Search

Your search keyword '"Khayyat, Ahdab N."' showing total 31 results
Start Over Author "Khayyat, Ahdab N."
31 results on '"Khayyat, Ahdab N."'

3. A green approach to the analysis of co-administered ampicillin/sulbactam and paracetamol in human urine

Author

SELIM BASMA M., ABDELSALAM RANDA A., EL-GINDY ALAA, EID BASMA G., NEAMATALLAH THIKRYAT, KHAYYAT AHDAB N., HADAD GHADA M., and ELKHOUDARY MAHMOUD M.

Subjects
ampicillin, paracetamol, sulbactam, hplc, green analytical chemistry, drug-drug interaction, urinary excretion, Pharmaceutical industry, HD9665-9675
Abstract

The novelty of this work is the simultaneous analysis of sulbactam (SUL), ampicillin (AMP), and paracetamol (PARA) in human urine samples, using the environmentally benign RP-HPLC method. A C18 column was used in chromatographic separation using potassium dihydrogen phosphate (10 mmol L–1, pH 5)/ethanol (90 %, V/V) as the mobile phase; flow rate was 1.00 mL min–1. UV detection at 220 nm was used for quantification. The proposed method showed good linearity in the concentration ranges of 2.20–250.00 μg mL–1 for SUL, 2.50–250.00 μg mL–1 for PARA, and 14.50–250.00 μg mL–1 for AMP. Direct injection of urine samples with no prior extraction was performed. This method was found successful in moving towards greener studies of drugs’ urinary excretion, by decreasing hazardous solvent consumption and waste. Moreover, the method was applied to investigate the urinary excretion of the drugs and possible interaction between ampicillin and paracetamol.

Published
2022
Full Text
View/download PDF

7. A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses.

Author

Khayat, Maan T., Ahmed, Hany E. A., Omar, Abdelsattar M., Muhammad, Yosra A., Mohammad, Khadijah A., Malebari, Azizah M., Khayyat, Ahdab N., Halawa, Ahmed H., Abulkhair, Hamada S., Al-Karmalawy, Ahmed A., Almaghrabi, Mohammed, Alharbi, Majed, Aljahdali, Anfal S., and El-Agrody, Ahmed M.

Published
2023
Full Text
View/download PDF

12. Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment

Author

Malebari, Azizah M., Kara, Aytug, Khayyat, Ahdab N., Mohammad, Khadijah A., Serrano López, Dolores Remedios, Malebari, Azizah M., Kara, Aytug, Khayyat, Ahdab N., Mohammad, Khadijah A., and Serrano López, Dolores Remedios

Abstract

The combination of lopinavir/ritonavir remains one of the first-line therapies for the initial antiretroviral regimen in pediatric HIV-infected children. However, the implementation of this recommendation has faced many challenges due to cold-chain requirements, high alcohol content, and unpalatability for ritonavir-boosted lopinavir syrup. In addition, the administration of crushed tablets has shown a detriment for the oral bioavailability of both drugs. Therefore, there is a clinical need to develop safer and better formulations adapted to children’s needs. This work has demonstrated, for the first time, the feasibility of using direct powder extrusion 3D printing to manufacture personalized pediatric HIV dosage forms based on 6 mm spherical tablets. H-bonding between drugs and excipients (hydroxypropyl methylcellulose and polyethylene glycol) resulted in the formation of amorphous solid dispersions with a zero-order sustained release profile, opposite to the commercially available formulation Kaletra, which exhibited marked drug precipitation at the intestinal pH., Institutional Fund Projects, Depto. de Farmacia Galénica y Tecnología Alimentaria, Fac. de Farmacia, TRUE, pub

Published
2022

13. Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa

Author

Khayat, Maan T., primary, Ibrahim, Tarek S., additional, Khayyat, Ahdab N., additional, Alharbi, Majed, additional, Shaldam, Moataz A., additional, Mohammad, Khadijah A., additional, Khafagy, El-Sayed, additional, El-damasy, Dalia A., additional, Hegazy, Wael A. H., additional, and Abbas, Hisham A., additional

Published
2022
Full Text
View/download PDF

19. Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer

Author

Khayyat, Ahdab N., primary, Abbas, Hisham A., additional, Mohamed, Mamdouh F. A., additional, Asfour, Hani Z., additional, Khayat, Maan T., additional, Ibrahim, Tarek S., additional, Youns, Mahmoud, additional, Khafagy, El-Sayed, additional, Abu Lila, Amr S., additional, Safo, Martin K., additional, and Hegazy, Wael A. H., additional

Published
2021
Full Text
View/download PDF

20. Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation

Author

Youns,Mahmoud, Askoura,Momen, Abbas,Hisham A, Attia,Gouda H, Khayyat,Ahdab N, Goda,Reham M, Almalki,Ahmad J, Khafagy,El-Sayed, Hegazy,Wael AH, Youns,Mahmoud, Askoura,Momen, Abbas,Hisham A, Attia,Gouda H, Khayyat,Ahdab N, Goda,Reham M, Almalki,Ahmad J, Khafagy,El-Sayed, and Hegazy,Wael AH

Abstract

Mahmoud Youns, 1, 2 Momen Askoura, 3 Hisham A Abbas, 3 Gouda H Attia, 4, 5 Ahdab N Khayyat, 6 Reham M Goda, 7 Ahmad J Almalki, 6 El-Sayed Khafagy, 8, 9 Wael AH Hegazy 3 1Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt; 2Department of Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; 3Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt; 4Department of Pharmacognosy, Faculty of Pharmacy, Kafr El-Shiekh University, Kafr El-Shiekh, Egypt; 5Department of Pharmacognosy, College of Pharmacy, Najran University, Najran, Saudi Arabia; 6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 7Department of Microbiology and Biotechnology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Mansoura, Egypt; 8Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, 11942, Saudi Arabia; 9Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, 41552, EgyptCorrespondence: Mahmoud Youns Tel +0096891742704Email dr.mahmoudyouns@yahoo.comBackground: Pancreatic cancer is one of the most serious and lethal human cancers with a snowballing incidence around the world. The natural product celastrol has also been widely documented as a potent anti-inflammatory, anti-angiogenic, and anti-oxidant.Purpose: To elucidate the antitumor effect of celastrol on pancreatic cancer cells and its modulatory role on whole genome expression.Methods: The antitumor activity of celastrol on a panel of pancreatic cancer cells has been evaluated by Sulforhodamine B assay. Caspase 3/7 and histone-associated DNA fragments assays were done for apoptosis measurement. Additionally, prostaglandin (PGE2) inhibition was evaluated. Moreover, a microarray gene expression profiling was carried out to detec

Published
2021

22. Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens

Author

Khayyat, Ahdab N., primary, Hegazy, Wael A. H., additional, Shaldam, Moataz A., additional, Mosbah, Rasha, additional, Almalki, Ahmad J., additional, Ibrahim, Tarek S., additional, Khayat, Maan T., additional, Khafagy, El-Sayed, additional, Soliman, Wafaa E., additional, and Abbas, Hisham A., additional

Published
2021
Full Text
View/download PDF

26. In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors

Author

Ibrahim, Tarek S., primary, Taher, Ehab S., additional, Samir, Ebtihal, additional, M. Malebari, Azizah, additional, Khayyat, Ahdab N., additional, Mohamed, Mamdouh F. A., additional, Bokhtia, Riham M., additional, AlAwadh, Mohammed A., additional, Seliem, Israa A., additional, Asfour, Hani Z., additional, Alhakamy, Nabil A., additional, Panda, Siva S., additional, and AL-Mahmoudy, Amany M. M., additional

Published
2020
Full Text
View/download PDF

30. HPLC Determination of Imidazoles with Variant Anti-Infective Activity in Their Dosage Forms and Human Plasma.

Author

Ali, Oday T., Hassan, Wafaa S., Khayyat, Ahdab N., Almalki, Ahmad J., and Sebaiy, Mahmoud M.

Subjects
HIGH performance liquid chromatography, OMEPRAZOLE, IMIDAZOLES, DRUG dosage, ALBENDAZOLE, DETECTION limit
Abstract

A suitable HPLC method has been selected and validated for rapid simultaneous separation and determination of four imidazole anti-infective drugs, secnidazole, omeprazole, albendazole, and fenbendazole, in their final dosage forms, in addition to human plasma within 5 min. The method suitability was derived from the superiority of using the environmentally benign solvent, methanol over acetonitrile as a mobile phase component in respect of safety issues and migration times. Separation of the four anti-infective drugs was performed on a Thermo Scientific® BDS Hypersil C8 column (5 µm, 2.50 × 4.60 mm) using a mobile phase consist of MeOH: 0.025 M KH2PO4 (70:30, v/v) adjusted to pH 3.20 with ortho-phosphoric acid at room temperature. The flow rate was 1.00 mL/min and maximum absorption was measured with UV detector set at 300 nm. Limits of detection were reported to be 0.41, 0.13, 0.18, and 0.15 µg/mL for secnidazole, omeprazole, albendazole, and fenbendazole, respectively, showing a high degree of the method sensitivity. The method of analysis was validated according to Food and Drug Administration (FDA)guidelines for the determination of the drugs, either in their dosage forms with highly precise recoveries, or clinically in human plasma, especially regarding pharmacokinetic and bioequivalence studies. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

31. A new approach for characterization of phosphatidylcholines and lyso phosphatidylcholine in human plasma.

Author

Khedr A, Khayat MT, and Khayyat AN

Subjects
Humans, Lysophosphatidylcholines blood, Phosphatidylcholines blood, Plasma chemistry
Abstract

Aim: Characterization of phosphatidylcholines (PCs) and lyso phosphatidylcholine in human plasma using LC-IT-MS n . The characterization approach was based on trapping the eluted positive ions and applying low voltage for fragmentation to MS 2 and further fragmentation of the most abundant two peaks to obtain MS 3 . This approach allowed linking the MS 3 data to MS 2 and precursor ion. Methodology: The fatty acid part, at sn -1 and sn -2 of the glycerol backbone, could be identified based on the favored cleavage pathway. Conclusion: The dysregulated PCs and lyso phosphatidylcholines in human plasma obtained from acute coronary syndrome cases, and Type 2 diabetes patients suffering no coronary syndromes were estimated and matched versus healthy volunteers. An epoxide form of 16:0-18:2 PC was confirmed, m/z 774.6.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results