The Biskra region has recently experienced remarkable economic development due to the extension of agricultural areas. This sustained development has led to increased water demand and exploitation of groundwater, which is the main source for irrigation, industry, and human consumption in the study area. This overexploitation has led to a water deficit throughout the region. Thus, the rational management of water resources has become an indispensable tool to ensure sustainable development. Several techniques and approaches have been developed for spatial groundwater recharge (GR) simulation in arid and semi-arid areas. The WetSpass approach is an exciting modeling technique with a high simulation capacity. After applying the model to the study area, the results show that the monthly average rainfall for the wet and dry periods is 9.6 mm and 8.2 mm, respectively. The rainfall distribution is 4 mm for surface runoff in the wet period and 0.4 mm in the dry period; the real evapotranspiration is 2.4 mm in the wet period and 4.7 mm in the dry period, and the amount of GR is estimated to be 0.4 mm and 0.01 mm in the wet and dry periods, respectively. It can therefore be concluded that WetSpass provides a good basis for simulating the components of the hydrological balance of the study region, and that groundwater recharge is essential for maintaining, utilizing, and preparing water supplies for sustainable management in the study area, particularly in Algeria and in the Mediterranean region in general.