Search

Your search keyword '"Kharasch, Evan D."' showing total 1,051 results
Start Over Author "Kharasch, Evan D."
1,051 results on '"Kharasch, Evan D."'

14. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy

Author

Robinson, Katherine M., primary, Eum, Seenae, additional, Desta, Zeruesenay, additional, Tyndale, Rachel F., additional, Gaedigk, Andrea, additional, Crist, Richard C., additional, Haidar, Cyrine E., additional, Myers, Alan L., additional, Samer, Caroline F., additional, Somogyi, Andrew A., additional, Zubiaur, Pablo, additional, Iwuchukwu, Otito F., additional, Whirl‐Carrillo, Michelle, additional, Klein, Teri E., additional, Caudle, Kelly E., additional, Donnelly, Roseann S., additional, and Kharasch, Evan D., additional

Published
2024
Full Text
View/download PDF

15. Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover‐design trial.

Author

Hincker, Alexander, Reschke, Matthew, Ginosar, Yehuda, Kagan, Leonid, Kharasch, Evan D., Siemiątkowska, Anna, Park, Celine, Bakos, Kristopher, Ben‐Abdallah, Arbi, and Haroutounian, Simon

Subjects
PAIN threshold, LUMBAR pain, POSTOPERATIVE pain, METHADONE hydrochloride, MORPHINE
Abstract

Aims: Epidural opioids can provide effective analgesia for acute postoperative pain. Due to its unique physicochemical properties and long systemic elimination half‐life, epidural methadone may provide lasting analgesia with minimal adverse effects; however, human studies are lacking. The aim of the study was to test the hypothesis that epidural methadone would exhibit greater segmental analgesia (analgesia at the dermatome of injection vs. distant dermatomes) than epidural morphine. Methods: In a prospective, randomized, double‐blinded, crossover study, thirteen healthy volunteers received a 4‐mg epidural bolus of methadone or morphine at L3–L4 and underwent repeated assessment of dermatomal heat pain tolerance and pressure pain threshold at lumbar (L3) and trigeminal (V2) dermatomes, pupil diameter, respiratory parameters and venous opioid concentration for 24 h. The primary outcome was selective (lumbar vs. trigeminal) segmental analgesia for heat pain, as a marker of a spinal analgesic mechanism. Results: The degree of segmental analgesia to heat pain tolerance was not different between morphine and methadone (P =.09), although morphine (P =.0009) but not methadone (P =.81) produced significant analgesia to heat pain at the lumbar vs. trigeminal dermatome over 0–12 h. Morphine overall provided longer lasting analgesia to heat pain vs. methadone (24 vs. 2 h, respectively). Morphine elicited greater systemic effects, including miosis (P =.009) and opioid‐related adverse effects (P =.002). Conclusions: These results suggest that, with equal epidural doses, both methadone and morphine produced analgesia and methadone did not produce greater segmental effects than morphine. Epidural methadone provided a more favourable adverse effect profile. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Cover

Author

Hannam, Jacqueline A., primary, Murto, Kimmo T., additional, Anderson, Brian J., additional, Dembo, Gregory, additional, and Kharasch, Evan D., additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results