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130 results on '"Khatri, Akshay"'

1. Sarcasm Detection in Tweets with BERT and GloVe Embeddings

Author

Khatri, Akshay, P, Pranav, and M, Anand Kumar

Subjects
Computer Science - Computation and Language, Computer Science - Machine Learning
Abstract

Sarcasm is a form of communication in whichthe person states opposite of what he actually means. It is ambiguous in nature. In this paper, we propose using machine learning techniques with BERT and GloVe embeddings to detect sarcasm in tweets. The dataset is preprocessed before extracting the embeddings. The proposed model also uses the context in which the user is reacting to along with his actual response., Comment: 5 pages Submitted to ACL 2020 conference

Published
2020

2. Dynamic Address Allocation Algorithm for Mobile Ad hoc Networks

Author

Khatri, Akshay, Kolhe, Sankalp, and Giri, Nupur

Subjects
Computer Science - Networking and Internet Architecture
Abstract

A Mobile Ad hoc network (MANET) consists of nodes which use multi-hop communication to establish connection between nodes. Traditional infrastructure based systems use a centralized architecture for address allocation. However, this is not possible in Ad hoc networks due to their dynamic structure. Many schemes have been proposed to solve this problem, but most of them use network-wide broadcasts to ensure the availability of a new address. This becomes extremely difficult as network size grows. In this paper, we propose an address allocation algorithm which avoids network-wide broadcasts to allocate address to a new node. Moreover, the algorithm allocates addresses dynamically such that the network maintains an "IP resembles topology" state. In such a state, routing becomes easier and the overall overhead in communication is reduced. This algorithm is particularly useful for routing protocols which use topology information to route messages in the network. Our solution is designed with scalability in mind such that the cost of address assignment to a new node is independent of the number of nodes in the network.

Published
2016

6. Breakthrough invasive fungal infections on isavuconazole prophylaxis in hematologic malignancy & hematopoietic stem cell transplant patients.

Author

Khatri, Akshay M., Natori, Yoichiro, Anderson, Anthony, Jabr, Ra'ed, Shah, Shreya A., Natori, Akina, Chandhok, Namrata S., Komanduri, Krishna, Morris, Michele I., Camargo, Jose F., and Raja, Mohammed

Subjects
*HEMATOPOIETIC stem cells, *STEM cell transplantation, *MYCOSES, *HEMATOLOGIC malignancies, *ACUTE myeloid leukemia, *PULMONARY aspergillosis
Abstract

Background: Isavuconazole (ISA) is a newer antifungal used in patients with history of hematologic malignancies and hematopoietic transplant and cellular therapies (HM/TCT). Although it has a more favorable side‐effect profile, breakthrough invasive fungal infections (bIFIs) while on ISA have been reported. Methods: In this single‐center retrospective study evaluating HM/TCT patients who received prophylactic ISA for ≥7 days, we evaluated the incidence and potential risk factors for bIFIs. Results: We evaluated 106 patients who received prophylactic ISA. The patients were predominantly male (60.4%) with median age of 65 (range: 21–91) years. Acute myeloid leukemia (48/106, 45.3%) was the most common HM, with majority having relapsed and/or refractory disease (43/106, 40.6%) or receiving ongoing therapy (38/106, 35.8%). Nineteen patients (17.9%) developed bIFIs–nine proven [Fusarium (3), Candida (2), Mucorales plus Aspergillus (2), Mucorales (1), Colletotrichum (1)], four probable invasive pulmonary Aspergillus, and six possible infections. Twelve patients were neutropenic for a median of 28 (8–253) days prior to bIFI diagnosis. ISA levels checked within 7 days of bIFI diagnosis (median: 3.65 μg/mL) were comparable to industry‐sponsored clinical trials. All‐cause mortality among the bIFI cases was 47.4% (9/19).We also noted clinically significant cytomegalovirus co‐infection in 5.3% (1/19). On univariate analysis, there were no significant differences in baseline comorbidities and potential risk factors between the two groups. Conclusion: ISA prophylaxis was associated with a significant cumulative incidence of bIFIs. Despite the appealing side‐effect and drug‐interaction profile of ISA, clinicians must be vigilant about the potential risk for bIFIs. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Early administration of SARS‐CoV‐2 monoclonal antibody reduces the risk of mortality in hematologic malignancy and hematopoietic cell transplant patients with COVID‐19

Author

Jabr, Ra'ed, primary, Khatri, Akshay, additional, Anderson, Anthony D., additional, Garcia, Leopoldo Cordova, additional, Viotti, Julia Bini, additional, Natori, Yoichiro, additional, Raja, Mohammed, additional, Camargo, Jose F., additional, and Morris, Michele I., additional

Published
2023
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9. Is the Omicron variant truly less virulent in solid organ transplant recipients?

Author

Anjan, Shweta, primary, Khatri, Akshay, additional, Viotti, Julia Bini, additional, Cheung, Teresa, additional, Garcia, Leopoldo A. Cordova, additional, Simkins, Jacques, additional, Loebe, Matthias, additional, Phancao, Anita, additional, O'Brien, Christopher B., additional, Sinha, Neeraj, additional, Ciancio, Gaetano, additional, Vianna, Rodrigo M., additional, Andrews, David, additional, Abbo, Lilian M., additional, Guerra, Giselle, additional, and Natori, Yoichiro, additional

Published
2022
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11. Passive Transfer of SARS‐CoV ‐2 Antibodies with Platelet Transfusions

Author

Ramirez, Guillermo, primary, Gautam‐Goyal, Pranisha, additional, Shariatmadar, Sherry, additional, Khatri, Akshay, additional, McCann‐Pineo, Molly, additional, Rasul, Rehana, additional, Karkenny, Gabriel, additional, Chang, Tylis, additional, Sfakianos, Maria, additional, Cassiere, Hugh, additional, and Epstein, Marcia, additional

Published
2022
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13. sj-docx-1-jia-10.1177_23259582221089194 - Supplemental material for Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review

Author

Adnani, Harsha, Agrawal, Nirav, Khatri, Akshay, Vialet, Jaclyn, Zhang, Meng, and Cervia, Joseph

Subjects
111708 Health and Community Services, 111799 Public Health and Health Services not elsewhere classified, 111702 Aged Health Care, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-jia-10.1177_23259582221089194 for Impact of Antiretroviral Therapy on Kidney Disease in HIV Infected Individuals – A Qualitative Systematic Review by Harsha Adnani, Nirav Agrawal, Akshay Khatri, Jaclyn Vialet, Meng Zhang and Joseph Cervia in Journal of the International Association of Providers of AIDS Care (JIAPAC)

Published
2022
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18. Hospital-Acquired Bloodstream Infections in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 Infection (Coronavirus Disease 2019): Association With Immunosuppressive Therapies

Author

Khatri, Akshay, primary, Malhotra, Prashant, additional, Izard, Stephanie, additional, Kim, Angela, additional, Oppenheim, Michael, additional, Gautam-Goyal, Pranisha, additional, Chen, Thomas, additional, Doan, Thien-ly, additional, Berlinrut, Ilan, additional, Niknam, Negin, additional, Flannery, Sarah, additional, Hirschwerk, David, additional, Epstein, Marcia, additional, and Farber, Bruce, additional

Published
2021
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21. An early experience on the effect of solid organ transplant status on hospitalized COVID‐19 patients

Author

Nair, Vinay, Jandovitz, Nicholas, Hirsch, Jamie S., Abate, Mersema, Satapathy, Sanjaya K., Roth, Nitzan, Miyara, Santiago J., Guevara, Sara, Kressel, Adam M., Xiang, Alec, Wu, Grace, Butensky, Samuel D., Lin, David, Williams, Stephanie, Bhaskaran, Madhu C., Majure, David T., Grodstein, Elliot, Lau, Lawrence, Nair, Gayatri, Fahmy, Ahmed E., Winnick, Aaron, Breslin, Nadine, Berlinrut, Ilan, Molmenti, Christine, Becker, Lance B., Malhotra, Prashant, Gautam‐Goyal, Pranisha, Lima, Brian, Maybaum, Simon, Shah, Samit K., Takegawa, Ryosuke, Hayashida, Kei, Shinozaki, Koichiro, Teperman, Lewis W., Molmenti, Ernesto P., Birabaharan, Morgan, Bodenheimer, Henry C., Bolourani, Siavash, Caruso, Vincenza A., Cohen, Stuart L., Dominello, Andrew J., Falzon, Louise, Cookingham, Jennifer, Johnson, Jennifer C., Minaya, Josue, Keel, Trey, Khatri, Akshay, Koshy, Robin V., Kozel, Zachary M., Kvasnovsky, Charlotte, Lesser, Martin, Maria, Naomi I., Mogavero, Jazmin N., Monane, Rachel, Najjar, Salem, Ng, Jia, Saif, M. Wasif, Sheppard, Acacia, Sison, Cristina, Stevens, Gerin R., Tan, Dylan, and Vullaganti, Sirish

Subjects
Adult, medicine.medical_specialty, Prognostic variable, medicine.medical_treatment, Population, 030230 surgery, Logistic regression, Article, Organ transplantation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Clinical endpoint, Humans, Immunology and Allergy, Pharmacology (medical), education, Immunosuppression Therapy, Mechanical ventilation, education.field_of_study, Transplantation, SARS-CoV-2, business.industry, COVID-19, Organ Transplantation, Odds ratio, Transplant Recipients, business, Body mass index
Abstract

We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID-19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity-matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR

Published
2021
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38. Primary Klebsiella pneumoniae Osteomyelitis with Bacteremia and Sepsis in a Patient with Cirrhosis

Author

Khatri, Akshay, Kanaparthy, Naga Sasidhar, Selvaraj, Bright Jebaraj, Cho, Eunna, and El Khoury, Marc Y.

Subjects
Article Subject
Abstract

Osteomyelitis is commonly caused by Staphylococci, Streptococci, Escherichia coli, and anaerobes. There have been cases of rare organisms like Klebsiella pneumoniae (Kp) being initially overlooked as causes of osteomyelitis. We report a case of an elderly cirrhotic adult male transferred for further management of liver failure, who was subsequently diagnosed with Kp osteomyelitis and sepsis. He had a history of blunt leg trauma, and MRI of the leg revealed osteomyelitis, with a negative workup for other sources of infection. Kp osteomyelitis is reported in less than 100 cases, mainly in pediatric and sickle-cell patients. There are no pathognomonic imaging findings. Lesions may be metastatic, with rapid widespread destruction and exuberant periosteal reaction. Kp is a rare, under recognized cause of osteomyelitis in immune-suppressed adults. Given its pathogenicity, early identification is critical.

Published
2018
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41. Sphingolipids in COPD.

Author

Chakinala, Raja Chandra, Khatri, Akshay, Gupta, Kriti, Koike, Kengo, and Epelbaum, Oleg

Subjects
OBSTRUCTIVE lung diseases, SPHINGOLIPIDS, CELL membranes, INFLAMMATION, PATHOLOGICAL physiology
Abstract

Sphingolipids are a distinct class of lipid molecules widely found in nature, principally as cell membrane constituents. After initial uncertainty about their function, sphingolipids have been increasingly recognised to be metabolically active entities involved in many biological processes, including the control of inflammation. Their role as mediators of inflammation may have significant implications for a range of lung diseases in which inflammation is a central element of pathogenesis. Chronic obstructive pulmonary disease (COPD), a highly prevalent and morbid condition predominantly affecting cigarette smokers, is a prime example of a respiratory illness with an inflammatory component. Understandably, sphingolipids have received growing attention for their increasingly demonstrated role in the pathophysiology of COPD. The present review aims to be among the first to focus exclusively on the connection between sphingolipids and lung inflammation in COPD, providing the reader with a clinically oriented synopsis of this intriguing association. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Subacute Thyroiditis from COVID-19 Infection: A Case Report and Review of Literature

Author

Khatri, Akshay, Charlap, Esti, and Kim, Angela

Abstract

Introduction:The novel severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) virus has led to the ongoing Coronavirus disease 2019 (COVID-19) disease pandemic. There are increasing reports of extrapulmonary clinical features of COVID-19, either as initial presentations or sequelae of disease. We report a patient diagnosed with subacute thyroiditis precipitated by COVID-19 infection, as well as review the literature of similar cases. Case Presentation:A 41-year-old female with no significant personal or family history of endocrinologic disorders presented with clinical features of thyroiditis that began after COVID-19 infection. Clinical, laboratory, and radiologic findings were indicative of subacute thyroiditis. Workup for potential triggers other than SARS-CoV-2 was negative. Discussion/Conclusion:We compared the clinical and diagnostic findings of our patient with other well-documented cases of subacute thyroiditis presumed to be triggered by SARS-CoV-2 viral infection. We also reviewed the literature related to the potential mechanisms leading to thyroiditis. Clinicians must be aware of the possibility of thyroid dysfunction after COVID-19 infection. Early recognition and timely anti-inflammatory therapy help in successful management.

Published
2021
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49. Addition of Oral Fosfomycin to Antimicrobial Salvage Therapy for Persistent Vancomycin-Resistant Enterococcal Bacteremia.

Author

Khatri, Akshay M, Anderson, Anthony D, and Camargo, Jose F

Subjects
*ANTIBIOTICS, *ENTEROCOCCAL infections, *BACTEREMIA, *VANCOMYCIN resistance, *TREATMENT effectiveness, *ENTEROCOCCUS, *DAPTOMYCIN
Abstract

The article describes the cases of two hematological patients with persistent vancomycin-resistant Enterococcus faecium (VRE) bacteremia that resolved with the addition of oral fosfomycin to antimicrobial salvage therapy. Topics covered include the medical history of the patients, the purpose of adding oral fosfomycin to antimicrobial salvage therapy in these 2 cases, and patient outcomes following treatment.

Published
2022
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