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Adenosine deaminases acting on RNAs convert adenosines (A) to inosines (I) in structured or double-stranded RNAs. In mammals, this process is widespread. In the human transcriptome, more than a million different sites have been identified that undergo an ADAR-mediated A-to-I exchange Inosines have an altered base pairing potential due to the missing amino group when compared to the original adenosine. Consequently, inosines prefer to base pair with cytosines but can also base pair with uracil or adenine. This altered base pairing potential not only affects protein decoding at the ribosome but also influences the folding of RNAs and the proteins that can associate with it. Consequently, an A to I exchange can also affect RNA processing and turnover (Nishikura K. Annu Rev Biochem 79: 321-349, 2010; Brümmer A, Yang Y, Chan TW, Xiao X. Nat Commun 8: 1255, 2017). All of these events will interfere with gene expression and therefore, can also affect cellular and organismic physiology. As double-stranded RNAs are a hallmark of viral pathogens RNA-editing not only affects RNA-processing, coding, and gene expression but also controls the antiviral response to double-stranded RNAs. Most interestingly, recent advances in our understanding of ADAR enzymes reveal multiple layers of regulation by which ADARs can control antiviral programs. In this review, we focus on the recoding of mRNAs where the altered translation products lead to physiological changes. We also address recent advances in our understanding of the multiple layers of antiviral responses and innate immune modulations mediated by ADAR1.

The article reports results from the largest international dose survey in paediatric computed tomography (CT) in 32 countries and proposes international diagnostic reference levels (DRLs) in terms of computed tomography dose index (CTDI vol) and dose length product (DLP). It also assesses whether mean or median values of individual facilities should be used. A total of 6115 individual patient data were recorded among four age groups: <1 y, >1-5 y, >5-10 y and >10-15 y. CTDIw, CTDI vol and DLP from the CT console were recorded in dedicated forms together with patient data and technical parameters. Statistical analysis was performed, and international DRLs were established at rounded 75th percentile values of distribution of median values from all CT facilities. The study presents evidence in favour of using median rather than mean of patient dose indices as the representative of typical local dose in a facility, and for establishing DRLs as third quartile of median values. International DRLs were established for paediatric CT examinations for routine head, chest and abdomen in the four age groups. DRLs for CTDI vol are similar to the reference values from other published reports, with some differences for chest and abdomen CT. Higher variations were observed between DLP values, based on a survey of whole multi-phase exams. It may be noted that other studies in literature were based on single phase only. DRLs reported in this article can be used in countries without sufficient medical physics support to identify non-optimised practice. Recommendations to improve the accuracy and importance of future surveys are provided., (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Dose calculation algorithm is one of the main sources of uncertainty in the radiotherapy sequences. The aim of this study was to compare the accuracy of different inhomogeneity correction algorithms for external photon beam dose calculations. The methodology was based on International Atomic Energy Agency TEC-DOC 1583. The phantom was scanned in every center, using computed tomography and seven tests were planned on three-dimensional treatment planning systems (TPSs). The doses were measured with ion chambers and the deviation between measured and TPS calculated dose was reported. This methodology was tested in five different hospitals which were using six different algorithms/inhomogeneity correction methods implemented in different TPSs. The algorithms in this study were divided into two groups: Measurement-based algorithms (type (a)) and model-based algorithms (type (b)). In type (a) algorithms, we saw 7.6% and 11.3% deviations out of agreement criteria for low- and high-energy photons, respectively. While in type (b) algorithms, these values were 4.3% and 5.1%, respectively. As a general trend, the numbers of measurements with results outside the agreement criteria increase with the beam energy and decrease with advancement of TPS algorithms. More advanced algorithm would be preferable and therefore should be implanted in clinical practice, especially for calculation in inhomogeneous medias like lung and bone and for high-energy beams calculation at low depth points.

Objective: To survey procedures and protocols in paediatric computed tomography (CT) in 40 less resourced countries., Methods: Under a project of the International Atomic Energy Agency, 146 CT facilities in 40 countries of Africa, Asia, Europe and Latin America responded to an electronic survey of CT technology, exposure parameters, CT protocols and doses., Results: Modern MDCT systems are available in 77 % of the facilities surveyed with dedicated paediatric CT protocols available in 94 %. However, protocols for some age groups were unavailable in around 50 % of the facilities surveyed. Indication-based protocols were used in 57 % of facilities. Estimates of radiation dose using CTDI or DLP from standard CT protocols demonstrated wide variation up to a factor of 100. CTDI(vol) values for the head and chest were between two and five times those for an adult at some sites. Sedation and use of shielding were frequently reported; immobilisation was not. Records of exposure factors were kept at 49 % of sites., Conclusion: There is significant potential for improvement in CT practice and protocol use for children in less resourced countries. Dose estimates for young children varied widely. This survey provides critical baseline data for ongoing quality improvement efforts by the IAEA.

The general population, everywhere in the world is exposed to a small dose of ionising radiation from natural sources. Stochastic effects such as cancer and genetic disorders are caused when living creatures are exposed to low doses. In Iran, it is measured in some cities, especially in high-background areas such as Ramsar, but so far there is no measurement in the Hamadan province. Hamadan is located in the west of Iran. Measurements were performed using a RDS-110 survey meter, CaSO(4):Dy thermoluminecense dosimetries (TLDs) and a Harshaw 4000 TLD reader. To estimate the dose rate  outdoors, four stations along the main directions (north, south, west and east) and one in the town centre were selected. Mean annual X and gamma equivalent dose in Hamadan province are 1.12±0.22  and 1.66±0.07 mSv, which related to RDS-110 survey meter and TLDs measurements, respectively. The TLDs and RDS-110 results are representative of the external photon radiation doses for the selected monitoring locations and for those locations for the hours during which the measurements were taken, respectively. Maximum and minimum of external photon radiation doses are related to Hamadan and Kaboudar-Ahang towns, respectively. According to the results of the study, it seems that the annual X and gamma equivalent dose in Hamadan province exceeded the global mean external exposure amounts by the UNSCEAR, and further studies are needed to measure internal exposures to determine the total environmental radiation level in  Hamadan province.

Recognizing the lack of information on image quality and patient doses in most countries in Asia, the International Atomic Energy Agency (IAEA) initiated a project to assess the status of imaging technology, practice in conventional radiography, mammography, computed tomography (CT) and interventional procedures, and to implement optimisation actions. A total of 20 countries participated. Obsolete practices of use of fluoroscopy for positioning, photofluorography, chest fluoroscopy and conventional tomography were reported by 4 out of 7 countries that provided this information. Low-kV technique for chest radiography is in use in participating countries for 20-85% of cases, and manual processing is in 5-85% of facilities in 5 countries. Instances of the use of adult CT protocol for children in three participating countries were observed in 10-40% of hospitals surveyed. After implementation of a Quality Control programme, the image quality in conventional radiography improved by zero to 13 percentage points in certain countries and dose reduction was from 10% to 85%. In mammography, poor quality, ranging from 10 to 29% of images in different countries was observed. The project increased attention to dose quantities and dose levels in computed tomography, although doses in most cases were not higher than reference levels. In this study 16-19% of patients in interventional cardiology received doses that have potential for either stochastic risk or tissue reaction. This multi-national study is the first of its kind in the Asia, and it provided insight into the situation and opportunities for improvement., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Various methods, such as those developed by the Medical Internal Radiation Dosimetry (MIRD) Committee of the Society of Nuclear Medicine or employing dose point kernels, have been applied to the radiation dosimetry of (131)I radionuclide therapy. However, studies have not shown a strong relationship between tumour absorbed dose and its overall therapeutic response, probably due in part to inaccuracies in activity and dose estimation. In the current study, the GATE Monte Carlo computer code was used to facilitate voxel-level radiation dosimetry for organ activities measured in an (131)I-treated thyroid cancer patient. This approach allows incorporation of the size, shape and composition of organs (in the current study, in the Zubal anthropomorphic phantom) and intra-organ and intra-tumour inhomogeneities in the activity distributions. The total activities of the tumours and their heterogeneous distributions were measured from the SPECT images to calculate the dose maps. For investigating the effect of activity distribution on dose distribution, a hypothetical homogeneous distribution of the same total activity was considered in the tumours. It was observed that the tumour mean absorbed dose rates per unit cumulated activity were 0.65E-5 and 0.61E-5 mGY MBq(-1) s(-1) for the uniform and non-uniform distributions in the tumour, respectively, which do not differ considerably. However, the dose-volume histograms (DVH) show that the tumour non-uniform activity distribution decreases the absorbed dose to portions of the tumour volume. In such a case, it can be misleading to quote the mean or maximum absorbed dose, because overall response is likely limited by the tumour volume that receives low (i.e. non-cytocidal) doses. Three-dimensional radiation dosimetry, and calculation of tumour DVHs, may lead to the derivation of clinically reliable dose-response relationships and therefore may ultimately improve treatment planning as well as response assessment for radionuclide therapy.

Objective: The purpose of this study was to assess the frequency of pediatric CT in 40 less-resourced countries and to determine the level of appropriateness in CT use., Materials and Methods: Data on the increase in the number of CT examinations during 2007 and 2009 and appropriate use of CT examinations were collected, using standard forms, from 146 CT facilities at 126 hospitals., Results: The lowest frequency of pediatric CT examinations in 2009 was in European facilities (4.3%), and frequencies in Asia (12.2%) and Africa (7.8%) were twice as high. Head CT is the most common CT examination in children, amounting to nearly 75% of all pediatric CT examinations. Although regulations in many countries assign radiologists with the main responsibility of deciding whether a radiologic examination should be performed, in fact, radiologists alone were responsible for only 6.3% of situations. Written referral guidelines for imaging were not available in almost one half of the CT facilities. Appropriateness criteria for CT examinations in children did not always follow guidelines set by agencies, in particular, for patients with accidental head trauma, infants with congenital torticollis, children with possible ventriculoperitoneal shunt malfunction, and young children (< 5 years old) with acute sinusitis. In about one third of situations, nonavailability of previous images and records on previously received patient doses have the potential to lead to unnecessary examinations and radiation doses., Conclusion: With increasing use of CT in children and a lack of use of appropriateness criteria, there is a strong need to implement guidelines to avoid unnecessary radiation doses to children.

Purpose: Different types of concretes are used for bunker construction for radiation therapy. As neutron production occurs in high-energy photon beams, the purpose of this study was to investigate the effect of different concretes on photoneutron doses at an isocenter and maze entrance door., Materials and Methods: The 18-MV photon beam of a Varian 2100 C/D linear accelerator and a radiation therapy bunker were simulated using the MCNPX Monte Carlo code. Different commercially available concretes were used in photoneutron calculations for the simulated bunker., Results: Higher neutron doses of the water phantom were seen for barytes and galena concretes, while there was no significant (less than 1%) difference between the neutron dose of the phantom for all other concretes. Also, the neutron fluence at the inner and outer maze entrance varied up to 36% depending on the concretes' atomic compositions., Conclusion: It can be concluded that application of high-density concretes in order to use limited space or for other purposes may cause higher neutron doses in the maze entrance door and consequently may impose stricter requirements for neutron shielding of maze entrance doors.

External dose rate (ED) and residual activity (RA) of patients treated with (131)I sodium iodide are two main factors, to consider before release of patients. In this study, six nuclear medicine centres out of total seven centres in Iran were selected and measurements have been done on 330 patients. ED of patients was measured by physicists of the centres for 6 months (May-November 2009) at a 1 m distance from the thyroid of each patient on the first, second and third days after administration by a calibrated survey meter. The maximum and minimum values of ED were 21 (SD = 18) and 11 (SD = 4) µSv h(-1), respectively. Furthermore, the maximum and minimum values of RA during release of patient were 720 and 250 MBq, respectively. According to the study, we recommend a release activity limit of 500 MBq (14 mCi) or a dose rate level of 20 µSv h(-1) at 1 m from the patient to be set instead of a release activity limit of 1100 MBq (30 mCi) as it is now for the country.

The X-ray body scanner (BS) is going to find common use as a body-checking equipment at the entrance borders of countries, to find illicit drugs or forbidden items which have been hidden inside the body cavities, or attached to the body parts of the passengers. Considering the tissue weighting factors of the sensitive organs, the total effective dose due to the scanning by the system was estimated to be 3.8 µSv per scan. The ambient dose equivalent rates within the distance range of 300-40 cm from the X-ray generator were measured to be 4.5 up to 50 µSv h(-1). It is concluded that, in general, BS systems could be a safe device for the operators and people who are being scanned. But using such systems should be justified for everybody and special care should be taken for children and pregnant ladies.

High diagnostic sensitivity and specificity while maintaining the least dose to the patient is the ideal mammography. The objective of this work was to evaluate patient dose and image quality of mammograms to propose corrective actions. The image quality for 1242 patient in 7 mammography facilities in Tehran city was evaluated based on selected image quality criteria using a three-point scale. Clinical image quality, the entrance surface air kerma, the average glandular dose and optical density of films for standard PMMA phantom of 4.5 cm thickness were evaluated. The results showed that up to 72 % of mammograms were in good condition to be diagnosed, and only about 3.4 % of the images were unacceptable or with suboptimal quality. The entrance surface air kerma values were in the range of 3.8-10.5 mGy, average glandular dose 0.5-1.8 mGy and optical density of films 0.74-2.03. The image quality evaluation after correction actions, periodic image quality evaluation and using the correct equipment certainly will improve patient dose.

The response of PADC was calculated by Monte Carlo simulation using MCNPX code. H, C and O recoils as well as nuclear reactions have been taken into account. The calculated results show important contribution to detection efficiency of PADC due to H, C and O recoils. The irradiated detectors with (241)Am-Be source and (241)Am-Be softened with a spherical polyethylene moderator were electrochemically etched. The paper presents the results of the experimental and Monte Carlo simulations, which are in a good agreement., (Copyright © 2010 Elsevier Ltd. All rights reserved.)