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6 results on '"Khattak, Faryal"'

2. Effect of Feeding Different Levels of Escherichia Coli Phytase and Buttiauxella Phytase on the Growth and Digestibility in Broiler

Author

Ahmad, Bashir, primary, Abro, Rani, additional, Kabir, Abdul, additional, Rehman, Bushra, additional, Khattak, Faryal, additional, Khan, Hamid Ali, additional, Rashid, Faiza, additional, Ullah, Muhammad Jawad, additional, Shadman, Muhammad, additional, Bibi, Mishal, additional, Ullah, Rizwan, additional, Ahmed, Zeeshan, additional, Hayat, Shubana, additional, and Ahmad, Junaid, additional

Published
2022
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4. Mathematical Modeling of E6-p53 interactions in Cervical Cancer

Author

Khattak, Faryal, Haseeb, Muhammad, Fazal, Sahar, Bhatti, AI, and Ullah, Mukhtar

Subjects
p53, small molecule drug, RITA, Cervical cancer, mathematical modeling, Research Article, E6
Abstract

Background: Cervical cancer is the third most common cancer in women throughout the world. The human papillomavirus (HPV) E6 viral protein plays an essential role in proteasomal degradation of the cancer suppressant protein p53. As a result, p53 negative regulation and apoptosis relevant activities are abrogated, facilitating development of cervical cancer. Methods: A mathematical model of E6-p53 interactions was developed using mathematical laws. In-silico simulations were carried out on CellDesigner and as a test case the small molecule drug RITA was considered for its ability to rescue the functions of tumor suppressor p53 by inhibiting E6 mediated proteasomal degradation. Results: Using a computational model we scrutinized how p53 responds to RITA, and chemical reactions of this small molecule drug were incorporated to perceive the full effects. The evolved strategy allowed the p53 response and rescue of its tumor suppressor function to be delineated, RITA being found to block p53 interactions with E6 associated proteins. Conclusion: We could develop a model of E6-p53 interactions with incorporation of actions of the small molecule drug RITA. Suppression of E6 associated proteins by RITA induces accumulation of tumor suppressant p53. Using CellDesigner to encode the model ensured that it can be easily modified and extended as more data become available. This strategy should play an effective role in the development of therapies against cancer.

Published
2017

6. Carbapenemases and Extended-Spectrum β-Lactamase–Producing Multidrug-Resistant Escherichia coliIsolated from Retail Chicken in Peshawar: First Report from Pakistan

Author

Ahmad, Kafeel, Khattak, Faryal, Ali, Amjad, Rahat, Shaista, Noor, Shazia, Mahsood, Nargas, and Somayya, Ramla

Abstract

We report the prevalence of extended-spectrum β-lactamases and carbapenemases in Escherichia coliisolated from retail chicken in Peshawar, Pakistan. One hundred E. coliisolates were recovered from retail chicken. Antibiotic susceptibility testing was carried out against ampicillin, chloramphenicol, kanamycin, nalidixic acid, cephalothin, gentamicin, sulfamethoxazole-trimethoprim, and streptomycin. Phenotypic detection of β-lactamase production was analyzed through double disc synergy test using the antibiotics amoxicillin-clavulanate, cefotaxime, ceftazidime, cefepime, and aztreonam. Fifty multidrug-resistant isolates were screened for detection of sul1, aadA, cmlA, int, blaTEM, blaSHV, blaCTX-M, blaOXA-10, blaVIM, blaIMP, and blaNDM-1genes. Resistance to ampicillin, nalidixic acid, kanamycin, streptomycin, cephalothin, sulfamethoxazole-trimethoprim, gentamicin, cefotaxime, ceftazidime, aztreonam, cefepime, amoxicillin-clavulanate, and chloramphenicol was 92, 91, 84, 73, 70, 67, 53, 48, 40, 39, 37, 36, and 23% respectively. Prevalence of sul1, aadA, cmlA, int, blaTEM, blaCTX-M, blaIMP, and blaNDM-1was 78% (n =39), 76% (n =38), 20% (n =10), 90% (n =45), 74% (n =37), 94% (n =47), 22% (n =11), and 4% (n =2), respectively. blaSHV, blaOXA-10, and blaVIMwere not detected. The coexistence of multiple antibiotic resistance genes in multidrug-resistant strains of E. coliis alarming. Hence, robust surveillance strategies should be developed with a focus on controlling the spread of antibiotic resistance genes via the food chain.

Published
2018
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