional
- Published
- 2018
- Full Text
- View/download PDF
30. Design and co-simulation of a fuzzy gain-scheduled PID controller based on particle swarm optimization algorithms for a quad tilt wing unmanned aerial vehicle
- Author
-
Khoud, Khaled Ben, primary, Bouallègue, Soufiene, additional, and Ayadi, Mounir, additional
- Published
- 2018
- Full Text
- View/download PDF
31. Médecin dentiste face aux maladies émergentes et réémergences à transmission aérienne
- Author
-
Dridi, Asma, primary, Khoud, Sihem Ben, additional, Bennou, Zina, additional, Hayder, Radhia, additional, and Annabi, Asma, additional
- Published
- 2018
- Full Text
- View/download PDF
32. Action Des Amines Et Des Hydrazines Sur Les Imidates Issus Du Methyl 3-Amino-2-Thiophene Carboxylate. Nouvelle Voie D'Acces Aux [3,2-d]4(3H)Thienopyrimidinones
- Author
-
B. Hajjem, M. L. Ben Khoud, and B. Baccar
- Subjects
chemistry.chemical_compound ,Methylhydrazine ,Pyrimidinones ,chemistry ,Stereochemistry ,Hydrazine ,General Chemistry ,Carboxylate ,Phenylhydrazine - Abstract
Methyl 3-amino-2-thiophene carboxylate reacts with orthoesters to produce N-(2-carbomethoxy thienyl) imidates 1. Treatment of these imidates with primary amines, hydrazine, methylhydrazine and phenylhydrazine yields only [3,2-d]4(3H)thieno- pyrimidinones 2 and not isomeric 1,3,4-thienotriazepin-5-ones. The type of products obtained gave information relevant to the elucidation of the mechanism of cyclization and the relative activities of the ester and imidate groups.
- Published
- 2010
33. Inclusion ectopique d'une dent de sagesse mandibulaire. A propos d'une observation
- Author
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M. Dhouib, AMohamed Abdelmoula, Ahmed Belghuith, Hanen Hablani, Fathi Karray, Mahmoud Maalej, Nabila Ben Khoud, and Hassen Chamli
- Subjects
Periodontics ,Dentistry (miscellaneous) ,Oral Surgery - Abstract
L'inclusion des dents de sagesse represente une pathologie frequente en stomatologie et chirurgie maxillofaciale. Cependant, l'inclusion en position ectopique est rare. Nous rapportons le cas d'une ectopie de la dent de sagesse inferieure gauche dans la branche montante, proche de l'echancrure sigmoide. Il s'agit d'un patient âge de 42 ans qui a ete adresse pour une cellulite de la region parotidienne gauche. Les explorations radiologiques ont montre une dent de sagesse inferieure gauche siegeant au niveau de l'echancrure sigmoide avec un kyste pericoronaire. L'etat local s'est ameliore par une antibiotherapie pendant 15 jours. Un mois apres, l'extraction de la dent a ete pratiquee par voie endobuccale. La conduite therapeutique devant une dent de sagesse mandibulaire ectopique necessite une bonne reflexion. Le choix de la voie d'abord depend du siege de la dent et de l'experience du chirurgien. Pour les cas asymptomatiques, l'abstention chirurgicale est conditionnee par une surveillance reguliere. (Med Buccale Chir Buccale 2009 ; 15 : 45-48).
- Published
- 2009
34. Maladie des brides amniotiques et malformations faciales
- Author
-
E. Landolsi, J. Bouguila, M. Mokhtar, N. Ben Khoud, Z. Bellalah, A. Belghith, I. Zairi, A. Ghrissi, and A. Adouani
- Subjects
business.industry ,Craniofacial abnormality ,Facial cleft ,Constriction ring syndrome ,Congenital malformations ,Anatomy ,medicine.disease ,stomatognathic diseases ,medicine.anatomical_structure ,Otorhinolaryngology ,Facial malformations ,Medicine ,Surgery ,Oral Surgery ,Craniofacial ,business ,Amniotic Band Syndrome ,Orbit (anatomy) - Abstract
Amniotic band syndrome (ABS) is a collection of fetal congenital malformations affecting mainly the limbs, but also the craniofacial area. The pathogenic mechanism is still unclear. The facial malformations in ABS are multiple, polymorphous, and asymmetric. The type and extent of facial defects depend on band location and time of onset. Defects may include a combination of facial cleft, cleft palate and lip, ocular lesions, and cranial malformations. The management of this disease must be multidisciplinary and the outcome depends on the gravity of malformations.
- Published
- 2007
35. Electrochemical synthesis of [1,2,4]oxadiazol-3-one derivatives: anodic oxidation of N-amidoimidates
- Author
-
M. L. Ben Khoud, Khaled Boujlel, N. Adhoum, and Issa Tapsoba
- Subjects
Intramolecular reaction ,General Chemical Engineering ,Inorganic chemistry ,chemistry.chemical_element ,Electrochemistry ,Medicinal chemistry ,Lithium perchlorate ,Analytical Chemistry ,chemistry.chemical_compound ,Deprotonation ,Transition metal ,chemistry ,Amide ,Platinum ,Acetonitrile - Abstract
Anodic oxidation of N-amidoimidates was performed in acetonitrile+lithium perchlorate as the electrolyte solution at platinum using controlled potentials. The products, isolated in good yield after oxidation of the amide group followed by deprotonation and intramolecular cyclization reactions, were identified as [1,2,4]oxadiazol-3-one derivatives.
- Published
- 2003
36. A New Route of Synthesis of 3a,6a-Dihydro-oxazolo[5,4-d]oxazole Derivatives
- Author
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R. Kossai, Issa Tapsoba, N. Adhoum, Khaled Boujlel, and M. L. Ben Khoud
- Subjects
Electrolysis ,Chemistry ,Organic Chemistry ,General Medicine ,Dropping mercury electrode ,Electrochemistry ,Combinatorial chemistry ,Medicinal chemistry ,law.invention ,Reduction (complexity) ,Solvent ,chemistry.chemical_compound ,law ,Organic chemistry ,Oxazole - Abstract
The electrochemical reduction of N-acylated imidates of a typical structure (Sch. 1) has been investigated by cyclic voltammetry and controlled potential electrolysis at mercury electrode in aprotic solvent. Electrodimerization occurs at the first wave and leads to the formation of 3a,6a-dihydro-oxazolo[5,4-d]oxazole 2 in good yields. 10.1081/SCC-120018929-SCH0001 Scheme 1.
- Published
- 2003
37. Kyste solitaire maxillomandibulaire
- Author
-
J. Lebeau, E. Orset, N. Ben Khoud, and M. Brix
- Subjects
medicine.medical_specialty ,Osteolysis ,business.industry ,Radiography ,medicine.medical_treatment ,Mandible ,medicine.disease ,Asymptomatic ,Curettage ,Surgery ,Otorhinolaryngology ,medicine ,Etiology ,Oral Surgery ,medicine.symptom ,Differential diagnosis ,business ,Bone cyst - Abstract
Summary The solitary maxillomandibular bone cyst is a benign bone lesion with a nontumoral osteolysis and a progressive growth potential. It is considered as a pseudocyst because of the absence of epithelium and accounts for 1% of bone cysts. Most facial solitary bone cysts are observed in the mandible, especially in the corpus, and in young patients. Its etiopathogeny is unknown. The solitary bone cyst is asymptomatic. It is often discovered accidentally by radiolucent lacuna. Adjacent teeth vitality is preserved. The differential diagnosis is that of mandibular radiolucent lacuna etiologies. The diagnosis is confirmed by the surgical approach. Treatment is based on wall cavity curettage. It is usually relatively benign but the issue is discussed in publications because of the up to 26% of recurrence, requiring radiographic follow-up.
- Published
- 2009
38. Integral Backstepping Control Prototyping for a Quad Tilt Wing Unmanned Aerial Vehicle
- Author
-
Bouallegue, Soufiene, primary and Khoud, Khaled Ben, additional
- Published
- 2016
- Full Text
- View/download PDF
39. [Oral manifestations of systemic sclerosis]
- Author
-
Bouomrani, Salem, Bel Hadj Ali, Rim, Ben Khoud, Sihem, and Béji, Maher
- Subjects
Adult ,Scleroderma, Systemic ,parodontite ,systemic sclerosis ,Subgingival Curettage ,Stomatognathic Diseases ,microstomia ,Case Report ,Dental Caries ,Oral Hygiene ,microstomie ,Sclérodermie systémique ,Humans ,Female ,periodontitis - Abstract
Nous rapportons l'observation d'une jeune femme de 26 ans ayant une sclérodermie systémique diffuse présentant une atteinte bucco-dentaire complexe: microstomie, hyperplasie gingivale, parodontite, dépôts tartriques, caries multiples et chevauchement dentaire antéro-inférieur. Nous discuterons à travers cette observation les manifestations bucco-dentaires de cette connectivite qui sont loin d’être rares mais souvent négligées par les cliniciens malgré leur retentissement fonctionnel majeur. Il convient de surveiller régulièrement l’état bucco-dentaire chez tout patient sclérodermique afin de diagnostiquer précocement ces atteintes. Diagnostiquées à un stade tardif les complications bucco-dentaires de la sclérodermie seront très difficiles à traiter.
- Published
- 2013
40. Manifestations bucco-dentaires de la sclérodermie systémique
- Author
-
Ben Khoud Sihem, Bouomrani Salem, Béji Maher, and Bel Hadj Ali Rim
- Subjects
Gynecology ,lcsh:R5-920 ,medicine.medical_specialty ,parodontite ,Microstomia ,business.industry ,lcsh:Public aspects of medicine ,lcsh:RA1-1270 ,General Medicine ,microstomie ,medicine.disease ,sclérodermie systémique ,medicine ,lcsh:Medicine (General) ,business - Abstract
Nous rapportons l'observation d'une jeune femme de 26 ans ayant une sclerodermie systemique diffuse presentant une atteinte bucco-dentaire complexe: microstomie, hyperplasie gingivale, parodontite, depots tartriques, caries multiples et chevauchement dentaire antero-inferieur. Nous discuterons a travers cette observation les manifestations bucco-dentaires de cette connectivite qui sont loin d’etre rares mais souvent negligees par les cliniciens malgre leur retentissement fonctionnel majeur. Il convient de surveiller regulierement l’etat bucco-dentaire chez tout patient sclerodermique afin de diagnostiquer precocement ces atteintes. Diagnostiquees a un stade tardif les complications bucco-dentaires de la sclerodermie seront tres difficiles a traiter.
- Published
- 2013
41. Integral Backstepping Control Prototyping for a Quad Tilt Wing Unmanned Aerial Vehicle
- Author
-
Soufiene Bouallègue and Khaled Ben Khoud
- Subjects
Fluid Flow and Transfer Processes ,0209 industrial biotechnology ,Engineering ,business.industry ,020208 electrical & electronic engineering ,Rapid control prototyping ,Aerospace Engineering ,PID controller ,Control engineering ,02 engineering and technology ,computer.software_genre ,Drone ,020901 industrial engineering & automation ,Software ,Control and Systems Engineering ,Control theory ,Backstepping ,0202 electrical engineering, electronic engineering, information engineering ,Computer Aided Design ,Electrical and Electronic Engineering ,Robust control ,Communications protocol ,business ,computer - Abstract
This paper deals with the design and hardware prototyping of Integral Backstepping controllers for a Quad Tilt Wing type of Unmanned Aerial Vehicles based on a National Instruments myRIO-1900 target and a host PC. The controllers’ parameters for the stabilization and tracking of the attitude and altitude hovering dynamics are tuned in real-time thanks to the proposed Computer Aided Design platform and within a Processor-In-the-Loop co-simulation framework. Such a developed software and hardware methodology is based on the Control Design and Simulation module of LabVIEW environment as well as a set-up Network Streams-based data communication protocol. A nonlinear model of the rotorcraft, which incorporates the dynamics of the vertical flight, is firstly given using the Newton-Euler formalism. Both Integral Backstepping controllers, for the attitude and heading dynamics as well as for the altitude and position states of the drone, are systematically designed and tuned. The proposed Integral Backstepping control strategy is compared to the classical Backstepping and PID control approaches in order to show its robustness superiority under external wind disturbances. Demonstrative software and hardware co-simulations are carried out and compared with each other in order to improve the real-world effectiveness of the proposed robust control approach for the Quad Tilt Wing aircraft navigation.
- Published
- 2016
42. ChemInform Abstract: Reaction of Amines and Hydrazines with the Imidates Derived from Methyl 3-Amino-2-thiophene Carboxylate. Novel Access to (3,2-d)4(3H) thienopyrimidinones
- Author
-
B. Hajjem, M. L. Ben Khoud, and B. Baccar
- Subjects
chemistry.chemical_compound ,Chemistry ,Thiophene ,Organic chemistry ,General Medicine ,Carboxylate - Published
- 2010
43. Electrogenerated base-promoted synthesis and antimicrobial activity of 2-(1,3-dithian-2-ylidene)-2-arylacetonitrile and 2-(1,3-dithiolan-2-ylidene)-2-arylacetonitrile
- Author
-
Hamrouni, Kaouthar, primary, Saied, Taieb, additional, El Abed, Nariman, additional, Ahmed, Sami Ben Hadj, additional, Boujlel, Khaled, additional, and Khoud, Mohamed Lamine Ben, additional
- Published
- 2015
- Full Text
- View/download PDF
44. [Solitary bone cyst of the jaws]
- Author
-
N, Ben Khoud, E, Orset, J, Lebeau, and M, Brix
- Subjects
Diagnosis, Differential ,Jaw Cysts ,Recurrence ,Humans ,Mandibular Diseases ,Osteolysis ,Maxillary Diseases - Abstract
The solitary maxillomandibular bone cyst is a benign bone lesion with a nontumoral osteolysis and a progressive growth potential. It is considered as a pseudocyst because of the absence of epithelium and accounts for 1% of bone cysts. Most facial solitary bone cysts are observed in the mandible, especially in the corpus, and in young patients. Its etiopathogeny is unknown. The solitary bone cyst is asymptomatic. It is often discovered accidentally by radiolucent lacuna. Adjacent teeth vitality is preserved. The differential diagnosis is that of mandibular radiolucent lacuna etiologies. The diagnosis is confirmed by the surgical approach. Treatment is based on wall cavity curettage. It is usually relatively benign but the issue is discussed in publications because of the up to 26% of recurrence, requiring radiographic follow-up.
- Published
- 2009
45. [A rare congenital gingival tumor]
- Author
-
Chiraz, Châari, Lilia Mnif, Hachicha, Nadia Ben, Khoud, Sameh, Ellouze, Fathi, Karray, Karima, Abbes, Mohamed, Abdelmoula, Saloua Makni, Krichen, and Tahia Sallami, Boudawara
- Subjects
Male ,Gingival Neoplasms ,Pulmonary Surfactant-Associated Protein B ,Homozygote ,Infant, Newborn ,Infant ,Genetic Counseling ,Pulmonary Alveolar Proteinosis ,Polymerase Chain Reaction ,Fatal Outcome ,Echocardiography ,Mutation ,Humans ,Female ,Radiography, Thoracic ,RNA, Messenger ,Lung - Abstract
Congenital epulis (CE) of the newborn also known as congenital granular cell tumor or Neumann tumor is an uncommun benign tumour occuring in the anterior alveolar ridge of the jaws. It may interfer with breathing and feeding. In our study, we discuss the clinicopathologic and evolutive caracteristics and the diagnosis problems of this entity.A newborn girl, two months old, presented at birth a nodular mass in the upper alveolar crete of the maxilla. The mass measured 1.5 cm and exhibited a smooth surface. Histologically, it was composed of diffuse sheets and clusters of granular cells with abundant coarsely granular cytoplasm. The evolution was good without recurrence after five months.CE is a rare tumor; its etiopathogenesis is still unclear. The diagnosis suspected clinically is confirmed by the histopathological study. The prognosis is exellent without recurrence.
- Published
- 2009
46. [Amniotic band syndrome and facial malformations]
- Author
-
J, Bouguila, N, Ben Khoud, A, Ghrissi, Z, Bellalah, A, Belghith, E, Landolsi, I, Zairi, M, Mokhtar, and A, Adouani
- Subjects
Cleft Palate ,Craniofacial Abnormalities ,Patient Care Team ,Face ,Infant, Newborn ,Humans ,Amniotic Band Syndrome ,Eye Abnormalities ,Prognosis ,Orbit ,Patient Care Planning - Abstract
Amniotic band syndrome (ABS) is a collection of fetal congenital malformations affecting mainly the limbs, but also the craniofacial area. The pathogenic mechanism is still unclear. The facial malformations in ABS are multiple, polymorphous, and asymmetric. The type and extent of facial defects depend on band location and time of onset. Defects may include a combination of facial cleft, cleft palate and lip, ocular lesions, and cranial malformations. The management of this disease must be multidisciplinary and the outcome depends on the gravity of malformations.
- Published
- 2006
47. Manifestations bucco-dentaires de la sclérodermie systémique
- Author
-
Salem, Bouomrani, primary, Ali, Bel Hadj, additional, Sihem, Ben Khoud, additional, and Maher, Béji, additional
- Published
- 2013
- Full Text
- View/download PDF
48. Action Des Amines Et Des Hydrazines Sur Les Imidates Issus Du Methyl 3-Amino-2-Thiophene Carboxylate. Nouvelle Voie D'Acces Aux [3,2-d]4(3H)Thienopyrimidinones
- Author
-
Hajjem, B., primary, Ben Khoud, M. L., additional, and Baccar, B., additional
- Published
- 2010
- Full Text
- View/download PDF
49. ChemInform Abstract: Reaction of Amines and Hydrazines with the Imidates Derived from Methyl 3-Amino-2-thiophene Carboxylate. Novel Access to (3,2-d)4(3H) thienopyrimidinones.
- Author
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HAJJEM, B., primary, BEN KHOUD, M. L., additional, and BACCAR, B., additional
- Published
- 2010
- Full Text
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50. Une tumeur gingivale congénitale rare
- Author
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Châari, Chiraz, primary, Hachicha, Lilia Mnif, additional, Khoud, Nadia Ben, additional, Ellouze, Sameh, additional, Karray, Fathi, additional, Abbes, Karima, additional, Abdelmoula, Mohamed, additional, Krichen, Saloua Makni, additional, and Boudawara, Tahia Sallami, additional
- Published
- 2009
- Full Text
- View/download PDF
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