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16. Integrated Science 2050: Multidisciplinarity and Interdisciplinarity in Health

Author

Rezaei, Nima, Saghazadeh, Amene, Ghani, Abdul Rahman Izaini, Vedadhir, AbouAli, Vahed, Aida, Vellido, Alfredo, Afshar, Alireza, Zali, Alireza, Kushniruk, Andre, Blacutt, Andrée-Anne, Pennisi, Antonino, Condino-Neto, Antonio, Khojasteh, Arash, Soto-Rojas, Armando E., Brown, Brian, Velasques, Bruna, Lucchiari, Claudio, Atilano-Barbosa, Daniel, Aprígio, Danielle, Kirsch, Donald R., Chiricò, Donata, Rayzan, Elham, Karakoc-Aydiner, Elif, Borycki, Elizabeth, Palmerini, Emilio Maria, Balogh, Esther A., Minutoli, Fabio, Ghobadinezhad, Farbod, Farrokhi, Farid, Reza, Faruque, Young, Gerald, Sierpiński, Grzegorz, Sajadi, Haniye Sadat, Ochs, Hans D., Murtomaa, Heikki, Monkman, Helen, Mojtabavi, Helia, Tonelli, Hélio A., Ziaei, Heliya, Sakly, Houneida, Jho, Hunkoog, Celiński, Ireneusz, Abdullah, Jafri Malin, Šrol, Jakub, Seekins, Jayne, Ravetz, Joe, Periñán, Juan José Garrido, Bittencourt, Juliana, Sarkar, Kaushik, Saleki, Kiarash, de Siqueira Rotenberg, Luisa, Jamee, Mahnaz, Keshavarz-Fathi, Mahsa, Gongora, Mariana, Cagy, Mauricio, Akhlaghdoust, Meisam, Lotfi, Melika, Baziar, Milad, Rafiaei, Milad, Amin Khazeei Tabari, Mohammad, Khami, Mohammad R., Golabchi, Mohammad Rasoul, Fadavipour, Mohammadreza, Tagina, Moncef, Lakhanpaul, Monica, Folayan, Morenike Oluwatoyin, Shamsizadeh, Morteza, Said, Mourad, Rambod Rad, Niloofar, Yazdanpanah, Niloufar, Samieefar, Noosha, Ribeiro, Pedro, Phantumvanit, Prathip, Parikh, Priti, van de Pas, Remco, Majdzadeh, Reza, Laudicella, Riccardo, Stein, Richard A., Mercadillo, Roberto E., Kelishadi, Roya, Behrouzieh, Sadra, Afkham, Saina Adiban, Momtazmanesh, Sara, Hosseini, Sayedeh Azimeh, Baldari, Sergio, Teixeira, Silmar, Seyedpour, Simin, Roche, Stéphane, Kekeghe, Stephen E., Feldman, Steven R., Fernandes, Thayaná, Ulrichs, Timo, Dorigo, Tommaso, Roudenok, Vasili, Iyer, Veeraraghavan J., Emmerich, Veronica K., Marinho, Victor, Čavojová, Vladimíra, Al-Herz, Waleed, Pirkoohi, Zahra Rahimi, Zakaria, Zaitun, Idris, Zamzuri, Izadi, Zhila, and Rezaei, Nima, Editor-in-Chief

Published
2022
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17. Integrated, Multidisciplinary, and Interdisciplinary Medical Education

Author

Samieefar, Noosha, Momtazmanesh, Sara, Ochs, Hans D., Ulrichs, Timo, Roudenok, Vasili, Golabchi, Mohammad Rasoul, Jamee, Mahnaz, Lotfi, Melika, Kelishadi, Roya, Tabari, Mohammad Amin Khazeei, Baziar, Milad, Hosseini, Sayedeh Azimeh, Rafiaei, Milad, Condino-Neto, Antonio, Karakoc-Aydiner, Elif, Al-Herz, Waleed, Shamsizadeh, Morteza, Rad, Niloofar Rambod, Fadavipour, Mohammadreza, Afshar, Alireza, Akhlaghdoust, Meisam, Saleki, Kiarash, Ghobadinezhad, Farbod, Izadi, Zhila, Khojasteh, Arash, Zali, Alireza, Rezaei, Nima, and Rezaei, Nima, Editor-in-Chief

Published
2022
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21. Implant-Assisted Orthognathic Surgery

Author

Khojasteh, Arash, Bastami, Farshid, Alikhasi, Marzieh, Keyhan, Seied Omid, editor, Fattahi, Tirbod, editor, Bagheri, Shahrokh C., editor, Bohluli, Behnam, editor, and Amirzade-Iranaq, Mohammad Hosein, editor

Published
2021
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31. Erratum to “Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model”

Author

Xie, Yilin, Su, Yingying, Min, Seiko, Tang, Jianxia, Goh, Bee Tin, Saigo, Leonardo, Ansari, Sahar, Moshaverinia, Alireza, Zhang, Chunmei, Wang, Jinsong, Liu, Yi, Khojasteh, Arash, Zadeh, Homayoun H, and Wang, Songlin

Subjects
Human Society, Biomedical and Clinical Sciences, Immunology, Biological Sciences, Information and Computing Sciences, Technology
Abstract

[This corrects the article DOI: 10.1155/2017/8094152.].

Published
2017

32. Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

Author

Xie, Yilin, Su, Yingying, Min, Seiko, Tang, Jianxia, Goh, Bee Tin, Saigo, Leonardo, Ansari, Sahar, Moshaverinia, Alireza, Zhang, Chunmei, Wang, Jinsong, Liu, Yi, Khojasteh, Arash, Zadeh, Homayoun H, and Wang, Songlin

Subjects
Engineering, Biomedical Engineering, Dental/Oral and Craniofacial Disease, Biotechnology, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Animals, Antibodies, Monoclonal, Bone Morphogenetic Protein 2, Bone Regeneration, Collagen, Disease Models, Animal, Humans, Macaca fascicularis, Mandible, Mandibular Diseases, Osteogenesis, Tissue Engineering, Tissue Scaffolds, Wound Healing, Biological Sciences, Information and Computing Sciences, Technology
Abstract

Antibody-mediated osseous regeneration (AMOR) has been introduced by our research group as a tissue engineering approach to capture of endogenous growth factors through the application of specific monoclonal antibodies (mAbs) immobilized on a scaffold. Specifically, anti-Bone Morphogenetic Protein- (BMP-) 2 mAbs have been demonstrated to be efficacious in mediating bone repair in a number of bone defects. The present study sought to investigate the application of AMOR for repair of mandibular continuity defect in nonhuman primates. Critical-sized mandibular continuity defects were created in Macaca fascicularis locally implanted with absorbable collagen sponges (ACS) functionalized with chimeric anti-BMP-2 mAb or isotype control mAb. 2D and 3D analysis of cone beam computed tomography (CBCT) imaging demonstrated increased bone density and volume observed within mandibular continuity defects implanted with collagen scaffolds functionalized with anti-BMP-2 mAb, compared with isotype-matched control mAb. Both CBCT imaging and histologic examination demonstrated de novo bone formation that was in direct apposition to the margins of the resected bone. It is hypothesized that bone injury may be necessary for AMOR. This is evidenced by de novo bone formation adjacent to resected bone margins, which may be the source of endogenous BMPs captured by anti-BMP-2 mAb, in turn mediating bone repair.

Published
2017

41. Physicochemical and Biological Characterization of Gelatin/Alginate Scaffolds Reinforced with β‐TCP, FDBA, and SrHA: Insights into Stem Cell Behavior and Osteogenic Differentiation.

Author

Mohaghegh, Sadra, Nokhbatolfoghahaei, Hanieh, Baniameri, Sahar, Farajpour, Hekmat, Fakhr, Massoumeh Jabbari, Shokrolahi, Fatemeh, Khojasteh, Arash, and El-Gendy, Nour

Subjects
CHEMICAL properties, 3-D printers, CELL adhesion, BONE marrow, STRONTIUM, TISSUE scaffolds
Abstract

Bone tissue engineering necessitates the development of scaffolds with optimal properties to provide a suitable microenvironment for cell adhesion, proliferation, and osteogenic differentiation. The selection of appropriate scaffold materials remains a critical challenge in this field. In this study, we aimed to address this challenge by evaluating and comparing the performance of hydrogel scaffolds reinforced with β‐tricalcium phosphate (β‐TCP), allograft, and a combination of allograft and strontium hydroxyapatite (SrHA). In this study, scaffolds containing the following compounds with a weight ratio of 75 : 25 : 50 were made using a 3D printer: group (1) alginate + gelatin + β‐TCP (TCP), group (2) alginate + gelatin + allograft (Allo), and group (3) alginate + gelatin + allograft + strontium hydroxyapatite (Str). Stem cells extracted from rat bone marrow (rBMSCs) were cultured on scaffolds, and cell proliferation and differentiation tests were performed. Also, the physical and chemical properties of the scaffolds were investigated. The two/one‐way analysis of variance (ANOVA) by Tukey's post hoc test was performed. There was no significant difference between scaffolds with pore size and porosity. TCP scaffolds' mechanical strength and degradation rate were significantly lower than the other two groups (P < 0.05). Also, the swelling ratio of Allo scaffolds was higher than in other samples. The amount of cell proliferation in the samples of the TCP group was lower than the other two, and the Allo samples had the best results in this concern (P < 0.01). However, the scaffolds containing strontium hydroxyapatite had significantly higher bone differentiation compared to the other two groups, and the lowest results were related to the scaffolds containing β‐TCP. Hydrogel scaffolds reinforced with allograft or its combination with strontium showed better physicochemical and biological behavior compared to those reinforced with β‐TCP. Besides, adding strontium had a limited impact on the physicochemical features of allograft‐containing scaffolds while improving their potential to induce osteogenic differentiation. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Animal Models in Dental Research

Author

Nokhbatolfoghahaei, Hanieh, primary, Paknejad, Zahrasadat, additional, Bohlouli, Mahboubeh, additional, Rezai Rad, Maryam, additional, and Khojasteh, Arash, additional

Published
2019
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