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Polymeric coating techniques have been widely used in the pharmaceutical industries for diversified reasons. Various materials are being investigated as polymers as there is scarcity of good polymeric materials to be used in pharmaceutical products. The present study was aimed at evaluating novel natural material gum sandarac, a resin obtained by incision from the stem of Callitris quadrivalvis , Ventenat (N.O. Coniferae) Pinaceae as a coating material for developing coated pellets for sustained release of drug and comparing it with well known ethyl cellulose as hydrophobic polymeric material. Drug layered NPS, drug loaded pellets prepared with extrusion spheronization and NPS coated with drug polymer matrix were used as multi particulate formulation. The results indicate that Gum Sandarac is very efficient in retarding release of drugs from different pellet formulations yielding very superior quality pellet.

The purpose of this study was to evaluate efficiency of fenugreek gum for developing gastro retentive floating tablets of Sumatriptan succinate when used alone or in combination with established polymers. The floating Tablet were prepared by direct compression and wet granulation technique and evaluated for various parameters like physical characterization, hardness, friability, weight variation, drug content uniformity, swelling index and in-vitro buoyancy and drug release. Fenugreek gum was efficient as release retardant and floating agent when used alone or in combinations with HPMC. The results indicated that fenugreek gum effectively sustained release for 12 hrs with parameters such as floating lag time, buoyancy, and floating time in acceptable range. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Higuchi release kinetics equation. This suggests that fenugreek gum can be a novel hydrophilic polymer in designing of FDDS.

Free hydroxyl groups of glucose monomer of starch substituted with steroyl group by chemical modification leads to the formation of starch stearate (SS). Modification changes the nature from hydrophilic to hydrophobic and thus used as controlled release excipient. In present study, SS was evaluated as release modifying polymer and MCC, Lactose, Dicalcium phosphate (DCP) and combinations of these were used to evaluate effect on drug release of Verapamil hydrochloride (VH) and Diclofenac sodium (DS). FT-IR studies of polymer with VH and DS have shown no significant drug:polymer interactions. Decrease in in-vitro drug dissolution was observed with increase in polymer concentration. Cumulative drug released for DS (hydrophobic) was more sustained than hydrophilic drug (VH). Drug release from formulations containing 30%w/w of SS after 8h was 81.61 (for VH) and 25.08% (for DS). DCP retarded drug release more when used alone. After 8h % drug release from formulations containing 30%w/w of SS was 49.86 (VH) and 24.19 (DS). The use of lactose alone increased the drug release and combination of DCP:Lactose in equal proportion with 15 %w/w SS sustained more i.e. 42.62% (VH) drug release at the end of 8h.

Sustained release, prolonged action, extended action are the terms used to identify drug delivery system that are designed to achieve prolong therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. Matrix systems, because of their ease of manufacture, their flexibility to obtain a desirable drug release profile, cost effectiveness, and broad regulatory acceptance are preferred for formulating these dosage forms. Polymers are the most important part in any type of release modified formulations. Predominantly hydrophobic materials are widely used to fabricate the matrix systems. Various materials are being investigated as polymers as there is scarcity of good polymeric materials to be used in pharmaceutical products. The present study was aimed at evaluating novel natural material gum sandarac, a resin obtained by incision from the stem of Callitris quadrivalvis, Ventenat (N.O. Coniferae) Pinaceae as a hydrophobic matrixing material for developing coated pellets for sustained release of drug and comparing it with well known ethyl cellulose as hydrophobic polymeric material.

The present investigation was planned to determine effect of Gender, Age and education on job stress in pharma industry employees. Today, human power as the most valuable investment in the organization, presents many problems, and management experts and organizational psychologists are paying more attention to the factors influencing an increase or a reduction in human efficiency and trying to improve the influence of positive factors and reduce the role of negative ones by identifying them and taking necessary actions.

Putranjiva roxburghii Wall is traditionally used by tribals for treating various health problems. In this study, Analgesic, anti-inflammatory and anti-oxidant activities of ethanolic extract of leaves and stem of Putranjiva roxburghii were evaluated in rats using different evaluatory models for each activity. Carrageenan-induced paw edema, croton oilinduced ear edema and anus edema models were used for evaluating anti-inflammatory activity. Analgesic activity was evaluated by acetic acid induced writhing model, Eddy hot plate model and tail flick models. The plant extract was also evaluated for its In-vitro anti oxidant activity in an attempt to find its potency in providing protection against free radical induced diseases. The results indicates significant dose dependant anti inflammatory activity of ethanolic extract (250 and 500 mg/kg, p.o.) of Putranjiva roxburghii wall with respect to standard drug Indomethacin. The extract showed dose dependent analgesic activity in acetic acid induced writhing model but dose independent activity in case of hot plate and tail flick models as compared to standard drug Indomethacin. The In-vitro antioxidant activity of the ethanolic extract was also significant and comparable with ascorbic acid in both DPPH and H2O2 models.